IL93682A - Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them - Google Patents

Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them

Info

Publication number: IL93682A
Authority: IL; Israel
Prior art keywords: compounds; accordance; micrograms; hypericin; wis
Prior art date: 1989-03-16

Application number

IL9368290A

Other languages

English (en)

Hebrew (he)

Original Assignee

Yeda Res & Dev

Univ New York

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-16

Filing date

1990-03-08

Publication date

1996-06-18

1990-03-08 Application filed by Yeda Res & Dev, Univ New York filed Critical Yeda Res & Dev

1996-06-18 Publication of IL93682A publication Critical patent/IL93682A/en

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 13
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239000003814 drug Substances 0.000 title claims description 11
238000004519 manufacturing process Methods 0.000 title claims description 7
125000003367 polycyclic group Chemical group 0.000 title description 8
239000003443 antiviral agent Substances 0.000 claims abstract description 18
241000124008 Mammalia Species 0.000 claims abstract description 14
150000001875 compounds Chemical class 0.000 claims description 187
239000000203 mixture Substances 0.000 claims description 38
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230000009385 viral infection Effects 0.000 claims description 9
125000000217 alkyl group Chemical group 0.000 claims description 6
239000003937 drug carrier Substances 0.000 claims description 5
239000003085 diluting agent Substances 0.000 claims description 4
229910052739 hydrogen Inorganic materials 0.000 claims description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
239000006201 parenteral dosage form Substances 0.000 claims description 2
125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
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238000007911 parenteral administration Methods 0.000 claims 1
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238000000034 method Methods 0.000 abstract description 15
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VVEKCQAFOLKNKB-UHFFFAOYSA-N 1,3,8-trihydroxyanthraquinone Chemical compound C1=CC=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1O VVEKCQAFOLKNKB-UHFFFAOYSA-N 0.000 description 4
MGRRGKWPEVFJSH-UHFFFAOYSA-N 10-(10-oxoanthracen-9-ylidene)anthracen-9-one Chemical compound C12=CC=CC=C2C(=O)C2=CC=CC=C2C1=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MGRRGKWPEVFJSH-UHFFFAOYSA-N 0.000 description 4
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229930002330 retinoic acid Natural products 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
231100000004 severe toxicity Toxicity 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000001119 stannous chloride Substances 0.000 description 1
235000011150 stannous chloride Nutrition 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000008685 targeting Effects 0.000 description 1
ARGOFCSACXCMNN-UHFFFAOYSA-N tetracene-2-carboxamide Chemical compound C1=CC=CC2=CC3=CC4=CC(C(=O)N)=CC=C4C=C3C=C21 ARGOFCSACXCMNN-UHFFFAOYSA-N 0.000 description 1
UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
QGVNJRROSLYGKF-UHFFFAOYSA-N thiobarbital Chemical compound CCC1(CC)C(=O)NC(=S)NC1=O QGVNJRROSLYGKF-UHFFFAOYSA-N 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000003868 tissue accumulation Effects 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
230000014723 transformation of host cell by virus Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
229960001727 tretinoin Drugs 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
241000712461 unidentified influenza virus Species 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
239000005723 virus inoculator Substances 0.000 description 1
238000010792 warming Methods 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IL9368290A 1989-03-16 1990-03-08 Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them IL93682A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US32417789A	1989-03-16	1989-03-16
US41716389A	1989-10-04	1989-10-04
US48851890A	1990-02-27	1990-02-27

Publications (1)

Publication Number	Publication Date
IL93682A true IL93682A (en)	1996-06-18

Family

ID=27406317

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9368290A IL93682A (en)	1989-03-16	1990-03-08	Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them

Country Status (11)

