JPH11506738A5 - - Google Patents

Info

Publication number
JPH11506738A5
JPH11506738A5 JP1997500832A JP50083297A JPH11506738A5 JP H11506738 A5 JPH11506738 A5 JP H11506738A5 JP 1997500832 A JP1997500832 A JP 1997500832A JP 50083297 A JP50083297 A JP 50083297A JP H11506738 A5 JPH11506738 A5 JP H11506738A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997500832A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11506738A (ja
JP3844504B2 (ja
Filing date
Publication date
Priority claimed from US08/484,220 external-priority patent/US5700904A/en
Application filed filed Critical
Publication of JPH11506738A publication Critical patent/JPH11506738A/ja
Publication of JPH11506738A5 publication Critical patent/JPH11506738A5/ja
Application granted granted Critical
Publication of JP3844504B2 publication Critical patent/JP3844504B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP50083297A 1995-06-07 1996-06-04 アシル化タンパク質粉末の製造 Expired - Fee Related JP3844504B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/484,220 1995-06-07
US08/484,220 US5700904A (en) 1995-06-07 1995-06-07 Preparation of an acylated protein powder
PCT/US1996/007963 WO1996040730A1 (en) 1995-06-07 1996-06-04 Preparation of an acylated protein powder

Publications (3)

Publication Number Publication Date
JPH11506738A JPH11506738A (ja) 1999-06-15
JPH11506738A5 true JPH11506738A5 (2) 2004-07-22
JP3844504B2 JP3844504B2 (ja) 2006-11-15

Family

ID=23923252

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50083297A Expired - Fee Related JP3844504B2 (ja) 1995-06-07 1996-06-04 アシル化タンパク質粉末の製造

Country Status (21)

