IL94862A - History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It - Google Patents

History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It

Info

Publication number: IL94862A
Authority: IL; Israel
Prior art keywords: compound; medium; nutrient medium; mannitol; milliliters
Prior art date: 1989-06-30

Application number

IL9486290A

Other languages

English (en)

Hebrew (he)

Other versions

IL94862A0 (en

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-30

Filing date

1990-06-25

Publication date

1994-10-07

1990-03-12 Priority claimed from US07/492,026 external-priority patent/US5021341A/en

1990-06-25 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1991-04-15 Publication of IL94862A0 publication Critical patent/IL94862A0/xx

1994-10-07 Publication of IL94862A publication Critical patent/IL94862A/en

Links

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WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
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LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
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NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
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239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
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229910052708 sodium Inorganic materials 0.000 description 1
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235000017550 sodium carbonate Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
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WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

IL9486290A 1989-06-30 1990-06-25 History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It IL94862A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US37441689A	1989-06-30	1989-06-30
US49202590A	1990-03-12	1990-03-12
US49202490A	1990-03-12	1990-03-12
US07/492,026 US5021341A (en)	1990-03-12	1990-03-12	Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol

Publications (2)

Publication Number	Publication Date
IL94862A0 IL94862A0 (en)	1991-04-15
IL94862A true IL94862A (en)	1994-10-07

Family

ID=27503114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9486290A IL94862A (en)	1989-06-30	1990-06-25	History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It

Country Status (16)

Country	Link
EP (1)	EP0405997B1 (de)
JP (1)	JPH0764873B2 (de)
KR (1)	KR0145693B1 (de)
AT (1)	ATE109160T1 (de)
AU (1)	AU639698B2 (de)
CA (1)	CA2020062C (de)
CY (1)	CY1962A (de)
DE (1)	DE69011006T2 (de)
DK (1)	DK0405997T3 (de)
ES (1)	ES2057413T3 (de)
FI (1)	FI93647C (de)
HK (1)	HK209496A (de)
IL (1)	IL94862A (de)
NO (1)	NO178343C (de)
NZ (1)	NZ234225A (de)
PT (1)	PT94555B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2037957A1 (en) *	1990-03-12	1991-09-13	Merck & Co., Inc.	N-acylated cyclohexapeptide compounds
US5310873A (en) *	1990-03-12	1994-05-10	Merck & Co., Inc.	Cyclohexapeptide compound
US5330973A (en)	1990-03-19	1994-07-19	Merck & Co., Inc.	Lipopeptide derivatives
JPH06502536A (ja) *	1990-10-09	1994-03-24	メルク　エンド　カンパニー　インコーポレーテッド	有機化合物の新規生物学的リン酸化方法
US5219985A (en) *	1990-10-31	1993-06-15	Merck & Co., Inc.	Antifungal agent
US5229363A (en) *	1991-02-19	1993-07-20	Merck & Co., Inc.	Cyclic hexapeptide compounds
US5369093A (en) *	1991-03-15	1994-11-29	Merck & Co., Inc.	Lipopeptide derivatives
US5336756A (en) *	1991-05-01	1994-08-09	Merck & Co., Inc.	Process for crystalline cyclic lipopeptides
US6030944A (en) *	1991-10-01	2000-02-29	Merck & Co., Inc.	Cyclohexapeptidyl bisamine compounds
US5348940A (en) *	1991-10-01	1994-09-20	Merck & Co., Inc.	Cyclohexapeptidyl hydroxypropionitrile compounds
EP0539088B1 (de) *	1991-10-17	1996-07-17	Merck & Co. Inc.	Echinocandin-B-Derivat
US5914313A (en) *	1991-10-17	1999-06-22	Merck & Co., Inc.	1- 4-hydroxy-5-aminoethyloxy-N2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3-hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof
US5378804A (en) *	1993-03-16	1995-01-03	Merck & Co., Inc.	Aza cyclohexapeptide compounds
CA2161149A1 (en) *	1993-05-04	1994-11-10	James M. Balkovec	Cyclohexapeptidyl aminoalkyl ethers
EP1646370A1 (de) *	2003-07-11	2006-04-19	Glaxo Group Limited	Pharmazeutische formulierungen
CN102618604B (zh) *	2011-01-31	2014-09-03	上海天伟生物制药有限公司	一种环脂肽化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1183127A (en) *	1979-12-13	1985-02-26	Manuel Debono	Process for the preparation of derivatives of cyclic peptide nuclei
CA1182812A (en) *	1979-12-13	1985-02-19	Bernard J. Abbott	Process for the preparation of derivatives of cyclic peptide nuclei
JPS57501266A (de) *	1980-08-15	1982-07-22
DE3886001T2 (de) *	1987-10-07	1994-05-26	Merck & Co Inc	Fungizides Fermentationsprodukt.