Country	Link
US (1)	US6150414A (de)
EP (1)	EP0426785B1 (de)
JP (1)	JPH04504849A (de)
AT (1)	ATE170399T1 (de)
AU (1)	AU640131B2 (de)
CA (1)	CA2029863C (de)
DE (1)	DE69032613T2 (de)
DK (1)	DK0426785T3 (de)
ES (1)	ES2123499T3 (de)
IL (1)	IL93682A (de)
WO (1)	WO1990010438A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1746392A (en) *	1991-04-10	1992-11-17	Octamer, Inc.	A method for inhibition of retroviral replication
US6576784B1 (en) *	1993-05-27	2003-06-10	Yeda Research And Development Co. Ltd.	Antiviral agents
IL121440A0 (en)	1997-07-31	1998-01-04	Yeda Res & Dev	The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
WO2000039304A2 (en)	1998-12-31	2000-07-06	Chiron Corporation	Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
EP1980617A1 (de)	1998-12-31	2008-10-15	Novartis Vaccines and Diagnostics, Inc.	Verbesserte Expression von HIV-Polypeptiden und Herstellung virusähnlicher Partikel
AU2596600A (en)	1998-12-31	2000-07-31	Chiron Corporation	Modified hiv env polypeptides
IL150457A0 (en) *	2000-01-31	2002-12-01	Yeda Res & Dev	Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents
CA2452015C (en)	2001-07-05	2012-07-03	Chiron Corporation	Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
EP1427806A4 (de)	2001-08-31	2006-04-26	Chiron Corp	Antigene hiv-typ-b-polypeptide codierende polynukleotide, polypeptide und verwendungen davon
US20030170614A1 (en)	2001-08-31	2003-09-11	Megede Jan Zur	Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
JP4076749B2 (ja) *	2001-10-15	2008-04-16	富士フイルム株式会社	導電性有機化合物及び電子素子
WO2016145279A2 (en) *	2015-03-12	2016-09-15	Stc.Unm	Compositions and methods that inhibit quorum sensing
JP6890616B2 (ja) *	2016-03-01	2021-06-18	ソリジェニックスインコーポレーテッド	合成ハイペリシンを製造するためのシステムおよび方法
US11807623B2 (en)	2017-11-30	2023-11-07	Arrakis Therapeutics, Inc.	Nucleic acid-binding photoprobes and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2707704A (en) *	1951-09-29	1955-05-03	Schenley Ind Inc	Process for the preparation of hypericin
US3974186A (en) *	1970-05-14	1976-08-10	Richardson-Merrell Inc.	Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones
US4540700A (en) *	1982-04-15	1985-09-10	Alcon Laboratories, Inc.	Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4670265A (en) *	1983-07-22	1987-06-02	Sydiskis Robert J	Aloe emodin and other anthraquinones and anthraquinone-like compounds from plants virucidal against herpes simplex viruses
US4724232A (en) *	1985-03-16	1988-02-09	Burroughs Wellcome Co.	Treatment of human viral infections
WO1987001284A1 (en) *	1985-08-26	1987-03-12	United States Of America, Represented By The Unite	Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
IL79661A (en) *	1986-08-08	1991-01-31	Yeda Res & Dev	Antiviral composition containing hypericin or pseudohypericin
US4898891A (en) *	1987-08-07	1990-02-06	Yeda Research And Development Company Ltd.	Antiviral compositions
EP0332679B1 (de) *	1987-08-10	1993-06-16	New York University	Antivirale zusammensetzungen mit aromatischen polycyclischen dionen sowie methode zur behandlung retroviraler infektionen
AU3294289A (en) *	1988-03-23	1989-10-16	New York University	Antiviral composition containing aromatic polycyclic diones and nucleoside analogs and method for treating retrovirus infections
JPH0244231A (ja) *	1988-08-04	1990-02-14	Fuji Electric Co Ltd	中和滴定装置

