IL97912A - 2-methyl-10-(4-methyl-1-piperazinyl)-4h-thieno [2,3-b] [1,5] benzodiazepine its preparation and pharmaceutical compositions containing it - Google Patents

2-methyl-10-(4-methyl-1-piperazinyl)-4h-thieno [2,3-b] [1,5] benzodiazepine its preparation and pharmaceutical compositions containing it

Info

Publication number: IL97912A
Authority: IL; Israel
Prior art keywords: compound; methyl; formula; thieno; pharmaceutically acceptable
Prior art date: 1990-04-25

Application number

IL9791291A

Other languages

English (en)

Other versions

IL97912A0 (en

Inventor

Jiban Kumar Chakrabarti

Terrence Michael Hotten

David Edward Tupper

Original Assignee

Lilly Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-25

Filing date

1991-04-22

Publication date

1995-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10674942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL97912(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-04-22 Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd

1991-04-22 Priority to IL11257591A priority Critical patent/IL112575A/xx

1992-06-21 Publication of IL97912A0 publication Critical patent/IL97912A0/xx

1995-10-31 Publication of IL97912A publication Critical patent/IL97912A/en

Links

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238000000034 method Methods 0.000 claims description 10
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VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
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ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 description 2
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UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 2
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CWXOAQXKPAENDI-UHFFFAOYSA-N sodium methylsulfinylmethylide Chemical compound [Na+].CS([CH2-])=O CWXOAQXKPAENDI-UHFFFAOYSA-N 0.000 description 2
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FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 2
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235000012222 talc Nutrition 0.000 description 2
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AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
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229940116362 tragacanth Drugs 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
230000001052 transient effect Effects 0.000 description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
229910052720 vanadium Inorganic materials 0.000 description 2
GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 2
229910052725 zinc Inorganic materials 0.000 description 2
239000011701 zinc Substances 0.000 description 2
229910052726 zirconium Inorganic materials 0.000 description 2
FDWMAKNNNPSUTL-UHFFFAOYSA-N 2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-amine hydrochloride Chemical compound Cl.N1C2=CC=CC=C2N=C(N)C2=C1SC(C)=C2 FDWMAKNNNPSUTL-UHFFFAOYSA-N 0.000 description 1
IIHSSPQNHPTWLK-UHFFFAOYSA-N C1(CCCO1)=O.C(CCC)[Li] Chemical compound C1(CCCO1)=O.C(CCC)[Li] IIHSSPQNHPTWLK-UHFFFAOYSA-N 0.000 description 1
OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
210000000653 nervous system Anatomy 0.000 description 1
239000012056 semi-solid material Substances 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Cephalosporin Compounds (AREA)

IL9791291A 1990-04-25 1991-04-22 2-methyl-10-(4-methyl-1-piperazinyl)-4h-thieno [2,3-b] [1,5] benzodiazepine its preparation and pharmaceutical compositions containing it IL97912A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL11257591A IL112575A (en)	1990-04-25	1991-04-22	4-Substituted 2-methyl-10h-thieno [2,3-b][1,5]benzodiazepine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909009229A GB9009229D0 (en)	1990-04-25	1990-04-25	Pharmaceutical compounds

Publications (2)

Publication Number	Publication Date
IL97912A0 IL97912A0 (en)	1992-06-21
IL97912A true IL97912A (en)	1995-10-31

Family

ID=10674942

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL9791291A IL97912A (en)	1990-04-25	1991-04-22	2-methyl-10-(4-methyl-1-piperazinyl)-4h-thieno [2,3-b] [1,5] benzodiazepine its preparation and pharmaceutical compositions containing it
IL11257595A IL112575A0 (en)	1990-04-25	1995-02-08	4-substituted 2-methyl-10h-thieno [2,3-b][1,5] benzodiazepine

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL11257595A IL112575A0 (en)	1990-04-25	1995-02-08	4-substituted 2-methyl-10h-thieno [2,3-b][1,5] benzodiazepine

Country Status (33)

Country	Link
EP (1)	EP0454436B1 (da)
JP (1)	JP2527860B2 (da)
KR (1)	KR100195566B1 (da)
CN (1)	CN1028429C (da)
AT (1)	ATE127804T1 (da)
AU (1)	AU643267B2 (da)
BG (1)	BG61710B2 (da)
CA (1)	CA2041113C (da)
CY (1)	CY1900A (da)
CZ (1)	CZ279937B6 (da)
DE (3)	DE69112895T4 (da)
DK (1)	DK0454436T3 (da)
ES (1)	ES2078440T3 (da)
FI (1)	FI101379B1 (da)
GB (1)	GB9009229D0 (da)
GE (1)	GEP20032965B (da)
GR (1)	GR3017877T3 (da)
HK (1)	HK87596A (da)
HU (2)	HU212416B (da)
IE (1)	IE68401B1 (da)
IL (2)	IL97912A (da)
LU (2)	LU90009I2 (da)
LV (1)	LV10262B (da)
MX (1)	MX173791B (da)
NL (2)	NL970015I2 (da)
NO (3)	NO178766C (da)
NZ (1)	NZ237932A (da)
PT (1)	PT97446B (da)
RU (1)	RU2043992C1 (da)
SI (1)	SI9110739A (da)
SK (1)	SK279196B6 (da)
YU (1)	YU48049B (da)
ZA (1)	ZA913085B (da)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5627178A (en) *	1991-04-23	1997-05-06	Lilly Industries Limited	2-methyl-thieno-benzodiazepine
US5817657A (en) *	1991-04-23	1998-10-06	Eli Lilly And Company	Psychoactive substance disorders
US5817656A (en) *	1991-04-23	1998-10-06	Eli Lilly And Company	Mental disorders
US5817655A (en) *	1991-04-23	1998-10-06	Eli Lilly And Company	Methods of treatment using a thieno-benzodiazepine
US6034078A (en) *	1992-05-29	2000-03-07	Eli Lilly And Company Limited	Thienobenzodiazepine compounds
PT582368E (pt) *	1992-05-29	2001-05-31	Lilly Co Eli	Derivados de tienobenzodiazepina para o tratamento de doencas de cns
JP3274579B2 (ja) *	1995-01-12	2002-04-15	住友製薬株式会社	脳血管障害に伴う精神症候治療剤
IL117612A0 (en) *	1995-03-24	1996-07-23	Lilly Co Eli	Granule formulation for olanzapine
CR5278A (es) *	1995-03-24	1996-07-04	Lilly Co Eli	Formulacion oral de 2-metil-tieno-benzodiacepina
EG24221A (en) *	1995-03-24	2008-11-10	Lilly Co Eli	Process for preparing olanzapine
EG23659A (en) *	1995-03-24	2007-03-26	Lilly Co Eli	Process and crystal forms of methyl-thieno-benzodiazepine
JPH11506096A (ja) *	1995-05-30	1999-06-02	イーライ・リリー・アンド・カンパニー	認識機能不全を処置する方法
CN1131035C (zh) *	1995-05-30	2003-12-17	伊莱利利公司	治疗识别机能障碍的方法
US6506746B2 (en)	1995-05-30	2003-01-14	Eli Lilly And Company	Method for treating cognitive dysfunction
US5891461A (en) *	1995-09-14	1999-04-06	Cygnus, Inc.	Transdermal administration of olanzapine
CA2240836A1 (en) *	1995-12-21	1997-07-03	Pierre Van Tran	Method for treating dermatitis
UA57727C2 (uk) *	1996-03-11	2003-07-15	Елі Ліллі Енд Компані	Спосіб лікування надмірної агресивності
JP2001500878A (ja) *	1996-09-23	2001-01-23	イーライ・リリー・アンド・カンパニー	オランザピン二水和物ｄ
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1990
- 1990-04-25 GB GB909009229A patent/GB9009229D0/en active Pending
1991
- 1991-04-22 AU AU75186/91A patent/AU643267B2/en not_active Expired
- 1991-04-22 IL IL9791291A patent/IL97912A/en not_active IP Right Cessation
- 1991-04-23 IE IE134891A patent/IE68401B1/en not_active IP Right Cessation
- 1991-04-23 PT PT97446A patent/PT97446B/pt not_active IP Right Cessation
- 1991-04-24 FI FI911986A patent/FI101379B1/fi active Protection Beyond IP Right Term
- 1991-04-24 CA CA002041113A patent/CA2041113C/en not_active Expired - Lifetime
- 1991-04-24 DE DE69112895T patent/DE69112895T4/de not_active Expired - Lifetime
- 1991-04-24 SK SK1168-91A patent/SK279196B6/sk not_active IP Right Cessation
- 1991-04-24 DE DE1996175046 patent/DE19675046I2/de active Active
- 1991-04-24 AT AT91303679T patent/ATE127804T1/de active
- 1991-04-24 YU YU73991A patent/YU48049B/sh unknown
- 1991-04-24 MX MX2550291A patent/MX173791B/es unknown
- 1991-04-24 CN CN91103346A patent/CN1028429C/zh not_active Expired - Lifetime
- 1991-04-24 NO NO911624A patent/NO178766C/no not_active IP Right Cessation
- 1991-04-24 DK DK91303679.4T patent/DK0454436T3/da active
- 1991-04-24 ES ES91303679T patent/ES2078440T3/es not_active Expired - Lifetime
- 1991-04-24 HU HU911372A patent/HU212416B/hu active IP Right Revival
- 1991-04-24 EP EP91303679A patent/EP0454436B1/en not_active Expired - Lifetime
- 1991-04-24 SI SI9110739A patent/SI9110739A/sl unknown
- 1991-04-24 CY CY190091A patent/CY1900A/xx unknown
- 1991-04-24 JP JP3228215A patent/JP2527860B2/ja not_active Expired - Lifetime
- 1991-04-24 NZ NZ237932A patent/NZ237932A/en unknown
- 1991-04-24 DE DE69112895A patent/DE69112895D1/de not_active Expired - Lifetime
- 1991-04-24 CZ CS911168A patent/CZ279937B6/cs not_active IP Right Cessation
- 1991-04-24 LU LU90009C patent/LU90009I2/fr unknown
- 1991-04-24 ZA ZA913085A patent/ZA913085B/xx unknown
- 1991-04-24 KR KR1019910006544A patent/KR100195566B1/ko not_active Expired - Lifetime
1992
- 1992-09-25 RU SU925052762A patent/RU2043992C1/ru active
1993
- 1993-06-08 LV LVP-93-517A patent/LV10262B/xx unknown
1994
- 1994-02-02 BG BG098434A patent/BG61710B2/bg unknown
1995
- 1995-02-08 IL IL11257595A patent/IL112575A0/xx unknown
- 1995-06-22 HU HU95P/P00335P patent/HU211575A9/hu unknown
- 1995-10-25 GR GR950402982T patent/GR3017877T3/el unknown
1996
- 1996-05-16 HK HK87596A patent/HK87596A/en not_active IP Right Cessation
1997
- 1997-03-21 NL NL970015C patent/NL970015I2/nl unknown
- 1997-05-12 NO NO1997005C patent/NO1997005I1/no unknown
2001
- 2001-10-18 GE GEAP20016159A patent/GEP20032965B/en unknown
- 2001-12-21 LU LU90869C patent/LU90869I2/fr unknown
- 2001-12-28 NO NO2001028C patent/NO2001028I1/no unknown
- 2001-12-28 NL NL300078C patent/NL300078I1/nl unknown

Also Published As

Publication number	Publication date
NO178766C (no)	1996-05-29
SK279196B6 (sk)	1998-07-08
KR100195566B1 (ko)	1999-06-15
LU90009I2 (fr)	1997-01-31
DE69112895T2 (de)	1996-03-07
NL970015I2 (nl)	1997-09-01
NL300078I1 (nl)	2002-03-01
MX173791B (es)	1994-03-25
AU7518691A (en)	1991-11-07
NO911624D0 (no)	1991-04-24
LU90869I2 (fr)	2002-02-21
CY1900A (en)	1991-04-24
GR3017877T3 (en)	1996-01-31
JP2527860B2 (ja)	1996-08-28
GEP20032965B (en)	2003-05-12
EP0454436A1 (en)	1991-10-30
KR910018387A (ko)	1991-11-30
DE69112895T4 (de)	2009-11-12
HU212416B (en)	1996-06-28
FI101379B (fi)	1998-06-15
ES2078440T3 (es)	1995-12-16
HK87596A (en)	1996-05-24
HU211575A9 (en)	1995-12-28
CA2041113A1 (en)	1991-10-26
HUT60503A (en)	1992-09-28
SI9110739A (en)	1997-10-31
NO2001028I1 (no)	2002-01-28
PT97446A (pt)	1992-01-31
CZ279937B6 (cs)	1995-09-13
JPH0789965A (ja)	1995-04-04
CA2041113C (en)	1998-07-14
EP0454436B1 (en)	1995-09-13
RU2043992C1 (ru)	1995-09-20
DE69112895D1 (de)	1995-10-19
AU643267B2 (en)	1993-11-11
NO178766B (no)	1996-02-19
NO1997005I1 (no)	1997-05-12
NO911624L (no)	1991-10-28
YU48049B (sh)	1996-10-18
HU911372D0 (en)	1991-10-28
NZ237932A (en)	1993-08-26
CN1028429C (zh)	1995-05-17
LV10262B (en)	1995-04-20
YU73991A (sh)	1994-01-20
IL112575A0 (en)	1995-05-26
ATE127804T1 (de)	1995-09-15
FI911986L (fi)	1991-10-26
IE68401B1 (en)	1996-06-12
GB9009229D0 (en)	1990-06-20
FI101379B1 (fi)	1998-06-15
CS9101168A2 (en)	1991-12-17
PT97446B (pt)	1997-07-31
BG61710B2 (bg)	1998-03-31
ZA913085B (en)	1992-12-30
CN1056693A (zh)	1991-12-04
NL970015I1 (nl)	1997-06-02
LV10262A (lv)	1994-10-20
DE19675046I2 (de)	2001-05-23
IE911348A1 (en)	1991-11-06
MX25502A (es)	1993-10-01
FI911986A0 (fi)	1991-04-24
IL97912A0 (en)	1992-06-21
DK0454436T3 (da)	1995-11-13

Legal Events

Date	Code	Title
1996-03-31	FF	Patent granted
1996-07-23	KB	Patent renewed
1999-06-20	HC	Change of name of proprietor(s)
2011-12-29	EXP	Patent expired

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KR100366895B1 (ko)	2003-03-15	인식기능장해치료용제약조성물
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US20020177590A1 (en)	2002-11-28	Method for treating cognitive dysfunction
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HK1009393B (en)	2003-05-16	Method for treating cognitive dysfunction