JO3775B1 - جزيئات رابطة لليمفو بويتين اللحمية بالغدة الصعترية أو الثيمية (tslp) وطرق لاستخدام تلك الجزيئات - Google Patents
جزيئات رابطة لليمفو بويتين اللحمية بالغدة الصعترية أو الثيمية (tslp) وطرق لاستخدام تلك الجزيئاتInfo
- Publication number
- JO3775B1 JO3775B1 JOP/2016/0200A JOP20160200A JO3775B1 JO 3775 B1 JO3775 B1 JO 3775B1 JO P20160200 A JOP20160200 A JO P20160200A JO 3775 B1 JO3775 B1 JO 3775B1
- Authority
- JO
- Jordan
- Prior art keywords
- molecules
- tslp
- methods
- thymic stromal
- stromal lymphopoietin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
يعمل هذا الاختراع على إعداد جزيئات على شكل شظيات من أجسام مضادة أو جسم مضاد، وإعداد تلك الشظيات التي تعمل بالتحديد على ربط الليمفوبويتين اللحمية بالغدة الصعترية TSLP، وكذا إعداد تركيبات متضمنة على تلك الجزيئات وطرق استخدام وانتاج تلك الجزيئات.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562216050P | 2015-09-09 | 2015-09-09 | |
| US201662342511P | 2016-05-27 | 2016-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3775B1 true JO3775B1 (ar) | 2021-01-31 |
Family
ID=62088889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2016/0200A JO3775B1 (ar) | 2015-09-09 | 2016-09-08 | جزيئات رابطة لليمفو بويتين اللحمية بالغدة الصعترية أو الثيمية (tslp) وطرق لاستخدام تلك الجزيئات |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US10745473B2 (ar) |
| EP (2) | EP3347377B1 (ar) |
| JP (4) | JP6516925B2 (ar) |
| KR (1) | KR20180042433A (ar) |
| CN (2) | CN114507281A (ar) |
| BR (1) | BR112018003326A2 (ar) |
| CA (1) | CA2996635A1 (ar) |
| CL (1) | CL2018000479A1 (ar) |
| CR (1) | CR20180154A (ar) |
| CU (1) | CU24533B1 (ar) |
| CY (1) | CY1124118T1 (ar) |
| DK (1) | DK3347377T3 (ar) |
| EC (1) | ECSP18023386A (ar) |
| ES (1) | ES2869970T3 (ar) |
| HR (1) | HRP20210650T1 (ar) |
| HU (1) | HUE053914T2 (ar) |
| IL (1) | IL257599A (ar) |
| JO (1) | JO3775B1 (ar) |
| LT (1) | LT3347377T (ar) |
| MA (1) | MA55472A (ar) |
| MX (2) | MX2018003038A (ar) |
| NZ (1) | NZ740067A (ar) |
| PE (1) | PE20181368A1 (ar) |
| PH (1) | PH12018500482A1 (ar) |
| PL (1) | PL3347377T3 (ar) |
| PT (1) | PT3347377T (ar) |
| RS (1) | RS61763B1 (ar) |
| RU (1) | RU2731644C2 (ar) |
| SI (1) | SI3347377T1 (ar) |
| TW (1) | TWI746458B (ar) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20210650T1 (hr) * | 2015-09-09 | 2021-05-28 | Novartis Ag | Protutijela koja vežu timusni stromalni limfopoetin (tslp) i postupci uporabe protutijela |
| WO2020071448A1 (ja) * | 2018-10-02 | 2020-04-09 | 学校法人名城大学 | 吸入粉末剤、その評価方法及びその用途 |
| KR20210079319A (ko) * | 2018-10-18 | 2021-06-29 | 도이체스 크렙스포르슝스첸트룸 | 흡입용 건조 약학적 조성물 |
| CA3147044A1 (en) * | 2019-07-11 | 2021-01-14 | Tavotek Biotherapeutics (Hong Kong) Limited | Agents that interfere with thymic stromal lymphopoietin (tslp)-receptor signaling |
| EP4025602A4 (en) * | 2019-09-04 | 2023-12-13 | Biosion, Inc. | TSLP BINDING ANTIBODIES AND USES THEREOF |
| PH12022551022A1 (en) | 2019-10-28 | 2023-03-06 | Medimmune Ltd | Dry powder formulations of thymic stromal lymphopoietin (tslp)-binding antibodies and methods of use thereof |
| CN114887053B (zh) * | 2019-11-29 | 2026-04-24 | 康诺亚生物医药科技(成都)有限公司 | 一种tslp相关病症治疗剂的开发和应用 |
| AU2020400221A1 (en) * | 2019-12-13 | 2022-05-19 | Harbour Biomed (Shanghai) Co., Ltd. | Anti-TSLP antibody and uses thereof |
| JP2023512286A (ja) * | 2020-01-31 | 2023-03-24 | サノフイ | 抗体の肺送達 |
| CN111171150B (zh) * | 2020-02-05 | 2020-12-08 | 北京智仁美博生物科技有限公司 | 抗人tslp抗体及其用途 |
| CN113388035B (zh) * | 2020-03-13 | 2026-02-27 | 迈威(上海)生物科技股份有限公司 | 特异性针对人tslp的抗体及其应用 |
| CN114437212B (zh) * | 2020-11-06 | 2023-03-14 | 上海麦济生物技术有限公司 | 抗人胸腺基质淋巴细胞生成素抗体及其制备方法和应用 |
| TW202219066A (zh) * | 2020-11-12 | 2022-05-16 | 大陸商上海濟煜醫藥科技有限公司 | 一種tslp抗原結合蛋白及其應用 |
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| WO2014031718A1 (en) | 2012-08-23 | 2014-02-27 | Merck Sharp & Dohme Corp. | Stable formulations of antibodies to tslp |
| US20160052985A1 (en) | 2013-04-04 | 2016-02-25 | Ieo - Istituto Europeo Di Oncologia Srl | Thymic stromal lymphopoietin fragments and uses thereof |
| WO2015009996A1 (en) | 2013-07-19 | 2015-01-22 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating eosinophilic esophagitis |
| EA038332B1 (ru) | 2015-09-09 | 2021-08-10 | Новартис Аг | Молекулы, связывающиеся с тимусным стромальным лимфопоэтином (tslp), и способы применения таких молекул |
| HRP20210650T1 (hr) * | 2015-09-09 | 2021-05-28 | Novartis Ag | Protutijela koja vežu timusni stromalni limfopoetin (tslp) i postupci uporabe protutijela |
| KR102666879B1 (ko) * | 2017-04-12 | 2024-05-23 | 암젠 인크 | 항-tslp 항체를 이용한 천식의 치료 |
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2016
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