SK29197A3 - Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring, preparation method thereof, pharmaceutical composition and use - Google Patents

Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring, preparation method thereof, pharmaceutical composition and use Download PDF

Info

Publication number: SK29197A3
Authority: SK; Slovakia
Prior art keywords: dichloro; benzimidazol; cyclopentanediol; hydroxymethyl; compound
Prior art date: 1994-09-09

Application number

SK291-97A

Other languages

English (en)

Slovak (sk)

Inventor

Leroy B Townsend

Susan M Daluge

Original Assignee

Wellcome Found

Univ Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-09

Filing date

1995-09-11

Publication date

1997-10-08

1994-09-09 Priority claimed from US08/304,006 external-priority patent/US5534535A/en

1995-09-11 Application filed by Wellcome Found, Univ Michigan filed Critical Wellcome Found

1997-10-08 Publication of SK29197A3 publication Critical patent/SK29197A3/sk

Links

238000002360 preparation method Methods 0.000 title claims description 8
239000008194 pharmaceutical composition Substances 0.000 title claims description 5
230000000840 anti-viral effect Effects 0.000 title abstract description 5
125000002837 carbocyclic group Chemical group 0.000 title abstract description 4
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 2
229940127073 nucleoside analogue Drugs 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 claims abstract description 130
-1 amino, cyclopropylamino, cyclobutylamino, isopropylamino, tert-butylamino Chemical group 0.000 claims abstract description 45
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 33
125000001963 4 membered heterocyclic group Chemical group 0.000 claims abstract description 5
125000002373 5 membered heterocyclic group Chemical group 0.000 claims abstract description 5
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238000000034 method Methods 0.000 claims description 18
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK291-97A 1994-09-09 1995-09-11 Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring, preparation method thereof, pharmaceutical composition and use SK29197A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/304,006 US5534535A (en)	1992-03-09	1994-09-09	Therapeutic nucleosides
PCT/US1995/011366 WO1996007646A1 (en)	1994-09-09	1995-09-11	Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring

Publications (1)

Publication Number	Publication Date
SK29197A3 true SK29197A3 (en)	1997-10-08

Family

ID=23174626

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK291-97A SK29197A3 (en)	1994-09-09	1995-09-11	Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring, preparation method thereof, pharmaceutical composition and use

Country Status (17)

Country	Link
EP (1)	EP0779885A1 (cs)
JP (1)	JPH10505092A (cs)
CN (1)	CN1164855A (cs)
AP (1)	AP741A (cs)
AU (1)	AU3692895A (cs)
BR (1)	BR9508826A (cs)
CA (1)	CA2199502A1 (cs)
CZ (1)	CZ71297A3 (cs)
FI (1)	FI970959A7 (cs)
HU (1)	HUT77440A (cs)
IS (1)	IS4436A (cs)
NO (1)	NO971070L (cs)
NZ (1)	NZ294095A (cs)
OA (1)	OA10601A (cs)
PL (1)	PL319440A1 (cs)
SK (1)	SK29197A3 (cs)
WO (1)	WO1996007646A1 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5912356A (en) *	1995-09-11	1999-06-15	Glaxo Wellcome Inc.	Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
GB9600142D0 (en) *	1996-01-05	1996-03-06	Wellcome Found	Chemical compounds
US6413938B1 (en)	1997-02-13	2002-07-02	The Regents Of The University Of Michigan	Benzimidazole derivatives for the treatment of viral infections
AU744176B2 (en)	1997-07-30	2002-02-14	Glaxo Group Limited	Lyxofuranosyl benzimidazoles as antiviral agents
US6770666B2 (en)	1999-12-27	2004-08-03	Japan Tobacco Inc.	Fused-ring compounds and use thereof as drugs
CZ20013424A3 (cs)	1999-12-27	2002-02-13	Japan Tobacco Inc.	Sloučeniny s fúzovanými kruhy a jejich pouľití jako léčiva
GB0008939D0 (en)	2000-04-11	2000-05-31	Glaxo Group Ltd	Process for preparing substituted benzimidazole compounds
AR035543A1 (es) *	2001-06-26	2004-06-16	Japan Tobacco Inc	Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
CN1834090B (zh) *	2005-03-18	2011-06-29	中国科学院上海药物研究所	苯并咪唑类化合物、其制备方法以及用途
EP2540727B1 (en)	2007-08-02	2018-07-25	Millennium Pharmaceuticals, Inc.	Sulfamoylating reagent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9205071D0 (en) *	1992-03-09	1992-04-22	Wellcome Found	Therapeutic nucleosides

