JP2005507365A5 - - Google Patents
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- Publication number
- JP2005507365A5 JP2005507365A5 JP2002573735A JP2002573735A JP2005507365A5 JP 2005507365 A5 JP2005507365 A5 JP 2005507365A5 JP 2002573735 A JP2002573735 A JP 2002573735A JP 2002573735 A JP2002573735 A JP 2002573735A JP 2005507365 A5 JP2005507365 A5 JP 2005507365A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- carbon atoms
- halogen
- substituted
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26265101P | 2001-01-22 | 2001-01-22 | |
| US26719601P | 2001-02-08 | 2001-02-08 | |
| US30614001P | 2001-07-19 | 2001-07-19 | |
| PCT/US2002/001508 WO2002074726A2 (en) | 2001-01-22 | 2002-01-22 | Aniline derivatives useful as phosphodiesterase 4 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005507365A JP2005507365A (ja) | 2005-03-17 |
| JP2005507365A5 true JP2005507365A5 (2) | 2008-02-21 |
| JP4223287B2 JP4223287B2 (ja) | 2009-02-12 |
Family
ID=27401532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573735A Expired - Fee Related JP4223287B2 (ja) | 2001-01-22 | 2002-01-22 | 新規な化合物及び製薬上許容し得るそれらの塩並びにそれらを用いた薬剤組成物 |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1353907A2 (2) |
| JP (1) | JP4223287B2 (2) |
| KR (1) | KR100856622B1 (2) |
| CN (1) | CN100378075C (2) |
| AU (1) | AU2002303078B2 (2) |
| BG (1) | BG108003A (2) |
| BR (1) | BR0206943A (2) |
| CA (1) | CA2435847A1 (2) |
| CL (1) | CL2004001165A1 (2) |
| CZ (1) | CZ20031986A3 (2) |
| EE (1) | EE05362B1 (2) |
| HR (1) | HRP20030662A2 (2) |
| HU (1) | HUP0302793A3 (2) |
| IL (1) | IL156958A0 (2) |
| MA (1) | MA25996A1 (2) |
| MX (1) | MXPA03006519A (2) |
| NO (1) | NO329548B1 (2) |
| NZ (1) | NZ527081A (2) |
| PL (1) | PL373301A1 (2) |
| SK (1) | SK9152003A3 (2) |
| WO (1) | WO2002074726A2 (2) |
| YU (1) | YU57603A (2) |
| ZA (1) | ZA200305623B (2) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7153871B2 (en) | 2001-01-22 | 2006-12-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs |
| MXPA03007261A (es) * | 2001-02-14 | 2006-03-09 | Abbott Lab | Moduladores del receptor de glucocorticoides. |
| DE60325984D1 (de) | 2002-07-19 | 2009-03-12 | Memory Pharmaceutical Corp | 4-aminobenzofuranverbindungen als phosphodiesterase-4-inhibitoren |
| AU2003256616B2 (en) * | 2002-07-19 | 2009-08-27 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs |
| CA2506297A1 (en) * | 2002-11-19 | 2004-06-03 | Memory Pharmaceuticals Corporation | Pyridine n-oxide compounds as phosphodiesterase 4 inhibitors |
| AU2003286024A1 (en) * | 2002-11-22 | 2004-06-18 | Daniel Dube | Use of phosphodiesterase-4 inhibitors as enhancers of cognition |
| ES2282701T3 (es) * | 2002-12-27 | 2007-10-16 | H. Lundbeck A/S | Derivados de 1,2,4-triaminobenceno utiles para tratar trastornos del sistema nervioso central. |
| FR2856595B1 (fr) * | 2003-06-27 | 2008-05-30 | Exonhit Therapeutics Sa | Methodes et compositions pour le traitement de deficits cognitifs. |
| JP2007504201A (ja) | 2003-09-05 | 2007-03-01 | アルタナ ファルマ アクチエンゲゼルシャフト | 真性糖尿病の治療のためのｐｄｅ４阻害剤の使用 |
| MY141255A (en) * | 2003-12-11 | 2010-03-31 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
| MX2007000480A (es) | 2004-07-15 | 2007-03-29 | Japan Tobacco Inc | Compuesto de benzamida fusionado e inhibidor de actividad de receptor de vainilloide 1. |
| US20070287716A1 (en) * | 2004-10-28 | 2007-12-13 | Hu Essa H | Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors |
| EP1874308A1 (en) | 2005-03-08 | 2008-01-09 | Nycomed GmbH | Roflumilast for the treatment of diabetes mellitus |
| JP2008543781A (ja) * | 2005-06-10 | 2008-12-04 | メモリー・ファーマシューティカルズ・コーポレイション | ホスフオジエステラーゼ４阻害剤 |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| US7906508B2 (en) | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
| CA2676715A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| EP2110375A1 (en) * | 2008-04-14 | 2009-10-21 | CHIESI FARMACEUTICI S.p.A. | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class |
| EP2291181B9 (en) | 2008-04-18 | 2013-09-11 | University College Dublin National University Of Ireland, Dublin | Captodiamine for the treatment of depression symptoms |
