JP3260378B2 - 腸感染に対する薬物の調製のためのフマギロールおよびその誘導体の使用 - Google Patents

腸感染に対する薬物の調製のためのフマギロールおよびその誘導体の使用

Info

Publication number: JP3260378B2
Authority: JP; Japan
Prior art keywords: pharmaceutical composition; fumagillol; composition according; patients; fumagillin
Prior art date: 1995-03-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP52900196A

Other languages

English (en)

Japanese (ja)

Other versions

JPH11506421A (ja

Inventor

モリナ，ジャン−ミシェル

デルーイン，フランシス

Original Assignee

サノフィーサンテラボ

アシスタンス・ピュブリーク−オピトー・ドゥ・パリ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-27

Filing date

1996-03-26

Publication date

2002-02-25

1996-03-26 Application filed by サノフィーサンテラボ, アシスタンス・ピュブリーク−オピトー・ドゥ・パリ filed Critical サノフィーサンテラボ

1999-06-08 Publication of JPH11506421A publication Critical patent/JPH11506421A/ja

2002-02-25 Application granted granted Critical

2002-02-25 Publication of JP3260378B2 publication Critical patent/JP3260378B2/ja

2016-03-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

CEVCTNCUIVEQOY-UHFFFAOYSA-N Fumagillol Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(O)CCC21CO2 CEVCTNCUIVEQOY-UHFFFAOYSA-N 0.000 title claims description 19
CEVCTNCUIVEQOY-STXHBLNNSA-N fumagillol Chemical compound C([C@@H](O)[C@H](C1[C@]2(C)[C@H](O2)CC=C(C)C)OC)C[C@@]21CO2 CEVCTNCUIVEQOY-STXHBLNNSA-N 0.000 title claims description 19
206010022678 Intestinal infections Diseases 0.000 title claims description 7
239000003814 drug Substances 0.000 title description 6
238000002360 preparation method Methods 0.000 title description 6
229940079593 drug Drugs 0.000 title description 4
239000008194 pharmaceutical composition Substances 0.000 claims description 14
150000002148 esters Chemical class 0.000 claims description 12
-1 unsaturated (C 1 -C 12 ) alkyl carboxylic acid Chemical class 0.000 claims description 12
239000003826 tablet Substances 0.000 claims description 10
NGGMYCMLYOUNGM-UHFFFAOYSA-N (-)-fumagillin Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(OC(=O)C=CC=CC=CC=CC(O)=O)CCC21CO2 NGGMYCMLYOUNGM-UHFFFAOYSA-N 0.000 claims description 9
NGGMYCMLYOUNGM-CSDLUJIJSA-N fumagillin Chemical group C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-N 0.000 claims description 9
229960000936 fumagillin Drugs 0.000 claims description 9
239000007903 gelatin capsule Substances 0.000 claims description 8
241001442406 Enterocytozoon bieneusi Species 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 6
244000045947 parasite Species 0.000 claims description 6
150000003839 salts Chemical class 0.000 claims description 5
229920006395 saturated elastomer Polymers 0.000 claims description 5
230000003111 delayed effect Effects 0.000 claims description 4
238000000034 method Methods 0.000 claims description 3
239000007912 modified release tablet Substances 0.000 claims description 3
239000000546 pharmaceutical excipient Substances 0.000 claims description 2
238000011282 treatment Methods 0.000 description 12
239000004480 active ingredient Substances 0.000 description 11
239000002253 acid Substances 0.000 description 7
150000001875 compounds Chemical class 0.000 description 5
230000008029 eradication Effects 0.000 description 5
208000015181 infectious disease Diseases 0.000 description 5
208000030507 AIDS Diseases 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000000843 powder Substances 0.000 description 4
238000001574 biopsy Methods 0.000 description 3
230000003071 parasitic effect Effects 0.000 description 3
206010001513 AIDS related complex Diseases 0.000 description 2
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
241000243190 Microsporidia Species 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000000921 anthelmintic agent Substances 0.000 description 2
229940124339 anthelmintic agent Drugs 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
QHYKVJVPIJCRRT-UHFFFAOYSA-N deca-2,4,6,8-tetraenedioic acid Chemical compound OC(=O)C=CC=CC=CC=CC(O)=O QHYKVJVPIJCRRT-UHFFFAOYSA-N 0.000 description 2
238000011161 development Methods 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
230000002183 duodenal effect Effects 0.000 description 2
238000001493 electron microscopy Methods 0.000 description 2
238000005538 encapsulation Methods 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000013355 food flavoring agent Nutrition 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
YRMCBQLZVBXOSJ-PCFSSPOYSA-N (e)-3-[(6r,6as)-4-hydroxy-6-methoxy-3-methyl-11-oxo-5,6,6a,7-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-8-yl]prop-2-enamide Chemical compound CO[C@H]1NC2=C(O)C(C)=CC=C2C(=O)N2C=C(\C=C\C(N)=O)C[C@@H]12 YRMCBQLZVBXOSJ-PCFSSPOYSA-N 0.000 description 1
241000220479 Acacia Species 0.000 description 1
229910002012 Aerosil® Inorganic materials 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
206010006895 Cachexia Diseases 0.000 description 1
206010048610 Cardiotoxicity Diseases 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
229920000858 Cyclodextrin Polymers 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
206010061598 Immunodeficiency Diseases 0.000 description 1
208000029462 Immunodeficiency disease Diseases 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
206010029155 Nephropathy toxic Diseases 0.000 description 1
208000001388 Opportunistic Infections Diseases 0.000 description 1
208000030852 Parasitic disease Diseases 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
230000000507 anthelmentic effect Effects 0.000 description 1
230000036436 anti-hiv Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
238000009341 apiculture Methods 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
239000002775 capsule Substances 0.000 description 1
231100000259 cardiotoxicity Toxicity 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
208000003167 cholangitis Diseases 0.000 description 1
239000008119 colloidal silica Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000012059 conventional drug carrier Substances 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
230000008034 disappearance Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000834 fixative Substances 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
230000002489 hematologic effect Effects 0.000 description 1
230000000652 homosexual effect Effects 0.000 description 1
230000007813 immunodeficiency Effects 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
206010023332 keratitis Diseases 0.000 description 1
201000010666 keratoconjunctivitis Diseases 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000006210 lotion Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
231100000417 nephrotoxicity Toxicity 0.000 description 1
230000007694 nephrotoxicity Effects 0.000 description 1
231100001092 no hepatotoxicity Toxicity 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
229940126701 oral medication Drugs 0.000 description 1
230000002688 persistence Effects 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
238000009372 pisciculture Methods 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
238000011160 research Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000002563 stool test Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000002636 symptomatic treatment Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000041 toxicology testing Toxicity 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
239000004562 water dispersible granule Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP52900196A 1995-03-27 1996-03-26 腸感染に対する薬物の調製のためのフマギロールおよびその誘導体の使用 Expired - Lifetime JP3260378B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR95/03549		1995-03-27
FR9503549		1995-03-27
PCT/FR1996/000448 WO1996030010A2 (fr)	1995-03-27	1996-03-26	Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales

