LT4020B - Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them - Google Patents

Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them Download PDF

Info

Publication number: LT4020B
Authority: LT; Lithuania
Prior art keywords: protein; amino acid; tdsl; headings; hernell
Prior art date: 1990-06-01

Application number

LTIP1736A

Other languages

English (en)

Lithuanian (lt)

Inventor

Gunnar Bjursell

Lars Blaeckberg

Peter Carlsson

Sven Enerbaeck

Olle Hernell

Jeanette Nilsson

Thomas Olivercrona

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-01

Filing date

1993-12-30

Publication date

1996-08-26

1993-12-30 Application filed by Astra Ab filed Critical Astra Ab

1995-08-25 Publication of LTIP1736A publication Critical patent/LTIP1736A/xx

1996-08-26 Publication of LT4020B publication Critical patent/LT4020B/lt

Links

239000008194 pharmaceutical composition Substances 0.000 title claims description 4
101000715643 Homo sapiens Bile salt-activated lipase Proteins 0.000 title abstract description 7
102000052905 human CEL Human genes 0.000 title abstract description 7
108090000623 proteins and genes Proteins 0.000 claims abstract description 101
102000004169 proteins and genes Human genes 0.000 claims abstract description 93
108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 29
239000013598 vector Substances 0.000 claims abstract description 26
238000000034 method Methods 0.000 claims abstract description 17
238000002360 preparation method Methods 0.000 claims abstract description 9
125000003275 alpha amino acid group Chemical group 0.000 claims description 32
102100035687 Bile salt-activated lipase Human genes 0.000 claims description 30
108090001060 Lipase Proteins 0.000 claims description 30
102000004882 Lipase Human genes 0.000 claims description 29
239000004367 Lipase Substances 0.000 claims description 29
235000019421 lipase Nutrition 0.000 claims description 29
239000002773 nucleotide Substances 0.000 claims description 15
125000003729 nucleotide group Chemical group 0.000 claims description 14
108010087173 bile salt-stimulated lipase Proteins 0.000 claims description 8
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 5
230000006870 function Effects 0.000 claims description 5
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 3
235000013350 formula milk Nutrition 0.000 claims description 3
229930182817 methionine Natural products 0.000 claims description 3
108020004414 DNA Proteins 0.000 claims 5
102000053602 DNA Human genes 0.000 claims 4
102000004190 Enzymes Human genes 0.000 abstract description 42
108090000790 Enzymes Proteins 0.000 abstract description 42
241000894006 Bacteria Species 0.000 abstract description 5
241001465754 Metazoa Species 0.000 abstract description 5
240000004808 Saccharomyces cerevisiae Species 0.000 abstract description 5
210000004962 mammalian cell Anatomy 0.000 abstract description 5
239000013612 plasmid Substances 0.000 abstract description 5
230000009261 transgenic effect Effects 0.000 abstract description 4
230000008569 process Effects 0.000 abstract description 3
235000018102 proteins Nutrition 0.000 description 69
229940088598 enzyme Drugs 0.000 description 40
239000002299 complementary DNA Substances 0.000 description 31
101710130200 Bile salt-activated lipase Proteins 0.000 description 26
210000004027 cell Anatomy 0.000 description 20
239000003833 bile salt Substances 0.000 description 17
239000000047 product Substances 0.000 description 16
108091032973 (ribonucleotides)n+m Proteins 0.000 description 15
229940040461 lipase Drugs 0.000 description 15
210000005075 mammary gland Anatomy 0.000 description 15
230000001419 dependent effect Effects 0.000 description 12
229940093761 bile salts Drugs 0.000 description 11
230000000694 effects Effects 0.000 description 11
235000013336 milk Nutrition 0.000 description 11
239000008267 milk Substances 0.000 description 11
210000004080 milk Anatomy 0.000 description 11
235000016709 nutrition Nutrition 0.000 description 10
230000035764 nutrition Effects 0.000 description 10
210000000496 pancreas Anatomy 0.000 description 10
230000029087 digestion Effects 0.000 description 8
239000012634 fragment Substances 0.000 description 8
150000002632 lipids Chemical class 0.000 description 8
238000004519 manufacturing process Methods 0.000 description 8
241000283690 Bos taurus Species 0.000 description 7
229940024606 amino acid Drugs 0.000 description 7
238000009396 hybridization Methods 0.000 description 7
239000000758 substrate Substances 0.000 description 7
239000011782 vitamin Substances 0.000 description 7
235000013343 vitamin Nutrition 0.000 description 7
229940088594 vitamin Drugs 0.000 description 7
229930003231 vitamin Natural products 0.000 description 7
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
241000588724 Escherichia coli Species 0.000 description 6
108090000371 Esterases Proteins 0.000 description 6
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
