JPH0678327B2 - ４，５，６，７，―四置換ベンゾオキサゾロン類 - Google Patents

４，５，６，７，―四置換ベンゾオキサゾロン類

Info

Publication number
JPH0678327B2
JPH0678327B2 JP1188683A JP18868389A JPH0678327B2 JP H0678327 B2 JPH0678327 B2 JP H0678327B2 JP 1188683 A JP1188683 A JP 1188683A JP 18868389 A JP18868389 A JP 18868389A JP H0678327 B2 JPH0678327 B2 JP H0678327B2
Authority
JP
Japan
Prior art keywords
group
hydrogen
formula
fluoro
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1188683A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0352875A (ja
Inventor
正己 中根
高司 真野
文隆 伊藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Japan Inc
Original Assignee
Pfizer Pharmaceuticals KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Pharmaceuticals KK filed Critical Pfizer Pharmaceuticals KK
Priority to JP1188683A priority Critical patent/JPH0678327B2/ja
Priority to AT90307618T priority patent/ATE106877T1/de
Priority to DK90307618.0T priority patent/DK0409484T3/da
Priority to EP90307618A priority patent/EP0409484B1/en
Priority to DE69009607T priority patent/DE69009607T2/de
Priority to ES90307618T priority patent/ES2055332T3/es
Priority to IL9508590A priority patent/IL95085A/en
Priority to CA002021421A priority patent/CA2021421A1/en
Priority to PT94750A priority patent/PT94750A/pt
Priority to US07/554,625 priority patent/US5071863A/en
Priority to IE263090A priority patent/IE63203B1/en
Priority to ZA905677A priority patent/ZA905677B/xx
Priority to FI903655A priority patent/FI95378C/fi
Priority to NZ234583A priority patent/NZ234583A/en
Priority to NO90903230A priority patent/NO903230L/no
Priority to KR1019900010969A priority patent/KR930002099B1/ko
Priority to AU59193/90A priority patent/AU616608B2/en
Priority to HU904565A priority patent/HU206101B/hu
Publication of JPH0352875A publication Critical patent/JPH0352875A/ja
Publication of JPH0678327B2 publication Critical patent/JPH0678327B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
JP1188683A 1989-07-20 1989-07-20 ４，５，６，７，―四置換ベンゾオキサゾロン類 Expired - Lifetime JPH0678327B2 (ja)

Priority Applications (18)

Application Number Priority Date Filing Date Title
JP1188683A JPH0678327B2 (ja) 1989-07-20 1989-07-20 ４，５，６，７，―四置換ベンゾオキサゾロン類
AT90307618T ATE106877T1 (de) 1989-07-20 1990-07-12 4,5,6,7-tetrasubstituierte benzoxazolone.
DK90307618.0T DK0409484T3 (da) 1989-07-20 1990-07-12 4,5,6,7-tetrasubstituerede benzoxazoloner
EP90307618A EP0409484B1 (en) 1989-07-20 1990-07-12 4,5,6,7-Tetrasubstituted benzoxazolones
DE69009607T DE69009607T2 (de) 1989-07-20 1990-07-12 4,5,6,7-Tetrasubstituierte Benzoxazolone.
ES90307618T ES2055332T3 (es) 1989-07-20 1990-07-12 Benzoxazolonas 4,5,6,7-tetrasustituidas.
IL9508590A IL95085A (en) 1989-07-20 1990-07-13 Benzoxazolones 4,5,6,7-Tetraforms are converted into anti-allergy and anti-allergy pharmaceuticals
CA002021421A CA2021421A1 (en) 1989-07-20 1990-07-18 4, 5, 6, 7, - tetrasubstituted benzoxazolones
PT94750A PT94750A (pt) 1989-07-20 1990-07-18 Processo para a preparacao de benzoxazolonas 4,5,6,7-tetra-substituidas
US07/554,625 US5071863A (en) 1989-07-20 1990-07-18 4,5,6,7-trisubstituted benzoxazolones
IE263090A IE63203B1 (en) 1989-07-20 1990-07-19 4,5,6,7-Tetrasubstituted benzoxazolones
ZA905677A ZA905677B (en) 1989-07-20 1990-07-19 4,5,6,7,-tetrasubstituted benzoxazolones
FI903655A FI95378C (fi) 1989-07-20 1990-07-19 Menetelmä terapeuttisesti käyttökelpoisten, bentsorenkaassa trisubstituoitujen bentsoksatsolonien valmistamiseksi
NZ234583A NZ234583A (en) 1989-07-20 1990-07-19 4,5,6,7-tetrasubstituted benzoxazoles and pharmaceutical compositions thereof
NO90903230A NO903230L (no) 1989-07-20 1990-07-19 Fremgangsmaate for fremstilling av benzoksazolon-derivater.
KR1019900010969A KR930002099B1 (ko) 1989-07-20 1990-07-19 4, 5, 6, 7-사치환된 벤즈옥사졸론
AU59193/90A AU616608B2 (en) 1989-07-20 1990-07-20 4,5,6,7-tetrasubstituted benzoxazolones
HU904565A HU206101B (en) 1989-07-20 1990-07-20 Process for producing benzoxazolone derivatives substituted in three positions at least out of 4-, 5-, 6- and 7-positions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1188683A JPH0678327B2 (ja) 1989-07-20 1989-07-20 ４，５，６，７，―四置換ベンゾオキサゾロン類

