JPS55145686A - Preparation of cephalosporin analog - Google Patents

Preparation of cephalosporin analog

Info

Publication number
JPS55145686A
JPS55145686A JP5307779A JP5307779A JPS55145686A JP S55145686 A JPS55145686 A JP S55145686A JP 5307779 A JP5307779 A JP 5307779A JP 5307779 A JP5307779 A JP 5307779A JP S55145686 A JPS55145686 A JP S55145686A
Authority
JP
Japan
Prior art keywords
compound
formula
solvent
oxo
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5307779A
Other languages
Japanese (ja)
Inventor
Tadashi Hirata
Hideo Matsushima
Shinji Tomioka
Hiromitsu Saito
Chihiro Shiraki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP5307779A priority Critical patent/JPS55145686A/en
Priority to DK178280A priority patent/DK178280A/en
Priority to NO801217A priority patent/NO801217L/en
Priority to ES490982A priority patent/ES490982A0/en
Publication of JPS55145686A publication Critical patent/JPS55145686A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To obtain the title compound readily in one step, by ring closure of an 2-[ 4-( 3-oxo-1-propenyl )-3-azido-2-oxo-azetidin-1-yl ]-2-dialkylphosphonocarboxylic acid.
CONSTITUTION: A compound of formula I (R' is carboxylic acid or its ester; R" is lower alkyl group) is subjected to ring closure in the presence of a base in a solvent, e.g. an ether, at room temperature to 100°C to give the compound of formula II. The starting compound of formula I can be obtained by condensing a compound of the formula HOCCH=CHCH(OMe)2 with a compound of formula III in a solvent, e.g. methylene chloride, at -20W50°C through dehydration, and by reacting the resulting compound of formula IV with N3CH2COCl in a nonaqueous solvent in the presence of a base to form a compound of formula V, which is hydrolyzed.
COPYRIGHT: (C)1980,JPO&Japio
JP5307779A 1979-04-28 1979-04-28 Preparation of cephalosporin analog Pending JPS55145686A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP5307779A JPS55145686A (en) 1979-04-28 1979-04-28 Preparation of cephalosporin analog
DK178280A DK178280A (en) 1979-04-28 1980-04-25 METHOD OF PREPARING CEPHALOSPORIN ANALOGUE
NO801217A NO801217L (en) 1979-04-28 1980-04-25 PROCEDURE FOR PREPARING CEPHALOSPORINE ANALOGS
ES490982A ES490982A0 (en) 1979-04-28 1980-04-28 A PROCEDURE FOR THE PREPARATION OF CEPHALUS-PORINA ANALOGS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5307779A JPS55145686A (en) 1979-04-28 1979-04-28 Preparation of cephalosporin analog

Publications (1)

Publication Number Publication Date
JPS55145686A true JPS55145686A (en) 1980-11-13

Family

ID=12932732

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5307779A Pending JPS55145686A (en) 1979-04-28 1979-04-28 Preparation of cephalosporin analog

Country Status (1)

Country Link
JP (1) JPS55145686A (en)

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