JO3658B1 - بروتينات اندماج - Google Patents

بروتينات اندماج

Info

Publication number
JO3658B1
JO3658B1 JOP/2016/0076A JOP20160076A JO3658B1 JO 3658 B1 JO3658 B1 JO 3658B1 JO P20160076 A JOP20160076 A JO P20160076A JO 3658 B1 JO3658 B1 JO 3658B1
Authority
JO
Jordan
Prior art keywords
span
fusion proteins
dir
ltr
present
Prior art date
Application number
JOP/2016/0076A
Other languages
English (en)
Inventor
Bruce Baldwin David
Duane Dickinson Craig
Alan Lazar Gregory
Wesley Day Johnathan
Ihor Korytko Andrew
Michael Beals John
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55953435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3658(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of JO3658B1 publication Critical patent/JO3658B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

يتعلق الاختراع الحالي ببروتينات اندماج تشتمل على مساعد مستقبل إنسولين مدمج مع منطقة<span dir="LTR">Fc </span> <span dir="LTR">IgG</span> بشرية من خلال استخدام رابط ببتيد، واستخدام بروتينات الاندماج المذكورة في معالجة مرض السكري. يكون لبروتينات الاندماج للاختراع الحالي خاصية ممتدة المفعول وتكون نافعة في توفير تحكم في مستوى الجلوكوز القاعدة لفترة زمنية ممتدة<span dir="LTR">.</span>
JOP/2016/0076A 2015-05-07 2016-04-21 بروتينات اندماج JO3658B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562158079P 2015-05-07 2015-05-07

Publications (1)

Publication Number Publication Date
JO3658B1 true JO3658B1 (ar) 2020-08-27

Family

ID=55953435

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0076A JO3658B1 (ar) 2015-05-07 2016-04-21 بروتينات اندماج

Country Status (40)

Country Link
US (5) US9855318B2 (ar)
EP (1) EP3292141B1 (ar)
JP (1) JP6591562B2 (ar)
KR (1) KR102059736B1 (ar)
CN (1) CN107531806B (ar)
AR (1) AR105616A1 (ar)
AU (1) AU2016257659B2 (ar)
CA (1) CA2981102A1 (ar)
CL (1) CL2017002761A1 (ar)
CO (1) CO2017011301A2 (ar)
CR (1) CR20170469A (ar)
CY (1) CY1122929T1 (ar)
DK (1) DK3292141T3 (ar)
DO (1) DOP2017000258A (ar)
EA (1) EA039770B1 (ar)
EC (1) ECSP17073650A (ar)
ES (1) ES2799099T3 (ar)
HR (1) HRP20200503T1 (ar)
IL (1) IL254965B (ar)
JO (1) JO3658B1 (ar)
LT (1) LT3292141T (ar)
MA (1) MA42037B1 (ar)
MD (1) MD3292141T2 (ar)
ME (1) ME03709B (ar)
MX (1) MX388594B (ar)
MY (1) MY183025A (ar)
NZ (1) NZ736470A (ar)
PE (1) PE20180507A1 (ar)
PH (1) PH12017502025B1 (ar)
PL (1) PL3292141T3 (ar)
PT (1) PT3292141T (ar)
RS (1) RS60044B1 (ar)
SG (1) SG11201708194WA (ar)
SI (1) SI3292141T1 (ar)
SV (1) SV2017005548A (ar)
TN (1) TN2018000059A1 (ar)
TW (1) TWI656132B (ar)
UA (1) UA122146C2 (ar)
WO (1) WO2016178905A1 (ar)
ZA (1) ZA201706334B (ar)

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MX2017014284A (es) 2018-03-23
US9855318B2 (en) 2018-01-02
SI3292141T1 (sl) 2020-04-30
PH12017502025A1 (en) 2018-04-02
US12059452B2 (en) 2024-08-13
CN107531806A (zh) 2018-01-02
DK3292141T3 (da) 2020-04-20
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