LT3455B - Intravaginal delivery system of active agent - Google Patents

Intravaginal delivery system of active agent Download PDF

Info

Publication number: LT3455B
Authority: LT; Lithuania
Prior art keywords: active agent; sleeve; delivery system; intravaginal; agent delivery
Prior art date: 1993-06-17

Application number

LTIP1957A

Other languages

English (en)

Lithuanian (lt)

Inventor

Matti Lehtinen

Christine Talling

Original Assignee

Leiras Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-17

Filing date

1994-06-16

Publication date

1995-10-25

1994-06-16 Application filed by Leiras Oy filed Critical Leiras Oy

1995-01-31 Publication of LTIP1957A publication Critical patent/LTIP1957A/xx

1995-10-25 Publication of LT3455B publication Critical patent/LT3455B/lt

Links

239000013543 active substance Substances 0.000 title claims abstract description 65
229920000642 polymer Polymers 0.000 claims abstract description 10
239000012528 membrane Substances 0.000 claims description 18
239000000463 material Substances 0.000 claims description 17
-1 polysiloxane Polymers 0.000 claims description 15
239000004205 dimethyl polysiloxane Substances 0.000 claims description 11
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 11
BFMKFCLXZSUVPI-UHFFFAOYSA-N ethyl but-3-enoate Chemical compound CCOC(=O)CC=C BFMKFCLXZSUVPI-UHFFFAOYSA-N 0.000 claims description 6
229920001577 copolymer Polymers 0.000 claims description 4
229920001971 elastomer Polymers 0.000 claims description 4
229920001296 polysiloxane Polymers 0.000 claims description 4
229920002635 polyurethane Polymers 0.000 claims description 4
239000004814 polyurethane Substances 0.000 claims description 4
238000009792 diffusion process Methods 0.000 claims description 3
230000000757 progestagenic effect Effects 0.000 claims description 3
244000043261 Hevea brasiliensis Species 0.000 claims description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 2
229920005549 butyl rubber Polymers 0.000 claims description 2
239000003795 chemical substances by application Substances 0.000 claims description 2
239000000806 elastomer Substances 0.000 claims description 2
239000000262 estrogen Substances 0.000 claims description 2
230000009245 menopause Effects 0.000 claims description 2
229920003052 natural elastomer Polymers 0.000 claims description 2
229920001194 natural rubber Polymers 0.000 claims description 2
229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 claims description 2
229920002725 thermoplastic elastomer Polymers 0.000 claims description 2
229920002397 thermoplastic olefin Polymers 0.000 claims description 2
229920005992 thermoplastic resin Polymers 0.000 claims description 2
238000000034 method Methods 0.000 claims 2
239000011149 active material Substances 0.000 claims 1
238000007664 blowing Methods 0.000 claims 1
238000001794 hormone therapy Methods 0.000 claims 1
239000003814 drug Substances 0.000 description 22
229940079593 drug Drugs 0.000 description 21
230000008878 coupling Effects 0.000 description 14
238000010168 coupling process Methods 0.000 description 14
238000005859 coupling reaction Methods 0.000 description 14
239000011159 matrix material Substances 0.000 description 11
239000010410 layer Substances 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
230000001419 dependent effect Effects 0.000 description 3
239000000835 fiber Substances 0.000 description 3
239000011521 glass Substances 0.000 description 3
229940088597 hormone Drugs 0.000 description 3
239000005556 hormone Substances 0.000 description 3
239000000203 mixture Substances 0.000 description 3
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
230000006835 compression Effects 0.000 description 2
238000007906 compression Methods 0.000 description 2
238000005520 cutting process Methods 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
210000001215 vagina Anatomy 0.000 description 2
WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 1
208000017657 Menopausal disease Diseases 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
238000011284 combination treatment Methods 0.000 description 1
238000010276 construction Methods 0.000 description 1
239000003433 contraceptive agent Substances 0.000 description 1
230000002254 contraceptive effect Effects 0.000 description 1
238000013270 controlled release Methods 0.000 description 1
229940124447 delivery agent Drugs 0.000 description 1
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
230000000694 effects Effects 0.000 description 1
229960005309 estradiol Drugs 0.000 description 1
230000001076 estrogenic effect Effects 0.000 description 1
230000029142 excretion Effects 0.000 description 1
238000004880 explosion Methods 0.000 description 1
239000012634 fragment Substances 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
229960004400 levonorgestrel Drugs 0.000 description 1
239000002184 metal Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229920006254 polymer film Polymers 0.000 description 1
239000010970 precious metal Substances 0.000 description 1
238000003825 pressing Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
239000011241 protective layer Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000035807 sensation Effects 0.000 description 1
229920002050 silicone resin Polymers 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000003892 spreading Methods 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000003612 virological effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Reproductive Health (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Infusion, Injection, And Reservoir Apparatuses (AREA)
Medicinal Preparation (AREA)
Paper (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)
Media Introduction/Drainage Providing Device (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Absorbent Articles And Supports Therefor (AREA)
External Artificial Organs (AREA)
Prostheses (AREA)
Details Of Garments (AREA)
Particle Formation And Scattering Control In Inkjet Printers (AREA)

