ES2084627T3 - Antagonistas de neuroquinina ciclica. - Google Patents

Antagonistas de neuroquinina ciclica.

Info

Publication number
ES2084627T3
ES2084627T3 ES90115309T ES90115309T ES2084627T3 ES 2084627 T3 ES2084627 T3 ES 2084627T3 ES 90115309 T ES90115309 T ES 90115309T ES 90115309 T ES90115309 T ES 90115309T ES 2084627 T3 ES2084627 T3 ES 2084627T3
Authority
ES
Spain
Prior art keywords
cyclic
neurokinin
antagonists
link
neuroquinine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90115309T
Other languages
English (en)
Inventor
Scott L Harbeson
Stephen H Buck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2084627T3 publication Critical patent/ES2084627T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNOS ANTAGONISTAS DE NEUROKININ A QUE SON DERIVADOS DE NEUROKININ A EXTRAIDO NATURALMENTE, EN EL CUAL, EL ENLACE AMIDA SE CONECTA A LOS DOS AMINO ACIDOS SOBRE EL EXTREMO TERMINAL DEL CARBOXIL. EL ANTAGONISMO SE CONFIRMA SUTILIZANDO UN ENLACE CONVENCIONAL Y ENSAYOS BIOQUIMICOS, ASI COMO TESTS PSICOLOGICOS CONVENCIONALES. IGUALMENTE, SE DESCRIBE EL USO DE ESTOS DERIVADOS EN UNA VARIEDAD DE CONDICIONES EN LAS QUE SE IMPLICA EL NEUROKININ A
ES90115309T 1989-08-10 1990-08-09 Antagonistas de neuroquinina ciclica. Expired - Lifetime ES2084627T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39223689A 1989-08-10 1989-08-10

Publications (1)

Publication Number Publication Date
ES2084627T3 true ES2084627T3 (es) 1996-05-16

Family

ID=23549831

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90115309T Expired - Lifetime ES2084627T3 (es) 1989-08-10 1990-08-09 Antagonistas de neuroquinina ciclica.

Country Status (22)

Country Link
US (1) US5731286A (es)
EP (1) EP0412542B1 (es)
JP (1) JP2829779B2 (es)
KR (1) KR0169123B1 (es)
CN (1) CN1035056C (es)
AR (1) AR246087A1 (es)
AT (1) ATE132503T1 (es)
AU (1) AU638264B2 (es)
CA (1) CA2022740C (es)
DD (1) DD297168A5 (es)
DE (1) DE69024555T2 (es)
DK (1) DK0412542T3 (es)
ES (1) ES2084627T3 (es)
FI (1) FI95913C (es)
GR (1) GR3018984T3 (es)
HU (1) HU206729B (es)
IE (1) IE69382B1 (es)
IL (1) IL95309A (es)
NO (1) NO177715C (es)
NZ (1) NZ234814A (es)
PT (1) PT94952B (es)
ZA (1) ZA906188B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA894533B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Neurokinin a antogonists
DE4034829A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh Cyclopeptide
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5625060A (en) * 1991-05-03 1997-04-29 Elf Sanofi Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present
JPH06509571A (ja) * 1991-08-08 1994-10-27 エイ・メナリニ・インダストリー・ファーマシューティケ・リウニテ・エスアールエル タキキニン拮抗薬としての環状ヘキサペプチドの製法およびその薬学的化合物
US5731285A (en) * 1992-04-15 1998-03-24 A. Menatini Industrie Farmaceutiche Tachiquinine antagonist tricyclic compounds, preparation of same and pharmaceutical compositions containing such compounds
ES2634431T3 (es) * 2009-03-16 2017-09-27 The Governing Council Of The University Of Toronto Moléculas de aminoácidos cíclicos y procedimientos de preparación de las mismas
EP3377471A4 (en) 2015-11-11 2019-11-20 Encycle Therapeutics, Inc. FRAGMENT SYNTHESIS OF CYCLIC PEPTIDES
EP3939989A1 (en) 2016-11-11 2022-01-19 Zealand Pharma A/S Cyclic peptides multimers targeting alpha 4beta 7 integrin
KR20200015540A (ko) 2017-05-10 2020-02-12 인사이클 세라퓨틱스, 인코포레이티드 α4β7 인테그린을 타겟팅하는 호모데틱 사이클릭 펩타이드

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742156A (en) * 1985-09-30 1988-05-03 Mcneilab, Inc. Peptide antagonists of neurokinin B and opthalmic solutions containing them
US4665157A (en) * 1985-09-30 1987-05-12 Mcneilab, Inc. Peptide antagonists of neurokinin B
DE3711335A1 (de) * 1987-04-03 1988-10-20 Merck Patent Gmbh Aminosaeurederivate
GB8807246D0 (en) * 1988-03-25 1988-04-27 Merck Sharp & Dohme Therapeutic agents
ZA894533B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Neurokinin a antogonists
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2677361A1 (fr) * 1991-06-04 1992-12-11 Adir Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
PT94952A (pt) 1991-04-18
DE69024555T2 (de) 1996-05-15
GR3018984T3 (en) 1996-05-31
KR0169123B1 (ko) 1999-01-15
CA2022740C (en) 2000-05-02
NO177715C (no) 1995-11-08
IE902886A1 (en) 1991-02-27
EP0412542A2 (en) 1991-02-13
DD297168A5 (de) 1992-01-02
EP0412542B1 (en) 1996-01-03
AR246087A1 (es) 1994-03-30
ATE132503T1 (de) 1996-01-15
JP2829779B2 (ja) 1998-12-02
ZA906188B (en) 1991-06-26
CN1049353A (zh) 1991-02-20
NZ234814A (en) 1992-03-26
JPH03141295A (ja) 1991-06-17
EP0412542A3 (en) 1991-07-24
IE69382B1 (en) 1996-09-04
NO177715B (no) 1995-07-31
DK0412542T3 (da) 1996-01-29
US5731286A (en) 1998-03-24
FI903922A0 (fi) 1990-08-08
HU904952D0 (en) 1991-01-28
NO903513L (no) 1991-02-11
NO903513D0 (no) 1990-08-09
HUT54713A (en) 1991-03-28
HU206729B (en) 1992-12-28
IL95309A0 (en) 1991-06-30
AU638264B2 (en) 1993-06-24
FI95913B (fi) 1995-12-29
FI95913C (fi) 1996-04-10
KR910004665A (ko) 1991-03-29
IL95309A (en) 1995-07-31
PT94952B (pt) 1997-07-31
AU6022290A (en) 1991-05-16
DE69024555D1 (de) 1996-02-15
CA2022740A1 (en) 1991-02-11
CN1035056C (zh) 1997-06-04

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