IL96507A0 - Nitrogen-containing spirocycles and pharmaceutical compositions containing them - Google Patents

Nitrogen-containing spirocycles and pharmaceutical compositions containing them

Info

Publication number
IL96507A0
IL96507A0 IL96507A IL9650790A IL96507A0 IL 96507 A0 IL96507 A0 IL 96507A0 IL 96507 A IL96507 A IL 96507A IL 9650790 A IL9650790 A IL 9650790A IL 96507 A0 IL96507 A0 IL 96507A0
Authority
IL
Israel
Prior art keywords
spirocycles
nitrogen
pharmaceutical compositions
compositions containing
chem
Prior art date
Application number
IL96507A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL96507A0 publication Critical patent/IL96507A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20Spiro-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Dental Preparations (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
IL96507A 1989-12-08 1990-11-29 Nitrogen-containing spirocycles and pharmaceutical compositions containing them IL96507A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44795089A 1989-12-08 1989-12-08
US61209190A 1990-11-16 1990-11-16

Publications (1)

Publication Number Publication Date
IL96507A0 true IL96507A0 (en) 1991-08-16

Family

ID=27035165

Family Applications (1)

Application Number Title Priority Date Filing Date
IL96507A IL96507A0 (en) 1989-12-08 1990-11-29 Nitrogen-containing spirocycles and pharmaceutical compositions containing them

Country Status (17)