LTIP1957A 1993-06-17 1994-06-16 Intravaginal delivery system of active agent LT3455B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI932789A FI95768C (fi)	1993-06-17	1993-06-17	Emättimensisäinen antosysteemi

Publications (2)

Publication Number	Publication Date
LTIP1957A LTIP1957A (en)	1995-01-31
LT3455B true LT3455B (en)	1995-10-25

Family

ID=8538154

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTIP1957A LT3455B (en)	1993-06-17	1994-06-16	Intravaginal delivery system of active agent

Country Status (24)

Country	Link
US (1)	US5694947A (et)
EP (1)	EP0703802B1 (et)
JP (1)	JP3803714B2 (et)
KR (1)	KR100312764B1 (et)
CN (1)	CN1126574C (et)
AT (1)	ATE177657T1 (et)
AU (1)	AU674758B2 (et)
BR (1)	BR9407118A (et)
CZ (1)	CZ284989B6 (et)
DE (1)	DE69417232T2 (et)
DK (1)	DK0703802T3 (et)
EE (1)	EE03202B1 (et)
ES (1)	ES2130423T3 (et)
FI (1)	FI95768C (et)
GR (1)	GR3030565T3 (et)
HU (1)	HU217950B (et)
LT (1)	LT3455B (et)
LV (1)	LV12452B (et)
MY (1)	MY113965A (et)
NO (1)	NO311498B1 (et)
PL (1)	PL176664B1 (et)
RU (1)	RU2121824C1 (et)
TW (1)	TW286273B (et)
WO (1)	WO1995000199A1 (et)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI95768C (fi) *	1993-06-17	1996-03-25	Leiras Oy	Emättimensisäinen antosysteemi
GB9522403D0 (en) *	1995-11-01	1996-01-03	Hoechst Roussel Ltd	Intravaginal drug delivery device
US5972372A (en) *	1996-07-31	1999-10-26	The Population Council, Inc.	Intravaginal rings with insertable drug-containing core
JP2002513690A (ja) *	1998-05-01	2002-05-14	エフイ−アイエンタープライジズ，リミティド	制御放出デバイスの射出成形製造方法
US6476079B1 (en) *	1999-12-23	2002-11-05	Leiras Oy	Devices for the delivery of drugs having antiprogestinic properties
GB0009914D0 (en)	2000-04-20	2000-06-07	Metris Therapeutics Limited	Device
CN1289064C (zh) *	2001-08-31	2006-12-13	先灵有限责任公司	药物输送体系
CA2531640C (en) *	2003-07-10	2013-06-18	Galen (Chemicals) Limited	Intravaginal drug delivery devices
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
ATE495752T1 (de)	2005-07-19	2011-02-15	Population Council Inc	Verfahren und zusammensetzungen zur notfallbedingten verhütung mithilfe von endothelin-rezeptor-antagonisten
CA2646593C (en) *	2006-03-20	2015-12-08	Duramed Pharmaceuticals, Inc.	Flexible, compressed intravaginal rings, methods of making and using the same, and apparatus for making the same
US20100136090A1 (en) *	2006-11-20	2010-06-03	N.V. Organon; Intervet International B.V.	Helically-Shaped Drug Delivery System
TW200927141A (en) *	2007-11-22	2009-07-01	Bayer Schering Pharma Oy	Vaginal delivery system
EP2062568A1 (en) *	2007-11-22	2009-05-27	Bayer Schering Pharma Oy	Vaginal delivery system
EP2244782A4 (en) *	2008-01-25	2011-09-14	Univ Utah Res Found	POLYMER WITH LINEAR ORDER RELEASE
WO2009099586A2 (en)	2008-02-04	2009-08-13	Duramed Pharmaceuticals, Inc.	Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof
FI20095550A0 (fi) *	2009-05-19	2009-05-19	Bayer Schering Pharma Oy	Vaginaalinen antojärjestelmä
FI20095563A7 (fi) *	2009-05-20	2010-11-21	Bayer Schering Pharma Oy	Vaginaalinen antojärjestelmä
AU2010256558B2 (en)	2009-06-03	2013-10-03	Forsight Labs, Llc	Anterior segment drug delivery