1990
- 1990-06-25 IL IL9486290A patent/IL94862A/en unknown
- 1990-06-25 NZ NZ234225A patent/NZ234225A/xx unknown
- 1990-06-28 AU AU57973/90A patent/AU639698B2/en not_active Expired
- 1990-06-28 CA CA002020062A patent/CA2020062C/en not_active Expired - Lifetime
- 1990-06-28 FI FI903280A patent/FI93647C/fi active IP Right Grant
- 1990-06-29 PT PT94555A patent/PT94555B/pt not_active IP Right Cessation
- 1990-06-29 DK DK90307124.9T patent/DK0405997T3/da active
- 1990-06-29 AT AT90307124T patent/ATE109160T1/de not_active IP Right Cessation
- 1990-06-29 JP JP2172568A patent/JPH0764873B2/ja not_active Expired - Lifetime
- 1990-06-29 EP EP90307124A patent/EP0405997B1/de not_active Expired - Lifetime
- 1990-06-29 ES ES90307124T patent/ES2057413T3/es not_active Expired - Lifetime
- 1990-06-29 KR KR1019900009708A patent/KR0145693B1/ko not_active Expired - Lifetime
- 1990-06-29 DE DE69011006T patent/DE69011006T2/de not_active Expired - Lifetime
- 1990-06-29 NO NO902921A patent/NO178343C/no not_active IP Right Cessation
1996
- 1996-11-21 HK HK209496A patent/HK209496A/en not_active IP Right Cessation
1997
- 1997-07-04 CY CY196297A patent/CY1962A/xx unknown

Also Published As

Publication number	Publication date
DE69011006T2 (de)	1995-01-26
EP0405997A1 (de)	1991-01-02
NO178343B (no)	1995-11-27
JPH03163096A (ja)	1991-07-15
PT94555B (pt)	1997-02-28
CA2020062C (en)	1997-01-14
IL94862A0 (en)	1991-04-15
NO902921D0 (no)	1990-06-29
HK209496A (en)	1996-11-29
ES2057413T3 (es)	1994-10-16
JPH0764873B2 (ja)	1995-07-12
DK0405997T3 (da)	1994-10-31
AU639698B2 (en)	1993-08-05
DE69011006D1 (de)	1994-09-01
FI903280A0 (fi)	1990-06-28
FI93647C (fi)	1995-05-10
EP0405997B1 (de)	1994-07-27
KR910001068A (ko)	1991-01-30
PT94555A (pt)	1991-05-22
FI93647B (fi)	1995-01-31
CA2020062A1 (en)	1990-12-31
ATE109160T1 (de)	1994-08-15
CY1962A (en)	1997-07-04
NZ234225A (en)	1993-09-27
KR0145693B1 (ko)	1998-08-01
NO178343C (no)	1996-03-06
AU5797390A (en)	1991-01-03
NO902921L (no)	1991-01-02

Legal Events

Date	Code	Title
1996-10-16	KB	Patent renewed
2004-07-25	KB	Patent renewed
2008-11-03	KB	Patent renewed

Publication	Publication Date	Title
US5202309A (en)	1993-04-13	Antibiotic cyclopeptide fermentation product
US5021341A (en)	1991-06-04	Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
CA1333150C (en)	1994-11-22	Method for the control of pneumocystis carinii
US4931352A (en)	1990-06-05	Antifungal fermentation product
US5166135A (en)	1992-11-24	Method for the control of pneumocystis carinii
US5049546A (en)	1991-09-17	Antibiotic agents
CA2020062C (en)	1997-01-14	Antibiotic agent
US5194377A (en)	1993-03-16	Antibiotic agent
US4968608A (en)	1990-11-06	Process for antifungal fermentation product
US5198421A (en)	1993-03-30	Phosphorylated cyclic lipopeptide
EP0311193B1 (de)	1993-12-01	Fungizides Fermentationsprodukt
US5021403A (en)	1991-06-04	Antibiotic agents
US5306708A (en)	1994-04-26	Antibiotic agent
US5366880A (en)	1994-11-22	Antibiotic agent
EP0405998A1 (de)	1991-01-02	Antibiotische Verbindungen
US5162211A (en)	1992-11-10	Process for producing a cyclic lipopeptide employing zalerion arboricola
IE63841B1 (en)	1995-06-14	Antibiotic agent
US5137813A (en)	1992-08-11	Process for production of an antibiotic compound using zalerion arboricola