239000003814 drug Substances 0.000 description 6
230000013595 glycosylation Effects 0.000 description 6
238000006206 glycosylation reaction Methods 0.000 description 6
235000020256 human milk Nutrition 0.000 description 6
210000004251 human milk Anatomy 0.000 description 6
108090000765 processed proteins & peptides Proteins 0.000 description 6
238000000636 Northern blotting Methods 0.000 description 5
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 5
108090000631 Trypsin Proteins 0.000 description 5
102000004142 Trypsin Human genes 0.000 description 5
238000010521 absorption reaction Methods 0.000 description 5
150000001413 amino acids Chemical class 0.000 description 5
238000004458 analytical method Methods 0.000 description 5
150000002148 esters Chemical class 0.000 description 5
210000001035 gastrointestinal tract Anatomy 0.000 description 5
235000021125 infant nutrition Nutrition 0.000 description 5
230000009984 peri-natal effect Effects 0.000 description 5
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 5
210000002784 stomach Anatomy 0.000 description 5
239000012588 trypsin Substances 0.000 description 5
238000011144 upstream manufacturing Methods 0.000 description 5
102100033639 Acetylcholinesterase Human genes 0.000 description 4
108010022752 Acetylcholinesterase Proteins 0.000 description 4
241000701822 Bovine papillomavirus Species 0.000 description 4
108010051152 Carboxylesterase Proteins 0.000 description 4
102000013392 Carboxylesterase Human genes 0.000 description 4
102100036045 Colipase Human genes 0.000 description 4
241000557626 Corvus corax Species 0.000 description 4
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
101000876022 Homo sapiens Colipase Proteins 0.000 description 4
239000007993 MOPS buffer Substances 0.000 description 4
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
108010058834 acylcarnitine hydrolase Proteins 0.000 description 4
210000000577 adipose tissue Anatomy 0.000 description 4
210000004899 c-terminal region Anatomy 0.000 description 4
238000005119 centrifugation Methods 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
230000007812 deficiency Effects 0.000 description 4
235000014113 dietary fatty acids Nutrition 0.000 description 4
239000013604 expression vector Substances 0.000 description 4
229930195729 fatty acid Natural products 0.000 description 4
239000000194 fatty acid Substances 0.000 description 4
150000004665 fatty acids Chemical class 0.000 description 4
LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 4
238000004128 high performance liquid chromatography Methods 0.000 description 4
238000000338 in vitro Methods 0.000 description 4
238000002955 isolation Methods 0.000 description 4
230000020958 lipid digestion Effects 0.000 description 4
239000000203 mixture Substances 0.000 description 4
239000000523 sample Substances 0.000 description 4
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 4
210000001519 tissue Anatomy 0.000 description 4
150000003626 triacylglycerols Chemical class 0.000 description 4
DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
102100035765 Angiotensin-converting enzyme 2 Human genes 0.000 description 3
201000003883 Cystic fibrosis Diseases 0.000 description 3
241000168726 Dictyostelium discoideum Species 0.000 description 3
241000196324 Embryophyta Species 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
101000929928 Homo sapiens Angiotensin-converting enzyme 2 Proteins 0.000 description 3
102000019280 Pancreatic lipases Human genes 0.000 description 3
108050006759 Pancreatic lipases Proteins 0.000 description 3
108010076504 Protein Sorting Signals Proteins 0.000 description 3
238000012300 Sequence Analysis Methods 0.000 description 3
229940022698 acetylcholinesterase Drugs 0.000 description 3
210000004102 animal cell Anatomy 0.000 description 3
230000001580 bacterial effect Effects 0.000 description 3
210000000481 breast Anatomy 0.000 description 3
235000014633 carbohydrates Nutrition 0.000 description 3
150000001720 carbohydrates Chemical class 0.000 description 3
238000004113 cell culture Methods 0.000 description 3
102000005311 colipase Human genes 0.000 description 3
108020002632 colipase Proteins 0.000 description 3
238000001962 electrophoresis Methods 0.000 description 3
239000000839 emulsion Substances 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
239000002609 medium Substances 0.000 description 3
108020004999 messenger RNA Proteins 0.000 description 3
238000010369 molecular cloning Methods 0.000 description 3
150000002759 monoacylglycerols Chemical class 0.000 description 3
210000001322 periplasm Anatomy 0.000 description 3
102000004196 processed proteins & peptides Human genes 0.000 description 3
238000012163 sequencing technique Methods 0.000 description 3
210000000813 small intestine Anatomy 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
-1 vitamin esters Chemical class 0.000 description 3
ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000283707 Capra Species 0.000 description 2
102000003914 Cholinesterases Human genes 0.000 description 2
108090000322 Cholinesterases Proteins 0.000 description 2
208000000668 Chronic Pancreatitis Diseases 0.000 description 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
108020004705 Codon Proteins 0.000 description 2
108020004635 Complementary DNA Proteins 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
241000255581 Drosophila <fruit fly, genus> Species 0.000 description 2
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 2
108700024394 Exon Proteins 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
102100031416 Gastric triacylglycerol lipase Human genes 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
241000238631 Hexapoda Species 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
241001529936 Murinae Species 0.000 description 2
229930193140 Neomycin Natural products 0.000 description 2
239000000020 Nitrocellulose Substances 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
206010033649 Pancreatitis chronic Diseases 0.000 description 2
108091005804 Peptidases Proteins 0.000 description 2
102000035195 Peptidases Human genes 0.000 description 2
239000004365 Protease Substances 0.000 description 2
101000715641 Rattus norvegicus Bile salt-activated lipase Proteins 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
241000700605 Viruses Species 0.000 description 2
239000002253 acid Substances 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
230000004913 activation Effects 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
239000011543 agarose gel Substances 0.000 description 2
125000000539 amino acid group Chemical group 0.000 description 2
235000012538 ammonium bicarbonate Nutrition 0.000 description 2
239000001099 ammonium carbonate Substances 0.000 description 2
238000010804 cDNA synthesis Methods 0.000 description 2
239000007795 chemical reaction product Substances 0.000 description 2
NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
235000012000 cholesterol Nutrition 0.000 description 2
238000003776 cleavage reaction Methods 0.000 description 2
238000010367 cloning Methods 0.000 description 2
150000001982 diacylglycerols Chemical class 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
238000004108 freeze drying Methods 0.000 description 2
108010091264 gastric triacylglycerol lipase Proteins 0.000 description 2
239000000499 gel Substances 0.000 description 2
229940015043 glyoxal Drugs 0.000 description 2
206010073071 hepatocellular carcinoma Diseases 0.000 description 2
230000007062 hydrolysis Effects 0.000 description 2
238000006460 hydrolysis reaction Methods 0.000 description 2
230000002779 inactivation Effects 0.000 description 2
238000011534 incubation Methods 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 2
230000002366 lipolytic effect Effects 0.000 description 2
239000000463 material Substances 0.000 description 2
239000000693 micelle Substances 0.000 description 2
229960004927 neomycin Drugs 0.000 description 2
229920001220 nitrocellulos Polymers 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
229940116369 pancreatic lipase Drugs 0.000 description 2
238000009928 pasteurization Methods 0.000 description 2
239000008188 pellet Substances 0.000 description 2
230000008488 polyadenylation Effects 0.000 description 2
238000012545 processing Methods 0.000 description 2
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
230000002441 reversible effect Effects 0.000 description 2
230000007017 scission Effects 0.000 description 2
238000012216 screening Methods 0.000 description 2
239000013049 sediment Substances 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
238000000527 sonication Methods 0.000 description 2
230000009469 supplementation Effects 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
238000013518 transcription Methods 0.000 description 2
230000035897 transcription Effects 0.000 description 2
230000002103 transcriptional effect Effects 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
CGRCVIZBNRUWLY-HNNXBMFYSA-N (2s)-2-[(4-methylphenyl)sulfonylamino]-3-phenylpropanoic acid Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 CGRCVIZBNRUWLY-HNNXBMFYSA-N 0.000 description 1
ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
ZBMRKNMTMPPMMK-UHFFFAOYSA-N 2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid;azane Chemical compound [NH4+].CP(O)(=O)CCC(N)C([O-])=O ZBMRKNMTMPPMMK-UHFFFAOYSA-N 0.000 description 1
208000007848 Alcoholism Diseases 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
241000287605 Androchela smithi Species 0.000 description 1
241000612703 Augusta Species 0.000 description 1
244000063299 Bacillus subtilis Species 0.000 description 1
235000014469 Bacillus subtilis Nutrition 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
102100036806 Carboxylesterase 5A Human genes 0.000 description 1
