IS2048B - Notkun fumagillóls og afleiða þess við framleiðslu lyfja gegn þarmasýkingu - Google Patents

Notkun fumagillóls og afleiða þess við framleiðslu lyfja gegn þarmasýkingu

Info

Publication number: IS2048B
Authority: IS; Iceland
Prior art keywords: fumagillol; derivatives; manufacture; inflammatory drugs; inflammatory
Prior art date: 1995-03-27

Application number

IS4557A

Other languages

English (en)

Icelandic (is)

Other versions

IS4557A (is

Inventor

Molina Jean-Michel

Derouin Francis

Original Assignee

Sanofi-Aventis

Assistance Publique-Hopitaux De Paris

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-27

Filing date

1997-09-11

Publication date

2005-09-15

1997-09-11 Application filed by Sanofi-Aventis, Assistance Publique-Hopitaux De Paris filed Critical Sanofi-Aventis

1997-09-11 Publication of IS4557A publication Critical patent/IS4557A/is

2005-09-15 Publication of IS2048B publication Critical patent/IS2048B/is

Links

CEVCTNCUIVEQOY-UHFFFAOYSA-N Fumagillol Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(O)CCC21CO2 CEVCTNCUIVEQOY-UHFFFAOYSA-N 0.000 title 1
229940124599 anti-inflammatory drug Drugs 0.000 title 1
CEVCTNCUIVEQOY-STXHBLNNSA-N fumagillol Chemical compound C([C@@H](O)[C@H](C1[C@]2(C)[C@H](O2)CC=C(C)C)OC)C[C@@]21CO2 CEVCTNCUIVEQOY-STXHBLNNSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IS4557A 1995-03-27 1997-09-11 Notkun fumagillóls og afleiða þess við framleiðslu lyfja gegn þarmasýkingu IS2048B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9503549		1995-03-27
PCT/FR1996/000448 WO1996030010A2 (fr)	1995-03-27	1996-03-26	Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales

Publications (2)

Publication Number	Publication Date
IS4557A IS4557A (is)	1997-09-11
IS2048B true IS2048B (is)	2005-09-15

Family

ID=9477436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS4557A IS2048B (is)	1995-03-27	1997-09-11	Notkun fumagillóls og afleiða þess við framleiðslu lyfja gegn þarmasýkingu

Country Status (25)

Country	Link
US (1)	US5900431A (2)
EP (1)	EP0817626B1 (2)
JP (1)	JP3260378B2 (2)
KR (1)	KR100286920B1 (2)
CN (1)	CN1072485C (2)
AP (1)	AP646A (2)
AT (1)	ATE172641T1 (2)
AU (1)	AU706161B2 (2)
CA (1)	CA2216623C (2)
CZ (1)	CZ286821B6 (2)
DE (1)	DE69600879T2 (2)
DK (1)	DK0817626T3 (2)
EA (1)	EA000150B1 (2)
ES (1)	ES2128846T3 (2)
FR (1)	FR06C0014I2 (2)
HU (1)	HU224028B1 (2)
IS (1)	IS2048B (2)
NO (1)	NO315968B1 (2)
NZ (1)	NZ304906A (2)
OA (1)	OA10515A (2)
PL (1)	PL183378B1 (2)
SK (1)	SK283883B6 (2)
TR (1)	TR199701048T1 (2)
UA (1)	UA41446C2 (2)
WO (1)	WO1996030010A2 (2)