DE102010003494A1 (de) *	2010-03-31	2011-10-06	Bayer Schering Pharma Aktiengesellschaft	Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
US8580294B2 (en)	2010-10-19	2013-11-12	International Partnership For Microbicides	Platinum-catalyzed intravaginal rings
EP2749286B1 (en)	2011-08-26	2017-03-01	Universidad De Santiago De Chile	Use of non-steroidal anti-inflammatory drugs meloxicam and piroxicam, administered intravaginally, for interruption of a woman's ovulation process
GB201115592D0 (en) *	2011-09-09	2011-10-26	Vivosens Medical Gmbh	Flexible ring pessary
RU2740680C2 (ru)	2011-09-14	2021-01-19	Форсайт Вижн5, Инк.	Глазное вкладочное устройство и способы
CN103007427B (zh) *	2011-09-21	2016-01-20	上海市计划生育科学研究所	缓控释宫内释药器及其制备方法
RS62297B1 (sr)	2011-11-23	2021-09-30	Therapeuticsmd Inc	Prirodne kombinovane hormonske supstitucione formulacije i terapije
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
EP2641602A1 (en)	2012-03-23	2013-09-25	PregLem S.A.	Method for treating gynecological diseases
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
PT2893804T (pt)	2012-09-03	2018-06-26	Ecosea Farming S A	Sistema de imersão de um reservatório-jaula destinado à cultura e/ou contenção de espécies hidrobiológicas
EP2911623B1 (en)	2012-10-26	2019-08-14	Forsight Vision5, Inc.	Ophthalmic system for sustained release of drug to eye
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
MY181448A (en)	2013-04-10	2020-12-22	Preglem Sa	Progesteron receptor modulators for use in the therapy of uterine fibroids
US10137031B2 (en)	2013-11-14	2018-11-27	International Partnership For Microbicides, Inc.	Combination therapy intravaginal rings
JP6667450B2 (ja) *	2014-04-01	2020-03-18	ポリ−メッドインコーポレイテッド	避妊具及び関連した器具
RU2016143081A (ru)	2014-05-22	2018-06-26	Терапьютиксмд, Инк.	Натуральные комбинированные гормонозаместительные составы и терапии
KR20230142816A (ko)	2014-06-26	2023-10-11	타리스 바이오메디컬 엘엘씨	탄성 폴리머-약물 매트릭스 시스템을 포함하는 방광내 약물 전달 장치 및 방법
US20160296532A1 (en)	2015-04-13	2016-10-13	Forsight Vision5, Inc.	Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
US10328087B2 (en)	2015-07-23	2019-06-25	Therapeuticsmd, Inc.	Formulations for solubilizing hormones
US10286077B2 (en)	2016-04-01	2019-05-14	Therapeuticsmd, Inc.	Steroid hormone compositions in medium chain oils
US9931349B2 (en)	2016-04-01	2018-04-03	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical composition
CN110403565B (zh) *	2018-04-27	2022-02-11	西安交通大学医学院第一附属医院	一种胶囊内窥镜磁与麦芒仿生双驱动装置
CN109771124A (zh) *	2019-01-31	2019-05-21	山东省药学科学院	一种具有形状记忆功能的子宫托
US11633405B2 (en)	2020-02-07	2023-04-25	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical formulations

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3545439A (en)	1968-01-04	1970-12-08	Upjohn Co	Medicated devices and methods
US3920805A (en)	1971-12-09	1975-11-18	Upjohn Co	Pharmaceutical devices and method
US4012496A (en)	1974-10-18	1977-03-15	Schering Aktiengesellschaft	Vaginal ring
US4292965A (en)	1978-12-29	1981-10-06	The Population Council, Inc.	Intravaginal ring
US4596576A (en)	1984-10-12	1986-06-24	Akzo N.V.	Release system for two or more active substances