102000004308 Carboxylic Ester Hydrolases Human genes 0.000 description 1
108090000863 Carboxylic Ester Hydrolases Proteins 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
108090000317 Chymotrypsin Proteins 0.000 description 1
108091026890 Coding region Proteins 0.000 description 1
102000012410 DNA Ligases Human genes 0.000 description 1
108010061982 DNA Ligases Proteins 0.000 description 1
108010066072 DNA modification methylase EcoRI Proteins 0.000 description 1
238000001712 DNA sequencing Methods 0.000 description 1
108700012227 Drosophila ase Proteins 0.000 description 1
241000206602 Eukaryota Species 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
108091005904 Hemoglobin subunit beta Proteins 0.000 description 1
229920002971 Heparan sulfate Polymers 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
102100031415 Hepatic triacylglycerol lipase Human genes 0.000 description 1
101000800133 Homo sapiens Thyroglobulin Proteins 0.000 description 1
102000004157 Hydrolases Human genes 0.000 description 1
108090000604 Hydrolases Proteins 0.000 description 1
208000026350 Inborn Genetic disease Diseases 0.000 description 1
241000235058 Komagataella pastoris Species 0.000 description 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
101710128782 Liver carboxylesterase Proteins 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
102100037611 Lysophospholipase Human genes 0.000 description 1
108020002496 Lysophospholipase Proteins 0.000 description 1
102100026001 Lysosomal acid lipase/cholesteryl ester hydrolase Human genes 0.000 description 1
101710099648 Lysosomal acid lipase/cholesteryl ester hydrolase Proteins 0.000 description 1
241001599018 Melanogaster Species 0.000 description 1
101710094503 Metallothionein-1 Proteins 0.000 description 1
102000014171 Milk Proteins Human genes 0.000 description 1
108010011756 Milk Proteins Proteins 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
230000004988 N-glycosylation Effects 0.000 description 1
125000000729 N-terminal amino-acid group Chemical group 0.000 description 1
BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 1
244000061176 Nicotiana tabacum Species 0.000 description 1
235000002637 Nicotiana tabacum Nutrition 0.000 description 1
208000036364 Normal newborn Diseases 0.000 description 1
108700026244 Open Reading Frames Proteins 0.000 description 1
208000016222 Pancreatic disease Diseases 0.000 description 1
108010033276 Peptide Fragments Proteins 0.000 description 1
102000007079 Peptide Fragments Human genes 0.000 description 1
108010090127 Periplasmic Proteins Proteins 0.000 description 1
108010064785 Phospholipases Proteins 0.000 description 1
102000015439 Phospholipases Human genes 0.000 description 1
108010058864 Phospholipases A2 Proteins 0.000 description 1
108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
108091034057 RNA (poly(A)) Proteins 0.000 description 1
101100235661 Rattus norvegicus Lpl gene Proteins 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
108010083644 Ribonucleases Proteins 0.000 description 1
102000006382 Ribonucleases Human genes 0.000 description 1
241000235070 Saccharomyces Species 0.000 description 1
206010039491 Sarcoma Diseases 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
238000002105 Southern blotting Methods 0.000 description 1
108091081024 Start codon Proteins 0.000 description 1
108010055297 Sterol Esterase Proteins 0.000 description 1
241000187747 Streptomyces Species 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
108020005038 Terminator Codon Proteins 0.000 description 1
108091036066 Three prime untranslated region Proteins 0.000 description 1
102100033504 Thyroglobulin Human genes 0.000 description 1
108010034949 Thyroglobulin Proteins 0.000 description 1
241000251735 Torpedo marmorata Species 0.000 description 1
MFGSTSNUMVXOHJ-UHFFFAOYSA-M [I+].CC([O-])=O Chemical compound [I+].CC([O-])=O MFGSTSNUMVXOHJ-UHFFFAOYSA-M 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000009471 action Effects 0.000 description 1
238000011360 adjunctive therapy Methods 0.000 description 1
230000002411 adverse Effects 0.000 description 1
238000003277 amino acid sequence analysis Methods 0.000 description 1
238000013103 analytical ultracentrifugation Methods 0.000 description 1
238000003556 assay Methods 0.000 description 1
238000000211 autoradiogram Methods 0.000 description 1
235000008452 baby food Nutrition 0.000 description 1
230000008901 benefit Effects 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000001045 blue dye Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
150000001733 carboxylic acid esters Chemical class 0.000 description 1
239000013592 cell lysate Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
229940048961 cholinesterase Drugs 0.000 description 1
239000000544 cholinesterase inhibitor Substances 0.000 description 1
229960002376 chymotrypsin Drugs 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000012258 culturing Methods 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
