LT3980B - New therapeutically active compound and a process for its preparation - Google Patents

New therapeutically active compound and a process for its preparation Download PDF

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Publication number
LT3980B
LT3980B LTIP1721A LTIP1721A LT3980B LT 3980 B LT3980 B LT 3980B LT IP1721 A LTIP1721 A LT IP1721A LT IP1721 A LTIP1721 A LT IP1721A LT 3980 B LT3980 B LT 3980B
Authority
LT
Lithuania
Prior art keywords
compound
cyclopropylmethoxy
compound according
preparation
benzimidazole
Prior art date
Application number
LTIP1721A
Other languages
English (en)
Lithuanian (lt)
Inventor
Arne Elof Braendstroem
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of LTIP1721A publication Critical patent/LTIP1721A/xx
Publication of LT3980B publication Critical patent/LT3980B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LTIP1721A 1988-12-22 1993-12-30 New therapeutically active compound and a process for its preparation LT3980B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19888804629A SE8804629D0 (sv) 1988-12-22 1988-12-22 New therapeutically active compounds

Publications (2)

Publication Number Publication Date
LTIP1721A LTIP1721A (en) 1995-07-25
LT3980B true LT3980B (en) 1996-06-25

Family

ID=20374310

Family Applications (2)

Application Number Title Priority Date Filing Date
LTIP1721A LT3980B (en) 1988-12-22 1993-12-30 New therapeutically active compound and a process for its preparation
LTIP1726A LT3914B (en) 1988-12-22 1993-12-30 Compound with gastric acid inhibitory effect and process for its preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTIP1726A LT3914B (en) 1988-12-22 1993-12-30 Compound with gastric acid inhibitory effect and process for its preparation

Country Status (32)

Country Link
US (2) US5008278A (de)
EP (1) EP0449940B1 (de)
JP (1) JP2793906B2 (de)
KR (1) KR910700249A (de)
CN (1) CN1028231C (de)
AR (1) AR248136A1 (de)
AT (1) ATE127799T1 (de)
AU (1) AU634741B2 (de)
BG (1) BG60102B2 (de)
CA (1) CA2005986C (de)
DD (2) DD296079A5 (de)
DE (1) DE68924273T2 (de)
DK (1) DK170800B1 (de)
EG (1) EG19303A (de)
FI (2) FI954768A0 (de)
GR (1) GR1002252B (de)
HR (1) HRP920831A2 (de)
HU (2) HU205926B (de)
IE (1) IE894048L (de)
IL (1) IL92798A0 (de)
LT (2) LT3980B (de)
LV (1) LV10187B (de)
NZ (1) NZ231872A (de)
PH (1) PH27400A (de)
PL (1) PL161150B1 (de)
PT (1) PT92648B (de)
RO (1) RO110494B1 (de)
RU (2) RU2073676C1 (de)
SE (1) SE8804629D0 (de)
WO (1) WO1990006925A1 (de)
YU (1) YU46806B (de)
ZA (2) ZA899795B (de)

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WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
DK0723436T3 (da) * 1994-07-08 2001-11-26 Astrazeneca Ab Tabletteret flerenhedsdoseringsform
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DE19758573C2 (de) * 1997-11-26 2001-03-01 Implex Hear Tech Ag Fixationselement für ein implantierbares Mikrofon
WO1999053918A1 (en) * 1998-04-20 1999-10-28 Eisai Co., Ltd. Stabilized compositions containing benzimidazole-type compounds
SE9900274D0 (sv) * 1999-01-28 1999-01-28 Astra Ab New compound
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
RU2232159C2 (ru) * 1999-07-29 2004-07-10 Регентский Совет Университета Калифорнии Производные бензимидазола и фармацевтические композиции, содержащие пролекарство ингибитора протонного насоса
AU782538B2 (en) 1999-10-20 2005-08-04 Eisai Co. Ltd. Method for stabilizing benzimidazole compounds
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
WO2003063840A2 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
CA2480358A1 (en) * 2002-03-26 2003-10-09 Dr. Reddy's Laboratories Limited Crystalline forms of rabeprazole sodium
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
WO2004073654A2 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained supression of gastric acid
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2531564C (en) * 2003-07-18 2016-01-19 Santarus, Inc. Pharmaceutical composition for inhibiting acid secretion
MXPA06000524A (es) * 2003-07-18 2006-08-11 Santarus Inc Formulacion farmaceutica y metodo para tratar desordenes gastrointestinales provocados por acido.
CA2540308C (en) 2003-09-26 2013-08-06 Alza Corporation Drug coating providing high drug loading and methods for providing the same
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
RU2325960C2 (ru) * 2005-09-22 2008-06-10 Белорусский Национальный Технический Университет Способ получения товарной продукции на литейно-прокатном комплексе металлургического мини-завода
PL2046334T3 (pl) 2006-07-25 2015-02-27 Vecta Ltd Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
US9220698B2 (en) 2008-09-09 2015-12-29 Pozen Inc. Method for delivering a pharmaceutical composition to patient in need thereof
KR20120030106A (ko) 2009-06-25 2012-03-27 아스트라제네카 아베 Ｎｓａｉｄ-연관된 궤양의 발생 위험이 있는 환자의 치료 방법
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (de) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Kombinationspräparat mit fester Dosierung zur Behandlung von Erkrankungen einhergehend mit Helicobacter pylori
EP2797600A4 (de) 2011-12-28 2015-09-16 Pozen Inc Verbesserte zusammensetzungen und verfahren zur abgabe von omeprazol und acetylsalicylsäure

