IL96654A - Hydroxybenzyl substituted sulfur containing heterocyclic derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Hydroxybenzyl substituted sulfur containing heterocyclic derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL96654A
IL96654A IL9665490A IL9665490A IL96654A IL 96654 A IL96654 A IL 96654A IL 9665490 A IL9665490 A IL 9665490A IL 9665490 A IL9665490 A IL 9665490A IL 96654 A IL96654 A IL 96654A
Authority
IL
Israel
Prior art keywords
compound
alkyl
formula
hydrogen
inclusive
Prior art date
Application number
IL9665490A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to IL10896290A priority Critical patent/IL108962A/en
Publication of IL96654A publication Critical patent/IL96654A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Surgical Instruments (AREA)
  • Nonmetallic Welding Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Eye Examination Apparatus (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL9665490A 1989-12-21 1990-12-13 Hydroxybenzyl substituted sulfur containing heterocyclic derivatives their preparation and pharmaceutical compositions containing them IL96654A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL10896290A IL108962A (en) 1989-12-21 1990-12-13 Use of hydroxybenzyl substituted sulfur containing heterocyclic derivatives a process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45420389A 1989-12-21 1989-12-21

Publications (1)

Publication Number Publication Date
IL96654A true IL96654A (en) 1995-06-29

Family

ID=23803709

Family Applications (3)

Application Number Title Priority Date Filing Date
IL10896290A IL108962A (en) 1989-12-21 1990-12-13 Use of hydroxybenzyl substituted sulfur containing heterocyclic derivatives a process for their preparation and pharmaceutical compositions containing them
IL9665490A IL96654A (en) 1989-12-21 1990-12-13 Hydroxybenzyl substituted sulfur containing heterocyclic derivatives their preparation and pharmaceutical compositions containing them
IL10896294A IL108962A0 (en) 1989-12-21 1994-03-14 Use of hydroxybenzyl substituted sulfur containing heterocyclic derivatives, a process for their preparation and pharmaceutical compositions containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL10896290A IL108962A (en) 1989-12-21 1990-12-13 Use of hydroxybenzyl substituted sulfur containing heterocyclic derivatives a process for their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL10896294A IL108962A0 (en) 1989-12-21 1994-03-14 Use of hydroxybenzyl substituted sulfur containing heterocyclic derivatives, a process for their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
EP (1) EP0434394B1 (de)
JP (1) JP3036853B2 (de)
KR (1) KR0176243B1 (de)
CN (1) CN1029846C (de)
AT (1) ATE169294T1 (de)
AU (1) AU639734B2 (de)
CA (1) CA2032330C (de)
CY (1) CY2100B1 (de)
DE (1) DE69032537T2 (de)
DK (1) DK0434394T3 (de)
ES (1) ES2121748T3 (de)
FI (2) FI104251B (de)
HU (1) HU216732B (de)
IE (1) IE904633A1 (de)
IL (3) IL108962A (de)
MX (1) MX23803A (de)
NO (1) NO300458B1 (de)
NZ (1) NZ236472A (de)
PT (1) PT96198B (de)
RU (2) RU2036915C1 (de)
YU (1) YU240690A (de)
ZA (1) ZA9010041B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87339A1 (fr) * 1988-09-20 1990-04-06 Oreal Nouveaux derives de benzylidene-cyclanones,leur procede de preparation,leur utilisation en tant qu'agents anti-oxydants et comme filtres solaires,compositions cosmetiques et pharmaceutiques les contenant
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
CZ181493A3 (en) * 1992-09-10 1994-03-16 Lilly Co Eli The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease
DK0595546T3 (da) * 1992-10-28 1996-04-15 Shionogi & Co Benzylidenderivater
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5563277A (en) * 1994-12-21 1996-10-08 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
DK0761657T3 (da) * 1995-09-07 2000-08-14 Lilly Co Eli Fremgangsmåde til fremstilling af benzylsubstituerede rhodaninderivater
PE23298A1 (es) * 1995-09-07 1998-05-05 Lilly Co Eli Forma cristalina alternativa de tazofelona
EP0779282A1 (de) * 1995-12-14 1997-06-18 Eli Lilly And Company Thiomorpholinon-Verbindungen zur Behandlung von Multiple-Sklerose
US5981523A (en) * 1996-02-05 1999-11-09 Eli Lilly And Company Compounds and methods for treating multiple sclerosis
US5773455A (en) * 1996-06-28 1998-06-30 Biomeasure, Incorporated Inhibitors of prenyl transferases
US6063799A (en) * 1996-09-03 2000-05-16 Eli Lilly And Company Alternate crystal form of Tazofelone
US6005142A (en) * 1996-09-03 1999-12-21 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
WO2000018748A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
JP2002525362A (ja) * 1998-09-30 2002-08-13 エスヴァイン、アンゲリカ 代謝性骨障害の治療および予防のためのロダニンカルボン酸誘導体
AU6331099A (en) * 1998-09-30 2000-04-17 Roche Diagnostics Gmbh Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
US7235573B2 (en) 2002-09-30 2007-06-26 The Regents Of The University Of California Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
PL376147A1 (en) * 2002-09-30 2005-12-27 The Regents Of The University Of California Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
AU2002953533A0 (en) 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
BR112012025343A2 (pt) * 2010-04-15 2016-06-28 Merck Patent Gmbh processo para a preparação de hidroquinonas

