JPH11506726A5 - - Google Patents

Info

Publication number
JPH11506726A5
JPH11506726A5 JP1997500559A JP50055997A JPH11506726A5 JP H11506726 A5 JPH11506726 A5 JP H11506726A5 JP 1997500559 A JP1997500559 A JP 1997500559A JP 50055997 A JP50055997 A JP 50055997A JP H11506726 A5 JPH11506726 A5 JP H11506726A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997500559A
Other languages
English (en)
Japanese (ja)
Other versions
JP3874306B2 (ja
JPH11506726A (ja
Filing date
Publication date
Priority claimed from US08/474,874 external-priority patent/US5637767A/en
Application filed filed Critical
Publication of JPH11506726A publication Critical patent/JPH11506726A/ja
Publication of JPH11506726A5 publication Critical patent/JPH11506726A5/ja
Application granted granted Critical
Publication of JP3874306B2 publication Critical patent/JP3874306B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP50055997A 1995-06-07 1996-05-13 （ｓ）−３−（アミノメチル）−５−メチルヘキサン酸を製造する方法 Expired - Lifetime JP3874306B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US08/474,874 1995-06-07
PCT/US1996/006819 WO1996040617A1 (en) 1995-06-07 1996-05-13 Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (3)

Publication Number Publication Date
JPH11506726A JPH11506726A (ja) 1999-06-15
JPH11506726A5 true JPH11506726A5 (2) 2004-07-08
JP3874306B2 JP3874306B2 (ja) 2007-01-31

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50055997A Expired - Lifetime JP3874306B2 (ja) 1995-06-07 1996-05-13 （ｓ）−３−（アミノメチル）−５−メチルヘキサン酸を製造する方法

Country Status (18)

Country Link
US (4) US5637767A (2)
EP (1) EP0830338B1 (2)
JP (1) JP3874306B2 (2)
AT (1) ATE210628T1 (2)
CA (1) CA2219150C (2)
CZ (2) CZ291147B6 (2)
DE (1) DE69617948T2 (2)
DK (1) DK0830338T3 (2)
EE (1) EE04053B1 (2)
ES (1) ES2170231T3 (2)
GE (1) GEP19991870B (2)
HU (2) HU228194B1 (2)
NZ (2) NZ308319A (2)
PL (3) PL185560B1 (2)
PT (1) PT830338E (2)
SI (1) SI0830338T1 (2)
SK (2) SK283507B6 (2)
WO (1) WO1996040617A1 (2)

