IL95309A - Cyclic peptides that are neurokinin A antagonists and pharmaceutical preparations containing them - Google Patents

Cyclic peptides that are neurokinin A antagonists and pharmaceutical preparations containing them

Info

Publication number: IL95309A
Authority: IL; Israel
Prior art keywords: phe; peptide derivative; trp; gly; gin
Prior art date: 1989-08-10

Application number

IL9530990A

Other languages

English (en)

Hebrew (he)

Other versions

IL95309A0 (en

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-10

Filing date

1990-08-07

Publication date

1995-07-31

1990-08-07 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1991-06-30 Publication of IL95309A0 publication Critical patent/IL95309A0/xx

1995-07-31 Publication of IL95309A publication Critical patent/IL95309A/en

Links

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125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
CTAPFRYPJLPFDF-UHFFFAOYSA-O hydron;1,2-oxazole Chemical class C=1C=[NH+]OC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-O 0.000 description 1
UWYVPFMHMJIBHE-OWOJBTEDSA-N hydroxymaleic acid group Chemical group O/C(/C(=O)O)=C/C(=O)O UWYVPFMHMJIBHE-OWOJBTEDSA-N 0.000 description 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
125000004464 hydroxyphenyl group Chemical group 0.000 description 1
150000007928 imidazolide derivatives Chemical class 0.000 description 1
229960003444 immunosuppressant agent Drugs 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
125000002346 iodo group Chemical group I* 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
229960003299 ketamine Drugs 0.000 description 1
150000003951 lactams Chemical class 0.000 description 1
GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 description 1
108010052968 leupeptin Proteins 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
239000011565 manganese chloride Substances 0.000 description 1
235000002867 manganese chloride Nutrition 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
108091005601 modified peptides Proteins 0.000 description 1
150000002763 monocarboxylic acids Chemical class 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
150000002825 nitriles Chemical class 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
238000005897 peptide coupling reaction Methods 0.000 description 1
230000010412 perfusion Effects 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
150000002994 phenylalanines Chemical class 0.000 description 1
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002243 precursor Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
230000007017 scission Effects 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
IJDNQMDRQITEOD-UHFFFAOYSA-N sec-butylidene Natural products CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
150000003354 serine derivatives Chemical class 0.000 description 1
229920000260 silastic Polymers 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000004945 silicone rubber Substances 0.000 description 1
WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
235000019254 sodium formate Nutrition 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000001117 sulphuric acid Substances 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
108060008037 tachykinin Proteins 0.000 description 1
IKRXSZUARJIXLZ-JTQLQIEISA-N tert-butyl n-[(2s)-1-[methoxy(methyl)amino]-4-methyl-1-oxopentan-2-yl]carbamate Chemical compound CON(C)C(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C IKRXSZUARJIXLZ-JTQLQIEISA-N 0.000 description 1
DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical compound OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 description 1
229950001139 timonacic Drugs 0.000 description 1
125000005147 toluenesulfonyl group Chemical group C=1(C(=CC=CC1)S(=O)(=O)*)C 0.000 description 1
230000036977 tonic contraction Effects 0.000 description 1
150000003628 tricarboxylic acids Chemical class 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical group C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
210000003708 urethra Anatomy 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Transplantation (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL9530990A 1989-08-10 1990-08-07 Cyclic peptides that are neurokinin A antagonists and pharmaceutical preparations containing them IL95309A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39223689A	1989-08-10	1989-08-10

Publications (2)

Publication Number	Publication Date
IL95309A0 IL95309A0 (en)	1991-06-30
IL95309A true IL95309A (en)	1995-07-31

Family

ID=23549831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9530990A IL95309A (en)	1989-08-10	1990-08-07	Cyclic peptides that are neurokinin A antagonists and pharmaceutical preparations containing them

Country Status (22)

Country	Link
US (1)	US5731286A (de)
EP (1)	EP0412542B1 (de)
JP (1)	JP2829779B2 (de)
KR (1)	KR0169123B1 (de)
CN (1)	CN1035056C (de)
AR (1)	AR246087A1 (de)
AT (1)	ATE132503T1 (de)
AU (1)	AU638264B2 (de)
CA (1)	CA2022740C (de)
DD (1)	DD297168A5 (de)
DE (1)	DE69024555T2 (de)
DK (1)	DK0412542T3 (de)
ES (1)	ES2084627T3 (de)
FI (1)	FI95913C (de)
GR (1)	GR3018984T3 (de)
HU (1)	HU206729B (de)
IE (1)	IE69382B1 (de)
IL (1)	IL95309A (de)
NO (1)	NO177715C (de)
NZ (1)	NZ234814A (de)
PT (1)	PT94952B (de)
ZA (1)	ZA906188B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA894533B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Neurokinin a antogonists
DE4034829A1 (de) *	1990-11-02	1992-05-07	Merck Patent Gmbh	Cyclopeptide
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5625060A (en) *	1991-05-03	1997-04-29	Elf Sanofi	Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present
EP0606222A1 (de) *	1991-08-08	1994-07-20	A. Menarini Industrie Farmaceutiche Riunite S.R.L.	Zyklische hexapeptide als tachykininantagonisten, verfahren zur herstellung und pharmazeutische zusammensetzungen
US5731285A (en) *	1992-04-15	1998-03-24	A. Menatini Industrie Farmaceutiche	Tachiquinine antagonist tricyclic compounds, preparation of same and pharmaceutical compositions containing such compounds
PT2408802T (pt) *	2009-03-16	2017-08-03	Governing Council Univ Toronto	Moléculas de aminoácido ciclicas e métodos para as preparar
US11072616B2 (en)	2015-11-11	2021-07-27	Universite De Montreal	Cyclic peptides targeting alpha-4-beta-7 integrin
ES2884107T3 (es)	2016-11-11	2021-12-10	Zealand Pharma As	Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7
US11286281B2 (en)	2017-05-10	2022-03-29	Zealand Pharma A/S	Homodetic cyclic peptides targeting alpha-4-beta-7 integrin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4742156A (en) *	1985-09-30	1988-05-03	Mcneilab, Inc.	Peptide antagonists of neurokinin B and opthalmic solutions containing them
US4665157A (en) *	1985-09-30	1987-05-12	Mcneilab, Inc.	Peptide antagonists of neurokinin B
DE3711335A1 (de) *	1987-04-03	1988-10-20	Merck Patent Gmbh	Aminosaeurederivate
GB8807246D0 (en) *	1988-03-25	1988-04-27	Merck Sharp & Dohme	Therapeutic agents
ZA894533B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Neurokinin a antogonists
FI97540C (fi) *	1989-11-06	1997-01-10	Sanofi Sa	Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2677361A1 (fr) *	1991-06-04	1992-12-11	Adir	Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

