JPS6153223A - ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法 - Google Patents

ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法

Info

Publication number
JPS6153223A
JPS6153223A JP59174351A JP17435184A JPS6153223A JP S6153223 A JPS6153223 A JP S6153223A JP 59174351 A JP59174351 A JP 59174351A JP 17435184 A JP17435184 A JP 17435184A JP S6153223 A JPS6153223 A JP S6153223A
Authority
JP
Japan
Prior art keywords
hemoglobin
polyalkylene glycol
acid
molecular weight
bonded compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59174351A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0564128B2 (fr
Inventor
Takaharu Iwasaki
敬治 岩崎
Yuji Iwashita
雄二 岩下
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Fujirebio Inc
Original Assignee
Ajinomoto Co Inc
Fujirebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc, Fujirebio Inc filed Critical Ajinomoto Co Inc
Priority to JP59174351A priority Critical patent/JPS6153223A/ja
Publication of JPS6153223A publication Critical patent/JPS6153223A/ja
Publication of JPH0564128B2 publication Critical patent/JPH0564128B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP59174351A 1984-08-22 1984-08-22 ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法 Granted JPS6153223A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP59174351A JPS6153223A (ja) 1984-08-22 1984-08-22 ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59174351A JPS6153223A (ja) 1984-08-22 1984-08-22 ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法

Publications (2)

Publication Number Publication Date
JPS6153223A true JPS6153223A (ja) 1986-03-17
JPH0564128B2 JPH0564128B2 (fr) 1993-09-14

Family

ID=15977118

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59174351A Granted JPS6153223A (ja) 1984-08-22 1984-08-22 ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法

Country Status (1)

Country Link
JP (1) JPS6153223A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100316154B1 (ko) * 1999-03-26 2001-12-12 노광 폴리에틸렌글리콜－헤모글로빈 결합체

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000230000A (ja) 1999-02-08 2000-08-22 Hokkaido Univ 一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612308A (en) * 1979-07-11 1981-02-06 Ajinomoto Co Inc Blood substitute
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
JPS5989629A (ja) * 1982-11-15 1984-05-23 Ajinomoto Co Inc 代用血液
JPS59104323A (ja) * 1982-12-07 1984-06-16 Ajinomoto Co Inc 代用血液

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612308A (en) * 1979-07-11 1981-02-06 Ajinomoto Co Inc Blood substitute
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
JPS5989629A (ja) * 1982-11-15 1984-05-23 Ajinomoto Co Inc 代用血液
JPS59104323A (ja) * 1982-12-07 1984-06-16 Ajinomoto Co Inc 代用血液

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100316154B1 (ko) * 1999-03-26 2001-12-12 노광 폴리에틸렌글리콜－헤모글로빈 결합체

Also Published As

Publication number Publication date
JPH0564128B2 (fr) 1993-09-14

Similar Documents

Publication Publication Date Title
US4301144A (en) Blood substitute containing modified hemoglobin
US4670417A (en) Hemoglobin combined with a poly(alkylene oxide)
US6962972B2 (en) Derivatization of proteins
US4412989A (en) Oxygen carrier
JPH084504B2 (ja) 安定化ス−パ−オキサイドジスムタ−ゼ
JP6686067B2 (ja) スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法
JPH07506123A (ja) 酸化開環サッカライドによるヘモグロビンの選択的架橋
JPH09504299A (ja) 非抗原性分枝ポリマー複合体
JPH04504872A (ja) ポリペプチドの修飾に使用するための活性ポリアルキレンオキシドカーボネート
JPS60123425A (ja) 高分子化合物とヘモグロビンとのコンジユゲート
RU1776275C (ru) Способ получени водорастворимого коньюгата С @ , Z @ -зависимой пероксид-дисмутазы
JP2000514434A (ja) ヘモグロビン―ヒドロキシエチルスターチ結合体含有酸素運搬剤、その製造方法及びその血液代用剤等としての使用
ES2284670T3 (es) Procedimiento para fabricacion de vehiculos de oxigeno sinteticos a partir de hemoglobinas reticuladas covalentemente con propiedades funcionales mejoradas mediante reticulacion en presencia de efectores que no reaccionan quimicamente de la afinidad por oxigeno de la hemoglobina.
ES2395894T3 (es) Hemoglobinas de mamífero compatibles con plasma sanguíneo, reticuladas y conjugadas con poli(óxidos de alquileno) como portadores de oxígeno médicos artificiales, su preparación y su uso
KR20150132235A (ko) 폴리알킬렌 산화물 발레르산염 헤모글로빈 접합체
KR20150009533A (ko) 다이아스피린 가교결합된 페길화 헤모글로빈
JPS6153223A (ja) ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法
AU742849B2 (en) Therapeutic hemoglobin composition having isotropically increased size
SU1428206A3 (ru) Способ получени производных неокарзиностатина
JP2000230000A (ja) 一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体
JP2531661B2 (ja) 酸素運搬剤
JPS59104323A (ja) 代用血液
JPS62185029A (ja) 修飾インタ−ロイキン−２
JPS63258896A (ja) 修飾インタ−ロイキン−２
ZA200305580B (en) Dextran-hemogloblin conjugates as blood substitute.

Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term