NO177715C - Analogifremgangsmåte for fremstilling av cykliske neurokinin A-antagonister - Google Patents

Analogifremgangsmåte for fremstilling av cykliske neurokinin A-antagonister

Info

Publication number: NO177715C
Authority: NO; Norway
Prior art keywords: antagonists; preparation; analogous procedure; neurokinin; cyclic
Prior art date: 1989-08-10

Application number

NO903513A

Other languages

English (en)

Norwegian (no)

Other versions

NO903513L (no

NO177715B (no

NO903513D0 (no

Inventor

Scott Lee Harbeson

Stephen Hendersen Buck

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-10

Filing date

1990-08-09

Publication date

1995-11-08

1990-08-09 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1990-08-09 Publication of NO903513D0 publication Critical patent/NO903513D0/no

1991-02-11 Publication of NO903513L publication Critical patent/NO903513L/no

1995-07-31 Publication of NO177715B publication Critical patent/NO177715B/no

1995-11-08 Publication of NO177715C publication Critical patent/NO177715C/no

Links

HEAUFJZALFKPBA-YRVBCFNBSA-N Neurokinin A Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-YRVBCFNBSA-N 0.000 title 1
102400000097 Neurokinin A Human genes 0.000 title 1
101800000399 Neurokinin A Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
125000004122 cyclic group Chemical group 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Transplantation (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO903513A 1989-08-10 1990-08-09 Analogifremgangsmåte for fremstilling av cykliske neurokinin A-antagonister NO177715C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39223689A	1989-08-10	1989-08-10

Publications (4)

Publication Number	Publication Date
NO903513D0 NO903513D0 (no)	1990-08-09
NO903513L NO903513L (no)	1991-02-11
NO177715B NO177715B (no)	1995-07-31
NO177715C true NO177715C (no)	1995-11-08

Family

ID=23549831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903513A NO177715C (no)	1989-08-10	1990-08-09	Analogifremgangsmåte for fremstilling av cykliske neurokinin A-antagonister

Country Status (22)

Country	Link
US (1)	US5731286A (de)
EP (1)	EP0412542B1 (de)
JP (1)	JP2829779B2 (de)
KR (1)	KR0169123B1 (de)
CN (1)	CN1035056C (de)
AR (1)	AR246087A1 (de)
AT (1)	ATE132503T1 (de)
AU (1)	AU638264B2 (de)
CA (1)	CA2022740C (de)
DD (1)	DD297168A5 (de)
DE (1)	DE69024555T2 (de)
DK (1)	DK0412542T3 (de)
ES (1)	ES2084627T3 (de)
FI (1)	FI95913C (de)
GR (1)	GR3018984T3 (de)
HU (1)	HU206729B (de)
IE (1)	IE69382B1 (de)
IL (1)	IL95309A (de)
NO (1)	NO177715C (de)
NZ (1)	NZ234814A (de)
PT (1)	PT94952B (de)
ZA (1)	ZA906188B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA894533B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Neurokinin a antogonists
DE4034829A1 (de) *	1990-11-02	1992-05-07	Merck Patent Gmbh	Cyclopeptide
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5625060A (en) *	1991-05-03	1997-04-29	Elf Sanofi	Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present
EP0606222A1 (de) *	1991-08-08	1994-07-20	A. Menarini Industrie Farmaceutiche Riunite S.R.L.	Zyklische hexapeptide als tachykininantagonisten, verfahren zur herstellung und pharmazeutische zusammensetzungen
US5731285A (en) *	1992-04-15	1998-03-24	A. Menatini Industrie Farmaceutiche	Tachiquinine antagonist tricyclic compounds, preparation of same and pharmaceutical compositions containing such compounds
PT2408802T (pt) *	2009-03-16	2017-08-03	Governing Council Univ Toronto	Moléculas de aminoácido ciclicas e métodos para as preparar
US11072616B2 (en)	2015-11-11	2021-07-27	Universite De Montreal	Cyclic peptides targeting alpha-4-beta-7 integrin
ES2884107T3 (es)	2016-11-11	2021-12-10	Zealand Pharma As	Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7
US11286281B2 (en)	2017-05-10	2022-03-29	Zealand Pharma A/S	Homodetic cyclic peptides targeting alpha-4-beta-7 integrin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4742156A (en) *	1985-09-30	1988-05-03	Mcneilab, Inc.	Peptide antagonists of neurokinin B and opthalmic solutions containing them
US4665157A (en) *	1985-09-30	1987-05-12	Mcneilab, Inc.	Peptide antagonists of neurokinin B
DE3711335A1 (de) *	1987-04-03	1988-10-20	Merck Patent Gmbh	Aminosaeurederivate
GB8807246D0 (en) *	1988-03-25	1988-04-27	Merck Sharp & Dohme	Therapeutic agents
ZA894533B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Neurokinin a antogonists
FI97540C (fi) *	1989-11-06	1997-01-10	Sanofi Sa	Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2677361A1 (fr) *	1991-06-04	1992-12-11	Adir	Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

