PL183378B1 - Zastosowanie fumagilolu i jego pochodnych do wytwarzania jelitowych środków przeciwinfekcyjnych - Google Patents

Zastosowanie fumagilolu i jego pochodnych do wytwarzania jelitowych środków przeciwinfekcyjnych

Info

Publication number: PL183378B1
Authority: PL; Poland
Prior art keywords: fumagylol; patients; intestinal; active ingredient; treatment
Prior art date: 1995-03-27

Application number

PL96322470A

Other languages

English (en)

Polish (pl)

Other versions

PL322470A1 (en

Inventor

Jean-Michel Molina

Francis Derouin

Original Assignee

Assist Publ Hopitaux De Paris

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-27

Filing date

1996-03-26

Publication date

2002-06-28

1996-03-26 Application filed by Assist Publ Hopitaux De Paris, Sanofi Synthelabo filed Critical Assist Publ Hopitaux De Paris

1998-02-02 Publication of PL322470A1 publication Critical patent/PL322470A1/xx

2002-06-28 Publication of PL183378B1 publication Critical patent/PL183378B1/pl

Links

230000000968 intestinal effect Effects 0.000 title description 3
230000002924 anti-infective effect Effects 0.000 title 1
150000002148 esters Chemical class 0.000 claims abstract description 12
239000003814 drug Substances 0.000 claims abstract description 10
238000002360 preparation method Methods 0.000 claims abstract description 8
150000003839 salts Chemical class 0.000 claims abstract description 7
229920006395 saturated elastomer Polymers 0.000 claims abstract description 7
206010022678 Intestinal infections Diseases 0.000 claims abstract description 6
239000002253 acid Substances 0.000 claims description 13
239000004480 active ingredient Substances 0.000 claims description 13
239000008194 pharmaceutical composition Substances 0.000 claims description 10
241001442406 Enterocytozoon bieneusi Species 0.000 claims description 7
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238000013270 controlled release Methods 0.000 claims description 3
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NGGMYCMLYOUNGM-UHFFFAOYSA-N (-)-fumagillin Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(OC(=O)C=CC=CC=CC=CC(O)=O)CCC21CO2 NGGMYCMLYOUNGM-UHFFFAOYSA-N 0.000 claims 2
NGGMYCMLYOUNGM-CSDLUJIJSA-N fumagillin Chemical group C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-N 0.000 claims 2
229960000936 fumagillin Drugs 0.000 claims 2
CEVCTNCUIVEQOY-UHFFFAOYSA-N Fumagillol Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(O)CCC21CO2 CEVCTNCUIVEQOY-UHFFFAOYSA-N 0.000 abstract 1
241000243190 Microsporidia Species 0.000 abstract 1
CEVCTNCUIVEQOY-STXHBLNNSA-N fumagillol Chemical compound C([C@@H](O)[C@H](C1[C@]2(C)[C@H](O2)CC=C(C)C)OC)C[C@@]21CO2 CEVCTNCUIVEQOY-STXHBLNNSA-N 0.000 abstract 1
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
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QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
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USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
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102000002260 Alkaline Phosphatase Human genes 0.000 description 1
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GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
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125000000217 alkyl group Chemical group 0.000 description 1
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239000012059 conventional drug carrier Substances 0.000 description 1
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229940097362 cyclodextrins Drugs 0.000 description 1
QHYKVJVPIJCRRT-UHFFFAOYSA-N deca-2,4,6,8-tetraenedioic acid Chemical compound OC(=O)C=CC=CC=CC=CC(O)=O QHYKVJVPIJCRRT-UHFFFAOYSA-N 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
150000001991 dicarboxylic acids Chemical class 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
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235000019359 magnesium stearate Nutrition 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
239000000203 mixture Substances 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
229940126701 oral medication Drugs 0.000 description 1
230000003108 parasitologic effect Effects 0.000 description 1
230000002688 persistence Effects 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
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235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
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238000012360 testing method Methods 0.000 description 1
206010043554 thrombocytopenia Diseases 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
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239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL96322470A 1995-03-27 1996-03-26 Zastosowanie fumagilolu i jego pochodnych do wytwarzania jelitowych środków przeciwinfekcyjnych PL183378B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9503549		1995-03-27
PCT/FR1996/000448 WO1996030010A2 (fr)	1995-03-27	1996-03-26	Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales

Publications (2)

Publication Number	Publication Date
PL322470A1 PL322470A1 (en)	1998-02-02
PL183378B1 true PL183378B1 (pl)	2002-06-28

