LT3781561T - Metilą modifikuojančių fermentų moduliatoriai, kompozicijos ir jų naudojimas - Google Patents

Metilą modifikuojančių fermentų moduliatoriai, kompozicijos ir jų naudojimas

Info

Publication number
LT3781561T
LT3781561T LTEPPCT/US2019/027932T LTUS2019027932T LT3781561T LT 3781561 T LT3781561 T LT 3781561T LT US2019027932 T LTUS2019027932 T LT US2019027932T LT 3781561 T LT3781561 T LT 3781561T
Authority
LT
Lithuania
Prior art keywords
compositions
methyl
modifying enzyme
enzyme modulators
modulators
Prior art date
Application number
LTEPPCT/US2019/027932T
Other languages
English (en)
Inventor
Alexandre Côté
Victor GEHLING
Avinash KHANNA
Ludivine MOINE
Jacob STUCKEY
Original Assignee
Constellation Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals, Inc. filed Critical Constellation Pharmaceuticals, Inc.
Publication of LT3781561T publication Critical patent/LT3781561T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
LTEPPCT/US2019/027932T 2018-04-18 2019-04-17 Metilą modifikuojančių fermentų moduliatoriai, kompozicijos ir jų naudojimas LT3781561T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862659408P 2018-04-18 2018-04-18
PCT/US2019/027932 WO2019204490A1 (en) 2018-04-18 2019-04-17 Modulators of methyl modifying enzymes, compositions and uses thereof

Publications (1)

Publication Number Publication Date
LT3781561T true LT3781561T (lt) 2024-07-10

Family

ID=66429588

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2019/027932T LT3781561T (lt) 2018-04-18 2019-04-17 Metilą modifikuojančių fermentų moduliatoriai, kompozicijos ir jų naudojimas

Country Status (34)

Country Link
US (3) US10689371B2 (lt)
EP (2) EP3781561B1 (lt)
JP (2) JP7256823B2 (lt)
KR (2) KR102798145B1 (lt)
CN (2) CN119954787A (lt)
AR (1) AR114793A1 (lt)
AU (1) AU2019255310B2 (lt)
BR (1) BR112020021194A2 (lt)
CL (1) CL2020002698A1 (lt)
CO (1) CO2020014217A2 (lt)
CR (1) CR20200553A (lt)
DK (1) DK3781561T3 (lt)
EA (1) EA202092490A1 (lt)
ES (1) ES2983344T3 (lt)
FI (1) FI3781561T3 (lt)
HR (1) HRP20240793T1 (lt)
HU (1) HUE066783T2 (lt)
IL (1) IL278013B2 (lt)
LT (1) LT3781561T (lt)
MA (1) MA52288B1 (lt)
MD (1) MD3781561T2 (lt)
MX (1) MX2020010999A (lt)
MY (1) MY208662A (lt)
PE (1) PE20201448A1 (lt)
PH (1) PH12020551578A1 (lt)
PL (1) PL3781561T3 (lt)
PT (1) PT3781561T (lt)
RS (1) RS65621B1 (lt)
SG (1) SG11202009438UA (lt)
SI (1) SI3781561T1 (lt)
SM (1) SMT202400233T1 (lt)
TW (1) TWI828677B (lt)
UA (1) UA127357C2 (lt)
WO (1) WO2019204490A1 (lt)

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SG11202009438UA (en) 2018-04-18 2020-11-27 Constellation Pharmaceuticals Inc Modulators of methyl modifying enzymes, compositions and uses thereof
CN112262143A (zh) 2018-05-21 2021-01-22 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
KR102689665B1 (ko) 2019-02-19 2024-07-31 한미약품 주식회사 신규한 헤테로트리시클릭 유도체 화합물 및 이의 용도
IL326442A (en) * 2019-07-24 2026-04-01 Constellation Pharmaceuticals Inc EZH2 inhibition in combination therapies for cancer treatment
PH12022550188A1 (en) * 2019-07-24 2022-11-21 Constellation Pharmaceuticals Inc Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide
US20230365541A1 (en) * 2020-03-13 2023-11-16 Haisco Pharmaceuticals Pte. Ltd. Inhibitor of enhancer of zeste homologue 2, and use thereof
CN113666920B (zh) * 2020-04-14 2025-10-03 浙江华海药业股份有限公司 苯并恶唑类化合物制备方法及其在医药领域的应用
WO2022009911A1 (ja) * 2020-07-08 2022-01-13 第一三共株式会社 １，３－ベンゾジオキソール誘導体の製造方法
AU2021382606A1 (en) * 2020-11-18 2023-06-22 Constellation Pharmaceuticals, Inc Ezh2 inhibition therapies for the treatment of androgen receptor mutated prostate cancers
KR102872076B1 (ko) 2021-01-11 2025-10-15 주식회사 엘지에너지솔루션 전극 슬러리의 유량 제어가 가능한 전극 슬러리 코팅 시스템 및 이를 이용한 전극 슬러리 코팅 방법
CN118541367A (zh) * 2022-01-14 2024-08-23 同和药品株式会社 1,3-苯并间二氧杂环戊烯衍生物化合物及包含该化合物的药物组合物
CN116496263A (zh) * 2022-01-27 2023-07-28 江苏天士力帝益药业有限公司 Ezh1/2抑制剂及其制备和抗肿瘤治疗中的应用
WO2023217018A1 (zh) * 2022-05-07 2023-11-16 贝达药业股份有限公司 Ezh2抑制剂及其在医药上的应用
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WO2025008783A1 (ko) * 2023-07-06 2025-01-09 동화약품주식회사 1,3-벤조다이옥솔 유도체 화합물을 포함하는 약학적 조성물
TW202542136A (zh) * 2023-12-15 2025-11-01 大陸商格物生物技術（江蘇）有限公司 １，３－苯并二氧雜環戊烯衍生物以及其用途
WO2026077358A1 (en) * 2024-10-07 2026-04-16 Constellation Pharmaceuticals, Inc. Solid forms and salts of 7-chloro-2- (4- (3-methoxyazetidin-1-yl) cyclohexyl) -2, 4-dimethyl-n- ( (6-methyl-4- (methylthio) -2-oxo-1, 2-dihydropyridin-3-yl) methyl) benzo [d] [1, 3] dioxole-5-carboxamide

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