JPH10505092A - 環状炭素に連結される置換されたベンズイミダゾール塩基を含む抗ウイルス性ヌクレオシドアナログ - Google Patents

環状炭素に連結される置換されたベンズイミダゾール塩基を含む抗ウイルス性ヌクレオシドアナログ

Info

Publication number
JPH10505092A
JPH10505092A JP8509679A JP50967996A JPH10505092A JP H10505092 A JPH10505092 A JP H10505092A JP 8509679 A JP8509679 A JP 8509679A JP 50967996 A JP50967996 A JP 50967996A JP H10505092 A JPH10505092 A JP H10505092A
Authority
JP
Japan
Prior art keywords
dichloro
benzimidazol
hydroxymethyl
cyclopentanediol
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP8509679A
Other languages
English (en)
Japanese (ja)
Inventor
タウンゼント，レロイ・ビー
ダルージュ，スーザン・メアリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan Ann Arbor
Original Assignee
University of Michigan System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/304,006 external-priority patent/US5534535A/en
Application filed by University of Michigan System filed Critical University of Michigan System
Publication of JPH10505092A publication Critical patent/JPH10505092A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP8509679A 1994-09-09 1995-09-11 環状炭素に連結される置換されたベンズイミダゾール塩基を含む抗ウイルス性ヌクレオシドアナログ Ceased JPH10505092A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US304,006 1994-09-09
US08/304,006 US5534535A (en) 1992-03-09 1994-09-09 Therapeutic nucleosides
PCT/US1995/011366 WO1996007646A1 (en) 1994-09-09 1995-09-11 Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring

Publications (1)

Publication Number Publication Date
JPH10505092A true JPH10505092A (ja) 1998-05-19

Family

ID=23174626

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8509679A Ceased JPH10505092A (ja) 1994-09-09 1995-09-11 環状炭素に連結される置換されたベンズイミダゾール塩基を含む抗ウイルス性ヌクレオシドアナログ

Country Status (17)

Country Link
EP (1) EP0779885A1 (cs)
JP (1) JPH10505092A (cs)
CN (1) CN1164855A (cs)
AP (1) AP741A (cs)
AU (1) AU3692895A (cs)
BR (1) BR9508826A (cs)
CA (1) CA2199502A1 (cs)
CZ (1) CZ71297A3 (cs)
FI (1) FI970959A7 (cs)
HU (1) HUT77440A (cs)
IS (1) IS4436A (cs)
NO (1) NO971070L (cs)
NZ (1) NZ294095A (cs)
OA (1) OA10601A (cs)
PL (1) PL319440A1 (cs)
SK (1) SK29197A3 (cs)
WO (1) WO1996007646A1 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912356A (en) * 1995-09-11 1999-06-15 Glaxo Wellcome Inc. Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
CA2280761A1 (en) 1997-02-13 1998-08-20 Stanley Dawes Chamberlain Benzimidazole derivatives
WO1999006424A1 (en) 1997-07-30 1999-02-11 The Regents Of The University Of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
HUP0202263A3 (en) 1999-12-27 2003-02-28 Japan Tobacco Inc Benzimidazole, indole and imidazo-pyridine derivatives and pharmaceutical compositions containing them
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
CN1834090B (zh) * 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途
EP2178880B1 (en) 2007-08-02 2017-10-04 Millennium Pharmaceuticals, Inc. Process for the synthesis of e1 activating enzyme inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides

Also Published As

Publication number Publication date
BR9508826A (pt) 1997-09-30
OA10601A (en) 2002-09-03
WO1996007646A1 (en) 1996-03-14
AP9700940A0 (en) 1997-04-30
EP0779885A1 (en) 1997-06-25
PL319440A1 (en) 1997-08-04
NO971070D0 (no) 1997-03-07
FI970959A7 (fi) 1997-05-06
IS4436A (is) 1997-03-07
CN1164855A (zh) 1997-11-12
AP741A (en) 1999-04-26
NZ294095A (en) 1998-08-26
NO971070L (no) 1997-05-07
FI970959A0 (fi) 1997-03-06
SK29197A3 (en) 1997-10-08
CZ71297A3 (en) 1997-08-13
HUT77440A (hu) 1998-04-28
CA2199502A1 (en) 1996-03-14
AU3692895A (en) 1996-03-27
MX9701789A (es) 1997-10-31

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Legal Events

Date Code Title Description
A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20040426

A02 Decision of refusal

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Effective date: 20040601