210000000805 cytoplasm Anatomy 0.000 description 1
230000001086 cytosolic effect Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
230000037213 diet Effects 0.000 description 1
230000000378 dietary effect Effects 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
MUCZHBLJLSDCSD-UHFFFAOYSA-N diisopropyl fluorophosphate Chemical compound CC(C)OP(F)(=O)OC(C)C MUCZHBLJLSDCSD-UHFFFAOYSA-N 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
235000004626 essential fatty acids Nutrition 0.000 description 1
238000010931 ester hydrolysis Methods 0.000 description 1
239000002329 esterase inhibitor Substances 0.000 description 1
229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
201000007089 exocrine pancreatic insufficiency Diseases 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
210000003754 fetus Anatomy 0.000 description 1
229960005051 fluostigmine Drugs 0.000 description 1
235000013305 food Nutrition 0.000 description 1
235000012041 food component Nutrition 0.000 description 1
239000005417 food ingredient Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000005194 fractionation Methods 0.000 description 1
235000021588 free fatty acids Nutrition 0.000 description 1
210000003736 gastrointestinal content Anatomy 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
230000034659 glycolysis Effects 0.000 description 1
230000012010 growth Effects 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
229960000789 guanidine hydrochloride Drugs 0.000 description 1
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
230000036541 health Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
102000047688 human TG Human genes 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
230000008105 immune reaction Effects 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
238000007373 indentation Methods 0.000 description 1
239000012678 infectious agent Substances 0.000 description 1
230000016507 interphase Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000002372 labelling Methods 0.000 description 1
230000006651 lactation Effects 0.000 description 1
238000011031 large-scale manufacturing process Methods 0.000 description 1
108010021666 lipase II Proteins 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
230000003908 liver function Effects 0.000 description 1
230000004807 localization Effects 0.000 description 1
150000004668 long chain fatty acids Chemical class 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
KRZWEBVPFGCYMY-UHFFFAOYSA-M methylmercury(1+);hydroxide Chemical compound [OH-].[Hg+]C KRZWEBVPFGCYMY-UHFFFAOYSA-M 0.000 description 1
235000021239 milk protein Nutrition 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004899 motility Effects 0.000 description 1
DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
238000007899 nucleic acid hybridization Methods 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000004203 pancreatic function Effects 0.000 description 1
210000001819 pancreatic juice Anatomy 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
235000020200 pasteurised milk Nutrition 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
OAHKWDDSKCRNFE-UHFFFAOYSA-N phenylmethanesulfonyl chloride Chemical compound ClS(=O)(=O)CC1=CC=CC=C1 OAHKWDDSKCRNFE-UHFFFAOYSA-N 0.000 description 1
239000006187 pill Substances 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
238000012257 pre-denaturation Methods 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
230000002028 premature Effects 0.000 description 1
230000000644 propagated effect Effects 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
235000020185 raw untreated milk Nutrition 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000006798 recombination Effects 0.000 description 1
238000005215 recombination Methods 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
150000003839 salts Chemical group 0.000 description 1
230000028327 secretion Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
108020002447 serine esterase Proteins 0.000 description 1
102000005428 serine esterase Human genes 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
230000011664 signaling Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
241000894007 species Species 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000009967 tasteless effect Effects 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000010257 thawing Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229960002175 thyroglobulin Drugs 0.000 description 1
238000001890 transfection Methods 0.000 description 1
238000013519 translation Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
241000701447 unidentified baculovirus Species 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
238000001262 western blot Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Birds (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Obesity (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