1990
- 1990-08-06 ZA ZA906188A patent/ZA906188B/xx unknown
- 1990-08-06 AU AU60222/90A patent/AU638264B2/en not_active Expired
- 1990-08-07 CA CA002022740A patent/CA2022740C/en not_active Expired - Lifetime
- 1990-08-07 AR AR90317547A patent/AR246087A1/es active
- 1990-08-07 IL IL9530990A patent/IL95309A/en not_active IP Right Cessation
- 1990-08-08 NZ NZ234814A patent/NZ234814A/en unknown
- 1990-08-08 FI FI903922A patent/FI95913C/fi active IP Right Grant
- 1990-08-09 AT AT90115309T patent/ATE132503T1/de not_active IP Right Cessation
- 1990-08-09 CN CN90106972A patent/CN1035056C/zh not_active Expired - Fee Related
- 1990-08-09 PT PT94952A patent/PT94952B/pt not_active IP Right Cessation
- 1990-08-09 KR KR1019900012226A patent/KR0169123B1/ko not_active Expired - Fee Related
- 1990-08-09 DE DE69024555T patent/DE69024555T2/de not_active Expired - Lifetime
- 1990-08-09 ES ES90115309T patent/ES2084627T3/es not_active Expired - Lifetime
- 1990-08-09 EP EP90115309A patent/EP0412542B1/de not_active Expired - Lifetime
- 1990-08-09 JP JP2209390A patent/JP2829779B2/ja not_active Expired - Lifetime
- 1990-08-09 DK DK90115309.8T patent/DK0412542T3/da active
- 1990-08-09 IE IE288690A patent/IE69382B1/en not_active IP Right Cessation
- 1990-08-09 NO NO903513A patent/NO177715C/no unknown
- 1990-08-09 HU HU904952A patent/HU206729B/hu not_active IP Right Cessation
- 1990-08-10 DD DD90343398A patent/DD297168A5/de unknown
1996
- 1996-02-14 GR GR960400385T patent/GR3018984T3/el unknown
1997
- 1997-03-05 US US08/811,913 patent/US5731286A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
GR3018984T3 (en)	1996-05-31
FI95913C (fi)	1996-04-10
ZA906188B (en)	1991-06-26
IL95309A0 (en)	1991-06-30
NO903513L (no)	1991-02-11
DK0412542T3 (da)	1996-01-29
DD297168A5 (de)	1992-01-02
PT94952A (pt)	1991-04-18
PT94952B (pt)	1997-07-31
ES2084627T3 (es)	1996-05-16
ATE132503T1 (de)	1996-01-15
JPH03141295A (ja)	1991-06-17
CA2022740C (en)	2000-05-02
DE69024555D1 (de)	1996-02-15
NZ234814A (en)	1992-03-26
DE69024555T2 (de)	1996-05-15
CN1035056C (zh)	1997-06-04
FI95913B (fi)	1995-12-29
HUT54713A (en)	1991-03-28
NO177715B (no)	1995-07-31
IE902886A1 (en)	1991-02-27
US5731286A (en)	1998-03-24
IE69382B1 (en)	1996-09-04
KR0169123B1 (ko)	1999-01-15
EP0412542B1 (de)	1996-01-03
CA2022740A1 (en)	1991-02-11
IL95309A (en)	1995-07-31
JP2829779B2 (ja)	1998-12-02
KR910004665A (ko)	1991-03-29
HU206729B (en)	1992-12-28
EP0412542A2 (de)	1991-02-13
AR246087A1 (es)	1994-03-30
NO903513D0 (no)	1990-08-09
EP0412542A3 (en)	1991-07-24
AU6022290A (en)	1991-05-16
CN1049353A (zh)	1991-02-20
HU904952D0 (en)	1991-01-28
AU638264B2 (en)	1993-06-24
FI903922A0 (fi)	1990-08-08

