JPS589114B2 - セスキテルペン類縁体、その製造法及び腎炎治療剤 - Google Patents

セスキテルペン類縁体、その製造法及び腎炎治療剤

Info

Publication number
JPS589114B2
JPS589114B2 JP52078641A JP7864177A JPS589114B2 JP S589114 B2 JPS589114 B2 JP S589114B2 JP 52078641 A JP52078641 A JP 52078641A JP 7864177 A JP7864177 A JP 7864177A JP S589114 B2 JPS589114 B2 JP S589114B2
Authority
JP
Japan
Prior art keywords
shm
compound
absorption
reaction
positive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52078641A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5436255A (en
Inventor
井沢武年
貝瀬洋次
宮崎和成
篠原正直
大城靖男
中野善正
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP52078641A priority Critical patent/JPS589114B2/ja
Priority to ZA00782683A priority patent/ZA782683B/xx
Priority to FR7813932A priority patent/FR2405941A1/fr
Priority to NZ187243A priority patent/NZ187243A/en
Priority to AR272175A priority patent/AR228011A1/es
Priority to ES469821A priority patent/ES469821A1/es
Priority to NLAANVRAGE7805160,A priority patent/NL181804C/xx
Priority to NO781704A priority patent/NO152220C/no
Priority to CH519378A priority patent/CH641452A5/de
Priority to GB19140/78A priority patent/GB1601479A/en
Priority to FI781517A priority patent/FI69485C/fi
Priority to PT68035A priority patent/PT68035B/pt
Priority to DK212778A priority patent/DK154704C/da
Priority to AU36086/78A priority patent/AU514815B2/en
Priority to AT0350878A priority patent/AT368188B/de
Priority to CA000303381A priority patent/CA1142106A/fr
Priority to US05/906,300 priority patent/US4229466A/en
Priority to IT49342/78A priority patent/IT1103138B/it
Priority to IE975/78A priority patent/IE46785B1/en
Priority to DE2821403A priority patent/DE2821403C2/de
Priority to SE7805606A priority patent/SE439322B/sv
Priority to BE187711A priority patent/BE867095A/fr
Priority to MX787121U priority patent/MX6053E/es
Priority to SU782633102A priority patent/SU980620A3/ru
Priority to ES477771A priority patent/ES477771A1/es
Publication of JPS5436255A publication Critical patent/JPS5436255A/ja
Priority to SU802998453A priority patent/SU1056901A3/ru
Publication of JPS589114B2 publication Critical patent/JPS589114B2/ja
Priority to SE8305390A priority patent/SE452008B/sv
Priority to NO834363A priority patent/NO154013C/no
Priority to FI853194A priority patent/FI79845C/fi
Priority to DK058487A priority patent/DK155670C/da
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP52078641A 1977-06-30 1977-06-30 セスキテルペン類縁体、その製造法及び腎炎治療剤 Expired JPS589114B2 (ja)

Priority Applications (30)

Application Number Priority Date Filing Date Title
JP52078641A JPS589114B2 (ja) 1977-06-30 1977-06-30 セスキテルペン類縁体、その製造法及び腎炎治療剤
ZA00782683A ZA782683B (en) 1977-06-30 1978-05-10 Sesquiterpene derivatives
FR7813932A FR2405941A1 (fr) 1977-06-30 1978-05-10 Nouveaux derives sesquiterpeniques utiles notamment comme inhibiteurs du systeme complementaire et leurs procedes de preparation
NZ187243A NZ187243A (en) 1977-06-30 1978-05-11 Sesquiterpenes from culturing a stachybotrys genus or memmoniella simplex strain microorganism
AR272175A AR228011A1 (es) 1977-06-30 1978-05-12 Procedimiento para la preparacion de derivados sustituidos de 2,5,5,8a-tetrametil-1,2,3,4,4a,5,6,7,8,8a-decahidronaftaleno-1-spiro-2'-(4',6',7'-sustituido-2',3'-dihidrobenzofurano)
ES469821A ES469821A1 (es) 1977-06-30 1978-05-12 Un procedimiento para la preparacion de un derivado de ses- quiterpeno
NLAANVRAGE7805160,A NL181804C (nl) 1977-06-30 1978-05-12 Sesquiterpeenderivaten met anticomplementwerking, werkwijze voor het winnen van een stof met anticomplementwerking en farmaceutische preparaten, die ze bevatten.
NO781704A NO152220C (no) 1977-06-30 1978-05-12 Fremgangsmaate for fremstilling av sesquiterpenderivat
CH519378A CH641452A5 (de) 1977-06-30 1978-05-12 Sesquiterpenderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen welche diese enthalten.
GB19140/78A GB1601479A (en) 1977-06-30 1978-05-12 6,7-dihydroxy-2,5,5,8a-tetramethyl-1,2,3,4,4a,5,6,7,8,8a-decahydro naphthalene-1-spiro-2'-(6',7'-diformyl-4'-hydroxy-2',3'-dihydrobenzofuran) and related compounds
FI781517A FI69485C (fi) 1977-06-30 1978-05-12 Foerfarande foer framstaellning av farmakologiskt aktiv 6,7-dihydroxi-2,5,5,8a-tetrametyl-1,2,3,4,4a,5,6,7,8,8a-dekahydronaftalen-1-spiro-2'-(6',7'-diformyl-4'-hydroxi-2',3'-dihydrobensofuran)
PT68035A PT68035B (en) 1977-06-30 1978-05-12 Process for preparing sesquiterpene derivatives
DK212778A DK154704C (da) 1977-06-30 1978-05-12 Fremgangsmaade til fremstilling af et sesquiterpenderivat eller salte deraf
AU36086/78A AU514815B2 (en) 1977-06-30 1978-05-12 Sesquiterpene derivatives
AT0350878A AT368188B (de) 1977-06-30 1978-05-12 Verfahren zur herstellung von sequiterpenderivaten
CA000303381A CA1142106A (fr) 1977-06-30 1978-05-15 Derives de sesquiterpene
US05/906,300 US4229466A (en) 1977-06-30 1978-05-15 Sesquiterpene derivatives having anti-complementary activity
IT49342/78A IT1103138B (it) 1977-06-30 1978-05-15 Derivati di sesquiterpeni e procedimento per prepararli ed applicarli
IE975/78A IE46785B1 (en) 1977-06-30 1978-05-15 6,7-dihydroxy-2,5,5,8a-tetramethyl-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalene-1-spiro-2'-(6',7'-diformyl-4'-hydroxy-2',3'-dihydrobenzofuran) and related compounds
DE2821403A DE2821403C2 (de) 1977-06-30 1978-05-16 Decahydronaphthalin-1-spiro-2'-dihydrobenzofurane, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel
SE7805606A SE439322B (sv) 1977-06-30 1978-05-16 Forfarande for framstellning av seskviterpenderivat genom odling av en mikroorganism tillhorande slektet stachybotrys
BE187711A BE867095A (fr) 1977-06-30 1978-05-16 Nouveaux derives sesquiterpeniques utiles notamment comme inhibiteurs du systeme complementaire et leurs procedes de preparation
MX787121U MX6053E (es) 1977-06-30 1978-06-02 Procedimiento microbiologico para la preparacion de derivados del sesquiterpeno
SU782633102A SU980620A3 (ru) 1977-06-30 1978-06-30 Способ получени сесквитерпенового производного
ES477771A ES477771A1 (es) 1977-06-30 1979-02-15 Un procedimiento para la preparacion de un derivado de ses- quiterpeno.
SU802998453A SU1056901A3 (ru) 1977-06-30 1980-10-28 Способ получени сесквитерпеновых производных или их солей
SE8305390A SE452008B (sv) 1977-06-30 1983-09-30 Forfarande for framstellning av seskviterpenderivat
NO834363A NO154013C (no) 1977-06-30 1983-11-28 Analogifremgangsmaate for fremstilling av terapeutisk aktive sesquiterpenderivater.
FI853194A FI79845C (fi) 1977-06-30 1985-08-20 Foerfarande foer framstaellnig av farmakologiskt aktiva 2,5,5,8a-tetrametyl-1,2,3,4,4a,5,6,7,8,8a- -dekahydronaftalen-1-spiro-2'-(2',3'-dihydrobensofuran)-derivat.
DK058487A DK155670C (da) 1977-06-30 1987-02-04 Analogifremgangsmaade til fremstilling af sesquiterpenderivater eller farmaceutisk acceptable salte deraf

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52078641A JPS589114B2 (ja) 1977-06-30 1977-06-30 セスキテルペン類縁体、その製造法及び腎炎治療剤

Publications (2)

Publication Number Publication Date
JPS5436255A JPS5436255A (en) 1979-03-16
JPS589114B2 true JPS589114B2 (ja) 1983-02-18

Family

ID=13667481

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52078641A Expired JPS589114B2 (ja) 1977-06-30 1977-06-30 セスキテルペン類縁体、その製造法及び腎炎治療剤

Country Status (5)

Country Link
JP (1) JPS589114B2 (fr)
AU (1) AU514815B2 (fr)
BE (1) BE867095A (fr)
SU (2) SU980620A3 (fr)
ZA (1) ZA782683B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6129009U (ja) * 1984-07-27 1986-02-21 トヨタ自動車株式会社 パテイキユレ−ト捕集用フイルタの詰まり防止装置

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366986A (en) * 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5173499A (en) * 1988-04-15 1992-12-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
CZ168896A3 (en) * 1995-06-27 1997-01-15 Egyt Gyogyszervegyeszeti Gyar Oxaindene derivatives and process for preparing thereof
KR100651650B1 (ko) * 2000-10-12 2006-11-30 한국화학연구원 아위로부터 분리된 세스키테르펜 화합물을 포함하는 항암제 조성물

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6129009U (ja) * 1984-07-27 1986-02-21 トヨタ自動車株式会社 パテイキユレ−ト捕集用フイルタの詰まり防止装置

Also Published As

Publication number Publication date
AU3608678A (en) 1979-11-15
SU980620A3 (ru) 1982-12-07
JPS5436255A (en) 1979-03-16
AU514815B2 (en) 1981-02-26
BE867095A (fr) 1978-11-16
ZA782683B (en) 1979-05-30
SU1056901A3 (ru) 1983-11-23

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