Country Link
EP (1) EP0431943B1 (de)
JP (1) JPH0747576B2 (de)
KR (1) KR910011859A (de)
CN (2) CN1053613A (de)
AT (1) ATE168377T1 (de)
AU (2) AU6787390A (de)
CA (1) CA2031633A1 (de)
DE (1) DE69032480T2 (de)
ES (1) ES2118715T3 (de)
FI (1) FI906045A7 (de)
HU (1) HU908122D0 (de)
IE (1) IE904430A1 (de)
IL (1) IL96507A0 (de)
NO (1) NO905306L (de)
NZ (1) NZ236315A (de)
PT (1) PT96126A (de)
YU (1) YU231790A (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0445974A3 (en) * 1990-03-05 1992-04-29 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
IE911192A1 (en) * 1990-04-12 1991-10-23 Merck & Co Inc Substituted aromatic sulfonamides as antiglaucoma agents
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
WO1994013696A1 (en) * 1992-12-11 1994-06-23 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone
US5578593A (en) * 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
CA2154569A1 (en) * 1993-01-28 1994-08-04 Jeffrey J. Hale Spiro-substituted azacycles as tachykinin receptor antagonists
JPH08511522A (ja) * 1993-06-07 1996-12-03 メルク エンド カンパニー インコーポレーテッド ニューロキニンアンタゴニストとしてのスピロ置換アザ環
US5484923A (en) * 1993-06-10 1996-01-16 Merck & Co., Inc. Process of making spirocycles and analogs thereof
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
WO1995028389A1 (en) * 1994-04-15 1995-10-26 Yamanouchi Pharmaceutical Co., Ltd. Spiro compound and medicinal composition thereof
US5434158A (en) * 1994-04-26 1995-07-18 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin-3 antagonists
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
HUP9600928A3 (en) * 1996-04-10 1999-03-29 Richter Gedeon Vegyeszet Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation
US6156783A (en) * 1996-04-30 2000-12-05 Smithkline Beecham P.L.C. Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
US6013652A (en) * 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
JP2003513006A (ja) * 1999-06-07 2003-04-08 ワーナー−ランバート・カンパニー 三環性鎮痛薬
HUP0203548A3 (en) * 1999-07-21 2003-04-28 Astrazeneca Ab New spirooxindole derivatives, process for their preparation, pharmaceutical compositions containing them and their use
MXPA02002283A (es) 1999-09-03 2002-07-30 Asahi Chemical Ind Proceso para preparar derivados triciclicos de amino alcoholes.
WO2003095427A1 (en) * 2002-05-10 2003-11-20 Taisho Pharmaceutical Co.,Ltd. Spiro-ring compound
JP4712384B2 (ja) 2002-09-09 2011-06-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Orl−1受容体介在障害の治療に有用なヒドロキシアルキル置換1,3,8−トリアザスピロ[4.5]デカン−4−オン誘導体
CN1768041A (zh) 2003-04-04 2006-05-03 麦克公司 作为黑皮质素-4受体激动剂的酰化螺哌啶衍生物
WO2004092179A1 (ja) * 2003-04-14 2004-10-28 Nippon Soda Co. Ltd. スピロ誘導体、製造法および抗酸化薬
US20060079566A1 (en) 2003-10-03 2006-04-13 Ching-Shih Chen PDK-1/Akt signaling inhibitors
US7354925B2 (en) 2004-03-29 2008-04-08 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SI1781618T1 (sl) 2004-08-27 2013-01-31 Laboratorios Del Dr. Esteve, S.A. Inhibitorji sigma receptorja
EP1634873A1 (de) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigmarezeptor-Inhibitoren
CA2576144C (en) 2004-08-27 2012-12-11 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
ATE520668T1 (de) 2004-08-27 2011-09-15 Esteve Labor Dr Sigmarezeptor-inhibitoren
WO2006130416A2 (en) * 2005-06-02 2006-12-07 Janssen Pharmaceutica, N.V. Novel 3-spirocyclic indolyl derivatives useful as orl-1 receptor modulators
WO2007011809A1 (en) * 2005-07-19 2007-01-25 Merck & Co., Inc. Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors
AR057570A1 (es) 2005-11-14 2007-12-05 Solvay Pharm Gmbh Derivados de n-sulfamoil-n'-benzopiranopiperidinas espirocondensadas, composiciones farmaceuticas que los comprenden, un procedimiento para su preparacion y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por las isoenzimas anhidrasas carbonicas subtipos ii y/o
WO2007063385A2 (en) * 2005-12-01 2007-06-07 Pfizer Products Inc. Spirocyclic amine histamine-3 receptor antagonists
EP1829875A1 (de) 2006-03-01 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrazolderivate als Inhibitoren des Sigma-Rezeptors
EP1829866A1 (de) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Inhibitoren von Sigmarezeptoren
EP1829867A1 (de) 2006-03-03 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Gegenüber dem Sigmarezeptor pharmazeutisch aktive Imidazolverbindungen
BRPI0721053A2 (pt) * 2006-11-29 2014-07-29 Pfizer Prod Inc INIBIDORES DE ESPIROCETONA ACETIL-CoA CARBOXILASE
PE20081559A1 (es) 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
AU2008205642B2 (en) * 2007-01-12 2013-06-06 Msd K.K. Spirochromanon derivatives
CA2683598C (en) 2007-04-09 2015-11-17 Janssen Pharmaceutica Nv 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
US8309544B2 (en) * 2007-05-16 2012-11-13 Merck Sharp & Dohme Corp. Spiroindalones
US8039502B2 (en) 2007-07-24 2011-10-18 The Ohio State University Research Foundation Anti-infective agents against intracellular pathogens
US8133695B2 (en) 2008-02-28 2012-03-13 Life Technologies Corporation Fluorescence polarization hERG assay
EP2116539A1 (de) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-Aryl-3-Amino-alkoxy-pyrazole als Sigma-Liganden zur Verbesserung der analgetischen Wirkung von Opioiden und zur Schwächung der Abhängigkeit davon
US10412788B2 (en) 2008-06-13 2019-09-10 Lg Chem, Ltd. Heating element and manufacturing method thereof
US20120108823A1 (en) 2009-04-22 2012-05-03 The Ohio State University Research Foundation Anti-francisella agents
UA107943C2 (xx) 2009-11-16 2015-03-10 Lilly Co Eli Сполуки спіропіперидину як антагоністи рецептора orl-1
EP2353598A1 (de) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma-Liganden zur Anwendung in der Vorbeugung und/oder Behandlung von postoperativem Schmerz
EP2353591A1 (de) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma-Liganden zur Verstärkung der analgesischen Wirkung von Opioden und Opiaten bei postoperativem Schmerz und zur Schwächung der Abhängigkeit davon
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
EP2388005A1 (de) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma-Liganden zur Vorbeugung und/oder Behandlung von Erbrechen infolge von Chemotherapie oder Strahlentherapie
EP2395003A1 (de) 2010-05-27 2011-12-14 Laboratorios Del. Dr. Esteve, S.A. Pyrazolverbindungen als Sigmarezeptor-Inhibitoren
TW201643169A (zh) 2010-07-09 2016-12-16 艾伯維股份有限公司 作為s1p調節劑的螺-哌啶衍生物
EP2415471A1 (de) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Verwendung von Sigmaliganden bei opioidinduzierter Hyperalgesie
KR101923367B1 (ko) 2011-02-02 2018-12-04 버텍스 파마슈티칼스 인코포레이티드 이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드
MX2013009393A (es) 2011-02-18 2013-08-29 Vertex Pharma Piperidinamidas cromano-espirociclicas como moduladores de canales de iones.
CN103517910B (zh) 2011-03-14 2016-12-14 沃泰克斯药物股份有限公司 作为离子通道调节剂的吗啉-螺环哌啶酰胺
EP2524694A1 (de) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Verwendung von Sigmaliganden bei Schmerz im Zusammenhang mit Typ-2-Diabetes
JP6402115B2 (ja) * 2013-02-04 2018-10-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung 神経学的疾患および状態の処置に有用なスピロ−キナゾリノン誘導体
TN2016000228A1 (en) 2013-12-17 2017-10-06 Esteve Labor Dr SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS.
WO2018108627A1 (de) 2016-12-12 2018-06-21 Bayer Cropscience Aktiengesellschaft Verwendung substituierter indolinylmethylsulfonamide oder deren salze zur steigerung der stresstoleranz in pflanzen
CN108752360B (zh) * 2018-04-12 2019-10-29 牡丹江医学院 一种治疗小儿腹泻的化合物及其制备方法
EP3820567A1 (de) * 2018-07-12 2021-05-19 UCB Biopharma SRL Spirocyclische indan-analoga als il-17-modulatoren
US11535632B2 (en) 2019-10-31 2022-12-27 ESCAPE Bio, Inc. Solid forms of an S1P-receptor modulator