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US5900431A (en) *	1995-03-27	1999-05-04	Sanofi	Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections
EP0799616A1 (en) *	1996-04-01	1997-10-08	Takeda Chemical Industries, Ltd.	Oral composition comprising a fumagillol derivative
ES2286998T3 (es)	1999-02-26	2007-12-16	Sanofi-Aventis	Formulacion estable que contiene fumagillina.
JP3265394B1 (ja) *	2001-03-14	2002-03-11	泰三矢野	アクリル系樹脂手袋
DE10341887A1 (de) *	2003-09-09	2005-03-31	Leopold Kostal Gmbh & Co. Kg	Elektrisches Schaltermodul
FR2886855B1 (fr) *	2005-06-08	2009-07-17	Agronomique Inst Nat Rech	Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
EP2217283A2 (en) *	2007-11-28	2010-08-18	Mersana Therapeutics, Inc.	Biocompatible biodegradable fumagillin analog conjugates
US8865746B2 (en) *	2008-07-18	2014-10-21	Zafgen, Inc.	Methods of treating an overweight or obese subject
WO2013055385A2 (en)	2011-10-03	2013-04-18	Zafgen Corporation	Methods of treating age related disorders
WO2010065877A2 (en)	2008-12-04	2010-06-10	Zafgen Corporation	Methods of treating an overweight or obese subject
US8642650B2 (en)	2008-12-04	2014-02-04	Zafgen, Inc.	Methods of treating an overweight or obese subject
CA2777108A1 (en)	2009-10-09	2011-04-14	Zafgen Corporation	Sulphone compounds and methods of making and using same
BR112012016793A2 (pt)	2010-01-08	2018-07-31	Zafgen Corp	compostos tipo fumagilol e métodos de fazer e usar os mesmos
US8815309B2 (en)	2010-01-08	2014-08-26	Zafgen, Inc.	Methods of treating a subject with benign prostate hyperplasia
WO2011127304A2 (en)	2010-04-07	2011-10-13	Zafgen Corporation	Methods of treating an overweight subject
CN103249735B (zh)	2010-07-22	2016-04-06	扎夫根股份有限公司	三环化合物及其制备和使用方法
PH12013500934A1 (en)	2010-11-09	2022-10-24	Zafgen Inc	Crystalline solids of a metap-2 inhibitor and methods of making and using same
US9173865B2 (en)	2010-11-29	2015-11-03	Zafgen, Inc.	Treatment of obesity using non-daily administration of 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol
MX344238B (es)	2011-01-26	2016-12-07	Zafgen Inc	Compuestos de tetrazol y métodos para preparar y usar los mismos.
EP2683706B1 (en)	2011-03-08	2018-02-21	Zafgen, Inc.	Oxaspiro [2.5]octane derivatives and analogs
EP2705036B1 (en)	2011-05-06	2015-08-12	Zafgen Inc.	Tricyclic sulfonamide compounds and methods of making and using same
CN103764641B (zh)	2011-05-06	2016-10-26	扎夫根股份有限公司	部分饱和的三环化合物及其制备和使用方法
BR112013028666A2 (pt)	2011-05-06	2017-08-08	Zafgen Inc	compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
JP2015509102A (ja)	2012-01-18	2015-03-26	ザフゲン，インコーポレイテッド	三環式スルホン化合物並びにその作製および使用方法
MX2014008706A (es)	2012-01-18	2015-03-05	Zafgen Inc	Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
BR112014027808A2 (pt)	2012-05-07	2017-06-27	Zafgen Inc	sal polimórfico do sal de oxalato de 6-o-(4-dimetilaminoetoxi) cinaroil fumagilol e métodos de produção e utilização do mesmo
MX2014013599A (es)	2012-05-08	2015-05-11	Zafgen Inc	Tratamiento de la obesidad hipotalamica con inhibidores de metap2.
BR112014027981A2 (pt)	2012-05-09	2017-06-27	Zafgen Inc	compostos do tipo fumagilol e métodos de produção e utilização dos mesmos
MX2015005733A (es)	2012-11-05	2016-02-10	Zafgen Inc	Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad.
NZ707773A (en)	2012-11-05	2019-05-31	Zafgen Inc	Methods of treating liver diseases
AU2013337282A1 (en)	2012-11-05	2015-05-21	Zafgen, Inc.	Tricyclic compounds and methods of making and using same
CN105228610A (zh)	2013-03-14	2016-01-06	扎夫根股份有限公司	治疗肾疾病和其它病症的方法
CN106432255A (zh)	2015-08-11	2017-02-22	扎夫根公司	烟曲霉素醇螺环化合物和制备和使用其的方法
AR105671A1 (es)	2015-08-11	2017-10-25	Zafgen Inc	Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106591389B (zh) *	2015-10-15	2019-10-11	中国科学院微生物研究所	一种利用烟曲霉菌生产烟曲霉素的方法
CN105622593B (zh) *	2016-02-25	2018-06-26	中国农业科学院蜜蜂研究所	一种烟曲霉素的提取方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2791530A (en) *	1953-08-31	1957-05-07	Abbott Lab	Stabilized fumagillin compositions
JPH0629278B2 (ja) *	1985-06-26	1994-04-20	藤沢薬品工業株式会社	オキサスピロオクタン化合物
US5135920A (en) *	1988-11-16	1992-08-04	Takeda Chemical Industries, Ltd.	Angiostatic agents
JPH06504262A (ja) *	1990-07-27	1994-05-19	レブリゲン　コーポレーション	脈管形成性の病気の処置用の新規な方法と組成物
US5328930A (en) *	1993-03-01	1994-07-12	Emory University	Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin
US5900431A (en) *	1995-03-27	1999-05-04	Sanofi	Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections
EP0799616A1 (en) *	1996-04-01	1997-10-08	Takeda Chemical Industries, Ltd.	Oral composition comprising a fumagillol derivative
CA2210600A1 (en) *	1996-07-17	1998-01-17	Takashi Houkan	Inhibitor of tumor metastasis or recurrence
AU3968597A (en) *	1996-08-02	1998-02-25	Children's Medical Center Corporation	Method of regulating the female reproductive system through angiogenesis inhibitors

