KR930700106A - 혈전증 치료제 및 포스포 디에스테라제 저해제 - Google Patents

혈전증 치료제 및 포스포 디에스테라제 저해제

Info

Publication number
KR930700106A
KR930700106A KR1019920703088A KR920703088A KR930700106A KR 930700106 A KR930700106 A KR 930700106A KR 1019920703088 A KR1019920703088 A KR 1019920703088A KR 920703088 A KR920703088 A KR 920703088A KR 930700106 A KR930700106 A KR 930700106A
Authority
KR
South Korea
Prior art keywords
carbostyryl
amino
derivative
hydroxy propoxy
carbostyryl derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019920703088A
Other languages
English (en)
Korean (ko)
Inventor
다까후미 후지오까
슈지 데라모또
미찌아끼 도미나가
요이지 야부우찌
Original Assignee
오스카 아끼히꼬
오스카 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오스카 아끼히꼬, 오스카 세이야꾸 가부시끼가이샤 filed Critical 오스카 아끼히꼬
Publication of KR930700106A publication Critical patent/KR930700106A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
KR1019920703088A 1991-04-03 1992-03-26 혈전증 치료제 및 포스포 디에스테라제 저해제 Ceased KR930700106A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP7022391 1991-04-03
JP91-70223 1991-04-03
JP2113792 1992-02-06
JP92-21137 1992-02-06
PCT/JP1992/000368 WO1992017178A1 (fr) 1991-04-03 1992-03-26 Remede contre la thrombose et inhibiteur de phosphodiesterase

Publications (1)

Publication Number Publication Date
KR930700106A true KR930700106A (ko) 1993-03-13

Family

ID=26358162

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920703088A Ceased KR930700106A (ko) 1991-04-03 1992-03-26 혈전증 치료제 및 포스포 디에스테라제 저해제

Country Status (8)

Country Link
US (2) US5401754A (2)
EP (2) EP0531548B1 (2)
JP (1) JPH05279256A (2)
KR (1) KR930700106A (2)
DE (2) DE69233356D1 (2)
DK (1) DK0531548T3 (2)
TW (1) TW201305B (2)
WO (1) WO1992017178A1 (2)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464833A (en) * 1992-08-19 1995-11-07 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulating composition
EP0660715B1 (en) * 1992-09-18 1997-12-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as antiarrhythmic agents
WO1996021447A1 (en) * 1995-01-09 1996-07-18 Otsuka Pharmaceutical Company, Limited Use of carbostyril compounds for inhibition of tnf-alpha
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
US5958982A (en) * 1998-04-17 1999-09-28 Cell Pathways, Inc. Method for treating patients with sarcoidosis by administering substituted sulfonyl indenyl acetic acids, esters and alcohols
US5902827A (en) * 1998-04-17 1999-05-11 Cell Pathways Method for treating patients with psoriasis by administering substituted sulfonyl indenyl acetic acids, esters and alcohols
US6025394A (en) * 1999-01-29 2000-02-15 Cell Pathways, Inc. Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
JP4712378B2 (ja) * 2002-06-05 2011-06-29 俊夫 小室 抗血栓性を有する白金含有セラミックス組成物及びそれを含む物品
CA2511496A1 (en) * 2002-12-23 2004-07-15 Artesian Therapeutics, Inc. Cardiotonic compounds with inhibitory activity against .beta.-adrenergic receptors and phosphodiesterase
US20060089374A1 (en) * 2003-07-17 2006-04-27 Glenn Cornett Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
CA2532807A1 (en) * 2003-07-17 2005-02-03 Cotherix, Inc. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
WO2005018563A2 (en) * 2003-08-22 2005-03-03 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury
CA2537180A1 (en) * 2003-08-29 2005-03-10 Cotherix, Inc. Cicletanine in combination with oral antidiabetic and/or blood lipid-lowering agents as a combination therapy for diabetes and metabolic syndrome
US20060154959A1 (en) * 2005-01-13 2006-07-13 Navitas Pharma Combination therapies of cicletanine and carvedilol
US20070141174A1 (en) * 2005-01-13 2007-06-21 Navitas Pharma, Inc. Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension
US20080096915A1 (en) * 2005-01-13 2008-04-24 Greenberg Traurig LLP Compositions for the treatment of metabolic disorders
US20070105817A1 (en) * 2005-11-09 2007-05-10 Jim Page Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension
JP2010514841A (ja) * 2007-01-03 2010-05-06 グレン ブイ． コルネット， 肺疾患および心疾患の処置におけるシクレタニンおよびｐｋｃ阻害剤