1990
- 1990-03-08 IL IL9368290A patent/IL93682A/en not_active IP Right Cessation
- 1990-03-16 AU AU53387/90A patent/AU640131B2/en not_active Ceased
- 1990-03-16 AT AT90905295T patent/ATE170399T1/de not_active IP Right Cessation
- 1990-03-16 JP JP90505265A patent/JPH04504849A/ja active Pending
- 1990-03-16 WO PCT/US1990/001463 patent/WO1990010438A1/en not_active Ceased
- 1990-03-16 CA CA002029863A patent/CA2029863C/en not_active Expired - Fee Related
- 1990-03-16 ES ES90905295T patent/ES2123499T3/es not_active Expired - Lifetime
- 1990-03-16 EP EP90905295A patent/EP0426785B1/de not_active Expired - Lifetime
- 1990-03-16 DE DE69032613T patent/DE69032613T2/de not_active Expired - Fee Related
- 1990-03-16 DK DK90905295T patent/DK0426785T3/da active
1992
- 1992-11-02 US US07/970,229 patent/US6150414A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU5338790A (en)	1990-10-09
AU640131B2 (en)	1993-08-19
EP0426785A4 (en)	1991-11-13
EP0426785A1 (de)	1991-05-15
EP0426785B1 (de)	1998-09-02
DK0426785T3 (da)	1999-05-31
CA2029863C (en)	2001-10-30
ATE170399T1 (de)	1998-09-15
US6150414A (en)	2000-11-21
CA2029863A1 (en)	1990-09-17
JPH04504849A (ja)	1992-08-27
DE69032613D1 (de)	1998-10-08
DE69032613T2 (de)	1999-02-25
WO1990010438A1 (en)	1990-09-20
ES2123499T3 (es)	1999-01-16

Legal Events

Date	Code	Title
1996-11-14	FF	Patent granted
1997-03-18	KB	Patent renewed
1997-06-10	KB	Patent renewed
2000-08-13	KB	Patent renewed
2004-05-12	KB	Patent renewed
2009-02-11	MM9K	Patent not in force due to non-payment of renewal fees
2010-04-14	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5047435A (en)	1991-09-10	Antiviral compositions containing aromatic polycyclic diones and method for treating retrovirus infections
Sarin et al.	1987	Inhibition of replication of the etiologic agent of acquired immune deficiency syndrome (human T-lymphotropic retrovirus/lymphadenopathy-associated virus) by avarol and avarone
Lin et al.	1989	Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol
US5679828A (en)	1997-10-21	Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US5521161A (en)	1996-05-28	Method of treating HIV in humans by administration of ddI and hydroxycarbamide
AU640131B2 (en)	1993-08-19	Compositions and methods for treating viral infections
US4916122A (en)	1990-04-10	3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
Royer et al.	1991	Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol
AU8230091A (en)	1992-03-02	Hexa-n-(o-hydroxybenzyl) neomycin b for inhibiting human retroviruses and for the treatment of aids
EP0332679B1 (de)	1993-06-16	Antivirale zusammensetzungen mit aromatischen polycyclischen dionen sowie methode zur behandlung retroviraler infektionen
WO2005112929A2 (en)	2005-12-01	Anti-hiv-1 activity of betulinol derivatives
WO1989009056A1 (en)	1989-10-05	Antiviral composition containing aromatic polycyclic diones and nucleoside analogs and method for treating retrovirus infections
US5026732A (en)	1991-06-25	Use of avarone for the control of AIDS and ARC
WO1989009055A1 (en)	1989-10-05	Antiviral composition containing aromatic polycyclic diones and nucleoside analogs and method for treating retrovirus infections
IL87424A (en)	1994-02-27	Pharmaceuticals containing hypericin and / or pseudo-hypericin, for the treatment of infections caused by retroviruses
US20050159390A1 (en)	2005-07-21	Treatment and prevention of HIV and other viral infections
EP1143981A1 (de)	2001-10-17	Behandlung und vorbeugung von hiv- und anderen virus infektionen
US5001162A (en)	1991-03-19	Use of avarone for the control of adult T-cell leukemia/lymphoma
AU718325B2 (en)	2000-04-13	Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread
JPH02504283A (ja)	1990-12-06	芳香族多環式ジオン化合物とヌクレオシド類似化合物とを含む抗ウイルス性組成物及びレトロウイルス感染を治療するための方法