Publications (2)

Publication Number	Publication Date
JPH11506421A JPH11506421A (ja)	1999-06-08
JP3260378B2 true JP3260378B2 (ja)	2002-02-25

Family

ID=9477436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP52900196A Expired - Lifetime JP3260378B2 (ja)	1995-03-27	1996-03-26	腸感染に対する薬物の調製のためのフマギロールおよびその誘導体の使用

Country Status (25)

Country	Link
US (1)	US5900431A (2)
EP (1)	EP0817626B1 (2)
JP (1)	JP3260378B2 (2)
KR (1)	KR100286920B1 (2)
CN (1)	CN1072485C (2)
AP (1)	AP646A (2)
AT (1)	ATE172641T1 (2)
AU (1)	AU706161B2 (2)
CA (1)	CA2216623C (2)
CZ (1)	CZ286821B6 (2)
DE (1)	DE69600879T2 (2)
DK (1)	DK0817626T3 (2)
EA (1)	EA000150B1 (2)
ES (1)	ES2128846T3 (2)
FR (1)	FR06C0014I2 (2)
HU (1)	HU224028B1 (2)
IS (1)	IS2048B (2)
NO (1)	NO315968B1 (2)
NZ (1)	NZ304906A (2)
OA (1)	OA10515A (2)
PL (1)	PL183378B1 (2)
SK (1)	SK283883B6 (2)
TR (1)	TR199701048T1 (2)
UA (1)	UA41446C2 (2)
WO (1)	WO1996030010A2 (2)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP646A (en) *	1995-03-27	1998-04-27	Sanofi Synthelabo	Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections.
EP0799616A1 (en) *	1996-04-01	1997-10-08	Takeda Chemical Industries, Ltd.	Oral composition comprising a fumagillol derivative
ES2286998T3 (es)	1999-02-26	2007-12-16	Sanofi-Aventis	Formulacion estable que contiene fumagillina.
JP3265394B1 (ja) *	2001-03-14	2002-03-11	泰三矢野	アクリル系樹脂手袋
DE10341887A1 (de) *	2003-09-09	2005-03-31	Leopold Kostal Gmbh & Co. Kg	Elektrisches Schaltermodul
FR2886855B1 (fr) *	2005-06-08	2009-07-17	Agronomique Inst Nat Rech	Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
CN101990441A (zh) *	2007-11-28	2011-03-23	默萨那治疗学股份有限公司	生物相容的生物可降解的烟曲霉素类似物轭合物
US8865746B2 (en) *	2008-07-18	2014-10-21	Zafgen, Inc.	Methods of treating an overweight or obese subject
WO2010065877A2 (en)	2008-12-04	2010-06-10	Zafgen Corporation	Methods of treating an overweight or obese subject
WO2010065883A2 (en)	2008-12-04	2010-06-10	Zafgen Corporation	Method of treating an overweight or obese subject
EP2486004B1 (en)	2009-10-09	2017-05-03	Zafgen, Inc.	Sulphone compounds for use in the treatment of obesity
AU2011204267B2 (en)	2010-01-08	2015-12-03	Zafgen Corporation	Fumagillol type compounds and methods of making and using same
US8815309B2 (en)	2010-01-08	2014-08-26	Zafgen, Inc.	Methods of treating a subject with benign prostate hyperplasia
WO2011127304A2 (en)	2010-04-07	2011-10-13	Zafgen Corporation	Methods of treating an overweight subject
CN103249735B (zh)	2010-07-22	2016-04-06	扎夫根股份有限公司	三环化合物及其制备和使用方法
PH12013500934A1 (en)	2010-11-09	2022-10-24	Zafgen Inc	Crystalline solids of a metap-2 inhibitor and methods of making and using same
WO2012075020A1 (en)	2010-11-29	2012-06-07	Zafgen Corporation	Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
KR20140006888A (ko)	2011-01-26	2014-01-16	자프겐 인크.	테트라졸화합물, 그리고, 이를 제조하는 방법 및 이를 이용하는 방법