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1264731A (en) *	1917-03-19	1918-04-30	Carl Willers	Pneumatic die-cushion.
US3967618A (en) *	1969-04-01	1976-07-06	Alza Corporation	Drug delivery device
US3911911A (en) *	1969-06-16	1975-10-14	Reese Hospital Michael	Anti-fertility device
GB1465684A (en) *	1973-07-27	1977-02-23	Emmett L	Contraceptive device
DE2616064A1 (de) *	1976-04-09	1977-10-20	Schering Ag	Vaginalring iii
US3995634A (en) *	1975-12-02	1976-12-07	The Procter & Gamble Company	Vaginal cavity dispensing means and method
US4215691A (en) *	1978-10-11	1980-08-05	Alza Corporation	Vaginal contraceptive system made from block copolymer
DE3040978A1 (de) *	1980-10-28	1982-05-27	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Vaginalring
DE3175137D1 (en) *	1981-12-30	1986-09-18	Population Council Inc	Method of making intrauterine devices
JPS5919151U (ja) *	1982-07-28	1984-02-06	ニツポ−株式会社	痔疾治療器
GB8403138D0 (en) *	1984-02-07	1984-03-14	Graham N B	Sustained release of active ingredient
ZA857643B (en) *	1984-10-12	1986-05-28	Akzo Nv	Release system for two or more active substances
SE8602666D0 (sv) *	1986-06-16	1986-06-16	Leo Ab	Intravaginal devices
US4822161A (en) *	1988-01-19	1989-04-18	Jimmy Michael F	Illuminating spectacle apparatus
JPH02185264A (ja) *	1988-12-16	1990-07-19	Ferring Bv	膀胱内又は尿管へ薬を送り込む方法及び装置
KR100236355B1 (ko) *	1990-03-16	2000-01-15	이데이 노부유끼	와이프 패턴의 발생장치
JP3186105B2 (ja) *	1991-07-26	2001-07-11	日本電気株式会社	半導体装置のテストモード設定・解除回路
FI95768C (fi) *	1993-06-17	1996-03-25	Leiras Oy	Emättimensisäinen antosysteemi

1993
- 1993-06-17 FI FI932789A patent/FI95768C/fi active
1994
- 1994-06-15 HU HU9503290A patent/HU217950B/hu not_active IP Right Cessation
- 1994-06-15 CZ CZ953208A patent/CZ284989B6/cs not_active IP Right Cessation
- 1994-06-15 RU RU96101160A patent/RU2121824C1/ru not_active IP Right Cessation
- 1994-06-15 AT AT94917022T patent/ATE177657T1/de not_active IP Right Cessation
- 1994-06-15 US US08/564,253 patent/US5694947A/en not_active Expired - Lifetime
- 1994-06-15 AU AU68481/94A patent/AU674758B2/en not_active Ceased
- 1994-06-15 JP JP52252194A patent/JP3803714B2/ja not_active Expired - Fee Related
- 1994-06-15 CN CN94192420A patent/CN1126574C/zh not_active Expired - Fee Related
- 1994-06-15 DE DE69417232T patent/DE69417232T2/de not_active Expired - Lifetime
- 1994-06-15 BR BR9407118A patent/BR9407118A/pt not_active IP Right Cessation
- 1994-06-15 ES ES94917022T patent/ES2130423T3/es not_active Expired - Lifetime
- 1994-06-15 MY MYPI94001519A patent/MY113965A/en unknown
- 1994-06-15 DK DK94917022T patent/DK0703802T3/da active
- 1994-06-15 EP EP94917022A patent/EP0703802B1/en not_active Expired - Lifetime
- 1994-06-15 PL PL94312193A patent/PL176664B1/pl not_active IP Right Cessation
- 1994-06-15 WO PCT/FI1994/000255 patent/WO1995000199A1/en not_active Ceased
- 1994-06-15 KR KR1019950705668A patent/KR100312764B1/ko not_active Expired - Fee Related
- 1994-06-15 TW TW083105534A patent/TW286273B/zh not_active IP Right Cessation
- 1994-06-16 LT LTIP1957A patent/LT3455B/lt not_active IP Right Cessation
- 1994-07-18 EE EE9400027A patent/EE03202B1/et not_active IP Right Cessation
1995
- 1995-12-12 NO NO19955029A patent/NO311498B1/no not_active IP Right Cessation
1999
- 1999-06-17 GR GR990401648T patent/GR3030565T3/el unknown
- 1999-12-01 LV LVP-99-169A patent/LV12452B/en unknown

