IL94317A - Substituted aminoalkylphosphinic acids, their production and pharmaceutical compositions containing them - Google Patents

Substituted aminoalkylphosphinic acids, their production and pharmaceutical compositions containing them

Info

Publication number: IL94317A
Authority: IL; Israel
Prior art keywords: methyl; hydroxy; denotes; phosphinic acid; hydrogen
Prior art date: 1989-05-13

Application number

IL94317A

Other languages

English (en)

Other versions

IL94317A0 (en

Inventor

Roger Graham Dr Hall

Ludwig Dr Maier

Wolfgang Dr Froestl

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-13

Filing date

1990-05-07

Publication date

1997-07-13

1990-05-07 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1991-03-10 Publication of IL94317A0 publication Critical patent/IL94317A0/xx

1997-07-13 Publication of IL94317A publication Critical patent/IL94317A/xx

Links

239000002253 acid Substances 0.000 title abstract 2
150000007513 acids Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
FUUPFUIGNBPCAY-UHFFFAOYSA-N (3-amino-2-hydroxypropyl)-methylphosphinic acid Chemical compound CP(O)(=O)CC(O)CN FUUPFUIGNBPCAY-UHFFFAOYSA-N 0.000 abstract 1
CJTIGOOCRLKWAP-UHFFFAOYSA-N (3-amino-2-oxopropyl)-methylphosphinic acid Chemical compound CP(O)(=O)CC(=O)CN CJTIGOOCRLKWAP-UHFFFAOYSA-N 0.000 abstract 1
206010013754 Drug withdrawal syndrome Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000008238 Muscle Spasticity Diseases 0.000 abstract 1
208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salts Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000003863 ammonium salts Chemical class 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000001663 anti-spastic effect Effects 0.000 abstract 1
206010008129 cerebral palsy Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
208000004296 neuralgia Diseases 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
NHVRIDDXGZPJTJ-UHFFFAOYSA-N skf-97,541 Chemical compound CP(O)(=O)CCCN NHVRIDDXGZPJTJ-UHFFFAOYSA-N 0.000 abstract 1
208000018198 spasticity Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/36—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Luminescent Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Detergent Compositions (AREA)

IL94317A 1989-05-13 1990-05-07 Substituted aminoalkylphosphinic acids, their production and pharmaceutical compositions containing them IL94317A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898911017A GB8911017D0 (en)	1989-05-13	1989-05-13	Substituted aminoalkylphosphinic acids

Publications (2)

Publication Number	Publication Date
IL94317A0 IL94317A0 (en)	1991-03-10
IL94317A true IL94317A (en)	1997-07-13

Family

ID=10656689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL94317A IL94317A (en)	1989-05-13	1990-05-07	Substituted aminoalkylphosphinic acids, their production and pharmaceutical compositions containing them

Country Status (24)

