IS2287B - Nýjar afleiður og hliðstæður af galantamíni - Google Patents

Nýjar afleiður og hliðstæður af galantamíni

Info

Publication number: IS2287B
Authority: IS; Iceland
Prior art keywords: galantamine; analogues; new derivatives; new; derivatives
Prior art date: 2000-03-31

Application number

IS6174A

Other languages

English (en)

Other versions

IS6174A (is

Inventor

Jordis Ulrich

Fr÷hlich Johannes

Treu Matthias

Hirnschall Manfred

Czollner Laszlo

Kälz Beate

Welzig Stefan

Original Assignee

Sanochemia Pharmazeutika Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-31

Filing date

2001-11-23

Publication date

2007-10-15

2001-11-23 Application filed by Sanochemia Pharmazeutika Aktiengesellschaft filed Critical Sanochemia Pharmazeutika Aktiengesellschaft

2001-11-23 Publication of IS6174A publication Critical patent/IS6174A/is

2007-10-15 Publication of IS2287B publication Critical patent/IS2287B/is

Links

ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical class O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IS6174A 2000-03-31 2001-11-23 Nýjar afleiður og hliðstæður af galantamíni IS2287B (is)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
AT5462000		2000-03-31
AT2382001		2001-02-15
PCT/AT2001/000082 WO2001074820A1 (de)	2000-03-31	2001-03-22	Neue derivate und analoga von galanthamin

Publications (2)

Publication Number	Publication Date
IS6174A IS6174A (is)	2001-11-23
IS2287B true IS2287B (is)	2007-10-15

Family

ID=25608130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6174A IS2287B (is)	2000-03-31	2001-11-23	Nýjar afleiður og hliðstæður af galantamíni

Country Status (26)

Country	Link
US (2)	US7166588B2 (is)
EP (1)	EP1181294B1 (is)
JP (1)	JP2003529602A (is)
CN (1)	CN1380883A (is)
AT (1)	ATE263171T1 (is)
AU (1)	AU785385B2 (is)
BG (1)	BG65134B1 (is)
BR (1)	BR0105563A (is)
CA (1)	CA2368966A1 (is)
CZ (1)	CZ300160B6 (is)
DE (1)	DE50101827D1 (is)
DK (1)	DK1181294T3 (is)
ES (1)	ES2215885T3 (is)
HK (1)	HK1049832A1 (is)
HU (1)	HUP0202233A3 (is)
IS (1)	IS2287B (is)
MX (1)	MXPA01012275A (is)
NO (1)	NO326458B1 (is)
NZ (1)	NZ516302A (is)
PL (1)	PL202463B1 (is)
PT (1)	PT1181294E (is)
RU (1)	RU2241001C2 (is)
SI (1)	SI1181294T1 (is)
SK (1)	SK285909B6 (is)
TR (1)	TR200400857T4 (is)
WO (1)	WO2001074820A1 (is)

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JP4721386B2 (ja) *	2001-07-10	2011-07-13	第一三共株式会社	新規ガランタミン類縁体
EP1681291A1 (de) *	2002-03-25	2006-07-19	Sanochemia Pharmazeutika Aktiengesellschaft	Verfahren zur Herstellung von Norgalanthamin, Ihren Isomeren, Salzen und Hydraten
AT414125B (de) *	2003-09-29	2006-09-15	Sanochemia Pharmazeutika Ag	Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln
AT500143A1 (de) *	2004-04-22	2005-11-15	Sanochemia Pharmazeutika Ag	Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
US7877350B2 (en) *	2005-06-27	2011-01-25	Ab Initio Technology Llc	Managing metadata for graph-based computations
DE602006015338D1 (de) *	2005-09-22	2010-08-19	Galantos Pharma Gmbh	Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2008022365A2 (de) *	2006-08-24	2008-02-28	Sanochemia Ltd.	Mittel zum beeinflussen der wirkungen von organophosphorverbindungen und verwendung von galanthamin, dessen derivaten und analoga zum herstellen solcher mittel
CN102007129B (zh)	2008-04-14	2014-05-07	神经动力生命科学公司	用作治疗人类脑疾病的前药的雪花胺衍生物
BG110141A (en) *	2008-05-23	2009-12-31	"Софарма" Ад	GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE
US8875145B2 (en)	2010-06-15	2014-10-28	Ab Initio Technology Llc	Dynamically loading graph-based computations
WO2013160728A1 (en)	2012-04-26	2013-10-31	Alma Mater Studiorum - Universita' Di Bologna	Dual targeting compounds for the treatment of alzheimer's disease
US10108521B2 (en) *	2012-11-16	2018-10-23	Ab Initio Technology Llc	Dynamic component performance monitoring
CN106170762B (zh)	2013-12-05	2020-01-14	起元技术有限责任公司	管理包括子图的数据流图所用的接口
KR102375347B1 (ko)	2014-09-02	2022-03-16	아브 이니티오 테크놀로지 엘엘시	사용자 상호작용을 통한 그래프 기반 프로그램에서 구성요소 서브세트의 시각적 명시
US9830343B2 (en)	2014-09-02	2017-11-28	Ab Initio Technology Llc	Compiling graph-based program specifications
US10657134B2 (en)	2015-08-05	2020-05-19	Ab Initio Technology Llc	Selecting queries for execution on a stream of real-time data
US12006301B1 (en)	2021-05-13	2024-06-11	Florida A&M University	And synthesis of dual 5-HT1A and 5-HT7 receptor ligands
CN116082352A (zh) *	2023-02-16	2023-05-09	西南交通大学	一种加兰他敏衍生物及其制备方法和用途
CN118908968B (zh) *	2024-10-09	2025-03-04	威胜生物医药(苏州)股份有限公司	一种加兰他敏中间体衍生物及其催化氧化制备方法
CN119528922B (zh) *	2024-11-22	2025-12-09	泰安汉威集团有限公司	一种氢溴酸加兰他敏关键杂质-氢溴酸表加兰他敏的手性合成方法

