JPS587279B2 - 抗生物質の検出方法 - Google Patents

抗生物質の検出方法

Info

Publication number: JPS587279B2
Authority: JP; Japan
Prior art keywords: antibiotic; microorganism; labeled; sample; labeling substance
Prior art date: 1977-11-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP53142927A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5496098A (en

Inventor

スタンリー・エリー・チヤーム

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Penicillin Assays Inc

Original Assignee

Penicillin Assays Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-11-21

Filing date

1978-11-21

Publication date

1983-02-09

1978-06-12 Priority claimed from US05/914,414 external-priority patent/US4239852A/en

1978-11-21 Application filed by Penicillin Assays Inc filed Critical Penicillin Assays Inc

1979-07-30 Publication of JPS5496098A publication Critical patent/JPS5496098A/ja

1983-02-09 Publication of JPS587279B2 publication Critical patent/JPS587279B2/ja

Status Expired legal-status Critical Current

Links

239000003242 anti bacterial agent Substances 0.000 title claims description 48
229940088710 antibiotic agent Drugs 0.000 title claims description 41
230000003115 biocidal effect Effects 0.000 claims description 106
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 70
238000000034 method Methods 0.000 claims description 49
238000012360 testing method Methods 0.000 claims description 45
244000005700 microbiome Species 0.000 claims description 28
102000004190 Enzymes Human genes 0.000 claims description 27
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230000027455 binding Effects 0.000 claims description 20
239000007788 liquid Substances 0.000 claims description 19
229940056360 penicillin g Drugs 0.000 claims description 18
239000000126 substance Substances 0.000 claims description 18
238000001514 detection method Methods 0.000 claims description 15
238000011534 incubation Methods 0.000 claims description 15
235000013336 milk Nutrition 0.000 claims description 15
239000008267 milk Substances 0.000 claims description 15
210000004080 milk Anatomy 0.000 claims description 15
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims description 14
239000000758 substrate Substances 0.000 claims description 14
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239000002243 precursor Substances 0.000 claims description 9
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AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 3
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RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 2
XIURVHNZVLADCM-IUODEOHRSA-N cefalotin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CC1=CC=CS1 XIURVHNZVLADCM-IUODEOHRSA-N 0.000 claims description 2
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LQOLIRLGBULYKD-JKIFEVAISA-N cloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl LQOLIRLGBULYKD-JKIFEVAISA-N 0.000 claims description 2
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UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 claims description 2
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NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 description 5
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ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
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239000004098 Tetracycline Substances 0.000 description 3
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LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
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238000000108 ultra-filtration Methods 0.000 description 1
229960003165 vancomycin Drugs 0.000 description 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1

Classifications

- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B39/00—Component parts, details, or accessories, of pumps or pumping systems specially adapted for elastic fluids, not otherwise provided for in, or of interest apart from, groups F04B25/00 - F04B37/00
- F04B39/12—Casings; Cylinders; Cylinder heads; Fluid connections
- F04B39/127—Mounting of a cylinder block in a casing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material

Landscapes

Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Toxicology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Mechanical Engineering (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)

JP53142927A 1977-11-21 1978-11-21 抗生物質の検出方法 Expired JPS587279B2 (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US85354177A	1977-11-21	1977-11-21
US05/914,414 US4239852A (en)	1978-06-12	1978-06-12	Antibiotic detection method

Publications (2)

Publication Number	Publication Date
JPS5496098A JPS5496098A (en)	1979-07-30
JPS587279B2 true JPS587279B2 (ja)	1983-02-09

Family

ID=27127165

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP53142927A Expired JPS587279B2 (ja)	1977-11-21	1978-11-21	抗生物質の検出方法

Country Status (10)

Country	Link
JP (1)	JPS587279B2 (de)
BR (1)	BR7807695A (de)
CA (1)	CA1108516A (de)
DE (1)	DE2850503C2 (de)
DK (1)	DK152383C (de)
FR (1)	FR2409517A1 (de)
GB (1)	GB2008248B (de)
IL (1)	IL55964A0 (de)
NL (1)	NL186930C (de)
NZ (1)	NZ188910A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL59723A (en) *	1980-03-27	1983-05-15	Teva Pharma	Determination of antibacterial agents
US4686182A (en) *	1984-10-17	1987-08-11	Minnesota Mining And Manufacturing Company	Method and kit for detecting antibiotics in a liquid sample
CN118725327B (zh) *	2024-07-10	2025-09-26	昆明医科大学	一种锌配位聚合物及其制备方法和在检测头孢他啶中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL154600B (nl) *	1971-02-10	1977-09-15	Organon Nv	Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL171930C (nl) *	1972-05-11	1983-06-01	Akzo Nv	Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.

1978
- 1978-11-10 CA CA316,133A patent/CA1108516A/en not_active Expired
- 1978-11-14 NZ NZ188910A patent/NZ188910A/xx unknown
- 1978-11-16 IL IL55964A patent/IL55964A0/xx not_active IP Right Cessation
- 1978-11-16 GB GB7844810A patent/GB2008248B/en not_active Expired
- 1978-11-20 FR FR7832671A patent/FR2409517A1/fr active Granted
- 1978-11-20 DK DK516878A patent/DK152383C/da active
- 1978-11-21 DE DE2850503A patent/DE2850503C2/de not_active Expired
- 1978-11-21 BR BR7807695A patent/BR7807695A/pt unknown
- 1978-11-21 JP JP53142927A patent/JPS587279B2/ja not_active Expired
- 1978-11-21 NL NLAANVRAGE7811478,A patent/NL186930C/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR7807695A (pt)	1979-07-31
GB2008248B (en)	1982-06-16
NL7811478A (nl)	1979-05-23
GB2008248A (en)	1979-05-31
DK152383B (da)	1988-02-22
NZ188910A (en)	1981-01-23
DE2850503C2 (de)	1985-09-12
NL186930C (nl)	1991-04-02
CA1108516A (en)	1981-09-08
FR2409517B1 (de)	1985-05-03
DK152383C (da)	1988-07-25
DE2850503A1 (de)	1979-05-23
NL186930B (nl)	1990-11-01
DK516878A (da)	1979-05-22
IL55964A0 (en)	1979-01-31
JPS5496098A (en)	1979-07-30
FR2409517A1 (fr)	1979-06-15

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