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4951271A (2) * 1972-09-28 1974-05-18
JPS5082218A (2) * 1973-11-10 1975-07-03
JPS5310989B2 (2) * 1974-04-25 1978-04-18
JPS5936617B2 (ja) * 1976-03-05 1984-09-05 大塚製薬株式会社 カルボスチリル誘導体
JPS6059912B2 (ja) * 1978-02-28 1985-12-27 大塚製薬株式会社 カルボスチリル誘導体
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation
JPS5430184A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
JPS5535019A (en) * 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
GB2043890B (en) * 1979-01-30 1983-09-07 Otsuka Pharma Co Ltd Determination of tumour associated glycolinkage and diagnosis of cancer
JPS55129268A (en) * 1979-03-28 1980-10-06 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5646812A (en) * 1979-09-27 1981-04-28 Otsuka Pharmaceut Co Ltd Central nervous system depressant
JPS568319A (en) * 1980-03-26 1981-01-28 Otsuka Pharmaceut Co Ltd Antihistamine
JPS572274A (en) * 1980-06-06 1982-01-07 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5714574A (en) * 1980-06-27 1982-01-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5780322A (en) * 1980-11-05 1982-05-19 Otsuka Pharmaceut Co Ltd Cardiotonic agent
JPS5793962A (en) * 1980-12-01 1982-06-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
ES2070151T3 (es) * 1988-08-10 1995-06-01 Otsuka Pharma Co Ltd Agentes cardiotonicos.

Also Published As

Publication number Publication date
EP0647447A1 (en) 1995-04-12
EP0647447B1 (en) 2004-05-26
US5532253A (en) 1996-07-02
DE69205106T2 (de) 1996-02-29
JPH05279256A (ja) 1993-10-26
DK0531548T3 (da) 1995-11-27
EP0531548A4 (en) 1993-12-08
WO1992017178A1 (fr) 1992-10-15
DE69233356D1 (de) 2004-07-01
EP0531548A1 (en) 1993-03-17
EP0531548B1 (en) 1995-09-27
DE69205106D1 (de) 1995-11-02
TW201305B (2) 1993-03-01
US5401754A (en) 1995-03-28

Similar Documents

Publication Publication Date Title
MA18694A1 (fr) Nouveaux derives de piperidinyl alkyl-quinazoline
MY111683A (en) Indole derivatives.
BG100154A (en) Carbazole derivatibes having inhibiting effect to 17,20-lyase
EP0531548A4 (en) Remedy for thrombosis and phosphodiesterase inhibitor
KR960007565A (ko) 약제로서의 치환된 4-페닐-6-아미노-니코틴산 유도체의 용도
MY115278A (en) Acylaminoindole derivatives
KR950703554A (ko) 피페라진 유도체 및 그의 염(piperazine derivatives and salts thereof)
KR960022486A (ko) 신규 티아졸리딘-4-온 유도체
ATE59632T1 (de) Dihydrodibenzocycloheptylidenethylamin-derivate
KR890012989A (ko) 아크릴산 모르폴리드, 그의 제조방법 및 용도
KR920004340A (ko) 술폰아미드 유도체
GB1169945A (en) Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives
KR900003122A (ko) 카테콜 유도체
YU91483A (en) Process for obtaining new thiomethylpyridine derivatives
YU140391A (sh) 6-supstituisani-heksahidrobenz (cd)-indoli
KR930021629A (ko) 피페라진 유도체
DK440183D0 (da) Ethanderivater med fungicid virkning
ES8704478A1 (es) Procedimiento para la obtencion de derivados de piridina
ES2043820T3 (es) Nuevas 1-1 alkil-1-sulfonil-2-alkoxicarbonilsulfenilhidrazinas que tienen actividad antineoplastica.
KR950704252A (ko) N-치환 이미다졸 유도체
EP0294937A3 (en) Novel cinnamoylamide derivatives
ES8602712A1 (es) Un procedimiento para preparar un derivado de rodanina
DK293885D0 (da) Aroylsubstituerede dihydro-1,4-thiaziner og salte deraf samt deres fremstilling og anvendelse
EP0116255A3 (en) Treatment of migraine with n-alkyl-piperidinyl benzoate derivatives
JPS52118474A (en) Alpha-substituted aminoalkanyol-3,4-dihydrocarbostyril derivatives and method of preparing the same

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19921203

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19960212

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19921203

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19980821

Patent event code: PE09021S01D

A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 19990121

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19990330

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19980821

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I