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US4663318A (en)	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
KR100195399B1 (ko) *	1987-05-04	1999-06-15	보니데이비스	알쯔하이머 병 치료용 의약
NL8800350A (nl)	1988-02-12	1989-09-01	Stichting Biomedical Research	Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
US4954502A (en)	1988-06-10	1990-09-04	Bristol-Myers Squibb Company	1-indolyalkyl-4-(substituted-pyridinyl)piperazines
US5336675A (en)	1991-05-14	1994-08-09	Ernir Snorrason	Method of treating mania in humans
US5153193A (en)	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US6323195B1 (en)	1993-10-15	2001-11-27	Aventis Pharmaceuticals Inc.	Galanthamine derivatives as acetylcholinesterase inhibitors
US6323196B1 (en)	1993-10-15	2001-11-27	Aventis Pharmaceuticals Inc.	Galanthamine derivatives as acetylcholinesterase inhibitors
US5428159A (en)	1994-04-08	1995-06-27	Ciba-Geigy Corporation	Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
AT401058B (de)	1994-10-21	1996-06-25	Waldheim Pharmazeutika Gmbh	Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins
US6407229B1 (en)	1994-10-21	2002-06-18	Sanochemia Pharmazeutika Ag	Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine
PL184590B1 (pl) *	1994-10-21	2002-11-29	Sanochemia Pharmazeutika Ag	Sposób wytwarzania pochodnych a heksahydro H benzofuro[ a ef][ ] benzoazepiny sposób odbromowania tych pochodnych sposób wytwarzania związków typu N demetylobromo i epibromo galantaminy oraz nowe związki z określonego zbioru
GB9514821D0 (en) *	1995-07-19	1995-09-20	Sod Conseils Rech Applic	Galanthamine derivatives
GB9519268D0 (en)	1995-09-21	1995-11-22	Chiroscience Ltd	Preparation of alkaloids
AT403803B (de)	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
GB9716879D0 (en) *	1997-08-08	1997-10-15	Shire Int Licensing Bv	Treatment of attention deficit disorders
AU1430099A (en) *	1998-12-01	2000-06-19	Sanochemia Pharmazeutika Aktiengesellschaft	Use of galanthamine and galanthamine derivatives in the case of acute functionalbrain damage
AT414125B (de)	2003-09-29	2006-09-15	Sanochemia Pharmazeutika Ag	Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln

2001
- 2001-03-22 JP JP2001572510A patent/JP2003529602A/ja active Pending
- 2001-03-22 DK DK01914813T patent/DK1181294T3/da active
- 2001-03-22 SI SI200130081T patent/SI1181294T1/xx unknown
- 2001-03-22 PT PT01914813T patent/PT1181294E/pt unknown
- 2001-03-22 MX MXPA01012275A patent/MXPA01012275A/es active IP Right Grant
- 2001-03-22 BR BR0105563-1A patent/BR0105563A/pt not_active IP Right Cessation
- 2001-03-22 PL PL352638A patent/PL202463B1/pl not_active IP Right Cessation
- 2001-03-22 NZ NZ516302A patent/NZ516302A/xx unknown
- 2001-03-22 WO PCT/AT2001/000082 patent/WO2001074820A1/de not_active Ceased
- 2001-03-22 TR TR2004/00857T patent/TR200400857T4/xx unknown
- 2001-03-22 CZ CZ20014178A patent/CZ300160B6/cs not_active IP Right Cessation
- 2001-03-22 SK SK1702-2001A patent/SK285909B6/sk not_active IP Right Cessation
- 2001-03-22 ES ES01914813T patent/ES2215885T3/es not_active Expired - Lifetime
- 2001-03-22 EP EP01914813A patent/EP1181294B1/de not_active Expired - Lifetime
- 2001-03-22 CA CA002368966A patent/CA2368966A1/en not_active Abandoned
- 2001-03-22 HK HK03101873.7A patent/HK1049832A1/zh unknown
- 2001-03-22 AU AU42085/01A patent/AU785385B2/en not_active Ceased
- 2001-03-22 CN CN01801342A patent/CN1380883A/zh active Pending
- 2001-03-22 RU RU2001135839/04A patent/RU2241001C2/ru not_active IP Right Cessation
- 2001-03-22 AT AT01914813T patent/ATE263171T1/de not_active IP Right Cessation
- 2001-03-22 HU HU0202233A patent/HUP0202233A3/hu unknown
- 2001-03-22 DE DE50101827T patent/DE50101827D1/de not_active Expired - Lifetime
- 2001-05-22 US US09/980,025 patent/US7166588B2/en not_active Expired - Fee Related
- 2001-11-23 IS IS6174A patent/IS2287B/is unknown
- 2001-11-28 BG BG106155A patent/BG65134B1/bg unknown
- 2001-11-30 NO NO20015857A patent/NO326458B1/no not_active IP Right Cessation
2006
- 2006-06-28 US US11/478,170 patent/US20070027138A1/en not_active Abandoned

Also Published As

Publication number	Publication date
SI1181294T1 (en)	2004-08-31
TR200400857T4 (tr)	2004-06-21
CZ20014178A3 (cs)	2002-11-13
PT1181294E (pt)	2004-07-30
BG106155A (en)	2002-08-30
ATE263171T1 (de)	2004-04-15
NO326458B1 (no)	2008-12-08
IS6174A (is)	2001-11-23
EP1181294B1 (de)	2004-03-31
DE50101827D1 (de)	2004-05-06
NO20015857D0 (no)	2001-11-30
HK1049832A1 (zh)	2003-05-30
CZ300160B6 (cs)	2009-02-25
SK17022001A3 (sk)	2003-02-04
RU2241001C2 (ru)	2004-11-27
BR0105563A (pt)	2002-04-02
SK285909B6 (sk)	2007-10-04
NO20015857L (no)	2002-01-29
AU785385B2 (en)	2007-03-29
HUP0202233A3 (en)	2004-12-28
JP2003529602A (ja)	2003-10-07
WO2001074820A1 (de)	2001-10-11
MXPA01012275A (es)	2003-06-24
HK1045990A1 (en)	2002-12-20
HUP0202233A2 (hu)	2002-11-28
CA2368966A1 (en)	2001-10-11
AU4208501A (en)	2001-10-15
CN1380883A (zh)	2002-11-20
US7166588B2 (en)	2007-01-23
US20070027138A1 (en)	2007-02-01
US20030199493A1 (en)	2003-10-23
PL352638A1 (en)	2003-09-08
EP1181294A1 (de)	2002-02-27
BG65134B1 (bg)	2007-03-30
NZ516302A (en)	2004-02-27
DK1181294T3 (da)	2004-08-02
ES2215885T3 (es)	2004-10-16
PL202463B1 (pl)	2009-06-30

Publication	Publication Date	Title
IS6174A (is)	2001-11-23	Nýjar afleiður og hliðstæður af galantamíni
SE0000540D0 (sv)	2000-02-18	New compounds
DOP2001000151A (es)	2002-05-15	Derivados de imidazopirimidina y derivados de triazolopimidina.
CY1107634T1 (el)	2013-04-18	Φαρμακευτικη συνθεση
DE60135919D1 (de)	2008-11-06	Farnesyl transferase-hemmende 6-heterocyclylmethyl-chinolin und chinazol-derivate
CY1111648T1 (el)	2015-10-07	Πολυαρυλκαρβοξαμιδια χρησιμα ως παραγοντες μειωσης λιπιδιων
ATE491703T1 (de)	2011-01-15	Phthalazinonderivate
CY1113648T1 (el)	2016-06-22	Παραγωγα πυριδινονης για θεραπεια αθηροσκληρωσης
DK1438306T3 (da)	2014-06-23	Derivater af UK-2A
CY1106132T1 (el)	2011-06-08	Παραγωγα πιπepιδινης ως αναστολεις καναλιου καλιου
CY1110104T1 (el)	2015-01-14	Παραγωγα της πιπεραζινης ως αναστολεις ταχυκινινων
DK1307181T3 (da)	2006-01-30	Hidtil ukendte sammensætninger af minoxidil
ATE506354T1 (de)	2011-05-15	Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
CY1109886T1 (el)	2014-09-10	Καινοφανεις ενωσεις ως αντι-φλεγμονωδεις, ανοσοτροποποιητικοι και αντι υπερπλαστικοι παραγοντες
TW200510368A (en)	2005-03-16	Pharmaceutical compositions and combinations of novel non-imidazole compounds
BR0213981A (pt)	2004-08-31	Fotoiniciadores difuncionais
CY1106544T1 (el)	2012-01-25	Μεθοδος συνθεσεως υπερινδοπριλης και τα φαρμακευτικως αποδεκτα αλατα αυτης
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
ATE259813T1 (de)	2004-03-15	Triazolopyrimidinderivate
BRPI0416678A (pt)	2007-02-13	pirazolpirimidinas
CY1105411T1 (el)	2010-04-28	Νεα παραγωγα πλευρομουτιλινης
DE60041001D1 (de)	2009-01-15	Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
DE60110124D1 (de)	2005-05-19	Kondensierte pyrazindionderivate als pde inhibitoren