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3301857A (en) 1963-08-26 1967-01-31 Hoffmann La Roche Spiro
US3649635A (en) * 1969-10-24 1972-03-14 Warner Lambert Co Spiropyranopyridines
US3686186A (en) * 1970-10-05 1972-08-22 William J Houlihan Substituted isochroman or phthalan piperidenes
JPS4867287A (de) * 1971-12-20 1973-09-13
JPS5224748B2 (de) * 1972-07-04 1977-07-02
JPS5343513B2 (de) * 1972-09-20 1978-11-20
IL45823A (en) * 1973-10-20 1977-10-31 Hoechst Ag Substituted 1-phenyl-4-alkyl(dialkyl or cyclic) aminoalkyl-1,4-dihydro-2h-isoquinoline-3-one derivatives
DE2353702C3 (de) * 1973-10-26 1979-03-29 Guenter 7000 Stuttgart Haag Einbruchsicherung für Flächen
US3962259A (en) 1973-12-12 1976-06-08 American Hoechst Corporation 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
JPS5089377A (de) * 1973-12-19 1975-07-17
JPS50111082A (de) * 1974-02-18 1975-09-01
DE2611910A1 (de) * 1976-03-20 1977-09-22 Bayer Ag Chromanone-(4)
DE2535338A1 (de) * 1975-08-07 1977-02-17 Bayer Ag Chromanone-(4)
JPS5368784A (en) * 1976-11-30 1978-06-19 Sumitomo Chem Co Ltd Novel spiroamine derivatives and their preparation
US4209625A (en) 1977-04-21 1980-06-24 American Hoechst Corporation Spiro[indoline-3,4'-piperidine]s
ES468860A1 (es) * 1977-04-21 1979-09-16 Hoechst Ag Un procedimiento para preparar espiro (indolin-3,4'-piperi- dina)s.
DE2745306A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide mittel
JPS54109983A (en) * 1978-02-13 1979-08-29 Sumitomo Chem Co Ltd Novel spiroamine derivative and its preparation
DE2814983A1 (de) * 1978-04-07 1979-10-18 Bayer Ag Neue chromanon-derivate
US4166120A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4166119A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4307235A (en) 1978-08-23 1981-12-22 American Hoechst Corporation Spiro[indoline-3,4'-piperidine]s
JPS55139333A (en) * 1979-04-13 1980-10-31 Dai Ichi Seiyaku Co Ltd Spiro compound
JPS55139381A (en) * 1979-04-13 1980-10-31 Dai Ichi Seiyaku Co Ltd Spiroisochroman
JPS55143980A (en) * 1979-04-27 1980-11-10 Dai Ichi Seiyaku Co Ltd Anti-allergic preparation
FR2498603A1 (fr) * 1981-01-29 1982-07-30 Delalande Sa Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique
US4349549A (en) * 1981-05-18 1982-09-14 Syntex (U.S.A.) Inc. Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s
JPS5815979A (ja) * 1981-07-11 1983-01-29 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体およびその製造法
US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
JPS5959685A (ja) * 1982-09-28 1984-04-05 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
US4558049A (en) * 1982-11-24 1985-12-10 Farmitalia Carlo Erba S.P.A. Antipsycotic benzoxazines
DE3308554A1 (de) * 1983-03-10 1984-09-13 Hoechst Ag, 6230 Frankfurt 1-/1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung
DK139684A (da) * 1983-04-11 1984-10-12 Janssen Pharmaceutica Nv N-aryl-alpha-amino-carboxamider
US4452802A (en) 1983-08-25 1984-06-05 Hoechst-Roussel Pharmaceuticals Incorporated Antihypertensive spiro[benzofuran-azalkanes]
JPS60158190A (ja) * 1984-01-30 1985-08-19 Eisai Co Ltd ヒダントイン誘導体およびその製法ならびにそれを含有する医薬