LTIP1736A 1990-06-01 1993-12-30 Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them LT4020B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9001985A SE9001985D0 (sv)	1990-06-01	1990-06-01	New chemical products

Publications (2)

Publication Number	Publication Date
LTIP1736A LTIP1736A (en)	1995-08-25
LT4020B true LT4020B (en)	1996-08-26

Family

ID=20379662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTIP1736A LT4020B (en)	1990-06-01	1993-12-30	Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them

Country Status (44)

Country	Link
EP (1)	EP0535048B1 (fr)
JP (1)	JPH05507201A (fr)
KR (1)	KR100212411B1 (fr)
CN (2)	CN1075113C (fr)
AP (1)	AP207A (fr)
AT (1)	ATE151077T1 (fr)
AU (1)	AU651979B2 (fr)
BG (1)	BG61165B1 (fr)
CA (1)	CA2083396C (fr)
CZ (1)	CZ287470B6 (fr)
DE (1)	DE69125489T2 (fr)
DK (1)	DK0535048T3 (fr)
DZ (1)	DZ1503A1 (fr)
EG (1)	EG19937A (fr)
ES (1)	ES2099159T3 (fr)
FI (1)	FI114639B (fr)
GR (1)	GR3023618T3 (fr)
HK (1)	HK62497A (fr)
HR (1)	HRP920771B1 (fr)
HU (1)	HU215258B (fr)
IE (1)	IE911844A1 (fr)
IL (1)	IL98273A (fr)
IS (1)	IS1751B (fr)
JO (1)	JO1694B1 (fr)
LT (1)	LT4020B (fr)
LV (1)	LV10292B (fr)
MA (1)	MA22166A1 (fr)
MY (1)	MY111245A (fr)
NO (1)	NO322962B1 (fr)
NZ (1)	NZ238223A (fr)
PH (1)	PH30761A (fr)
PL (1)	PL166534B1 (fr)
PT (1)	PT97836B (fr)
RO (1)	RO114793B1 (fr)
RU (1)	RU2140983C1 (fr)
SE (1)	SE9001985D0 (fr)
SG (1)	SG48078A1 (fr)
SK (1)	SK281089B6 (fr)
TN (1)	TNSN91041A1 (fr)
TW (1)	TW221712B (fr)
UA (1)	UA39165C2 (fr)
WO (1)	WO1991018923A1 (fr)
YU (1)	YU49138B (fr)
ZA (1)	ZA913778B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5616483A (en) *	1992-06-11	1997-04-01	Aktiebolaget Astra	Genomic DNA sequences encoding human BSSL/CEL
IS4130A (is) *	1993-03-01	1994-09-02	Ab Astra	Ný fjölpeptíð
SE9300686D0 (sv)	1993-03-01	1993-03-01	Astra Ab	Novel polypeptides
FR2754827B1 (fr) *	1996-10-17	1998-12-24	Biocem	Lipases pancreatiques et/ou colipases recombinantes et polypeptides dervies produits par les plantes, leurs procedes d'obtention et leurs utilisations
JP2000026311A (ja) *	1998-07-02	2000-01-25	Amano Pharmaceut Co Ltd	胃排出能亢進剤組成物
EP1963524A2 (fr) *	2005-12-01	2008-09-03	University of Bergen	Diagnostic et traitement des dysfonctionnements de l'exocrine pancreas et des diabetes
MX338426B (es)	2010-04-23	2016-04-15	Synageva Biopharma Corp	Enzima de enfermedad del almacenamiento lisosomico.
DK2613798T4 (en)	2010-09-09	2018-04-16	Synageva Biopharma Corp	USING LYSOSOMAL SUR LIPASE TO TREAT PATIENTS WITHOUT LYSOSOMAL SUR LIPASE
CA2812852A1 (fr)	2010-10-21	2012-04-26	Swedish Orphan Biovitrum Ab (Publ)	Procede pour augmenter l'absorption d'acides gras insatures par des nourrissons humains
DK2629790T3 (en) *	2010-10-21	2016-10-24	Swedish Orphan Biovitrum Ab (Publ)	Approach to increase growth rate of human babies
KR20200018781A (ko) *	2017-06-19	2020-02-20	스위디쉬 오르펀 바이오비트럼 에이비 (피유비엘)	반감기 연장 폴리펩티드를 갖는 융합 단백질
MX2022002473A (es)	2019-08-30	2022-08-02	Codexis Inc	Variantes de lipasa modificadas geneticamente.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3107684A (en) *	1983-07-01	1985-02-07	Celltech Limited	Proteins, pharmaceutical compositions, genes, vectors, host organisms and processes for their production