Family

ID=9477436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL96322470A PL183378B1 (pl)	1995-03-27	1996-03-26	Zastosowanie fumagilolu i jego pochodnych do wytwarzania jelitowych środków przeciwinfekcyjnych

Country Status (25)

Country	Link
US (1)	US5900431A (2)
EP (1)	EP0817626B1 (2)
JP (1)	JP3260378B2 (2)
KR (1)	KR100286920B1 (2)
CN (1)	CN1072485C (2)
AP (1)	AP646A (2)
AT (1)	ATE172641T1 (2)
AU (1)	AU706161B2 (2)
CA (1)	CA2216623C (2)
CZ (1)	CZ286821B6 (2)
DE (1)	DE69600879T2 (2)
DK (1)	DK0817626T3 (2)
EA (1)	EA000150B1 (2)
ES (1)	ES2128846T3 (2)
FR (1)	FR06C0014I2 (2)
HU (1)	HU224028B1 (2)
IS (1)	IS2048B (2)
NO (1)	NO315968B1 (2)
NZ (1)	NZ304906A (2)
OA (1)	OA10515A (2)
PL (1)	PL183378B1 (2)
SK (1)	SK283883B6 (2)
TR (1)	TR199701048T1 (2)
UA (1)	UA41446C2 (2)
WO (1)	WO1996030010A2 (2)

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JP3265394B1 (ja) *	2001-03-14	2002-03-11	泰三矢野	アクリル系樹脂手袋
DE10341887A1 (de) *	2003-09-09	2005-03-31	Leopold Kostal Gmbh & Co. Kg	Elektrisches Schaltermodul
FR2886855B1 (fr) *	2005-06-08	2009-07-17	Agronomique Inst Nat Rech	Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
CN101990441A (zh) *	2007-11-28	2011-03-23	默萨那治疗学股份有限公司	生物相容的生物可降解的烟曲霉素类似物轭合物
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WO2010065883A2 (en)	2008-12-04	2010-06-10	Zafgen Corporation	Method of treating an overweight or obese subject
EP2486004B1 (en)	2009-10-09	2017-05-03	Zafgen, Inc.	Sulphone compounds for use in the treatment of obesity
AU2011204267B2 (en)	2010-01-08	2015-12-03	Zafgen Corporation	Fumagillol type compounds and methods of making and using same
US8815309B2 (en)	2010-01-08	2014-08-26	Zafgen, Inc.	Methods of treating a subject with benign prostate hyperplasia
WO2011127304A2 (en)	2010-04-07	2011-10-13	Zafgen Corporation	Methods of treating an overweight subject
CN103249735B (zh)	2010-07-22	2016-04-06	扎夫根股份有限公司	三环化合物及其制备和使用方法
PH12013500934A1 (en)	2010-11-09	2022-10-24	Zafgen Inc	Crystalline solids of a metap-2 inhibitor and methods of making and using same
WO2012075020A1 (en)	2010-11-29	2012-06-07	Zafgen Corporation	Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
KR20140006888A (ko)	2011-01-26	2014-01-16	자프겐 인크.	테트라졸화합물, 그리고, 이를 제조하는 방법 및 이를 이용하는 방법
CN103534244B (zh)	2011-03-08	2016-10-12	扎夫根股份有限公司	氧杂螺[2.5]辛烷衍生物及类似物
BR112013028666A2 (pt)	2011-05-06	2017-08-08	Zafgen Inc	compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
CA2835261C (en)	2011-05-06	2019-06-04	Zafgen, Inc.	Partially saturated tricyclic compounds and methods of making and using same
AU2012253759B2 (en)	2011-05-06	2016-01-21	Zafgen Inc.	Tricyclic sulfonamide compounds and methods of making and using same
EP2763671A2 (en)	2011-10-03	2014-08-13	Zafgen, Inc.	Methods of treating age related disorders
JP2015509102A (ja)	2012-01-18	2015-03-26	ザフゲン，インコーポレイテッド	三環式スルホン化合物並びにその作製および使用方法
MX2014008706A (es)	2012-01-18	2015-03-05	Zafgen Inc	Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
US9260419B2 (en)	2012-05-07	2016-02-16	Zafgen, Inc.	Polymorphic salt of a metap-2 inhibitor and methods of making and using same
AU2013259617A1 (en)	2012-05-08	2014-11-27	Zafgen, Inc.	Treating hypothalamic obesity with MetAP2 inhibitors
MX356755B (es)	2012-05-09	2018-06-11	Zafgen Inc	Compuestos de tipo fumagilol y metodos para su elaboración y uso.
BR112015010223A2 (pt)	2012-11-05	2017-07-11	Zafgen Inc	compostos tricíclicos para o uso no tratamento e/ou controle de obesidade
NZ707773A (en)	2012-11-05	2019-05-31	Zafgen Inc	Methods of treating liver diseases
JP2015536981A (ja)	2012-11-05	2015-12-24	ザフゲン，インコーポレイテッド	三環式化合物ならびにその製造および使用方法
CN105228610A (zh)	2013-03-14	2016-01-06	扎夫根股份有限公司	治疗肾疾病和其它病症的方法
CN106432255A (zh)	2015-08-11	2017-02-22	扎夫根公司	烟曲霉素醇螺环化合物和制备和使用其的方法
AR105671A1 (es)	2015-08-11	2017-10-25	Zafgen Inc	Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
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EP0799616A1 (en) *	1996-04-01	1997-10-08	Takeda Chemical Industries, Ltd.	Oral composition comprising a fumagillol derivative
CA2210600A1 (en) *	1996-07-17	1998-01-17	Takashi Houkan	Inhibitor of tumor metastasis or recurrence
AU3968597A (en) *	1996-08-02	1998-02-25	Children's Medical Center Corporation	Method of regulating the female reproductive system through angiogenesis inhibitors