Also Published As

Publication number Publication date
FI906045A0 (fi) 1990-12-07
EP0431943A3 (en) 1992-03-25
CA2031633A1 (en) 1991-06-09
HU908122D0 (en) 1991-06-28
NZ236315A (en) 1994-09-27
CN1110685A (zh) 1995-10-25
EP0431943A2 (de) 1991-06-12
CN1053613A (zh) 1991-08-07
ES2118715T3 (es) 1998-10-01
AU6329794A (en) 1994-07-21
DE69032480T2 (de) 1999-05-06
JPH0747576B2 (ja) 1995-05-24
EP0431943B1 (de) 1998-07-15
PT96126A (pt) 1991-09-30
NO905306L (no) 1991-06-10
IE904430A1 (en) 1991-06-19
YU231790A (sh) 1993-05-28
FI906045L (fi) 1991-06-09
JPH04217960A (ja) 1992-08-07
FI906045A7 (fi) 1991-06-09
KR910011859A (ko) 1991-08-07
AU6787390A (en) 1991-06-13
NO905306D0 (no) 1990-12-07
ATE168377T1 (de) 1998-08-15
DE69032480D1 (de) 1998-08-20

Similar Documents

Publication Publication Date Title
IL96507A0 (en) Nitrogen-containing spirocycles and pharmaceutical compositions containing them
EG17753A (en) Novel pharmacological compounds
IL94915A0 (en) Substituted quinazolinones and pharmaceutical compositions containing them
IL82342A (en) Alkoxybenzene derivatives and pharmaceutical compositions containing them
IL87908A (en) Azaspirane derivatives and immunomodulating pharmaceutical compositions containing same
IL103875A0 (en) Piperazinyl-and piperidinyl-cyclohexanol derivatives and pharmaceutical compositions containing the same
GR3025151T3 (en) Derivatized alkanolamines as cardiovascular agents
FI920023A0 (fi) Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
IL109610A0 (en) Amide derivatives, their preparation and pharmaceutical compositions containing them
IT1228288B (it) Composti ad attivita' antiserotoninica
SE8404065D0 (sv) Novel biologically active compounds
SE8600658D0 (sv) Novel composition of matter
IL112099A (en) N-oxides of 4-arylpiperazines and 4-arylpiperidines and pharmaceutical compositions containing them
GR3007498T3 (de)
GR3005900T3 (de)
DK0418990T3 (da) 13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
NZ231087A (en) Piperidino-ethoxy benzoyl benzoate derivatives and pharmaceutical compositions
IL95384A0 (en) 1,3-oxazines,their preparation and pharmaceutical compositions containing them