1990
- 1990-06-01 SE SE9001985A patent/SE9001985D0/xx unknown
1991
- 1991-05-17 ZA ZA913778A patent/ZA913778B/xx unknown
- 1991-05-18 TW TW080103838A patent/TW221712B/zh not_active IP Right Cessation
- 1991-05-20 DZ DZ910064A patent/DZ1503A1/fr active
- 1991-05-22 NZ NZ238223A patent/NZ238223A/xx not_active IP Right Cessation
- 1991-05-23 MY MYPI91000877A patent/MY111245A/en unknown
- 1991-05-27 IL IL9827391A patent/IL98273A/xx not_active IP Right Cessation
- 1991-05-29 YU YU95191A patent/YU49138B/sh unknown
- 1991-05-29 MA MA22438A patent/MA22166A1/fr unknown
- 1991-05-29 EG EG33391A patent/EG19937A/xx active
- 1991-05-30 AT AT91911030T patent/ATE151077T1/de not_active IP Right Cessation
- 1991-05-30 PL PL91296937A patent/PL166534B1/pl unknown
- 1991-05-30 HU HU9203774A patent/HU215258B/hu unknown
- 1991-05-30 WO PCT/SE1991/000381 patent/WO1991018923A1/fr not_active Ceased
- 1991-05-30 EP EP91911030A patent/EP0535048B1/fr not_active Expired - Lifetime
- 1991-05-30 JP JP91510382A patent/JPH05507201A/ja active Pending
- 1991-05-30 SG SG1996006887A patent/SG48078A1/en unknown
- 1991-05-30 UA UA93003780A patent/UA39165C2/uk unknown
- 1991-05-30 RO RO92-01490A patent/RO114793B1/ro unknown
- 1991-05-30 RU RU92016526/13A patent/RU2140983C1/ru active
- 1991-05-30 DE DE69125489T patent/DE69125489T2/de not_active Expired - Lifetime
- 1991-05-30 DK DK91911030.4T patent/DK0535048T3/da active
- 1991-05-30 IE IE184491A patent/IE911844A1/en not_active IP Right Cessation
- 1991-05-30 AU AU79645/91A patent/AU651979B2/en not_active Expired
- 1991-05-30 CA CA002083396A patent/CA2083396C/fr not_active Expired - Lifetime
- 1991-05-30 ES ES91911030T patent/ES2099159T3/es not_active Expired - Lifetime
- 1991-05-31 CZ CS19911644A patent/CZ287470B6/cs not_active IP Right Cessation
- 1991-05-31 IS IS3710A patent/IS1751B/is unknown
- 1991-05-31 SK SK1644-91A patent/SK281089B6/sk not_active IP Right Cessation
- 1991-05-31 PT PT97836A patent/PT97836B/pt not_active IP Right Cessation
- 1991-05-31 TN TNTNSN91041A patent/TNSN91041A1/fr unknown
- 1991-06-01 JO JO19911694A patent/JO1694B1/en active
- 1991-06-01 CN CN91104368A patent/CN1075113C/zh not_active Expired - Lifetime
- 1991-06-01 AP APAP/P/1991/000270A patent/AP207A/en active
- 1991-10-11 PH PH43285A patent/PH30761A/en unknown
1992
- 1992-10-01 HR HRP-951/91A patent/HRP920771B1/xx not_active IP Right Cessation
- 1992-11-24 NO NO19924528A patent/NO322962B1/no not_active IP Right Cessation
- 1992-11-26 BG BG97123A patent/BG61165B1/bg unknown
- 1992-11-30 FI FI925453A patent/FI114639B/fi active IP Right Grant
- 1992-11-30 KR KR1019920703049A patent/KR100212411B1/ko not_active Expired - Lifetime
1993
- 1993-07-30 LV LVP-93-1005A patent/LV10292B/en unknown
- 1993-12-30 LT LTIP1736A patent/LT4020B/lt not_active IP Right Cessation
1997
- 1997-05-08 HK HK62497A patent/HK62497A/en not_active IP Right Cessation
- 1997-05-30 GR GR970401262T patent/GR3023618T3/el unknown
2000
- 2000-11-20 CN CN00130975A patent/CN1326782A/zh active Pending

