JP2661699B2 - ピペリジンオピオイド拮抗剤 - Google Patents
ピペリジンオピオイド拮抗剤Info
- Publication number
- JP2661699B2 JP2661699B2 JP63094395A JP9439588A JP2661699B2 JP 2661699 B2 JP2661699 B2 JP 2661699B2 JP 63094395 A JP63094395 A JP 63094395A JP 9439588 A JP9439588 A JP 9439588A JP 2661699 B2 JP2661699 B2 JP 2661699B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- trans
- dimethyl
- hydroxyphenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3912187A | 1987-04-16 | 1987-04-16 | |
| US39121 | 1987-04-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63277661A JPS63277661A (ja) | 1988-11-15 |
| JP2661699B2 true JP2661699B2 (ja) | 1997-10-08 |
Family
ID=21903800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63094395A Expired - Lifetime JP2661699B2 (ja) | 1987-04-16 | 1988-04-15 | ピペリジンオピオイド拮抗剤 |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0287339B1 (de) |
| JP (1) | JP2661699B2 (de) |
| KR (1) | KR960015087B1 (de) |
| CN (1) | CN1017992B (de) |
| AR (1) | AR245933A1 (de) |
| AT (1) | ATE110057T1 (de) |
| AU (1) | AU596290B2 (de) |
| CA (1) | CA1321792C (de) |
| DE (1) | DE3851081T2 (de) |
| DK (1) | DK204388A (de) |
| EG (1) | EG18864A (de) |
| ES (1) | ES2058265T3 (de) |
| HU (1) | HU202492B (de) |
| IE (1) | IE64508B1 (de) |
| IL (1) | IL86061A (de) |
| MX (1) | MX11117A (de) |
| NZ (1) | NZ224236A (de) |
| PH (1) | PH24752A (de) |
| PT (1) | PT87233B (de) |
| SU (1) | SU1598869A3 (de) |
| ZA (1) | ZA882640B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0299549A3 (de) * | 1987-07-09 | 1989-02-08 | Duphar International Research B.V | Tertiäre 2,5-Dialkyl-3-phenyl-piperidin-Derivate mit Opiatantagonistischer Wirkung |
| ZA922180B (en) * | 1991-03-29 | 1993-09-27 | Lilly Co Eli | Piperidine derivatives |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| RU2133744C1 (ru) * | 1993-07-30 | 1999-07-27 | Дельта Фармасьютикалз, Инк. | Пиперазиновые соединения |
| GB9725114D0 (en) * | 1997-11-28 | 1998-01-28 | Pfizer Ltd | Treatment of pruritus |
| GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| GB9815618D0 (en) * | 1998-07-18 | 1998-09-16 | Univ Manchester | Treatment of dyskinesia |
| TWI244481B (en) | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912415D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912416D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| MXPA02005335A (es) * | 1999-11-29 | 2003-01-28 | Adolor Corp | Metodos y composiciones novedosos que incluyen opioides y antagonistas de los mismos. |
| GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| DE60226161T2 (de) | 2001-10-22 | 2009-07-02 | Pfizer Products Inc., Groton | 3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren |
| MY140236A (en) * | 2002-09-19 | 2009-12-31 | Lilly Co Eli | Diarylether compounds useful as opioid receptor antagonists |
| US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
| EP2734041A4 (de) * | 2011-07-18 | 2015-03-25 | Adolor Corp | Verfahren zur herstellung von peripheren opioid-antagonisten-verbindungen und zwischenprodukten davon |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR206937A1 (es) * | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
-
1988
- 1988-04-13 AT AT88303302T patent/ATE110057T1/de not_active IP Right Cessation
- 1988-04-13 ES ES88303302T patent/ES2058265T3/es not_active Expired - Lifetime
- 1988-04-13 IL IL86061A patent/IL86061A/xx not_active IP Right Cessation
- 1988-04-13 CA CA000563995A patent/CA1321792C/en not_active Expired - Fee Related
- 1988-04-13 DE DE3851081T patent/DE3851081T2/de not_active Expired - Fee Related
- 1988-04-13 PH PH36789A patent/PH24752A/en unknown
- 1988-04-13 NZ NZ224236A patent/NZ224236A/xx unknown
- 1988-04-13 EP EP88303302A patent/EP0287339B1/de not_active Expired - Lifetime
- 1988-04-13 AR AR88310556A patent/AR245933A1/es active
- 1988-04-14 IE IE112588A patent/IE64508B1/en not_active IP Right Cessation
- 1988-04-14 EG EG21388A patent/EG18864A/xx active
- 1988-04-14 PT PT87233A patent/PT87233B/pt active IP Right Grant
- 1988-04-14 AU AU14624/88A patent/AU596290B2/en not_active Ceased
- 1988-04-14 MX MX1111788A patent/MX11117A/es unknown
- 1988-04-14 DK DK204388A patent/DK204388A/da not_active Application Discontinuation
- 1988-04-14 KR KR1019880004245A patent/KR960015087B1/ko not_active Expired - Fee Related
- 1988-04-14 ZA ZA882640A patent/ZA882640B/xx unknown
- 1988-04-14 SU SU884355530A patent/SU1598869A3/ru active
- 1988-04-15 HU HU881968A patent/HU202492B/hu not_active IP Right Cessation
- 1988-04-15 CN CN88102191A patent/CN1017992B/zh not_active Expired
- 1988-04-15 JP JP63094395A patent/JP2661699B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT87233B (pt) | 1992-07-31 |
| AU1462488A (en) | 1988-10-20 |
| AR245933A1 (es) | 1994-03-30 |
| EG18864A (en) | 1995-06-29 |
| DK204388A (da) | 1989-01-05 |
| EP0287339A3 (de) | 1991-05-15 |
| CN88102191A (zh) | 1988-11-02 |
| IE881125L (en) | 1988-10-16 |
| IL86061A (en) | 1992-07-15 |
| EP0287339B1 (de) | 1994-08-17 |
| PT87233A (pt) | 1988-05-01 |
| ATE110057T1 (de) | 1994-09-15 |
| NZ224236A (en) | 1990-08-28 |
| PH24752A (en) | 1990-10-01 |
| CA1321792C (en) | 1993-08-31 |
| KR880012551A (ko) | 1988-11-28 |
| JPS63277661A (ja) | 1988-11-15 |
| CN1017992B (zh) | 1992-08-26 |
| AU596290B2 (en) | 1990-04-26 |
| DE3851081D1 (de) | 1994-09-22 |
| KR960015087B1 (ko) | 1996-10-24 |
| EP0287339A2 (de) | 1988-10-19 |
| DK204388D0 (da) | 1988-04-14 |
| SU1598869A3 (ru) | 1990-10-07 |
| HUT46892A (en) | 1988-12-28 |
| DE3851081T2 (de) | 1995-02-16 |
| HU202492B (en) | 1991-03-28 |
| IL86061A0 (en) | 1988-09-30 |
| ZA882640B (en) | 1989-12-27 |
| ES2058265T3 (es) | 1994-11-01 |
| IE64508B1 (en) | 1995-08-09 |
| MX11117A (es) | 1993-11-01 |
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