ECSP066271A - Un método para la preparación de mirtazapina enantioméricamente pura - Google Patents
Un método para la preparación de mirtazapina enantioméricamente puraInfo
- Publication number
- ECSP066271A ECSP066271A EC2006006271A ECSP066271A ECSP066271A EC SP066271 A ECSP066271 A EC SP066271A EC 2006006271 A EC2006006271 A EC 2006006271A EC SP066271 A ECSP066271 A EC SP066271A EC SP066271 A ECSP066271 A EC SP066271A
- Authority
- EC
- Ecuador
- Prior art keywords
- preparation
- enantiomerically pure
- mirtazapine
- acid
- pure mirtazapine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención provee un método para la preparación de mirtazapina enantioméricamente pura, el cual comprende una etapa de cierre en anillo de un compuesto de la fórmula (II) en donde X es un grupo saliente, comprendiendo dicha etapa un tratamiento con un ácido, en donde se forma mirtazapina con un exceso enantiomérico por medio del cierre en anillo del compuesto de la fórmula (II) con un exceso enantiomérico a través de tratamiento con un ácido adecuado en ausencia de un solvente o con una combinación adecuada de un ácido y de un solvente orgánico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03102095 | 2003-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP066271A true ECSP066271A (es) | 2006-07-28 |
Family
ID=34042934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2006006271A ECSP066271A (es) | 2003-07-10 | 2006-01-09 | Un método para la preparación de mirtazapina enantioméricamente pura |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US8058436B2 (es) |
| EP (1) | EP1656365B1 (es) |
| JP (1) | JP4668184B2 (es) |
| KR (1) | KR20060056315A (es) |
| CN (1) | CN100558722C (es) |
| AR (1) | AR046494A1 (es) |
| AT (1) | ATE433965T1 (es) |
| AU (1) | AU2004255874B2 (es) |
| BR (1) | BRPI0412447A (es) |
| CA (1) | CA2531165C (es) |
| CO (1) | CO5640123A2 (es) |
| CY (1) | CY1109327T1 (es) |
| DE (1) | DE602004021605D1 (es) |
| DK (1) | DK1656365T3 (es) |
| EC (1) | ECSP066271A (es) |
| ES (1) | ES2327123T3 (es) |
| HR (1) | HRP20051019A2 (es) |
| IL (1) | IL172549A0 (es) |
| IS (1) | IS2674B (es) |
| LT (1) | LT5382B (es) |
| LV (1) | LV13441B (es) |
| MX (1) | MXPA06000325A (es) |
| NO (1) | NO20056175L (es) |
| NZ (1) | NZ544360A (es) |
| PE (1) | PE20050323A1 (es) |
| PL (1) | PL1656365T3 (es) |
| PT (1) | PT1656365E (es) |
| RS (1) | RS20050972A (es) |
| RU (1) | RU2352566C2 (es) |
| SG (1) | SG144914A1 (es) |
| SI (1) | SI1656365T1 (es) |
| TW (1) | TWI335915B (es) |
| UA (1) | UA83666C2 (es) |
| WO (1) | WO2005005410A1 (es) |
| ZA (1) | ZA200600019B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153620A (zh) * | 2005-09-26 | 2011-08-17 | 住友化学株式会社 | 光学活性的哌嗪化合物的制造方法 |
| JP5080050B2 (ja) * | 2005-09-26 | 2012-11-21 | 住友化学株式会社 | 光学活性なピペラジン化合物の製造方法 |
| TW200808804A (en) * | 2006-05-22 | 2008-02-16 | Organon Nv | Mirtazapine for the treatment of neuropathic pain |
| TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
| JP5438976B2 (ja) * | 2007-02-09 | 2014-03-12 | 株式会社カネカ | 光学活性２−アリールピペラジン誘導体の製造法 |
| JP5192707B2 (ja) | 2007-03-22 | 2013-05-08 | 住友化学株式会社 | ミルタザピンの製造方法 |
| EP2146993B1 (en) * | 2007-04-11 | 2015-08-05 | Merck Sharp & Dohme B.V. | A method for the preparation of mirtazapine |
| US7994314B2 (en) | 2007-04-11 | 2011-08-09 | N.V. Organon | Method for the preparation of an enantiomerically pure benzazepine |
| KR101485418B1 (ko) * | 2013-05-29 | 2015-01-26 | 주식회사 메디켐코리아 | 고순도 미르타자핀의 제조방법 |
| PT3261645T (pt) | 2015-02-27 | 2021-06-17 | Dechra Ltd | Estimulação do apetite, gestão da perda de peso, e tratamento da anorexia em cães e gatos |
| KR102540021B1 (ko) * | 2020-12-02 | 2023-06-07 | (주)유케이케미팜 | 대량 생산에 적합한 미르타자핀의 제조방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3959470A (en) * | 1972-11-28 | 1976-05-25 | Mikhail Davidovich Mashkovsky | Psychotropic medicinal preparation |
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| PT95522B (pt) * | 1989-10-05 | 1997-08-29 | Sankyo Co | Processo para a preparacao de novos compostos tetraciclicos com accao anti-alergica e anti-asmatica e de composicoes farmaceuticas que os contem |