Country	Link
EP (1)	EP0399949B1 (de)
JP (1)	JP2930366B2 (de)
KR (1)	KR0159501B1 (de)
AT (1)	ATE121095T1 (de)
AU (1)	AU629335B2 (de)
CA (1)	CA2016631C (de)
DD (1)	DD294265A5 (de)
DE (1)	DE69018514T2 (de)
DK (1)	DK0399949T3 (de)
ES (1)	ES2070303T3 (de)
FI (1)	FI94416C (de)
GB (1)	GB8911017D0 (de)
GR (1)	GR3015770T3 (de)
HR (1)	HRP940178A2 (de)
HU (1)	HU206885B (de)
IE (1)	IE66165B1 (de)
IL (1)	IL94317A (de)
MX (1)	MX20639A (de)
NO (1)	NO176761C (de)
NZ (1)	NZ233647A (de)
PT (1)	PT94014B (de)
SI (1)	SI9010917B (de)
YU (1)	YU91790A (de)
ZA (1)	ZA903611B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0543780A3 (en) *	1991-11-21	1993-09-01	Ciba-Geigy Ag	Novel aminoalkanephosphinic acids and their salts
PL189872B1 (pl)	1996-07-24	2005-10-31	Warner Lambert Co	Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
BR9912062A (pt)	1998-07-15	2001-04-03	Hassan Jomaa	Compostos orgânicos fosforosos e seu uso
GB9906882D0 (en) *	1999-03-25	1999-05-19	Novartis Ag	Organic compounds
SE9904508D0 (sv)	1999-12-09	1999-12-09	Astra Ab	New compounds
SE9904507D0 (sv)	1999-12-09	1999-12-09	Astra Ab	New compounds
US7319095B2 (en)	1999-12-09	2008-01-15	Astrazeneca Ab	Use of GABAB receptor agonists
SE0102055D0 (sv) *	2001-06-08	2001-06-08	Astrazeneca Ab	New Compounds
AR033779A1 (es)	2001-06-08	2004-01-07	Astrazeneca Ab	Compuestos utiles en la enfermedad de reflujo
PL1691811T3 (pl)	2003-12-11	2014-12-31	Sunovion Pharmaceuticals Inc	Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
SE0401653D0 (sv)	2004-06-24	2004-06-24	Astrazeneca Ab	New compounds
CA2632021A1 (en)	2005-12-23	2007-06-28	Astrazeneca Ab	Gaba-b receptor modulators
KR20080091452A (ko)	2005-12-23	2008-10-13	아스트라제네카 아베	위장 장애의 치료를 위한 이미다졸 유도체
DE102008056228A1 (de) *	2008-11-06	2010-05-12	Clariant International Limited	Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, deren Salze und Ester und ihre Verwendung
DE102008056339A1 (de) *	2008-11-07	2010-05-12	Clariant International Limited	Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
WO2011113904A1 (en)	2010-03-17	2011-09-22	INSERM (Institut National de la Santé et de la Recherche Médicale)	Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
DK2621282T3 (da)	2010-09-28	2020-05-04	Univ California	Gaba-agonister i behandlingen af forstyrrelser forbundet med metabolisk syndrom og gaba-kombinationer i behandling eller profylakse af type i diabetes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3311475C1 (de) *	1983-03-29	1984-08-16	Siemens AG, 1000 Berlin und 8000 München	Mikroprogramm-Steuereinrichtung
DE3312165A1 (de) *	1983-04-02	1984-10-04	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von phosphinothricin
GB8728483D0 (en) *	1987-12-04	1988-01-13	Ciba Geigy Ag	Chemical compounds
GB8820266D0 (en) *	1988-08-26	1988-09-28	Smith Kline French Lab	Compounds

1989
- 1989-05-13 GB GB898911017A patent/GB8911017D0/en active Pending
1990
- 1990-05-07 AU AU54809/90A patent/AU629335B2/en not_active Ceased
- 1990-05-07 IL IL94317A patent/IL94317A/xx not_active IP Right Cessation
- 1990-05-08 DK DK90810346.8T patent/DK0399949T3/da active
- 1990-05-08 DE DE69018514T patent/DE69018514T2/de not_active Expired - Fee Related
- 1990-05-08 ES ES90810346T patent/ES2070303T3/es not_active Expired - Lifetime
- 1990-05-08 EP EP90810346A patent/EP0399949B1/de not_active Expired - Lifetime
- 1990-05-08 AT AT90810346T patent/ATE121095T1/de not_active IP Right Cessation
- 1990-05-09 MX MX2063990A patent/MX20639A/es unknown
- 1990-05-10 YU YU91790A patent/YU91790A/sh unknown
- 1990-05-10 SI SI9010917A patent/SI9010917B/sl unknown
- 1990-05-11 ZA ZA903611A patent/ZA903611B/xx unknown
- 1990-05-11 KR KR1019900006687A patent/KR0159501B1/ko not_active Expired - Fee Related
- 1990-05-11 FI FI902368A patent/FI94416C/fi not_active IP Right Cessation
- 1990-05-11 CA CA002016631A patent/CA2016631C/en not_active Expired - Lifetime
- 1990-05-11 NO NO902109A patent/NO176761C/no not_active IP Right Cessation
- 1990-05-11 NZ NZ233647A patent/NZ233647A/en unknown
- 1990-05-11 IE IE171690A patent/IE66165B1/en not_active IP Right Cessation
- 1990-05-11 DD DD90340576A patent/DD294265A5/de not_active IP Right Cessation
- 1990-05-11 PT PT94014A patent/PT94014B/pt not_active IP Right Cessation
- 1990-05-11 HU HU903012A patent/HU206885B/hu not_active IP Right Cessation
- 1990-05-14 JP JP2121395A patent/JP2930366B2/ja not_active Expired - Fee Related
1994
- 1994-03-18 HR HRP-917/90A patent/HRP940178A2/hr not_active Application Discontinuation
1995
- 1995-04-13 GR GR950400747T patent/GR3015770T3/el unknown

