JPH07508044A - レンチウイルス原因疾患の治療において有効な，生物学的に活性なウレイド誘導体 - Google Patents

レンチウイルス原因疾患の治療において有効な，生物学的に活性なウレイド誘導体

Info

Publication number: JPH07508044A
Authority: JP; Japan
Prior art keywords: bis; methyl; carbonylimino; carbonyl; imino
Prior art date: 1993-04-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP6522676A

Other languages

English (en)

Japanese (ja)

Inventor

モンジエーリ，ニコラ

ビアソーリ，ジヨバンニ

グランデイ，マリア

チヨメイ，マリナ

ジエローニ，マリア・クリステイーナ

Original Assignee

フアルマシア・エ・アツプジヨン・エツセ・ピー・アー

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-16

Filing date

1994-03-29

Publication date

1995-09-07

1994-03-29 Application filed by フアルマシア・エ・アツプジヨン・エツセ・ピー・アー filed Critical フアルマシア・エ・アツプジヨン・エツセ・ピー・アー

1995-09-07 Publication of JPH07508044A publication Critical patent/JPH07508044A/ja

Status Pending legal-status Critical Current

Links

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238000005469 granulation Methods 0.000 description 1
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SKDRUFXXSNZGKK-UHFFFAOYSA-H hexasodium naphthalene-1,3,5-trisulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)c1cc(c2cccc(c2c1)S([O-])(=O)=O)S([O-])(=O)=O.[O-]S(=O)(=O)c1cc(c2cccc(c2c1)S([O-])(=O)=O)S([O-])(=O)=O SKDRUFXXSNZGKK-UHFFFAOYSA-H 0.000 description 1
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239000006210 lotion Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
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239000002207 metabolite Substances 0.000 description 1
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YPLIFKZBNCNJJN-UHFFFAOYSA-N n,n-bis(ethylamino)ethanamine Chemical compound CCNN(CC)NCC YPLIFKZBNCNJJN-UHFFFAOYSA-N 0.000 description 1
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239000001267 polyvinylpyrrolidone Substances 0.000 description 1
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230000002265 prevention Effects 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
150000003233 pyrroles Chemical class 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
229960000329 ribavirin Drugs 0.000 description 1
HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
239000003419 rna directed dna polymerase inhibitor Substances 0.000 description 1
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239000000741 silica gel Substances 0.000 description 1
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239000000377 silicon dioxide Substances 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
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241000894007 species Species 0.000 description 1
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238000012360 testing method Methods 0.000 description 1
SSPQHAKUUKFFBB-UHFFFAOYSA-J tetrasodium naphthalene-1,3-disulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].C1(=CC(=CC2=CC=CC=C12)S(=O)(=O)[O-])S(=O)(=O)[O-].C1(=CC(=CC2=CC=CC=C12)S(=O)(=O)[O-])S(=O)(=O)[O-] SSPQHAKUUKFFBB-UHFFFAOYSA-J 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
229960000707 tobramycin Drugs 0.000 description 1
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
125000001425 triazolyl group Chemical group 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000004784 trichloromethoxy group Chemical group ClC(O*)(Cl)Cl 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229960002555 zidovudine Drugs 0.000 description 1
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP6522676A 1993-04-16 1994-03-29 レンチウイルス原因疾患の治療において有効な，生物学的に活性なウレイド誘導体 Pending JPH07508044A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939307948A GB9307948D0 (en)	1993-04-16	1993-04-16	Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease
GB9307948.1		1993-04-16
PCT/EP1994/000984 WO1994023718A1 (en)	1993-04-16	1994-03-29	Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease

Publications (1)

Publication Number	Publication Date
JPH07508044A true JPH07508044A (ja)	1995-09-07

Family

ID=10733998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP6522676A Pending JPH07508044A (ja)	1993-04-16	1994-03-29	レンチウイルス原因疾患の治療において有効な，生物学的に活性なウレイド誘導体

Country Status (15)

