KR920700620A - 서방성 경구 제형 - Google Patents

서방성 경구 제형

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Publication number
KR920700620A
KR920700620A KR1019910701307A KR910701307A KR920700620A KR 920700620 A KR920700620 A KR 920700620A KR 1019910701307 A KR1019910701307 A KR 1019910701307A KR 910701307 A KR910701307 A KR 910701307A KR 920700620 A KR920700620 A KR 920700620A
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KR
South Korea
Prior art keywords
formulation
crosslinked
particles
drug
stomach
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Application number
KR1019910701307A
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English (en)
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KR0167078B1 (ko
Inventor
더블유. 쉘 존
Original Assignee
원본미기재
디폼드 시스템즈 인코오퍼레이티드
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Publication of KR920700620A publication Critical patent/KR920700620A/ko
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Publication of KR0167078B1 publication Critical patent/KR0167078B1/ko
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Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

서방성 경구 제형
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 약제 용액을 위속으로 방출하기 위한 서방성 경구제형에 있어서, (i) 지속적인 기간에 걸친 위에서의 보유를 촉진하는 수준까지 입경을 증가시키기 위해, 위액의 흡수를 통해 팽윤하고, (ii) 약제가 입자내에 있으면서 흡수된 위액에 의해 분산된 약제가 용해 되도록하고 입자로부터 삼출작용에 의해 결과 용액이 방출되도록하여 용액중의 약제만이 위점막과 접촉하도록하며, (iii) 약제가 위속으로 방출되고 그런다음 신속히 용해되는 투약시간의 적어도 상당한 부분동안 물리적인 일체성을 유지하는 친수성, 수팽윤성 중합체내에 분산된 고체상 약재의 복수개의 고체입자들로 이루어지고, 상기한 제형은 섭취되기에 앞서 입자들을 둘러싸인 덩어리내에 유지하고 그런다음 위액으로 신속하게 분해되어 섭취후 입자가 위에서 신속하게 분산되도록 하는 정제 또는 캡슐제 형태인 것을 특징으로하는 서방성 경구제형.
  2. 제1항에 있어서, 지속시간은 2내지 6시간인 것을 특징으로 하는 제형.
  3. 제1항에 있어서, 상당한 부분은 투약시간의 적어도 90%인 것을 특징으로 하는 제형.
  4. 제3항에 있어서, 중합체는 투약 시간의 상당한 부분의 종료후 4내지 8시간 내에 용해되는 것을 특징으로 하는 제형.
  5. 제1항에 있어서, 입자의 행윤된 크기는 약 1내지 3㎜인 것을 특징으로 하는 제형.
  6. 제5항에 있어서, 팽윤되지 않는 크기는 약 50미크론 내지 2㎜인 것을 특징으로 하는 제형.
  7. 제1항에 있어서, 약제의 물에 대한 용해도는 37℃에서, 0.001%내지 35%인 것을 특징으로 하는 제형.
  8. 제1항에 있어서, 약제는 탄산칼슘, 인도메타신, 이부프로펜, 나프록센, 피록시캄, 프레드니손 프레드니솔론, 덱사메타손, 아스피린,. 시메티딘, 니페디핀. 또는 염화 칼륨인 것을 특징으로 하는 제형.
  9. 제1항에 있어서, 중합체는 가교결합된 폴리비닐 알코올 또는 가교결합된 알부민, 가교결합된 카르복시메틸셀룰로오스, 가교결합된 알기네이트, 가교결합된 폴리비닐 알코올 또는 가교결합된 치틴인 것을 특징으로 하는 제형.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910701307A 1989-04-11 1990-04-10 서방성 경구 제형 Expired - Lifetime KR0167078B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US336,440 1989-04-11
US336440 1989-04-11
US07/336,440 US5007790A (en) 1989-04-11 1989-04-11 Sustained-release oral drug dosage form
PCT/US1990/001933 WO1990011757A1 (en) 1989-04-11 1990-04-10 Sustained-release oral drug dosage form

Publications (2)

Publication Number Publication Date
KR920700620A true KR920700620A (ko) 1992-08-10
KR0167078B1 KR0167078B1 (ko) 1999-01-15

Family

ID=23316106

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910701307A Expired - Lifetime KR0167078B1 (ko) 1989-04-11 1990-04-10 서방성 경구 제형

Country Status (10)

Country Link
US (1) US5007790A (ko)
EP (1) EP0467975B1 (ko)
JP (1) JP2878837B2 (ko)
KR (1) KR0167078B1 (ko)
AT (1) ATE106717T1 (ko)
AU (1) AU638012B2 (ko)
CA (1) CA2014451C (ko)
DE (1) DE69009755T2 (ko)
FI (1) FI914765A0 (ko)
WO (1) WO1990011757A1 (ko)

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EP0467975A1 (en) 1992-01-29
FI914765A7 (fi) 1991-10-09
JPH04507088A (ja) 1992-12-10
WO1990011757A1 (en) 1990-10-18
KR0167078B1 (ko) 1999-01-15
EP0467975B1 (en) 1994-06-08
US5007790A (en) 1991-04-16
JP2878837B2 (ja) 1999-04-05
AU5523490A (en) 1990-11-05
ATE106717T1 (de) 1994-06-15
CA2014451A1 (en) 1990-10-11
DE69009755D1 (de) 1994-07-14
DE69009755T2 (de) 1994-10-20
AU638012B2 (en) 1993-06-17
CA2014451C (en) 1996-08-06
FI914765A0 (fi) 1991-10-09
EP0467975A4 (en) 1992-03-11

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