| WO2010041449A1 (ja) * | 2008-10-09 | 2010-04-15 | 国立大学法人 岡山大学 | Rxr作動性物質を有効成分とする抗アレルギー剤 |
| HRP20191460T1 (hr) * | 2009-06-12 | 2019-11-15 | Abivax | Spojevi korisni za liječenje raka |
| US10253020B2 (en) | 2009-06-12 | 2019-04-09 | Abivax | Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging |
| SI2440547T1 (sl) | 2009-06-12 | 2023-05-31 | Abivax | Nove kemične molekule, ki zavirajo mehanizem spajanja za zdravljenje bolezni, ki so posledica napak pri spajanju |
| JP6023926B2 (ja) | 2010-02-12 | 2016-11-09 | 株式会社ＡｓｋＡｔ | 認知症治療のための５−ｈｔ４受容体アゴニスト |
| WO2013118855A1 (ja) | 2012-02-09 | 2013-08-15 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
| CN102603676B (zh) * | 2012-02-20 | 2014-02-12 | 徐江平 | 一种能避免呕吐反应的磷酸二酯酶4抑制剂 |
| CA2859842C (en) * | 2012-03-14 | 2016-11-08 | Sinochem Corporation | Substitute diphenylamine compounds use thereof as antitumor agents |
| EP2757161A1 (en) | 2013-01-17 | 2014-07-23 | Splicos | miRNA-124 as a biomarker of viral infection |
| CN105530938B (zh) | 2013-07-05 | 2019-10-22 | Abivax公司 | 用于治疗由逆转录病毒引起的疾病的化合物 |
| AU2014307803A1 (en) | 2013-08-16 | 2016-03-10 | Universiteit Maastricht | Treatment of cognitive impairment with PDE4 inhibitor |
| EP2974729A1 (en) | 2014-07-17 | 2016-01-20 | Abivax | Quinoline derivatives for use in the treatment of inflammatory diseases |
| EP3669873A1 (en) | 2018-12-20 | 2020-06-24 | Abivax | Quinoline derivatives for use ine the traeatment of inflammation diseases |
| CN121609673A (zh) * | 2026-02-02 | 2026-03-06 | 五邑大学 | 一种pde4抑制剂及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6971894A (en) * | 1993-05-27 | 1994-12-20 | Smithkline Beecham Laboratoires Pharmaceutiques | Anti-arrhythmic n-substituted 3-benzazepines or isoquinolines |
| JPH07206789A (ja) * | 1993-09-01 | 1995-08-08 | Taisho Pharmaceut Co Ltd | コンブレタスタチン類縁化合物 |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| FR2729142A1 (fr) * | 1995-01-06 | 1996-07-12 | Smithkline Beecham Lab | Nouvelles amines heterocycliques, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu'agents anti-arythmiques |
| CA2295106C (en) * | 1997-06-24 | 2007-03-13 | Nikken Chemicals Co., Ltd. | 3-anilino-2-cycloalkenone derivatives |
| JP4649046B2 (ja) * | 1999-05-21 | 2011-03-09 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼのピロロトリアジン阻害剤 |
| EP1116711B1 (de) * | 1999-12-18 | 2005-12-14 | Wella Aktiengesellschaft | 2-Aminoalkyl-1,4-diaminobenzol-Derivate und diese Verbindungen enthaltende Färbemittel |
-
2002
- 2002-01-22 KR KR1020037009624A patent/KR100856622B1/ko not_active Expired - Fee Related
- 2002-01-22 PL PL02373301A patent/PL373301A1/xx not_active Application Discontinuation
- 2002-01-22 WO PCT/US2002/001508 patent/WO2002074726A2/en not_active Ceased
- 2002-01-22 HU HU0302793A patent/HUP0302793A3/hu unknown
- 2002-01-22 YU YU57603A patent/YU57603A/sh unknown
- 2002-01-22 CN CNB028070100A patent/CN100378075C/zh not_active Expired - Fee Related
- 2002-01-22 EP EP02731078A patent/EP1353907A2/en not_active Withdrawn
- 2002-01-22 BR BR0206943-1A patent/BR0206943A/pt not_active Application Discontinuation
- 2002-01-22 SK SK915-2003A patent/SK9152003A3/sk unknown
- 2002-01-22 EE EEP200300347A patent/EE05362B1/xx not_active IP Right Cessation
- 2002-01-22 MX MXPA03006519A patent/MXPA03006519A/es active IP Right Grant
- 2002-01-22 NZ NZ527081A patent/NZ527081A/xx unknown
- 2002-01-22 IL IL15695802A patent/IL156958A0/xx unknown
- 2002-01-22 AU AU2002303078A patent/AU2002303078B2/en not_active Ceased
- 2002-01-22 CZ CZ20031986A patent/CZ20031986A3/cs unknown
- 2002-01-22 CA CA002435847A patent/CA2435847A1/en not_active Abandoned
- 2002-01-22 JP JP2002573735A patent/JP4223287B2/ja not_active Expired - Fee Related
- 2002-01-22 HR HR20030662A patent/HRP20030662A2/hr not_active Application Discontinuation
-
2003
- 2003-07-18 BG BG108003A patent/BG108003A/bg unknown
- 2003-07-21 ZA ZA2003/05623A patent/ZA200305623B/en unknown
- 2003-07-21 NO NO20033288A patent/NO329548B1/no not_active IP Right Cessation
- 2003-07-22 MA MA27246A patent/MA25996A1/fr unknown
-
2004
- 2004-05-20 CL CL200401165A patent/CL2004001165A1/es unknown
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