JPH08502082A - 生体適合性ポリマー結合体 - Google Patents

生体適合性ポリマー結合体

Info

Publication number
JPH08502082A
JPH08502082A JP6503427A JP50342794A JPH08502082A JP H08502082 A JPH08502082 A JP H08502082A JP 6503427 A JP6503427 A JP 6503427A JP 50342794 A JP50342794 A JP 50342794A JP H08502082 A JPH08502082 A JP H08502082A
Authority
JP
Japan
Prior art keywords
collagen
peg
conjugate
polymer
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6503427A
Other languages
English (en)
Japanese (ja)
Inventor
リー,ウーンザ
ジー. ウォレス,ドナルド
エス. マイケルズ,アラン
エイ.,ジュニア バーンズ,レイモン
フリース,ルイス
デラストロ,フランク
ベンツ,ハンネ
マッカルラフ,キンバリー
ダマニ,ラメシュ
エイ. バーグ,リチャード
Original Assignee
コラーゲン コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/907,518 external-priority patent/US5324775A/en
Application filed by コラーゲン コーポレイション filed Critical コラーゲン コーポレイション
Publication of JPH08502082A publication Critical patent/JPH08502082A/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/102Collagen
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    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
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    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/041Mixtures of macromolecular compounds
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    • A61L31/10Macromolecular materials
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
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    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
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    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08HDERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00Macromolecular products derived from proteins
    • C08H1/06Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09JADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J189/00Adhesives based on proteins; Adhesives based on derivatives thereof
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00365Proteins; Polypeptides; Degradation products thereof
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    • A61L2430/16Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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    • C08L2666/02Organic macromolecular compounds, natural resins, waxes or and bituminous materials

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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Composite Materials (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
JP6503427A 1992-07-02 1993-07-01 生体適合性ポリマー結合体 Pending JPH08502082A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US07/907,518 US5324775A (en) 1988-11-21 1992-07-02 Biologically inert, biocompatible-polymer conjugates
US07/907,518 1992-07-02
US07/922,541 1992-07-30
US07/922,541 US5328955A (en) 1988-11-21 1992-07-30 Collagen-polymer conjugates
US98493392A 1992-12-02 1992-12-02
US07/984,197 US5308889A (en) 1988-11-21 1992-12-02 Dehydrated collagen-polymer strings
US07/984,933 1992-12-02
US07/984,197 1992-12-02
US07/985,680 1992-12-02
US07/985,680 US5292802A (en) 1988-11-21 1992-12-02 Collagen-polymer tubes for use in vascular surgery
US2503293A 1993-03-02 1993-03-02
US08/025,032 1993-03-02
PCT/US1993/006292 WO1994001483A1 (fr) 1992-07-02 1993-07-01 Conjugues polymeres biocompatibles

Publications (1)

Publication Number Publication Date
JPH08502082A true JPH08502082A (ja) 1996-03-05

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EP (1) EP0648239A4 (fr)
JP (1) JPH08502082A (fr)
AU (1) AU677789B2 (fr)
WO (1) WO1994001483A1 (fr)

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JP2005272398A (ja) * 2004-03-25 2005-10-06 Shiseido Co Ltd 皮膚のシワを改善する方法及びシワ改善具
JP2007023280A (ja) * 2005-07-12 2007-02-01 Kwangju Inst Of Science & Technol シクロデキストリンとポリ(オキシエチレン)の結合体、及びその製造方法
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WO2010070775A1 (fr) * 2008-12-19 2010-06-24 株式会社ネクスト21 Hydrogel injectable à ultra-haute résistance et procédé de fabrication associé
JP2010528046A (ja) * 2007-05-23 2010-08-19 アラーガン、インコーポレイテッド 架橋コラーゲンおよびその使用
WO2013021836A1 (fr) * 2011-08-05 2013-02-14 公立大学法人大阪市立大学 Hydrogel fonctionnel
JP2015061606A (ja) * 2006-03-29 2015-04-02 インセプト エルエルシー 医療用高吸収性凍結乾燥ヒドロゲル
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JP2004173941A (ja) * 2002-11-27 2004-06-24 Olympus Corp カルシウム傾斜材料とその製造方法
JP2004359895A (ja) * 2003-06-06 2004-12-24 Mcrotech Kk 医療用組成物
JP2005272398A (ja) * 2004-03-25 2005-10-06 Shiseido Co Ltd 皮膚のシワを改善する方法及びシワ改善具
JP2007023280A (ja) * 2005-07-12 2007-02-01 Kwangju Inst Of Science & Technol シクロデキストリンとポリ(オキシエチレン)の結合体、及びその製造方法
WO2007083522A1 (fr) * 2006-01-18 2007-07-26 Next21 K. K. Composition formant gel a usage medical, dispositifs d'application de la composition et vehicule reglant la liberation de medicament
JPWO2007083522A1 (ja) * 2006-01-18 2009-06-11 株式会社ネクスト21 医療用ゲル形成組成物,その組成物の投与デバイス及び薬剤放出制御担体
JP2015061606A (ja) * 2006-03-29 2015-04-02 インセプト エルエルシー 医療用高吸収性凍結乾燥ヒドロゲル
JP2010528046A (ja) * 2007-05-23 2010-08-19 アラーガン、インコーポレイテッド 架橋コラーゲンおよびその使用
WO2010070775A1 (fr) * 2008-12-19 2010-06-24 株式会社ネクスト21 Hydrogel injectable à ultra-haute résistance et procédé de fabrication associé
JPWO2010070775A1 (ja) * 2008-12-19 2012-05-24 株式会社ネクスト21 超高強度インジェクタブルハイドロゲル及びその製造方法
WO2013021836A1 (fr) * 2011-08-05 2013-02-14 公立大学法人大阪市立大学 Hydrogel fonctionnel
JPWO2013021836A1 (ja) * 2011-08-05 2015-03-05 公立大学法人大阪市立大学 機能性ハイドロゲル
JPWO2021025005A1 (fr) * 2019-08-05 2021-02-11

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AU4662093A (en) 1994-01-31
AU677789B2 (en) 1997-05-08
EP0648239A1 (fr) 1995-04-19
EP0648239A4 (fr) 1995-09-27
WO1994001483A1 (fr) 1994-01-20

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