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83152B (pt) * 1985-08-09 1989-03-30 Lilly Co Eli Processo para a preparacao de compostos di-t-butilfenoicos
IE62214B1 (en) * 1988-05-25 1995-01-11 Warner Lambert Co Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents
ZA902520B (en) * 1989-04-07 1991-12-24 Lilly Co Eli Aryl-substituted rhodanine derivatives

Also Published As

Publication number Publication date
IL108962A (en) 1996-12-05
DE69032537T2 (de) 1999-01-21
RU2036915C1 (ru) 1995-06-09
YU240690A (sh) 1992-12-21
RU2050355C1 (ru) 1995-12-20
ATE169294T1 (de) 1998-08-15
DK0434394T3 (da) 1998-12-14
FI906273L (fi) 1991-06-22
DE69032537D1 (de) 1998-09-10
NO905478L (no) 1991-06-24
ZA9010041B (en) 1992-08-26
FI906273A0 (fi) 1990-12-19
KR910011812A (ko) 1991-08-07
CA2032330A1 (en) 1991-06-22
FI19991698L (fi) 1999-08-10
KR0176243B1 (ko) 1999-03-20
NZ236472A (en) 1993-03-26
AU6826690A (en) 1991-06-27
HU908368D0 (en) 1991-07-29
CA2032330C (en) 2001-05-08
IL108962A0 (en) 1994-06-24
NO905478D0 (no) 1990-12-19
HUT59915A (en) 1992-07-28
EP0434394B1 (de) 1998-08-05
FI19991698A7 (fi) 1999-08-10
CN1052668A (zh) 1991-07-03
CN1029846C (zh) 1995-09-27
MX23803A (es) 1994-02-28
HU216732B (hu) 1999-08-30
PT96198A (pt) 1991-09-30
AU639734B2 (en) 1993-08-05
EP0434394A3 (en) 1992-01-08
CY2100B1 (en) 2002-04-05
PT96198B (pt) 1998-05-29
ES2121748T3 (es) 1998-12-16
EP0434394A2 (de) 1991-06-26
FI104251B1 (fi) 1999-12-15
JP3036853B2 (ja) 2000-04-24
FI104251B (fi) 1999-12-15
JPH04279573A (ja) 1992-10-05
IE904633A1 (en) 1991-07-17
NO300458B1 (no) 1997-06-02

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Legal Events

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KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees