NO300458B1 - Analogifremgangsmåte for fremstilling av terapeutisk aktive benzylsubstituerte rhodaninderivater - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive benzylsubstituerte rhodaninderivater Download PDF

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Publication number
NO300458B1
NO300458B1 NO905478A NO905478A NO300458B1 NO 300458 B1 NO300458 B1 NO 300458B1 NO 905478 A NO905478 A NO 905478A NO 905478 A NO905478 A NO 905478A NO 300458 B1 NO300458 B1 NO 300458B1
Authority
NO
Norway
Prior art keywords
compound
formula
hydrogen
compounds
thiazolidinone
Prior art date
Application number
NO905478A
Other languages
English (en)
Norwegian (no)
Other versions
NO905478D0 (no
NO905478L (no
Inventor
Jaswant Singh Gidda
Jill Ann Panetta
Michael Leroy Phillips
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO905478D0 publication Critical patent/NO905478D0/no
Publication of NO905478L publication Critical patent/NO905478L/no
Publication of NO300458B1 publication Critical patent/NO300458B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Surgical Instruments (AREA)
  • Nonmetallic Welding Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Eye Examination Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO905478A 1989-12-21 1990-12-19 Analogifremgangsmåte for fremstilling av terapeutisk aktive benzylsubstituerte rhodaninderivater NO300458B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45420389A 1989-12-21 1989-12-21

Publications (3)

Publication Number Publication Date
NO905478D0 NO905478D0 (no) 1990-12-19
NO905478L NO905478L (no) 1991-06-24
NO300458B1 true NO300458B1 (no) 1997-06-02

Family

ID=23803709

Family Applications (1)

Application Number Title Priority Date Filing Date
NO905478A NO300458B1 (no) 1989-12-21 1990-12-19 Analogifremgangsmåte for fremstilling av terapeutisk aktive benzylsubstituerte rhodaninderivater

Country Status (22)

Country Link
EP (1) EP0434394B1 (de)
JP (1) JP3036853B2 (de)
KR (1) KR0176243B1 (de)
CN (1) CN1029846C (de)
AT (1) ATE169294T1 (de)
AU (1) AU639734B2 (de)
CA (1) CA2032330C (de)
CY (1) CY2100B1 (de)
DE (1) DE69032537T2 (de)
DK (1) DK0434394T3 (de)
ES (1) ES2121748T3 (de)
FI (2) FI104251B1 (de)
HU (1) HU216732B (de)
IE (1) IE904633A1 (de)
IL (3) IL108962A (de)
MX (1) MX23803A (de)
NO (1) NO300458B1 (de)
NZ (1) NZ236472A (de)
PT (1) PT96198B (de)
RU (2) RU2036915C1 (de)
YU (1) YU240690A (de)
ZA (1) ZA9010041B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87339A1 (fr) * 1988-09-20 1990-04-06 Oreal Nouveaux derives de benzylidene-cyclanones,leur procede de preparation,leur utilisation en tant qu'agents anti-oxydants et comme filtres solaires,compositions cosmetiques et pharmaceutiques les contenant
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
EP0915090A1 (de) * 1992-09-10 1999-05-12 Eli Lilly And Company Thiazolidinone Derivate als hypoglykämisches Mittel und für die Behandlung der Alzheimer Krankheit
ATE135697T1 (de) * 1992-10-28 1996-04-15 Shionogi & Co Benzylidenderivate
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5563277A (en) * 1994-12-21 1996-10-08 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
DK0761657T3 (da) * 1995-09-07 2000-08-14 Lilly Co Eli Fremgangsmåde til fremstilling af benzylsubstituerede rhodaninderivater
AR003483A1 (es) * 1995-09-07 1998-08-05 Lilly Co Eli Procedimiento para preparar y aislar la forma ii de la (±)-5-[3,5-bis(1,1- dimetil)-4-hidroxifenil)-metil)-4-tiazolidinona.
EP0779282A1 (de) * 1995-12-14 1997-06-18 Eli Lilly And Company Thiomorpholinon-Verbindungen zur Behandlung von Multiple-Sklerose
US5981523A (en) * 1996-02-05 1999-11-09 Eli Lilly And Company Compounds and methods for treating multiple sclerosis
US5773455A (en) * 1996-06-28 1998-06-30 Biomeasure, Incorporated Inhibitors of prenyl transferases
US6005142A (en) * 1996-09-03 1999-12-21 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
US6063799A (en) * 1996-09-03 2000-05-16 Eli Lilly And Company Alternate crystal form of Tazofelone
EP1117655A1 (de) 1998-09-30 2001-07-25 Angelika Esswein Rhodanincarbonsäure-derivate zur behandlung und prävention von knochenstoffwechselstörungen
WO2000018748A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
AU6331099A (en) * 1998-09-30 2000-04-17 Roche Diagnostics Gmbh Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
US7235573B2 (en) 2002-09-30 2007-06-26 The Regents Of The University Of California Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
BR0314943A (pt) * 2002-09-30 2005-08-02 Univ California Inibidores da proteìna reguladora da condutância transmembrana da fibrose cìstica e usos destes
AU2002953533A0 (en) * 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
JP5778755B2 (ja) * 2010-04-15 2015-09-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ヒドロキノンの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79648A (en) * 1985-08-09 1991-12-12 Lilly Co Eli Pharmaceutical anti-inflammatory and ischemia preventing compositions containing di-t-butylphenol derivatives,some such novel compounds and process for their preparation
IE62214B1 (en) * 1988-05-25 1995-01-11 Warner Lambert Co Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents
ES2088965T3 (es) * 1989-04-07 1996-10-01 Lilly Co Eli Derivados de rodanina aril-sustituidos.

Also Published As

Publication number Publication date
DE69032537D1 (de) 1998-09-10
YU240690A (sh) 1992-12-21
EP0434394A2 (de) 1991-06-26
FI19991698A7 (fi) 1999-08-10
MX23803A (es) 1994-02-28
FI19991698L (fi) 1999-08-10
FI906273A0 (fi) 1990-12-19
IL108962A0 (en) 1994-06-24
DE69032537T2 (de) 1999-01-21
FI104251B (fi) 1999-12-15
HU908368D0 (en) 1991-07-29
IL108962A (en) 1996-12-05
HU216732B (hu) 1999-08-30
IE904633A1 (en) 1991-07-17
AU6826690A (en) 1991-06-27
JP3036853B2 (ja) 2000-04-24
CY2100B1 (en) 2002-04-05
CN1029846C (zh) 1995-09-27
RU2050355C1 (ru) 1995-12-20
JPH04279573A (ja) 1992-10-05
NO905478D0 (no) 1990-12-19
NO905478L (no) 1991-06-24
ES2121748T3 (es) 1998-12-16
CN1052668A (zh) 1991-07-03
EP0434394A3 (en) 1992-01-08
PT96198A (pt) 1991-09-30
DK0434394T3 (da) 1998-12-14
ZA9010041B (en) 1992-08-26
PT96198B (pt) 1998-05-29
NZ236472A (en) 1993-03-26
ATE169294T1 (de) 1998-08-15
FI906273L (fi) 1991-06-22
CA2032330A1 (en) 1991-06-22
AU639734B2 (en) 1993-08-05
CA2032330C (en) 2001-05-08
FI104251B1 (fi) 1999-12-15
IL96654A (en) 1995-06-29
KR910011812A (ko) 1991-08-07
EP0434394B1 (de) 1998-08-05
RU2036915C1 (ru) 1995-06-09
HUT59915A (en) 1992-07-28
KR0176243B1 (ko) 1999-03-20

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MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JUNE 2002