Country	Link
EP (1)	EP0646004A1 (cs)
JP (1)	JPH07508044A (cs)
KR (1)	KR950701812A (cs)
AU (1)	AU670194B2 (cs)
CA (1)	CA2137148A1 (cs)
CZ (1)	CZ282988B6 (cs)
GB (1)	GB9307948D0 (cs)
HU (1)	HU216834B (cs)
IL (1)	IL109235A (cs)
NO (1)	NO307126B1 (cs)
PL (1)	PL306798A1 (cs)
RU (1)	RU2142798C1 (cs)
TW (1)	TW308593B (cs)
UA (1)	UA42693C2 (cs)
WO (1)	WO1994023718A1 (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9504065D0 (en) *	1995-03-01	1995-04-19	Pharmacia Spa	Poly-pyrrolecarboxamidonaphthalenic acid derivatives
GB9602721D0 (en) *	1996-02-09	1996-04-10	Pharmacia Spa	Biologically active ureido derivatives useful in the treatment of multiple sclerosis
GB2310207A (en) *	1996-02-15	1997-08-20	Pharmacia Spa	Antiviral ureido derivatives of substituted heterocyclic compounds
GB9713733D0 (en) *	1997-06-27	1997-09-03	Pharmacia & Upjohn Spa	Poly-branched polycarboxamido compounds
EP3381897A1 (en)	2017-03-27	2018-10-03	Leadiant Biosciences SA	Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9000644D0 (en) *	1990-01-11	1990-03-14	Erba Carlo Spa	New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
AU1224392A (en) *	1991-02-06	1992-09-07	Synphar Laboratories, Inc.	Oligopeptide antiretroviral agents
IT1247878B (it) *	1991-02-15	1995-01-05	Menarini Farma Ind	Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono

1993
- 1993-04-16 GB GB939307948A patent/GB9307948D0/en active Pending
1994
- 1994-03-29 HU HU9500120A patent/HU216834B/hu not_active IP Right Cessation
- 1994-03-29 EP EP94913075A patent/EP0646004A1/en not_active Withdrawn
- 1994-03-29 WO PCT/EP1994/000984 patent/WO1994023718A1/en not_active Ceased
- 1994-03-29 UA UA94129236A patent/UA42693C2/uk unknown
- 1994-03-29 RU RU94046312A patent/RU2142798C1/ru active
- 1994-03-29 JP JP6522676A patent/JPH07508044A/ja active Pending
- 1994-03-29 AU AU65371/94A patent/AU670194B2/en not_active Ceased
- 1994-03-29 CZ CZ95107A patent/CZ282988B6/cs unknown
- 1994-03-29 CA CA002137148A patent/CA2137148A1/en not_active Abandoned
- 1994-03-29 PL PL94306798A patent/PL306798A1/xx unknown
- 1994-04-06 IL IL10923594A patent/IL109235A/en not_active IP Right Cessation
- 1994-04-12 TW TW083103216A patent/TW308593B/zh active
- 1994-12-12 NO NO944809A patent/NO307126B1/no not_active IP Right Cessation
- 1994-12-15 KR KR1019940704567A patent/KR950701812A/ko not_active Ceased

Also Published As

Publication number	Publication date
AU670194B2 (en)	1996-07-04
CZ10795A3 (en)	1995-09-13
NO944809D0 (no)	1994-12-12
RU94046312A (ru)	1996-10-20
KR950701812A (ko)	1995-05-17
HUT71838A (en)	1996-02-28
HU9500120D0 (en)	1995-03-28
NO307126B1 (no)	2000-02-14
CZ282988B6 (cs)	1997-12-17
HU216834B (hu)	1999-09-28
PL306798A1 (en)	1995-04-18
WO1994023718A1 (en)	1994-10-27
EP0646004A1 (en)	1995-04-05
TW308593B (cs)	1997-06-21
GB9307948D0 (en)	1993-06-02
IL109235A0 (en)	1994-07-31
UA42693C2 (uk)	2001-11-15
NO944809L (no)	1994-12-12
RU2142798C1 (ru)	1999-12-20
CA2137148A1 (en)	1994-10-27
IL109235A (en)	1998-09-24
AU6537194A (en)	1994-11-08

Publication	Publication Date	Title
RU2136692C1 (ru)	1999-09-10	Уреидопроизводные нафталинфосфоновых кислот или их фармацевтически приемлемые соли и фармацевтическая композиция на их основе
RU2078079C1 (ru)	1997-04-27	Производные пирролзамещенных уреидов, и их фармацевтически приемлемые соли, способ их получения и фармацевтическая композиция, обладающая ингибирующей ангиогенезис активностью
JPH0649652B2 (ja)	1994-06-29	３’―アジド―２’，３’―ジデオキシウリジン抗レトロウィルス組成物
JP4099234B2 (ja)	2008-06-11	抗ウイルス活性を有する新規化合物
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