1995
- 1995-09-11 JP JP8509679A patent/JPH10505092A/ja not_active Ceased
- 1995-09-11 HU HU9702310A patent/HUT77440A/hu unknown
- 1995-09-11 AU AU36928/95A patent/AU3692895A/en not_active Abandoned
- 1995-09-11 SK SK291-97A patent/SK29197A3/sk unknown
- 1995-09-11 AP APAP/P/1997/000940A patent/AP741A/en active
- 1995-09-11 CZ CZ97712A patent/CZ71297A3/cs unknown
- 1995-09-11 WO PCT/US1995/011366 patent/WO1996007646A1/en not_active Ceased
- 1995-09-11 CN CN95196148A patent/CN1164855A/zh active Pending
- 1995-09-11 PL PL95319440A patent/PL319440A1/xx unknown
- 1995-09-11 EP EP95934402A patent/EP0779885A1/en not_active Withdrawn
- 1995-09-11 NZ NZ294095A patent/NZ294095A/en unknown
- 1995-09-11 CA CA002199502A patent/CA2199502A1/en not_active Abandoned
- 1995-09-11 BR BR9508826A patent/BR9508826A/pt not_active Application Discontinuation
1997
- 1997-03-06 FI FI970959A patent/FI970959A7/fi unknown
- 1997-03-07 OA OA60973A patent/OA10601A/en unknown
- 1997-03-07 IS IS4436A patent/IS4436A/is unknown
- 1997-03-07 NO NO971070A patent/NO971070L/no unknown

Also Published As

Publication number	Publication date
JPH10505092A (ja)	1998-05-19
PL319440A1 (en)	1997-08-04
MX9701789A (es)	1997-10-31
CZ71297A3 (en)	1997-08-13
AU3692895A (en)	1996-03-27
CN1164855A (zh)	1997-11-12
EP0779885A1 (en)	1997-06-25
FI970959A0 (fi)	1997-03-06
NO971070L (no)	1997-05-07
WO1996007646A1 (en)	1996-03-14
IS4436A (is)	1997-03-07
AP9700940A0 (en)	1997-04-30
HUT77440A (hu)	1998-04-28
CA2199502A1 (en)	1996-03-14
FI970959A7 (fi)	1997-05-06
BR9508826A (pt)	1997-09-30
NZ294095A (en)	1998-08-26
OA10601A (en)	2002-09-03
NO971070D0 (no)	1997-03-07
AP741A (en)	1999-04-26

Publication	Publication Date	Title
OA10610A (en)	2002-09-06	Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists.
EP0630368B1 (en)	1998-09-09	Antiviral nucleoside analogues
JP3225045B2 (ja)	2001-11-05	治療用化合物
US5840990A (en)	1998-11-24	Intermediates to carbocyclic nucleosides
JP2023537402A (ja)	2023-08-31	抗ウイルス剤としての機能化ペプチド
US5399580A (en)	1995-03-21	Therapeutic nucleosides-uses
AP741A (en)	1999-04-26	Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring.
JP2000515119A (ja)	2000-11-14	医薬組成物
AU1438997A (en)	1997-08-01	2-amino-5,6-dichlorobenzimidazole derivatives having antiviral activity
US5912356A (en)	1999-06-15	Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
MXPA97001789A (en)	1998-07-03	Antiviral nucleosid analogues containing a substitute benzymidazole base united to a carbocicl ring