Country Link
US (1) US5700904A (2)
EP (1) EP0747391B1 (2)
JP (1) JP3844504B2 (2)
KR (1) KR19990022590A (2)
CN (1) CN1192218A (2)
AT (1) ATE263185T1 (2)
AU (1) AU703032B2 (2)
BR (1) BR9608729A (2)
CA (1) CA2223389A1 (2)
CZ (1) CZ388197A3 (2)
DE (1) DE69631996T2 (2)
DK (1) DK0747391T3 (2)
EA (1) EA199800042A1 (2)
ES (1) ES2216039T3 (2)
HU (1) HUP9900877A3 (2)
IL (1) IL122460A0 (2)
NO (1) NO975583L (2)
NZ (1) NZ309371A (2)
PL (1) PL323994A1 (2)
TR (1) TR199701528T1 (2)
WO (1) WO1996040730A1 (2)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9316895D0 (en) 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
US5986050A (en) * 1996-12-26 1999-11-16 Poly-Med, Inc. Peracylated proteins and synthetic polypeptides and process for making the same
US5898067A (en) * 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
ATE294189T1 (de) * 1997-02-07 2005-05-15 Novo Nordisk As Kristallisation von proteinen
US6310038B1 (en) * 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
CA2283705A1 (en) * 1997-03-20 1998-10-01 Novo Nordisk A/S Zinc free insulin crystals for use in pulmonary compositions
US5898028A (en) * 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
EP0911035A3 (en) * 1997-10-24 2002-08-21 Eli Lilly And Company Insoluble insulin compositions
HUP0004169A3 (en) * 1997-10-24 2001-06-28 Lilly Co Eli Insoluble insulin compositions and process for production thereof
ZA989744B (en) * 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
CO4970787A1 (es) * 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
EP1396272A1 (en) * 1997-12-23 2004-03-10 Eli Lilly & Company Insoluble Insulin Compositions for Controlling Blood Glucose
US6855260B1 (en) * 1999-06-07 2005-02-15 Roe-Hoan Yoon Methods of enhancing fine particle dewatering
US6526675B1 (en) * 1999-06-07 2003-03-04 Roe-Hoan Yoon Methods of using natural products as dewatering aids for fine particles
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6799682B1 (en) 2000-05-16 2004-10-05 Roe-Hoan Yoon Method of increasing flotation rate
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
WO2003088961A1 (en) * 2002-04-19 2003-10-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders
WO2003105768A2 (en) 2002-06-13 2003-12-24 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
WO2004037843A2 (en) * 2002-10-25 2004-05-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
US7530968B2 (en) 2003-04-23 2009-05-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
ES2421139T3 (es) 2003-07-30 2013-08-29 Rigel Pharmaceuticals, Inc. Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
CN101027318B (zh) 2004-07-19 2016-05-25 比奥孔有限公司 胰岛素-低聚物共轭物，制剂及其用途
PL1804865T3 (pl) 2004-10-21 2010-03-31 Novo Nordisk As Mechanizm wkręcania dla nawijanych penów
JP4022595B2 (ja) * 2004-10-26 2007-12-19 コニカミノルタオプト株式会社 撮影装置
AU2006210497A1 (en) 2005-02-04 2006-08-10 Mineral And Coal Technologies, Inc. Improving the separation of diamond from gangue minerals
JP4979686B2 (ja) 2005-04-24 2012-07-18 ノボ・ノルデイスク・エー／エス 注入デバイス
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
WO2006133426A2 (en) 2005-06-08 2006-12-14 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US7741281B2 (en) * 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2007098507A2 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
JP5062768B2 (ja) 2006-03-10 2012-10-31 ノボ・ノルデイスク・エー／エス 注射装置および該装置のカートリッジを交換する方法
CN101400394B (zh) 2006-03-10 2012-07-04 诺沃-诺迪斯克有限公司 具有传动部件的注射装置
CN103239773B (zh) 2006-03-30 2015-08-26 瓦莱里塔斯公司 多筒式流体递送器械
US8088900B2 (en) 2006-03-30 2012-01-03 Novo Nordisk A/S Two-phase precipitation of proteins
US7714025B2 (en) * 2006-05-10 2010-05-11 Arizona Biomedical Research Commission Modified chalcone compounds as antimitotic agents
DE602007004972D1 (de) 2006-05-16 2010-04-08 Novo Nordisk As Getriebemechanismus für ein injektionsgerät
JP5253387B2 (ja) 2006-05-18 2013-07-31 ノボ・ノルデイスク・エー／エス モード固定手段を備えている注入装置
WO2008116766A1 (en) 2007-03-23 2008-10-02 Novo Nordisk A/S An injection device comprising a locking nut
US9241908B2 (en) 2007-10-16 2016-01-26 Biocon Limited Orally administrable solid pharmaceutical composition and a process thereof
PL2389372T3 (pl) 2009-01-23 2016-02-29 Rigel Pharmaceuticals Inc Kompozycje i sposoby hamowania szlaku JAK
CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
KR101937495B1 (ko) 2010-07-28 2019-01-10 리겔 파마슈티칼스, 인크. Ｊａｋ 경로의 억제를 위한 조성물 및 방법
MX2014007375A (es) 2011-12-29 2014-08-22 Novo Nordisk As Jeringa autoinyectora de cuerda basada en resorte de torsion con mecanismo dosificador giratorio de aumento/disminucion.
WO2013142038A2 (en) 2012-03-23 2013-09-26 Oxigene, Inc. Compositions and methods for inhibition of cathepsins
US11206846B2 (en) 2017-05-02 2021-12-28 Leprino Foods Company High purity alpha lactalbumin and methods of making
CN111386281B (zh) 2017-09-26 2024-03-19 拜康生物制品印度有限公司 用于肽晶体的分离、洗涤和干燥的集成的自动化过滤
US20220000880A1 (en) 2018-11-01 2022-01-06 Rigel Pharmaceuticals, Inc. Method and composition embodiments for treating acute myeloid leukemia
US20200377518A1 (en) 2019-05-29 2020-12-03 Rigel Pharmaceuticals, Inc. Method of preventing and treating thrombosis
EP4009974A1 (en) 2019-08-08 2022-06-15 Rigel Pharmaceuticals, Inc. Compounds and method for treating cytokine release syndrome
CA3147444A1 (en) 2019-08-14 2021-02-18 Rigel Pharmaceuticals, Inc. Method of blocking or ameliorating cytokine release syndrome
ES3075943T3 (en) 2022-03-23 2026-08-10 Rigel Pharmaceuticals Inc Pyrimid-2-yl-pyrazole compounds as irak inhibitors