1990
- 1990-08-06 ZA ZA906188A patent/ZA906188B/xx unknown
- 1990-08-06 AU AU60222/90A patent/AU638264B2/en not_active Expired
- 1990-08-07 CA CA002022740A patent/CA2022740C/en not_active Expired - Lifetime
- 1990-08-07 AR AR90317547A patent/AR246087A1/es active
- 1990-08-07 IL IL9530990A patent/IL95309A/en not_active IP Right Cessation
- 1990-08-08 NZ NZ234814A patent/NZ234814A/en unknown
- 1990-08-08 FI FI903922A patent/FI95913C/fi active IP Right Grant
- 1990-08-09 AT AT90115309T patent/ATE132503T1/de not_active IP Right Cessation
- 1990-08-09 CN CN90106972A patent/CN1035056C/zh not_active Expired - Fee Related
- 1990-08-09 PT PT94952A patent/PT94952B/pt not_active IP Right Cessation
- 1990-08-09 KR KR1019900012226A patent/KR0169123B1/ko not_active Expired - Fee Related
- 1990-08-09 DE DE69024555T patent/DE69024555T2/de not_active Expired - Lifetime
- 1990-08-09 ES ES90115309T patent/ES2084627T3/es not_active Expired - Lifetime
- 1990-08-09 EP EP90115309A patent/EP0412542B1/de not_active Expired - Lifetime
- 1990-08-09 JP JP2209390A patent/JP2829779B2/ja not_active Expired - Lifetime
- 1990-08-09 DK DK90115309.8T patent/DK0412542T3/da active
- 1990-08-09 IE IE288690A patent/IE69382B1/en not_active IP Right Cessation
- 1990-08-09 NO NO903513A patent/NO177715C/no unknown
- 1990-08-09 HU HU904952A patent/HU206729B/hu not_active IP Right Cessation
- 1990-08-10 DD DD90343398A patent/DD297168A5/de unknown
1996
- 1996-02-14 GR GR960400385T patent/GR3018984T3/el unknown
1997
- 1997-03-05 US US08/811,913 patent/US5731286A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
GR3018984T3 (en)	1996-05-31
FI95913C (fi)	1996-04-10
ZA906188B (en)	1991-06-26
IL95309A0 (en)	1991-06-30
NO903513L (no)	1991-02-11
DK0412542T3 (da)	1996-01-29
DD297168A5 (de)	1992-01-02
PT94952A (pt)	1991-04-18
PT94952B (pt)	1997-07-31
ES2084627T3 (es)	1996-05-16
ATE132503T1 (de)	1996-01-15
JPH03141295A (ja)	1991-06-17
CA2022740C (en)	2000-05-02
NO177715C (no)	1995-11-08
DE69024555D1 (de)	1996-02-15
NZ234814A (en)	1992-03-26
DE69024555T2 (de)	1996-05-15
CN1035056C (zh)	1997-06-04
FI95913B (fi)	1995-12-29
HUT54713A (en)	1991-03-28
NO177715B (no)	1995-07-31
IE902886A1 (en)	1991-02-27
US5731286A (en)	1998-03-24
IE69382B1 (en)	1996-09-04
KR0169123B1 (ko)	1999-01-15
EP0412542B1 (de)	1996-01-03
CA2022740A1 (en)	1991-02-11
JP2829779B2 (ja)	1998-12-02
KR910004665A (ko)	1991-03-29
HU206729B (en)	1992-12-28
EP0412542A2 (de)	1991-02-13
AR246087A1 (es)	1994-03-30
NO903513D0 (no)	1990-08-09
EP0412542A3 (en)	1991-07-24
AU6022290A (en)	1991-05-16
CN1049353A (zh)	1991-02-20
HU904952D0 (en)	1991-01-28
AU638264B2 (en)	1993-06-24
FI903922A0 (fi)	1990-08-08

Legal Events

Date

Code

Title

Description

1996-11-14

KB

Patent renewed

2001-06-14

RH

Patent void

2006-09-05

HC

Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.

Publication	Publication Date	Title
CA1341336C (en)	2002-01-29	Neuropeptide y agonists
IE880167L (en)	1988-07-23	Anticoagulant peptides
NZ230385A (en)	1992-04-28	Peptide derivatives having antagonist properties against neuropeptide
CA1340646C (en)	1999-07-13	Cyclic anticoagulant peptides
CA2022740C (en)	2000-05-02	Cyclic neurokinin a antagonists
CA1341354C (en)	2002-04-02	Anticoagulant peptide alcohols
EP0421367B1 (de)	1998-04-22	Antikoagulierende Peptide
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