JPS6445363A - Manufacture of mexamine - Google Patents

Manufacture of mexamine

Info

Publication number: JPS6445363A
Authority: JP; Japan
Prior art keywords: serotonine; acetyl; mexamine; manufacture; diacetyl
Prior art date: 1983-07-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP63171971A

Other languages

English (en)

Other versions

JPH0438748B2 (ja

Inventor

Berusore Reimon

Irusuburunaa Pieeru

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Societe des Produits Nestle SA

Nestle SA

Original Assignee

Societe des Produits Nestle SA

Nestle SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-01

Filing date

1988-07-12

Publication date

1989-02-17

1988-07-12 Application filed by Societe des Produits Nestle SA, Nestle SA filed Critical Societe des Produits Nestle SA

1989-02-17 Publication of JPS6445363A publication Critical patent/JPS6445363A/ja

1992-06-25 Publication of JPH0438748B2 publication Critical patent/JPH0438748B2/ja

Status Granted legal-status Critical Current

Links

JTEJPPKMYBDEMY-UHFFFAOYSA-N 5-methoxytryptamine Chemical compound COC1=CC=C2NC=C(CCN)C2=C1 JTEJPPKMYBDEMY-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
MVAWJSIDNICKHF-UHFFFAOYSA-N N-acetylserotonin Chemical compound C1=C(O)C=C2C(CCNC(=O)C)=CNC2=C1 MVAWJSIDNICKHF-UHFFFAOYSA-N 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
229960003987 melatonin Drugs 0.000 abstract 1
230000001035 methylating effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
External Artificial Organs (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

JP63171971A 1983-07-01 1988-07-12 Manufacture of mexamine Granted JPS6445363A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/510,167 US4506080A (en)	1983-07-01	1983-07-01	Preparation of serotonine and derivatives

Publications (2)

Publication Number	Publication Date
JPS6445363A true JPS6445363A (en)	1989-02-17
JPH0438748B2 JPH0438748B2 (ja)	1992-06-25

Family

ID=24029637

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
JP59103799A Granted JPS6025966A (ja)	1983-07-01	1984-05-24	セロトニンの分離方法
JP63171969A Granted JPS6445361A (en)	1983-07-01	1988-07-12	Manufacture of n-acetylserotonin
JP63171970A Granted JPS6445362A (en)	1983-07-01	1988-07-12	Manufacture of melatonin
JP63171971A Granted JPS6445363A (en)	1983-07-01	1988-07-12	Manufacture of mexamine

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
JP59103799A Granted JPS6025966A (ja)	1983-07-01	1984-05-24	セロトニンの分離方法
JP63171969A Granted JPS6445361A (en)	1983-07-01	1988-07-12	Manufacture of n-acetylserotonin
JP63171970A Granted JPS6445362A (en)	1983-07-01	1988-07-12	Manufacture of melatonin

Country Status (10)

Country	Link
US (1)	US4506080A (ja)
EP (3)	EP0197389B1 (ja)
JP (4)	JPS6025966A (ja)
AT (2)	ATE38514T1 (ja)
DE (1)	DE3462794D1 (ja)
ES (4)	ES533890A0 (ja)
GB (3)	GB2142622B (ja)
IL (1)	IL71737A (ja)
OA (1)	OA07734A (ja)
ZM (1)	ZM3384A1 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5877176A (en) *	1991-12-26	1999-03-02	Cornell Research Foundation, Inc.	Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
US6080773A (en)	1997-10-14	2000-06-27	Akzo Nobel, N.V.	Benzylamine derivatives which are useful in treating psychiatric disorders
IL155666A (en)	2003-04-29	2013-12-31	Neurim Pharma 1991	Insomnia treatment
US9119846B2 (en)	2003-04-29	2015-09-01	Neurim Pharmaceuticals (1991) Ltd.	Method and composition for enhancing cognition in alzheimer's patients
CN104496882A (zh) *	2014-11-29	2015-04-08	湖北金赛药业有限公司	一种褪黑素的合成方法
EP3781149A4 (en) *	2018-04-20	2022-03-16	The General Hospital Corporation	ACETYLATED PRODRUGS FOR ADMINISTRATION ACROSS THE BLOOD-BRAIN BARRIER
CN110105261A (zh) *	2018-12-24	2019-08-09	武汉工程大学	一种利用微反应器连续、快速合成及提纯褪黑素的方法
ES1237024Y (es)	2019-09-20	2020-01-30	Normagrup Tech S A	Dispositivo de iluminacion autonomo para la regulacion de ciclos circadianos
CN113402437B (zh) *	2021-06-29	2023-07-14	河北维达康生物科技有限公司	一种合成膳食补充剂褪黑素的新方法
CN113788780B (zh) *	2021-10-15	2023-06-16	河北维达康生物科技有限公司	一种n-乙酰基-5-甲氧基色胺的合成方法
CN119406261B (zh) *	2024-11-15	2025-11-04	万华化学集团股份有限公司	一种高分离选择性纳滤膜及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2156944C3 (de) *	1971-11-16	1974-10-17	Hag Ag, 2800 Bremen	Verfahren zur Gewinnung von Serotonin aus Kaffeewachs
CH568719A5 (en) *	1973-08-22	1975-11-14	Haco Ag	Extracting carboxylic acid 5-hydroxy-tryptamide irritants - from coffee without caffeine extn. by using caffeine - enriched solvents
DE2435365A1 (de) *	1973-12-31	1976-01-29	Luigi Di Bella	Pharmazeutisches mittel fuer die behandlung von allen leukaemieformen und neurotischen syndromen
CH601227A5 (ja) *	1975-05-30	1978-06-30	Nestle Sa
CH608790A5 (en) *	1976-11-18	1979-01-31	Nestle Sa	Process for separating serotonin from coffee waxes

1983
- 1983-07-01 US US06/510,167 patent/US4506080A/en not_active Expired - Lifetime
1984
- 1984-04-26 EP EP86103841A patent/EP0197389B1/en not_active Expired
- 1984-04-26 DE DE8484104696T patent/DE3462794D1/de not_active Expired
- 1984-04-26 EP EP86103842A patent/EP0197390B1/en not_active Expired
- 1984-04-26 AT AT86103842T patent/ATE38514T1/de not_active IP Right Cessation
- 1984-04-26 AT AT86103841T patent/ATE38513T1/de not_active IP Right Cessation
- 1984-04-26 EP EP84104696A patent/EP0130303B1/en not_active Expired
- 1984-05-02 GB GB08411197A patent/GB2142622B/en not_active Expired
- 1984-05-03 IL IL71737A patent/IL71737A/xx unknown
- 1984-05-23 ZM ZM33/84A patent/ZM3384A1/xx unknown
- 1984-05-24 JP JP59103799A patent/JPS6025966A/ja active Granted
- 1984-06-29 OA OA58329A patent/OA07734A/xx unknown
- 1984-06-30 ES ES533890A patent/ES533890A0/es active Granted
1985
- 1985-07-16 ES ES545231A patent/ES8604142A1/es not_active Expired
- 1985-07-16 ES ES545232A patent/ES8603411A1/es not_active Expired
- 1985-07-16 ES ES545230A patent/ES545230A0/es active Granted
- 1985-08-29 GB GB08521544A patent/GB2165838B/en not_active Expired
- 1985-08-29 GB GB08521543A patent/GB2165837B/en not_active Expired
1988
- 1988-07-12 JP JP63171969A patent/JPS6445361A/ja active Granted
- 1988-07-12 JP JP63171970A patent/JPS6445362A/ja active Granted
- 1988-07-12 JP JP63171971A patent/JPS6445363A/ja active Granted

Also Published As

Publication number	Publication date
JPS6025966A (ja)	1985-02-08
EP0197389A3 (en)	1986-12-03
EP0197390A3 (en)	1986-12-03
DE3462794D1 (en)	1987-04-30
ES8603410A1 (es)	1986-01-01
EP0130303A1 (en)	1985-01-09
GB8521543D0 (en)	1985-10-02
GB2142622A (en)	1985-01-23
IL71737A0 (en)	1984-09-30
EP0197389A2 (en)	1986-12-03
US4506080A (en)	1985-03-19
JPH0466866B2 (ja)	1992-10-26
EP0197390A2 (en)	1986-12-03
ES545232A0 (es)	1986-01-01
EP0130303B1 (en)	1987-03-25
ZM3384A1 (en)	1984-12-21
ES545231A0 (es)	1986-01-16
ES545230A0 (es)	1986-01-01
OA07734A (fr)	1985-08-30
IL71737A (en)	1987-07-31
GB8521544D0 (en)	1985-10-02
EP0197390B1 (en)	1988-11-09
JPS6410511B2 (ja)	1989-02-22
ES8603411A1 (es)	1986-01-01
GB2142622B (en)	1987-04-01
GB2165838A (en)	1986-04-23
ES8602653A1 (es)	1985-12-16
ES8604142A1 (es)	1986-01-16
EP0197389B1 (en)	1988-11-09
GB8411197D0 (en)	1984-06-06
ATE38514T1 (de)	1988-11-15
ATE38513T1 (de)	1988-11-15
GB2165838B (en)	1987-04-01
JPH0438748B2 (ja)	1992-06-25
GB2165837B (en)	1987-04-01
GB2165837A (en)	1986-04-23
JPH0438747B2 (ja)	1992-06-25
ES533890A0 (es)	1985-12-16
JPS6445361A (en)	1989-02-17
JPS6445362A (en)	1989-02-17

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