Publication	Publication Date	Title
NO914429D0 (no)	1991-11-12	Fremgangsmaate for fremstilling av piperidinylkamfersulfonyloxytocin-antagonister
FI914765A7 (fi)	1991-10-09	Hidastetusti vapauttava oraalinen lääkeannosmuoto
PT91631A (pt)	1990-03-30	A process for the preparation of cyclic graf-analogs ii
NO171678C (no)	1993-04-21	Fremgangsmaate for fremstilling av cykliske sulfater
NO934897L (no)	1993-12-29	Fremgangsmaate for fremstilling av et farmasoeytisk preparat
MX11117A (es)	1993-11-01	Procedimiento para la preparacion de nuevos antagonistas opioides de la piperidina.
PT89570A (pt)	1989-10-04	Processo para a preparacao de novos compostos de 1,3-dicarbonilo ciclicos
NO901232L (no)	1990-09-18	Fremgangsmaate for fremstilling av et farmasoeytisk preparat
FI92403C (fi)	1994-11-10	Menetelmä Cefodizim-dinatriumin valmistamiseksi
NO177715C (no)	1995-11-08	Analogifremgangsmåte for fremstilling av cykliske neurokinin A-antagonister
NO870177D0 (no)	1987-01-15	Fremgangsmaate for fremstilling av et soetemiddel.
IT1211268B (it)	1989-10-12	Procedimento per la fabbricazione di un capo di vestiario modellato lavorato a maglia
FI904570A7 (fi)	1991-03-20	Menetelmä uusien alkanofenonien valmistamiseksi I
FI891111A7 (fi)	1989-09-09	Menetelmä 1,4-dihydropyridiinijohdannaisten valmistamiseksi
FI102613B1 (fi)	1999-01-15	Menetelmä NMDA-antagonistien valmistamiseksi
NO905373D0 (no)	1990-12-12	Fremgangsmaate for fremstilling av nye fosfolipid-derivater
PT87528A (pt)	1989-05-31	Process for the preparation of vasopressin antagonists
NO893006L (no)	1990-01-23	Fremgangsmaate for fremstilling av nye allylaminoetylazoler
BR9005401A (pt)	1991-09-17	Preparacao de iminodiacetonitrila a partir de glicolonitrila
FI904571A7 (fi)	1991-03-20	Menetelmä uusien alkanofenonien valmistamiseksi II
IT9047639A0 (it)	1990-02-16	Dispositivo per la produzione di filato di fiocco
SE8902501D0 (sv)	1989-07-11	Foerfarande foer framstaellning av effektgarn
NO180296C (no)	1997-03-26	Fremgangsmåte for fremstilling av cykliske aminosyre-forbindelser
IE862569L (en)	1987-03-30	Decapeptide antagonists of neurokinin b
RO96842A (ro)	1989-04-28	Procedeu pentru prepararea 4,4-dimetil-1,3-dioxanului