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
EP0124495A2 (de) 1983-03-04 1984-11-07 Aktiebolaget Hässle Omeprazol-Salze
US4555518A (en) 1983-05-03 1985-11-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
US4628098A (en) 1984-08-16 1986-12-09 Takeda Chemical Industries, Ltd. 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles
EP0208452A2 (de) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridinderivate, deren Herstellung und Anwendung
US4727150A (en) 1984-08-16 1988-02-23 Takeda Chemical Industries, Ltd. Pyridyl methylsulfinyl benzimidazole derivatives

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US428098A (en) 1890-05-20 Electric railway
US727150A (en) 1902-06-18 1903-05-05 Peter Paul Keller Adjustable hanger for incandescent lamps.
DE3215503A1 (de) 1982-04-26 1983-11-03 Zängl GmbH, 8000 München Elektrisch beheiztes schneidgeraet
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd ５−フルオロ−１ｈ−ベンズイミダゾ−ル誘導体
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
JPH0676323B2 (ja) * 1987-08-28 1994-09-28 東京田辺製薬株式会社 抗潰瘍剤

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
EP0124495A2 (de) 1983-03-04 1984-11-07 Aktiebolaget Hässle Omeprazol-Salze
US4555518A (en) 1983-05-03 1985-11-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors
US4628098A (en) 1984-08-16 1986-12-09 Takeda Chemical Industries, Ltd. 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles
US4727150A (en) 1984-08-16 1988-02-23 Takeda Chemical Industries, Ltd. Pyridyl methylsulfinyl benzimidazole derivatives
EP0208452A2 (de) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridinderivate, deren Herstellung und Anwendung

Non-Patent Citations (1)

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Title
A. GOTH: "Medical Pharmacology, 7th ed.", pages: 19

Also Published As

Publication number Publication date
LTIP1726A (en) 1995-07-25
HRP920831A2 (en) 1995-12-31
FI954768A7 (fi) 1995-10-06
PT92648A (pt) 1990-06-29
RU2073676C1 (ru) 1997-02-20
DK170800B1 (da) 1996-01-22
LV10187A (lv) 1994-10-20
CN1028231C (zh) 1995-04-19
RU2042673C1 (ru) 1995-08-27
RO110494B1 (ro) 1996-01-30
AR248136A1 (es) 1995-06-30
US5008278A (en) 1991-04-16
GR1002252B (en) 1996-04-23
FI954768L (fi) 1995-10-06
JP2793906B2 (ja) 1998-09-03
PH27400A (en) 1993-06-21
YU46806B (sh) 1994-06-10
AU634741B2 (en) 1993-03-04
ZA899794B (en) 1990-08-29
YU242689A (en) 1991-04-30
LT3914B (en) 1996-04-25
GR890100838A (el) 1991-03-15
US5039808A (en) 1991-08-13
CA2005986A1 (en) 1990-06-22
ATE127799T1 (de) 1995-09-15
FI913035A7 (fi) 1991-06-20
CA2005986C (en) 1999-08-03
WO1990006925A1 (en) 1990-06-28
SE8804629D0 (sv) 1988-12-22
FI913035A0 (fi) 1991-06-20
IE894048L (en) 1990-06-22
HUT57202A (en) 1991-11-28
HU205926B (en) 1992-07-28
PT92648B (pt) 1995-09-12
EP0449940B1 (de) 1995-09-13
LTIP1721A (en) 1995-07-25
HU901084D0 (en) 1991-09-30
DK122291A (da) 1991-06-24
LV10187B (en) 1995-04-20
ZA899795B (en) 1990-08-29
DD296078A5 (de) 1991-11-21
IL92798A0 (en) 1990-09-17
PL161150B1 (en) 1993-05-31
DK122291D0 (da) 1991-06-21
DD296079A5 (de) 1991-11-21
DE68924273T2 (de) 1996-02-15
KR910700249A (ko) 1991-03-14
BG60102B2 (bg) 1993-10-29
JPH04502461A (ja) 1992-05-07
FI954768A0 (fi) 1995-10-06
AU4817590A (en) 1990-07-10
EG19303A (en) 1994-11-30
NZ231872A (en) 1992-03-26
DE68924273D1 (de) 1995-10-19
CN1043713A (zh) 1990-07-11
HU205927B (en) 1992-07-28
EP0449940A1 (de) 1991-10-09

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Effective date: 19961230