1996
- 1996-03-26 US US08/913,360 patent/US5900431A/en not_active Expired - Lifetime
- 1996-03-26 AP APAP/P/1997/001092A patent/AP646A/en active
- 1996-03-26 PL PL96322470A patent/PL183378B1/pl unknown
- 1996-03-26 EP EP96909200A patent/EP0817626B1/fr not_active Expired - Lifetime
- 1996-03-26 AU AU52786/96A patent/AU706161B2/en not_active Expired
- 1996-03-26 DE DE69600879T patent/DE69600879T2/de not_active Expired - Lifetime
- 1996-03-26 TR TR97/01048T patent/TR199701048T1/xx unknown
- 1996-03-26 SK SK1307-97A patent/SK283883B6/sk not_active IP Right Cessation
- 1996-03-26 UA UA97094765A patent/UA41446C2/uk unknown
- 1996-03-26 ES ES96909200T patent/ES2128846T3/es not_active Expired - Lifetime
- 1996-03-26 CZ CZ19973049A patent/CZ286821B6/cs not_active IP Right Cessation
- 1996-03-26 KR KR1019970706675A patent/KR100286920B1/ko not_active Expired - Lifetime
- 1996-03-26 WO PCT/FR1996/000448 patent/WO1996030010A2/fr not_active Ceased
- 1996-03-26 HU HU9801220A patent/HU224028B1/hu active IP Right Grant
- 1996-03-26 AT AT96909200T patent/ATE172641T1/de active
- 1996-03-26 EA EA199700267A patent/EA000150B1/ru not_active IP Right Cessation
- 1996-03-26 CA CA002216623A patent/CA2216623C/en not_active Expired - Lifetime
- 1996-03-26 CN CN96192923A patent/CN1072485C/zh not_active Expired - Lifetime
- 1996-03-26 JP JP52900196A patent/JP3260378B2/ja not_active Expired - Lifetime
- 1996-03-26 DK DK96909200T patent/DK0817626T3/da active
- 1996-03-26 NZ NZ304906A patent/NZ304906A/xx not_active IP Right Cessation
1997
- 1997-09-11 IS IS4557A patent/IS2048B/is unknown
- 1997-09-26 OA OA70088A patent/OA10515A/fr unknown
- 1997-09-26 NO NO19974466A patent/NO315968B1/no not_active IP Right Cessation
2006
- 2006-04-04 FR FR06C0014C patent/FR06C0014I2/fr active Active