| JPH11222407A (ja) * | 1997-11-14 | 1999-08-17 | Sankyo Co Ltd | 新規殺菌剤 |
| DK1030667T3 (da) | 1997-11-14 | 2005-06-20 | Akzo Nobel Nv | Anvendelse af mirtazapin til fremstilling af et lægemiddel til behandling af sövnapnö |
| US20030069417A1 (en) * | 1999-04-19 | 2003-04-10 | Claude Singer | Novel synthesis and crystallization of piperazine ring-containing compounds |
| CZ20013658A3 (cs) * | 1999-04-19 | 2002-08-14 | Teva Pharmaceutical Industries Ltd. | Syntéza a krystalizace sloučenin obsahujících piperazinový kruh |
| US6068695A (en) * | 1999-07-13 | 2000-05-30 | Bayer Corporation | Process for the continuous preparation of quinacridones |
| WO2001025185A1 (en) | 1999-09-30 | 2001-04-12 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a piperazine derivative |
| WO2001042239A1 (en) * | 1999-12-13 | 2001-06-14 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
| IL150290A0 (en) | 2000-02-11 | 2002-12-01 | Akzo Nobel Nv | The use of mirtazapine for the treatment of sleep disorders |
| JP2001342188A (ja) * | 2000-03-27 | 2001-12-11 | Takeda Chem Ind Ltd | 縮合ピラゾール誘導体、その製造法および用途 |
| TW200538100A (en) * | 2004-04-21 | 2005-12-01 | Akzo Nobel Nv | Mirtazapine salts |
-
2004
- 2004-05-07 UA UAA200600274A patent/UA83666C2/ru unknown
- 2004-06-28 TW TW093118845A patent/TWI335915B/zh not_active IP Right Cessation
- 2004-07-05 PT PT04741958T patent/PT1656365E/pt unknown
- 2004-07-05 MX MXPA06000325A patent/MXPA06000325A/es active IP Right Grant
- 2004-07-05 JP JP2006518216A patent/JP4668184B2/ja not_active Expired - Lifetime
- 2004-07-05 HR HR20051019A patent/HRP20051019A2/xx not_active Application Discontinuation
- 2004-07-05 WO PCT/EP2004/051357 patent/WO2005005410A1/en not_active Ceased
- 2004-07-05 SG SG200805127-8A patent/SG144914A1/en unknown
- 2004-07-05 SI SI200431183T patent/SI1656365T1/sl unknown
- 2004-07-05 PL PL04741958T patent/PL1656365T3/pl unknown
- 2004-07-05 KR KR1020067000511A patent/KR20060056315A/ko not_active Abandoned
- 2004-07-05 NZ NZ544360A patent/NZ544360A/en not_active IP Right Cessation
- 2004-07-05 CA CA2531165A patent/CA2531165C/en not_active Expired - Fee Related
- 2004-07-05 AT AT04741958T patent/ATE433965T1/de active
- 2004-07-05 US US10/564,193 patent/US8058436B2/en not_active Expired - Fee Related
- 2004-07-05 RS YUP-2005/0972A patent/RS20050972A/sr unknown
- 2004-07-05 BR BRPI0412447-2A patent/BRPI0412447A/pt not_active IP Right Cessation
- 2004-07-05 ES ES04741958T patent/ES2327123T3/es not_active Expired - Lifetime
- 2004-07-05 RU RU2006103992/04A patent/RU2352566C2/ru not_active IP Right Cessation
- 2004-07-05 DK DK04741958T patent/DK1656365T3/da active
- 2004-07-05 CN CNB2004800194891A patent/CN100558722C/zh not_active Expired - Lifetime
- 2004-07-05 EP EP04741958A patent/EP1656365B1/en not_active Expired - Lifetime
- 2004-07-05 AU AU2004255874A patent/AU2004255874B2/en not_active Expired
- 2004-07-05 DE DE602004021605T patent/DE602004021605D1/de not_active Expired - Lifetime
- 2004-07-07 PE PE2004000653A patent/PE20050323A1/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102412A patent/AR046494A1/es not_active Application Discontinuation
-
2005
- 2005-12-12 LT LT2005107A patent/LT5382B/lt not_active IP Right Cessation
- 2005-12-13 IL IL172549A patent/IL172549A0/en not_active IP Right Cessation
- 2005-12-15 IS IS8184A patent/IS2674B/is unknown
- 2005-12-23 NO NO20056175A patent/NO20056175L/no not_active Application Discontinuation
-
2006
- 2006-01-03 ZA ZA200600019A patent/ZA200600019B/en unknown
- 2006-01-09 EC EC2006006271A patent/ECSP066271A/es unknown
- 2006-01-10 CO CO06001617A patent/CO5640123A2/es not_active Application Discontinuation
- 2006-02-10 LV LVP-06-21A patent/LV13441B/en unknown
-
2008
- 2008-07-02 US US12/667,969 patent/US20100179319A1/en not_active Abandoned
-
2009
- 2009-08-25 CY CY20091100894T patent/CY1109327T1/el unknown
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