1996
- 1996-03-26 AP APAP/P/1997/001092A patent/AP646A/en active
- 1996-03-26 WO PCT/FR1996/000448 patent/WO1996030010A2/fr not_active Ceased
- 1996-03-26 JP JP52900196A patent/JP3260378B2/ja not_active Expired - Lifetime
- 1996-03-26 EP EP96909200A patent/EP0817626B1/fr not_active Expired - Lifetime
- 1996-03-26 CA CA002216623A patent/CA2216623C/en not_active Expired - Lifetime
- 1996-03-26 ES ES96909200T patent/ES2128846T3/es not_active Expired - Lifetime
- 1996-03-26 EA EA199700267A patent/EA000150B1/ru not_active IP Right Cessation
- 1996-03-26 TR TR97/01048T patent/TR199701048T1/xx unknown
- 1996-03-26 DE DE69600879T patent/DE69600879T2/de not_active Expired - Lifetime
- 1996-03-26 CN CN96192923A patent/CN1072485C/zh not_active Expired - Lifetime
- 1996-03-26 PL PL96322470A patent/PL183378B1/pl unknown
- 1996-03-26 UA UA97094765A patent/UA41446C2/uk unknown
- 1996-03-26 SK SK1307-97A patent/SK283883B6/sk not_active IP Right Cessation
- 1996-03-26 HU HU9801220A patent/HU224028B1/hu active IP Right Grant
- 1996-03-26 US US08/913,360 patent/US5900431A/en not_active Expired - Lifetime
- 1996-03-26 AU AU52786/96A patent/AU706161B2/en not_active Expired
- 1996-03-26 KR KR1019970706675A patent/KR100286920B1/ko not_active Expired - Lifetime
- 1996-03-26 CZ CZ19973049A patent/CZ286821B6/cs not_active IP Right Cessation
- 1996-03-26 NZ NZ304906A patent/NZ304906A/xx not_active IP Right Cessation
- 1996-03-26 DK DK96909200T patent/DK0817626T3/da active
- 1996-03-26 AT AT96909200T patent/ATE172641T1/de active
1997
- 1997-09-11 IS IS4557A patent/IS2048B/is unknown
- 1997-09-26 OA OA70088A patent/OA10515A/fr unknown
- 1997-09-26 NO NO19974466A patent/NO315968B1/no not_active IP Right Cessation
2006
- 2006-04-04 FR FR06C0014C patent/FR06C0014I2/fr active Active

