IL94254A - 5ht3 antagonist heterocyclicguanidines - Google Patents

5ht3 antagonist heterocyclicguanidines

Info

Publication number
IL94254A
IL94254A IL9425490A IL9425490A IL94254A IL 94254 A IL94254 A IL 94254A IL 9425490 A IL9425490 A IL 9425490A IL 9425490 A IL9425490 A IL 9425490A IL 94254 A IL94254 A IL 94254A
Authority
IL
Israel
Prior art keywords
indol
thiazole
product
guanidinomethyl
compound
Prior art date
Application number
IL9425490A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL94254A publication Critical patent/IL94254A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
IL9425490A 1989-05-19 1990-05-02 5ht3 antagonist heterocyclicguanidines IL94254A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/349,189 US4963689A (en) 1989-05-19 1989-05-19 Heterocyclicguanidines as 5HT3 antagonists

Publications (1)

Publication Number Publication Date
IL94254A true IL94254A (en) 1994-05-30

Family

ID=23371270

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9425490A IL94254A (en) 1989-05-19 1990-05-02 5ht3 antagonist heterocyclicguanidines

Country Status (19)

Country Link
US (1) US4963689A (fr)
EP (1) EP0397364B1 (fr)
JP (1) JPH0635454B2 (fr)
KR (1) KR920003927B1 (fr)
AT (1) ATE92062T1 (fr)
AU (1) AU615385B2 (fr)
CA (1) CA2016182C (fr)
DE (1) DE69002384T2 (fr)
DK (1) DK0397364T3 (fr)
ES (1) ES2058795T3 (fr)
FI (1) FI902291A7 (fr)
HU (1) HUT58063A (fr)
IE (1) IE62935B1 (fr)
IL (1) IL94254A (fr)
MY (1) MY105555A (fr)
NO (1) NO902029L (fr)
NZ (1) NZ233576A (fr)
PT (1) PT93979B (fr)
ZA (1) ZA903478B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140034A (en) * 1989-03-14 1992-08-18 Merck Sharp & Dohme Ltd. Five-membered ring systems with bonded imidazolyl ring substituents
WO1994006791A1 (fr) * 1992-09-14 1994-03-31 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive de thiazole condense, son procede de production et composition pharmaceutique le contenant
EP0749966A4 (fr) * 1994-03-11 1997-07-02 Yamanouchi Pharma Co Ltd Agoniste de recepteur 5-ht 3, nouveau derive de thiazole et intermediaire destine a son obtention
GB9406857D0 (en) * 1994-04-07 1994-06-01 Sandoz Ltd Improvements in or relating to organic compounds
US5887415A (en) * 1995-05-11 1999-03-30 Bernard Matthews Plc Cooked, extruded meat product comprising additive
US5811425A (en) * 1997-03-04 1998-09-22 Abbott Laboratories Heterocyclic compounds as COX-2 inhibitors
DE102005027193A1 (de) * 2005-06-06 2006-12-07 Wilhelm Stahlecker Gmbh Zwillingseinheit mit zwei Streckwerken für eine Spinnmaschine
EP2253316B1 (fr) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistes du récepteur 5-HT3 de la sérotonine pour une utilisation dans le traitement ou la prévention d'une pathologie de l'oreille interne avec déficits vestibulaires
JP5955767B2 (ja) 2009-05-20 2016-07-20 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 損傷性前庭障害の処置における使用のためのセロトニン５−ｈｔ３受容体拮抗薬
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031165A (en) * 1965-08-18 1966-05-25 Wellcome Found Guanidines, isoureas and isothioureas
GB1305549A (fr) * 1969-10-29 1973-02-07
DE2739723A1 (de) * 1977-09-03 1979-03-08 Merck Patent Gmbh 2-guanidinomethyl-indoline und verfahren zu ihrer herstellung
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds

Also Published As

Publication number Publication date
IE62935B1 (en) 1995-03-08
KR900018054A (ko) 1990-12-20
EP0397364B1 (fr) 1993-07-28
JPH0635454B2 (ja) 1994-05-11
FI902291A0 (fi) 1990-05-08
IE901664L (en) 1990-11-09
NO902029D0 (no) 1990-05-08
ZA903478B (en) 1991-12-24
FI902291A7 (fi) 1990-11-10
AU5476790A (en) 1990-11-15
CA2016182A1 (fr) 1990-11-09
ATE92062T1 (de) 1993-08-15
US4963689A (en) 1990-10-16
PT93979A (pt) 1991-01-08
HU902976D0 (en) 1990-09-28
NZ233576A (en) 1991-06-25
PT93979B (pt) 1996-11-29
MY105555A (en) 1994-10-31
DE69002384T2 (de) 1993-11-18
DK0397364T3 (da) 1993-09-27
NO902029L (no) 1990-11-12
JPH0311070A (ja) 1991-01-18
KR920003927B1 (ko) 1992-05-18
CA2016182C (fr) 1996-03-12
ES2058795T3 (es) 1994-11-01
AU615385B2 (en) 1991-09-26
EP0397364A1 (fr) 1990-11-14
HUT58063A (en) 1992-01-28
DE69002384D1 (de) 1993-09-02

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Legal Events

Date Code Title Description
KB Patent renewed
RH Patent void