CN103534244B (zh)	2011-03-08	2016-10-12	扎夫根股份有限公司	氧杂螺[2.5]辛烷衍生物及类似物
BR112013028666A2 (pt)	2011-05-06	2017-08-08	Zafgen Inc	compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
CA2835261C (en)	2011-05-06	2019-06-04	Zafgen, Inc.	Partially saturated tricyclic compounds and methods of making and using same
AU2012253759B2 (en)	2011-05-06	2016-01-21	Zafgen Inc.	Tricyclic sulfonamide compounds and methods of making and using same
EP2763671A2 (en)	2011-10-03	2014-08-13	Zafgen, Inc.	Methods of treating age related disorders
JP2015509102A (ja)	2012-01-18	2015-03-26	ザフゲン，インコーポレイテッド	三環式スルホン化合物並びにその作製および使用方法
MX2014008706A (es)	2012-01-18	2015-03-05	Zafgen Inc	Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
US9260419B2 (en)	2012-05-07	2016-02-16	Zafgen, Inc.	Polymorphic salt of a metap-2 inhibitor and methods of making and using same
AU2013259617A1 (en)	2012-05-08	2014-11-27	Zafgen, Inc.	Treating hypothalamic obesity with MetAP2 inhibitors
MX356755B (es)	2012-05-09	2018-06-11	Zafgen Inc	Compuestos de tipo fumagilol y metodos para su elaboración y uso.
BR112015010223A2 (pt)	2012-11-05	2017-07-11	Zafgen Inc	compostos tricíclicos para o uso no tratamento e/ou controle de obesidade
NZ707773A (en)	2012-11-05	2019-05-31	Zafgen Inc	Methods of treating liver diseases
JP2015536981A (ja)	2012-11-05	2015-12-24	ザフゲン，インコーポレイテッド	三環式化合物ならびにその製造および使用方法
CN105228610A (zh)	2013-03-14	2016-01-06	扎夫根股份有限公司	治疗肾疾病和其它病症的方法
CN106432255A (zh)	2015-08-11	2017-02-22	扎夫根公司	烟曲霉素醇螺环化合物和制备和使用其的方法
AR105671A1 (es)	2015-08-11	2017-10-25	Zafgen Inc	Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106591389B (zh) *	2015-10-15	2019-10-11	中国科学院微生物研究所	一种利用烟曲霉菌生产烟曲霉素的方法
CN105622593B (zh) *	2016-02-25	2018-06-26	中国农业科学院蜜蜂研究所	一种烟曲霉素的提取方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5328930A (en)	1993-03-01	1994-07-12	Emory University	Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2791530A (en) *	1953-08-31	1957-05-07	Abbott Lab	Stabilized fumagillin compositions
JPH0629278B2 (ja) *	1985-06-26	1994-04-20	藤沢薬品工業株式会社	オキサスピロオクタン化合物
US5135920A (en) *	1988-11-16	1992-08-04	Takeda Chemical Industries, Ltd.	Angiostatic agents
WO1992002240A2 (en) *	1990-07-27	1992-02-20	Repligen Corporation	Novel methods and compositions for treatment of angiogenic diseases
AP646A (en) *	1995-03-27	1998-04-27	Sanofi Synthelabo	Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections.
EP0799616A1 (en) *	1996-04-01	1997-10-08	Takeda Chemical Industries, Ltd.	Oral composition comprising a fumagillol derivative
CA2210600A1 (en) *	1996-07-17	1998-01-17	Takashi Houkan	Inhibitor of tumor metastasis or recurrence
AU3968597A (en) *	1996-08-02	1998-02-25	Children's Medical Center Corporation	Method of regulating the female reproductive system through angiogenesis inhibitors