Also Published As

Publication number	Publication date
AP646A (en)	1998-04-27
IS4557A (is)	1997-09-11
FR06C0014I2 (2)	2006-12-29
PL322470A1 (en)	1998-02-02
DE69600879T2 (de)	1999-06-02
HUP9801220A3 (en)	2001-10-29
EP0817626B1 (fr)	1998-10-28
CZ286821B6 (en)	2000-07-12
CN1072485C (zh)	2001-10-10
CA2216623A1 (en)	1996-10-03
OA10515A (fr)	2002-04-24
CZ304997A3 (en)	1997-12-17
SK130797A3 (en)	1998-03-04
UA41446C2 (uk)	2001-09-17
HU224028B1 (hu)	2005-05-30
NZ304906A (en)	1999-06-29
AP9701092A0 (en)	1997-10-31
NO974466D0 (no)	1997-09-26
MX9707150A (es)	1998-07-31
JPH11506421A (ja)	1999-06-08
TR199701048T1 (xx)	1998-01-21
KR100286920B1 (ko)	2001-04-16
WO1996030010A3 (fr)	1996-11-28
US5900431A (en)	1999-05-04
WO1996030010A2 (fr)	1996-10-03
JP3260378B2 (ja)	2002-02-25
DK0817626T3 (da)	1999-07-12
NO974466L (no)	1997-09-26
ES2128846T3 (es)	1999-05-16
NO315968B1 (no)	2003-11-24
SK283883B6 (sk)	2004-04-06
EA000150B1 (ru)	1998-10-29
EA199700267A1 (ru)	1998-04-30
ATE172641T1 (de)	1998-11-15
AU5278696A (en)	1996-10-16
AU706161B2 (en)	1999-06-10
KR19980703271A (ko)	1998-10-15
FR06C0014I1 (2)	2006-11-17
DE69600879D1 (de)	1998-12-03
EP0817626A2 (fr)	1998-01-14
CN1179715A (zh)	1998-04-22
PL183378B1 (pl)	2002-06-28
CA2216623C (en)	2005-05-31
HUP9801220A2 (hu)	1999-09-28

Publication	Publication Date	Title
IS4557A (is)	1997-09-11	Notkun fumagillóls og afleiða þess við framleiðslu lyfja gegn þarmasýkingu
FI953479A7 (fi)	1996-01-20	1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö
NO308740B1 (no)	2000-10-23	Kinazolinderivater, anvendelse derav og farmasøytisk blanding
NO961425D0 (no)	1996-04-11	1N-alkyl-N-arylpyrimidinaminer og derivater derav
FI961599A7 (fi)	1996-06-07	1N-alkyyli-N-aryylipyrimidiiniamiineja ja niiden johdannaisia
FI945556A7 (fi)	1995-05-27	Tulehdustenvastaiset 3-aryyli-2-isoksatsoliinijohdannaiset
FI20000516A7 (fi)	2000-03-07	Bis-indolyylimaleimidijohdannaiset ja niiden valmistus
DE69618587D1 (de)	2002-02-21	Chinazoline und pharmazeutische zusammensetzungen
ITMI920528A0 (it)	1992-03-06	14-beta idrossi-10-de acetil-baccatina iii, suoi derivati, loro preparazione ed impiego terapeutico
NO943511D0 (no)	1994-09-21	Farmasöytiske preparater og anvendelse derav
DE59208263D1 (de)	1997-04-30	3-Aryl-4-hydroxy-delta3-dihydrofuranon- und 3-Aryl-4-hydroxy-delta3-dihydrothiophenon-Derivate
FI961939A7 (fi)	1996-05-07	Antitromboottiset amidinofenyylialaniini- ja amidinopyridyylialaniinijohdannaiset
NO20011157L (no)	2001-04-25	Benzenderivater og farmasöytisk anvendelse derav
DK0804078T3 (da)	2000-04-10	Sammensætning og anvendelse deraf
BR9602915A (pt)	1998-04-22	Medicamentos uso e formulação farmacêutica
FI953358L (fi)	1995-07-07	Uudet paksusuolelle- ja sykkyräsuolelle spesifiset steroidijohdannaiset
ITMI942026A0 (it)	1994-10-05	Derivati della colchicina e loro impiego terapeutico
BR9509688A (pt)	1997-09-30	Composto e composição farmacêutica
NO971449D0 (no)	1997-03-26	Nye hormonelle medikamenter og anvendelse derav for korrigering av östrogen-mangel
FI942294A7 (fi)	1994-11-19	Bentsopyraanijohdannaiset ja niiden käyttö
NO973980D0 (no)	1997-08-29	Imiadazolderivater og medisinsk preparat
IS4140A (is)	1994-09-21	Notkun á ferróseni og/eða ferrósenafleiðum
FI933307L (fi)	1994-01-24	Anti-inflammatoriska indolinyl-n-hydroxiurea- och indolinyl-n-hydroxamsyraderivat
EE03419B1 (et)	2001-06-15	Välispidiselt kasutatav põletikuvastane vahend
ITMI931678A1 (it)	1995-01-28	Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi