IS8184A - Aðferð við framleiðslu á handhverfulega hreinu mírtasapíni - Google Patents

Aðferð við framleiðslu á handhverfulega hreinu mírtasapíni

Info

Publication number
IS8184A
IS8184A IS8184A IS8184A IS8184A IS 8184 A IS8184 A IS 8184A IS 8184 A IS8184 A IS 8184A IS 8184 A IS8184 A IS 8184A IS 8184 A IS8184 A IS 8184A
Authority
IS
Iceland
Prior art keywords
myrtasapine
production
enantiomerically pure
enantiomerically
pure
Prior art date
Application number
IS8184A
Other languages
English (en)
Other versions
IS2674B (is
Inventor
Hubertus Wieringa Johannes
Antonius Martinus Van De Ven Adrianus
Johannes Kemperman Gerardus
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of IS8184A publication Critical patent/IS8184A/is
Publication of IS2674B publication Critical patent/IS2674B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IS8184A 2003-07-10 2005-12-15 Aðferð við framleiðslu á handhverfulega hreinu mírtasapíni IS2674B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03102095 2003-07-10
PCT/EP2004/051357 WO2005005410A1 (en) 2003-07-10 2004-07-05 A method for the preparation of enantiomerically pure mirtazapine

Publications (2)

Publication Number Publication Date
IS8184A true IS8184A (is) 2005-12-15
IS2674B IS2674B (is) 2010-09-15

Family

ID=34042934

Family Applications (1)

Application Number Title Priority Date Filing Date
IS8184A IS2674B (is) 2003-07-10 2005-12-15 Aðferð við framleiðslu á handhverfulega hreinu mírtasapíni

Country Status (35)

Country Link
US (2) US8058436B2 (is)
EP (1) EP1656365B1 (is)
JP (1) JP4668184B2 (is)
KR (1) KR20060056315A (is)
CN (1) CN100558722C (is)
AR (1) AR046494A1 (is)
AT (1) ATE433965T1 (is)
AU (1) AU2004255874B2 (is)
BR (1) BRPI0412447A (is)
CA (1) CA2531165C (is)
CO (1) CO5640123A2 (is)
CY (1) CY1109327T1 (is)
DE (1) DE602004021605D1 (is)
DK (1) DK1656365T3 (is)
EC (1) ECSP066271A (is)
ES (1) ES2327123T3 (is)
HR (1) HRP20051019A2 (is)
IL (1) IL172549A0 (is)
IS (1) IS2674B (is)
LT (1) LT5382B (is)
LV (1) LV13441B (is)
MX (1) MXPA06000325A (is)
NO (1) NO20056175L (is)
NZ (1) NZ544360A (is)
PE (1) PE20050323A1 (is)
PL (1) PL1656365T3 (is)
PT (1) PT1656365E (is)
RS (1) RS20050972A (is)
RU (1) RU2352566C2 (is)
SG (1) SG144914A1 (is)
SI (1) SI1656365T1 (is)
TW (1) TWI335915B (is)
UA (1) UA83666C2 (is)
WO (1) WO2005005410A1 (is)
ZA (1) ZA200600019B (is)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102153620A (zh) * 2005-09-26 2011-08-17 住友化学株式会社 光学活性的哌嗪化合物的制造方法
JP5080050B2 (ja) * 2005-09-26 2012-11-21 住友化学株式会社 光学活性なピペラジン化合物の製造方法
TW200808804A (en) * 2006-05-22 2008-02-16 Organon Nv Mirtazapine for the treatment of neuropathic pain
TW200815370A (en) * 2006-06-16 2008-04-01 Organon Nv Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine
JP5438976B2 (ja) * 2007-02-09 2014-03-12 株式会社カネカ 光学活性２−アリールピペラジン誘導体の製造法
JP5192707B2 (ja) 2007-03-22 2013-05-08 住友化学株式会社 ミルタザピンの製造方法
JP5635905B2 (ja) * 2007-04-11 2014-12-03 メルク・シャープ・エンド・ドーム・ベー・フェー ミルタザピンの調製方法
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine
KR101485418B1 (ko) * 2013-05-29 2015-01-26 주식회사 메디켐코리아 고순도 미르타자핀의 제조방법
SI3261645T1 (sl) 2015-02-27 2021-08-31 Dechra Limited Stimulacija apetita, uravnavanje izgube mase in zdravljenje anoreksije pri psih in mačkah
KR102540021B1 (ko) * 2020-12-02 2023-06-07 (주)유케이케미팜 대량 생산에 적합한 미르타자핀의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959470A (en) * 1972-11-28 1976-05-25 Mikhail Davidovich Mashkovsky Psychotropic medicinal preparation
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
CA2026925A1 (en) * 1989-10-05 1991-04-06 Hiroshi Fukumi Tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use
PT1030667E (pt) 1997-11-14 2005-06-30 Akzo Nobel Nv Utilizacao de mirtazapina para o fabrico de um medicamento para o tratamento de apenas do sono
JPH11222407A (ja) * 1997-11-14 1999-08-17 Sankyo Co Ltd 新規殺菌剤
CN1679586A (zh) * 1999-04-19 2005-10-12 特瓦制药工业有限公司 含哌嗪环化合物的新型合成和结晶方法
US20030069417A1 (en) * 1999-04-19 2003-04-10 Claude Singer Novel synthesis and crystallization of piperazine ring-containing compounds
US6068695A (en) * 1999-07-13 2000-05-30 Bayer Corporation Process for the continuous preparation of quinacridones
WO2001025185A1 (en) 1999-09-30 2001-04-12 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a piperazine derivative
AU6474200A (en) * 1999-12-13 2001-06-18 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
ES2258071T3 (es) 2000-02-11 2006-08-16 Akzo Nobel N.V. Utilizacion de mirtazepina para trastornos del sueño.
JP2001342188A (ja) * 2000-03-27 2001-12-11 Takeda Chem Ind Ltd 縮合ピラゾール誘導体、その製造法および用途
TW200538100A (en) * 2004-04-21 2005-12-01 Akzo Nobel Nv Mirtazapine salts