Also Published As

Publication number	Publication date
NO176761C (no)	1995-05-24
JP2930366B2 (ja)	1999-08-03
NZ233647A (en)	1992-08-26
ZA903611B (en)	1991-02-27
PT94014B (pt)	1996-12-31
GR3015770T3 (en)	1995-07-31
DD294265A5 (de)	1991-09-26
IE66165B1 (en)	1995-12-13
CA2016631A1 (en)	1990-11-13
MX20639A (es)	1993-12-01
GB8911017D0 (en)	1989-06-28
HU903012D0 (en)	1990-09-28
EP0399949A1 (de)	1990-11-28
YU91790A (sh)	1992-07-20
FI902368A0 (fi)	1990-05-11
HUT53656A (en)	1990-11-28
NO902109D0 (no)	1990-05-11
KR0159501B1 (ko)	1999-01-15
NO176761B (no)	1995-02-13
ATE121095T1 (de)	1995-04-15
CA2016631C (en)	2000-08-29
FI94416C (fi)	1995-09-11
FI94416B (fi)	1995-05-31
DE69018514D1 (de)	1995-05-18
JPH0395195A (ja)	1991-04-19
NO902109L (no)	1990-11-14
AU629335B2 (en)	1992-10-01
PT94014A (pt)	1991-01-08
KR900018124A (ko)	1990-12-20
IE901716L (en)	1990-11-13
HRP940178A2 (en)	1996-08-31
ES2070303T3 (es)	1995-06-01
IL94317A0 (en)	1991-03-10
HU206885B (en)	1993-01-28
SI9010917B (sl)	1999-10-31
DE69018514T2 (de)	1995-09-21
DK0399949T3 (da)	1995-07-03
SI9010917A (en)	1997-06-30
EP0399949B1 (de)	1995-04-12
AU5480990A (en)	1990-11-15

Legal Events

Date	Code	Title
1998-02-08	FF	Patent granted
1998-04-05	KB	Patent renewed
2000-08-31	KB	Patent renewed
2004-06-20	KB	Patent renewed
2008-07-09	KB	Patent renewed
2011-04-28	EXP	Patent expired

Publication	Publication Date	Title
IL94317A (en)	1997-07-13	Substituted aminoalkylphosphinic acids, their production and pharmaceutical compositions containing them
ZA944884B (en)	1995-02-20	Derivatives of valproic acid amides and 2-valproenoic acid amides method of making and use thereof as anticonvulsant agent
MX9604020A (es)	1997-03-29	Arilalquildiazinonas.
ATE20467T1 (de)	1986-07-15	Tromboxane synthetase-inhibitoren, verfahren zu deren herstellung, und deren pharmazeutische zusammenstellungen.
DE3375137D1 (en)	1988-02-11	Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
GEP20012555B (en)	2001-10-25	Pyrazine Compounds, Method for Its Production, Their Use As a Medicinal Means, Pharmaceutical Composition and Method for Treatment
MX9701292A (es)	1997-05-31	Compuestos espiro-azabiciclicos utiles en la terapia.
MY102866A (en)	1993-03-31	Amide derivatives.
AU636351B2 (en)	1993-04-29	N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments
MXPA03000547A (es)	2004-04-05	Uso de derivados de amidas de acido valproico y de acido 2-valproenico, para el tratamiento de manias en trastornos bipolares.
GR3023934T3 (en)	1997-09-30	New naphthalene amides and sulfonamides, process for their preparation and pharmaceutical compositions containing them
UA61124C2 (en)	2003-11-17	New pentasaccharides, a method for preparing thereof and pharmaceutical compositions containing them
UA66751C2 (en)	2004-06-15	Benzamides as medicament for treatment of neurodegenerative state, a method for the preparation thereof (variants), pharnaceutical composition for treatment of neurodegenerative states and a method for treatment
ZA916977B (en)	1992-06-24	Pharmaceutical compositions for use in treating aids
GR3021765T3 (en)	1997-02-28	Aminoalkylchomones, process for their preparation and pharmaceutical compositions containing them.
IE810901L (en)	1981-10-22	Naphthotriazoles.
ES2002113A6 (es)	1988-07-16	Procedimiento para la preparacion de derivados de 1-alquil-ergolinil-tiourea
ES8201575A1 (es)	1981-12-16	Procedimiento de obtencion de nuevos 2-aminoetanoles
ATE82289T1 (de)	1992-11-15	1-hydroxyalkylxanthine, verfahren zu ihrer herstellung und sie enthaltende medikamente.
AU659738B2 (en)	1995-05-25	New pyrrolothienopyrazine compounds, processes for the preparation thereof, and pharmaceutical compositions containing them
ATE43586T1 (de)	1989-06-15	Arphameninderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
TH14417A (th)	1994-07-29	กรรมวิธีสำหรับการเตรียมซับสทิทิวเทด สเทอรอยคอล ไดอีน