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1468831A (fr) * 1965-10-05 1967-02-10 Roussel Uclaf Procédé de préparation de nouveaux composés polypeptidiques et produits en résultant
DE1902865A1 (de) * 1968-02-01 1969-09-11 American Home Prod Substituierte Insulin-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
US3591574A (en) * 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
US3528960A (en) * 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins
US3823125A (en) * 1969-10-14 1974-07-09 American Home Prod N-aminoacyl-substituted insulins
US3752798A (en) * 1969-12-02 1973-08-14 G Amird Tris-na1,nb1,nepsilonb29 - (3-x-3-oxo - 1-y-prop-1-en-1-yl)(ndelta-(4-z-6-r-pyrimidin - 2 - yl) ornithine b22)-insulins and their preparation
US3950517A (en) * 1970-05-08 1976-04-13 National Research Development Corporation Insulin derivatives
US3869437A (en) * 1970-05-08 1975-03-04 Nat Res Dev Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
GB1381274A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
GB1381273A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
US3864325A (en) * 1971-11-18 1975-02-04 Nat Res Dev (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives
BE791949A (fr) * 1971-11-27 1973-05-28 Schering Ag Derives d'insuline, leur preparation et leur utilisation
US3843815A (en) * 1972-02-10 1974-10-22 Gen Foods Corp Inhibiting gel formation in meat-in-gravy products
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
DE2252157C3 (de) * 1972-10-25 1976-03-18 Hoechst Ag Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
NL7314766A (2) * 1972-10-31 1974-05-02
DE2428412A1 (de) * 1974-06-12 1976-01-15 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DE2439296A1 (de) * 1974-08-16 1976-02-26 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
GB1492997A (en) * 1976-07-21 1977-11-23 Nat Res Dev Insulin derivatives
EP0014815A3 (de) * 1978-12-20 1980-10-29 Ciba-Geigy Ag Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen
US4486458A (en) * 1982-09-07 1984-12-04 A. E. Staley Manufacturing Company Non-gelling corn steep liquor
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
JPS6255096A (ja) * 1986-06-12 1987-03-10 Nippon Shinyaku Co Ltd 新規な脂肪酸アシル化合物
JPH01254699A (ja) * 1988-04-05 1989-10-11 Kodama Kk インスリン誘導体及びその用途
IL93282A (en) * 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogues
WO1992001476A1 (en) * 1990-07-26 1992-02-06 University Of Iowa Research Foundation Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
CA2150470A1 (en) * 1992-11-30 1994-06-09 S.P.I. Synthetic Peptides Incorporated Polyunsaturated fatty acyl-peptide composition

Similar Documents

Publication Publication Date Title
JP2000500033A5 (2)
JP2000500228A5 (2)
JP2000500440A5 (2)
JPH11501950A5 (2)
JP2000500327A5 (2)
JP2000500155A5 (2)
JP2000500406A5 (2)
JP2000500361A5 (2)
JP2000500115A5 (2)
JP2000500322A5 (2)
JP2000500258A5 (2)
JP2000500342A5 (2)
JP2000500192A5 (2)
JP2000501954A5 (2)
JP2000500112A5 (2)
JP2000500166A5 (2)
JP2000500051A5 (2)
JP2000500397A5 (2)
JP2000500019A5 (2)
JP2000500125A5 (2)
JP2000500346A5 (2)
JP2000500044A5 (2)
JP2000500090A5 (2)
JP2000500257A5 (2)
JP2000500429A5 (2)