1996
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5328930A (en)	1993-03-01	1994-07-12	Emory University	Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ＡｍｅｒｉｃａｎＪｏｕｒｎａｌｏｆＯｐｈｔｈａｌｍｏｌｏｇｙ，１９９３年３月１５日，Ｖｏｌ．１１５，Ｎｏ．３，ｐ．２７３−２７８
ＣａｎｃｅｒＲｅｓｅａｒｃｈ，Ｖｏｌ．５５，Ｎｏ．４，ｐ．８３６−３８９
Ｃｏｒｎｅａ，１９９３年５月１日，Ｖｏｌ．１２，Ｎｏ．３，ｐ．２６１−２６５
ＩｎｆｅｃｔｉｏｕｓＤｉｓｅａｓｅＣｌｉｎｉｃｓｏｆＮｏｒｔｈＡｍｅｒｉｃａ，１９９４年６月９日，Ｖｏｌ．８，Ｎｏ．２，ｐ．４８３−４９８
ＲｅｖｉｅｗｓｉｎＭｅｄｉｃａｌＭｉｃｒｏｂｉｏｌｏｇｙ，１９９２年１月１日，Ｖｏｌ．３，Ｎｏ．１，ｐ．３５−４２

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Publication number	Publication date
DE69600879D1 (de)	1998-12-03
HUP9801220A3 (en)	2001-10-29
NO974466L (no)	1997-09-26
SK283883B6 (sk)	2004-04-06
NO974466D0 (no)	1997-09-26
HUP9801220A2 (hu)	1999-09-28
HU224028B1 (hu)	2005-05-30
KR19980703271A (ko)	1998-10-15
WO1996030010A2 (fr)	1996-10-03
ATE172641T1 (de)	1998-11-15
CZ286821B6 (en)	2000-07-12
CA2216623C (en)	2005-05-31
PL322470A1 (en)	1998-02-02
CZ304997A3 (en)	1997-12-17
NO315968B1 (no)	2003-11-24
JPH11506421A (ja)	1999-06-08
AU706161B2 (en)	1999-06-10
EP0817626A2 (fr)	1998-01-14
MX9707150A (es)	1998-07-31
CN1072485C (zh)	2001-10-10
UA41446C2 (uk)	2001-09-17
CN1179715A (zh)	1998-04-22
EA000150B1 (ru)	1998-10-29
AU5278696A (en)	1996-10-16
DK0817626T3 (da)	1999-07-12
EA199700267A1 (ru)	1998-04-30
CA2216623A1 (en)	1996-10-03
TR199701048T1 (xx)	1998-01-21
WO1996030010A3 (fr)	1996-11-28
KR100286920B1 (ko)	2001-04-16
IS4557A (is)	1997-09-11
FR06C0014I1 (2)	2006-11-17
DE69600879T2 (de)	1999-06-02
EP0817626B1 (fr)	1998-10-28
IS2048B (is)	2005-09-15
NZ304906A (en)	1999-06-29
US5900431A (en)	1999-05-04
SK130797A3 (en)	1998-03-04
OA10515A (fr)	2002-04-24
AP9701092A0 (en)	1997-10-31
ES2128846T3 (es)	1999-05-16
FR06C0014I2 (2)	2006-12-29
AP646A (en)	1998-04-27
PL183378B1 (pl)	2002-06-28

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