Also Published As

Publication number Publication date
PT1656365E (pt) 2009-09-01
IS2674B (is) 2010-09-15
US20100179319A1 (en) 2010-07-15
DE602004021605D1 (de) 2009-07-30
LT5382B (lt) 2006-11-27
WO2005005410A1 (en) 2005-01-20
ZA200600019B (en) 2007-01-31
MXPA06000325A (es) 2006-03-30
EP1656365A1 (en) 2006-05-17
CO5640123A2 (es) 2006-05-31
LV13441B (en) 2006-08-20
LT2005107A (en) 2006-06-27
SI1656365T1 (sl) 2009-10-31
AU2004255874A1 (en) 2005-01-20
JP4668184B2 (ja) 2011-04-13
DK1656365T3 (da) 2009-09-14
US20060229300A1 (en) 2006-10-12
CN1820000A (zh) 2006-08-16
EP1656365B1 (en) 2009-06-17
NO20056175L (no) 2006-01-23
CA2531165A1 (en) 2005-01-20
NZ544360A (en) 2008-05-30
CA2531165C (en) 2011-08-30
CY1109327T1 (el) 2014-07-02
HK1086841A1 (en) 2006-09-29
KR20060056315A (ko) 2006-05-24
PE20050323A1 (es) 2005-05-16
RU2006103992A (ru) 2006-06-27
TW200510426A (en) 2005-03-16
ATE433965T1 (de) 2009-07-15
UA83666C2 (ru) 2008-08-11
AR046494A1 (es) 2005-12-14
ECSP066271A (es) 2006-07-28
US8058436B2 (en) 2011-11-15
RU2352566C2 (ru) 2009-04-20
SG144914A1 (en) 2008-08-28
HRP20051019A2 (en) 2006-02-28
BRPI0412447A (pt) 2006-09-19
JP2009513537A (ja) 2009-04-02
ES2327123T3 (es) 2009-10-26
AU2004255874B2 (en) 2010-10-28
TWI335915B (en) 2011-01-11
IL172549A0 (en) 2006-04-10
CN100558722C (zh) 2009-11-11
PL1656365T3 (pl) 2009-10-30
RS20050972A (sr) 2008-06-05

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