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PT1250311E (pt) * 2000-01-27 2004-07-30 Warner Lambert Co Sintese assimetrica de pregabalina
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EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
RU2335342C2 (ru) * 2004-03-12 2008-10-10 Уорнер-Ламберт Компани Ллс C1-симметричные бисфосфиновые лиганды и их применение в асимметрическом синтезе прегабалина
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
MXPA06014228A (es) * 2004-06-21 2007-02-14 Warner Lambert Co Preparacion de pregabalina y compuestos relacionados.
EP1866275A1 (en) * 2005-04-06 2007-12-19 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
CA2603215A1 (en) * 2005-04-11 2006-10-19 Teva Pharmaceutical Industries Ltd. Process for making (s)-pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
US7462737B2 (en) * 2005-05-10 2008-12-09 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
ATE486841T1 (de) * 2005-05-10 2010-11-15 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
WO2006121557A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
US20070043241A1 (en) * 2005-05-10 2007-02-22 Lilach Hedvati Optical resolution of 3-carbamoylmethyl-5-methylhexanoic acid
KR20070087596A (ko) * 2005-09-19 2007-08-28 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸헥산산의 비대칭 합성
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
BRPI0702865A2 (pt) * 2006-04-24 2012-08-07 Teva Pharma processos para preparaÇço do Ácido 3-isobutilglutÁrico e de (s)- pregabalin, a partir de combinaÇÕes de composiÇÕes com fàrmulas especÍficas para uso na dita preparaÇço
US7462738B2 (en) * 2006-05-24 2008-12-09 Teva Pharmaceutical Industries Ltd. Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
KR20080036060A (ko) 2006-05-31 2008-04-24 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린의 중간체의 제조에 효소 분할을 이용하는 방법
EP1912931A2 (en) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
EP2054375A2 (en) 2006-07-12 2009-05-06 Merck Generics (UK) Limited Process of preparing a gamma-amino acid
WO2008062460A2 (en) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
MX2008014759A (es) * 2007-03-22 2009-03-09 Teva Pharma Sintesis del acido (s)-(+)-3-(aminometil)-5-metil hexanoico.
WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
EP1992609A1 (en) * 2007-05-14 2008-11-19 Dipharma Francis S.r.l. A process for the preparation of a (S)(+)-3-(aminomethyl)-5-methylhexanoic acid
WO2009001372A2 (en) * 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
WO2009044409A2 (en) * 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
ITMI20072262A1 (it) * 2007-12-03 2009-06-04 Dipharma Francis Srl Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
US20100312010A1 (en) * 2007-12-18 2010-12-09 Watson Pharma Private Limited Process for the Preparation of (S)-Pregabalin
WO2009081208A1 (en) * 2007-12-26 2009-07-02 Generics [Uk] Limited Processes to pregabalin
KR101489267B1 (ko) * 2007-12-27 2015-02-04 도오레 화인케미칼 가부시키가이샤 광학 활성 3-아미노피롤리딘염, 그 제조 방법 및 3-아미노피롤리딘의 광학 분할 방법
WO2009082861A1 (en) * 2008-01-02 2009-07-09 Zhejiang Jiuzhou Pharmaceutical Co., Ltd. New resolution process of (s)-3-aminomethyl-5-methylhexanoic acid
US20110144383A1 (en) * 2008-02-18 2011-06-16 Matrix Laboratories Limited Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid
EP2262761A1 (en) * 2008-04-04 2010-12-22 Generics [UK] Limited Novel process
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
US8546112B2 (en) * 2008-05-21 2013-10-01 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
EP2280930A1 (en) * 2008-06-03 2011-02-09 Generics [UK] Limited A novel and efficient method for the synthesis of an amino acid
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010061403A2 (en) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Process to prepare highly pure (s)-pregabalin
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
IT1394292B1 (it) 2009-05-07 2012-06-06 Dipharma Francis Srl Procedimento per la sintesi di pregabalina
ES2362913B1 (es) 2009-12-24 2012-05-24 Moehs Iberica S.L. Nuevo método para la preparación de (s)-pregabalina.
HUP1000186A2 (en) * 2010-04-08 2011-10-28 Richter Gedeon Nyrt Novel industrial process of preparing (s)-(+) pregabalin
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
US8895769B2 (en) 2011-04-20 2014-11-25 Kemphys Ltd. Silicon-containing carboxylic acid derivative
EP2527319A1 (en) 2011-05-24 2012-11-28 Laboratorios Del. Dr. Esteve, S.A. Crystalline forms of pregabalin and co-formers in the treatment of pain
CN104781264A (zh) * 2012-10-18 2015-07-15 有限会社肯菲思 含有硅的羧酸衍生物
JP6482465B2 (ja) 2012-11-07 2019-03-13 ハイカル リミテッド プレガバリンの調製方法
CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
US9745249B2 (en) 2014-06-12 2017-08-29 Siegfried Ltd. Method for the preparation of beta-substituted gamma-amino carboxylic acids
CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
JP2018520112A (ja) 2015-05-26 2018-07-26 オディディ，イサ 制御持続放出プレガバリン
CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
WO2022119430A1 (es) 2020-12-04 2022-06-09 Laboratorios Silanes S.A. De C.V. Composición farmacéutica sólida recubierta y estable de un analgésico opioide y un antiepiléptico para el dolor
CN112939809A (zh) * 2020-12-30 2021-06-11 江苏恒沛药物科技有限公司 一种1-氰基-3-甲基丁基丙二酸二乙酯的制备方法
CN116041214B (zh) * 2022-11-15 2025-04-22 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

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