Also Published As

Publication number	Publication date
DE69600879D1 (de)	1998-12-03
HUP9801220A3 (en)	2001-10-29
NO974466L (no)	1997-09-26
SK283883B6 (sk)	2004-04-06
NO974466D0 (no)	1997-09-26
HUP9801220A2 (hu)	1999-09-28
HU224028B1 (hu)	2005-05-30
KR19980703271A (ko)	1998-10-15
WO1996030010A2 (fr)	1996-10-03
ATE172641T1 (de)	1998-11-15
CZ286821B6 (en)	2000-07-12
CA2216623C (en)	2005-05-31
PL322470A1 (en)	1998-02-02
CZ304997A3 (en)	1997-12-17
NO315968B1 (no)	2003-11-24
JPH11506421A (ja)	1999-06-08
AU706161B2 (en)	1999-06-10
EP0817626A2 (fr)	1998-01-14
MX9707150A (es)	1998-07-31
CN1072485C (zh)	2001-10-10
UA41446C2 (uk)	2001-09-17
CN1179715A (zh)	1998-04-22
EA000150B1 (ru)	1998-10-29
AU5278696A (en)	1996-10-16
DK0817626T3 (da)	1999-07-12
EA199700267A1 (ru)	1998-04-30
CA2216623A1 (en)	1996-10-03
TR199701048T1 (xx)	1998-01-21
JP3260378B2 (ja)	2002-02-25
WO1996030010A3 (fr)	1996-11-28
KR100286920B1 (ko)	2001-04-16
IS4557A (is)	1997-09-11
FR06C0014I1 (2)	2006-11-17
DE69600879T2 (de)	1999-06-02
EP0817626B1 (fr)	1998-10-28
IS2048B (is)	2005-09-15
NZ304906A (en)	1999-06-29
US5900431A (en)	1999-05-04
SK130797A3 (en)	1998-03-04
OA10515A (fr)	2002-04-24
AP9701092A0 (en)	1997-10-31
ES2128846T3 (es)	1999-05-16
FR06C0014I2 (2)	2006-12-29
AP646A (en)	1998-04-27

Publication	Publication Date	Title
US5900431A (en)	1999-05-04	Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections
US5240922A (en)	1993-08-31	Fertility enhancement
BG63612B1 (bg)	2002-07-31	Състав и метод за профилактика и лечение на нiv идруги инфекциозни заболявания при човека
US5348744A (en)	1994-09-20	Antidiarrheal compositions containing loperamide hydrochloride and a saccharide
CN1105361A (zh)	1995-07-19	抑制血管生成和血管原性疾病的方法
US20100021543A1 (en)	2010-01-28	Peroral solid pain killer preparation
NO324357B1 (no)	2007-10-01	Anvendelse av et ostroprogestagenhormonpreparat ved fremstillingen av et medikament for behandling av ostrogenforstyrrelser og osteoporose hos postmenopausale kvinner, samt anvendelse av et farmasoytisk preparat ved fremstilling av et medikament for a stoppe ovulasjon
JPH0232093A (ja)	1990-02-01	抗レトロウィルスジフルオロ化ヌクレオシド類
US5840741A (en)	1998-11-24	Arteriosclerosis depressant
EP0443028B1 (en)	1993-09-29	Non-injection carcinostatic agent for suppressing occurrence of inflammation due to 5-fluorouracil and method for curing cancer
MXPA97007150A (en)	1998-11-09	Use of fumagilol and its derivatives to prepare medicines intended to combat intestine infections
EP1197214A1 (en)	2002-04-17	Medicinal compositions for preventing or treating diarrhea
KR880002266B1 (ko)	1988-10-21	종양 발육 억제 조성물
RU2020931C1 (ru)	1994-10-15	Способ получения лекарственного средства для лечения язвенной болезни желудочно-кишечного тракта млекопитающих
US4062964A (en)	1977-12-13	Antifertility-combinations
EP0402477B1 (en)	1997-03-19	Use of isocarbacyclins for preventing or treating organ diseases
DE60104693T2 (de)	2005-08-11	Behandlung von septischem schock
JPH0132804B2 (2)	1989-07-10
US4470974A (en)	1984-09-11	Gastric cytoprotection with L-363,586
JP3386873B2 (ja)	2003-03-17	消化器系疾患用剤
EP1513539B1 (de)	2008-02-13	Verwendung von amphiphilen nucleosid-phosphonoameisensäure-derivaten zur behandlung von viralen infektionskrankheiten
KR100532542B1 (ko)	2005-12-01	아르세닉산, 메타아르세나이트 또는 이들의 약제학적허용가능한 염을 함유한 에이즈 예방 및 치료용 약제 조성물
JPH05339156A (ja)	1993-12-21	ヒト腫瘍細胞に対する選択的細胞障害剤
JPH05501541A (ja)	1993-03-25	繁殖力増強
US20040044016A1 (en)	2004-03-04	Antiviral agents