Publications (2)

Publication Number Publication Date
JPH0352875A JPH0352875A (ja) 1991-03-07
JPH0678327B2 true JPH0678327B2 (ja) 1994-10-05

Family

ID=16228012

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1188683A Expired - Lifetime JPH0678327B2 (ja) 1989-07-20 1989-07-20 ４，５，６，７，―四置換ベンゾオキサゾロン類

Country Status (18)

Country Link
US (1) US5071863A (pt)
EP (1) EP0409484B1 (pt)
JP (1) JPH0678327B2 (pt)
KR (1) KR930002099B1 (pt)
AT (1) ATE106877T1 (pt)
AU (1) AU616608B2 (pt)
CA (1) CA2021421A1 (pt)
DE (1) DE69009607T2 (pt)
DK (1) DK0409484T3 (pt)
ES (1) ES2055332T3 (pt)
FI (1) FI95378C (pt)
HU (1) HU206101B (pt)
IE (1) IE63203B1 (pt)
IL (1) IL95085A (pt)
NO (1) NO903230L (pt)
NZ (1) NZ234583A (pt)
PT (1) PT94750A (pt)
ZA (1) ZA905677B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674524B1 (fr) * 1991-03-25 1993-05-21 Adir Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US7794761B2 (en) * 2000-04-13 2010-09-14 Seroctin Research & Technology, Inc. Methods for inducing anti-anxiety and calming effects in animals and humans
US20040192669A1 (en) * 2000-04-13 2004-09-30 Rosenfeld Mark J. Novel compounds for use in weight loss and appetite suppression in humans
US7524877B2 (en) 2003-11-20 2009-04-28 Seroctin Research & Technology, Inc. Compounds for use in weight loss and appetite suppression in humans
JP4695012B2 (ja) * 2006-04-21 2011-06-08 セイコークロック株式会社 アラーム時計
BRPI0917540A2 (pt) 2008-08-05 2015-11-17 Daiichi Sankyo Co Ltd composto, sal farmacologicamente aceitavél, composição farmacêutica, e, uso de um composto ou sal farmacologicamente aceitável

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3256293A (en) * 1964-02-05 1966-06-14 Monsanto Co 3-(phenylcarbamoyl) benzoxazolinones-2
US3657265A (en) * 1968-06-21 1972-04-18 Olin Corp Process for preparing benzoxazolones from aromatic nitro compounds
CS167359B2 (pt) * 1971-09-28 1976-04-29
US4227915A (en) * 1978-05-18 1980-10-14 Monsanto Company N-Substituted oxobenzothiazoline and oxobenzoxazoline derivatives and their use as plant growth regulants
JPS57123103A (en) * 1981-01-26 1982-07-31 Hokko Chem Ind Co Ltd Agricultural and horticultural fungicide
GB8325370D0 (en) * 1983-09-22 1983-10-26 Fujisawa Pharmaceutical Co Benzoxazoline and benzothiazoline derivatives
JPS6293283A (ja) * 1985-10-18 1987-04-28 Idemitsu Kosan Co Ltd ベンゾオキサゾロン誘導体，その製造方法およびそれを有効成分とする農園芸用殺菌剤
US4835166A (en) * 1986-06-09 1989-05-30 Pfizer Inc. Antiallergy and antiinflammatory agents
DK288287A (da) * 1986-06-09 1987-12-10 Pfizer Heterocycliske forbindelser samt farmaceutiske praeparater til behandling af allergiske eller inflammatoriske tilstande
IL93473A0 (en) * 1989-02-28 1990-11-29 Pfizer Antiinflammatory benzoxazolones

Also Published As

Publication number Publication date
FI903655A0 (fi) 1990-07-19
HU904565D0 (en) 1990-12-28
IE902630A1 (en) 1991-02-27
ZA905677B (en) 1992-02-26
NO903230D0 (no) 1990-07-19
JPH0352875A (ja) 1991-03-07
EP0409484A3 (en) 1991-05-15
EP0409484A2 (en) 1991-01-23
US5071863A (en) 1991-12-10
AU616608B2 (en) 1991-10-31
KR930002099B1 (ko) 1993-03-26
HU206101B (en) 1992-08-28
ATE106877T1 (de) 1994-06-15
IE63203B1 (en) 1995-04-05
AU5919390A (en) 1991-01-24
DK0409484T3 (da) 1994-07-04
ES2055332T3 (es) 1994-08-16
IL95085A (en) 1994-10-21
DE69009607T2 (de) 1994-09-22
IL95085A0 (en) 1991-06-10
PT94750A (pt) 1991-03-20
NZ234583A (en) 1991-12-23
HUT57745A (en) 1991-12-30
DE69009607D1 (de) 1994-07-14
EP0409484B1 (en) 1994-06-08
KR910002818A (ko) 1991-02-26
NO903230L (no) 1991-01-21
FI95378C (fi) 1996-01-25
CA2021421A1 (en) 1991-01-21
FI95378B (fi) 1995-10-13

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