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3545439A (en)	1968-01-04	1970-12-08	Upjohn Co	Medicated devices and methods
US3920805A (en)	1971-12-09	1975-11-18	Upjohn Co	Pharmaceutical devices and method
US4012496A (en)	1974-10-18	1977-03-15	Schering Aktiengesellschaft	Vaginal ring
US4292965A (en)	1978-12-29	1981-10-06	The Population Council, Inc.	Intravaginal ring
US4596576A (en)	1984-10-12	1986-06-24	Akzo N.V.	Release system for two or more active substances

Also Published As

Publication number	Publication date
MY113965A (en)	2002-07-31
NO311498B1 (no)	2001-12-03
JPH08511240A (ja)	1996-11-26
DE69417232D1 (de)	1999-04-22
NO955029D0 (no)	1995-12-12
CZ320895A3 (en)	1996-07-17
EP0703802A1 (en)	1996-04-03
PL176664B1 (pl)	1999-07-30
LV12452A (lv)	2000-04-20
WO1995000199A1 (en)	1995-01-05
HU217950B (hu)	2000-05-28
AU674758B2 (en)	1997-01-09
NO955029L (no)	1995-12-12
GR3030565T3 (en)	1999-10-29
DE69417232T2 (de)	1999-11-04
LV12452B (en)	2000-09-20
TW286273B (et)	1996-09-21
CN1125403A (zh)	1996-06-26
BR9407118A (pt)	1996-09-03
HU9503290D0 (en)	1996-01-29
ATE177657T1 (de)	1999-04-15
FI95768B (fi)	1995-12-15
KR960703024A (ko)	1996-06-19
FI932789A0 (fi)	1993-06-17
CN1126574C (zh)	2003-11-05
RU2121824C1 (ru)	1998-11-20
FI95768C (fi)	1996-03-25
KR100312764B1 (ko)	2002-11-23
AU6848194A (en)	1995-01-17
ES2130423T3 (es)	1999-07-01
US5694947A (en)	1997-12-09
HUT74548A (en)	1997-01-28
JP3803714B2 (ja)	2006-08-02
EP0703802B1 (en)	1999-03-17
EE03202B1 (et)	1999-08-16
DK0703802T3 (da)	1999-10-11
FI932789L (fi)	1994-12-18
LTIP1957A (en)	1995-01-31
CZ284989B6 (cs)	1999-04-14
PL312193A1 (en)	1996-04-01

Legal Events

Date	Code	Title	Description
2012-01-25	MM9A	Lapsed patents	Effective date: 20110616

Publication	Publication Date	Title
US5694947A (en)	1997-12-09	Intravaginal delivery system
ES2160675T3 (es)	2001-11-16	Dispositivo implantable debajo de la dermis.
KR100492676B1 (ko)	2005-10-19	2종이상의활성물질을위한약물전달시스템
JP5017109B2 (ja)	2012-09-05	プロゲステロン受容体モジュレーターを含有する徐放性組成物
US3765414A (en)	1973-10-16	Drug release system
EP0862396A4 (en)	2000-09-06	INTRAVAGINAL RINGS WITH READY-TO-USE MEDICINE-BASED CORE
RU96101160A (ru)	1998-03-27	Внутривлагалищная система доставки
JPH0881364A (ja)	1996-03-26	プリントされた皮膚透過性薬剤投与具
PT97441B (pt)	1998-08-31	Processo para a preparacao de composicoes farmaceuticas que compreendem agentes vasodilatadores, nomeadamente, nitratos, alcaloides ergoticos ou prostaglandinas, ou agentes vasoconstritores, nomeadamente, alcoois benzilicos ou benzenodiois substituidos ou ainda agentes antiflamatorios esteroides e nao esteroides e dispositivos para a sua administracao transuretral
EP1003448B1 (en)	2003-10-01	Condoms with improved security
EP0016051A1 (en)	1980-10-01	Contraceptive-antivenereal disease tampon
WO2010133757A1 (en)	2010-11-25	Vaginal delivery system
CA2165282C (en)	2006-10-10	Intravaginal delivery system
US20230404910A1 (en)	2023-12-21	Implantable cannabis transdermal
MXPA06000428A (en)	2007-04-20	Intravaginal drug delivery devices