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ABOUAKIL N, ET AL.: "Purification of pancreatic carboxylic-ester hydrolase by immunoaffinity and its application to the human bile-salt-stimulated lipase.", BIOCHIM. BIOPHYS. ACTA, 1988, pages 299 - 388
BLÄCKBERG L, ET AL.: "Bile salt-stimulated lipase in human milk and carboxyl ester hydrolase in pancreatic juice: are they identical enzymes?", FEBS LETTERS, 1981, pages 284 - 288
BLÄCKBERG L, ET AL.: "Bile-salt-stimulated lipase in human milk: evidence for its synthesis in the lactating mammary gland", FEBS LETT., 1987, pages 37 - 41, XP025602095, DOI: doi:10.1016/0014-5793(87)81237-1
BLÄCKBERG, L., HERNELL, O: "Further characterization of the bile salt-stimulated lipase in human milk", FEBS LETTERS, 1983, pages 337 - 341, XP025594547, DOI: doi:10.1016/0014-5793(83)80571-7

Also Published As

Publication number	Publication date
EP0535048B1 (fr)	1997-04-02
HU215258B (hu)	1998-11-30
HRP920771B1 (en)	1999-10-31
AP9100270A0 (en)	1991-07-31
SK164491A3 (en)	1995-07-11
SE9001985D0 (sv)	1990-06-01
RO114793B1 (ro)	1999-07-30
GR3023618T3 (en)	1997-08-29
IL98273A0 (en)	1992-06-21
IL98273A (en)	2005-11-20
EP0535048A1 (fr)	1993-04-07
NO924528D0 (no)	1992-11-24
CN1326782A (zh)	2001-12-19
HUT63184A (en)	1993-07-28
NZ238223A (en)	1993-05-26
JO1694B1 (en)	1992-08-09
FI925453L (fi)	1992-11-30
LTIP1736A (en)	1995-08-25
IE911844A1 (en)	1991-12-04
NO924528L (no)	1992-11-24
HRP920771A2 (en)	1997-04-30
DE69125489T2 (de)	1997-08-14
BG97123A (bg)	1993-12-24
HK62497A (en)	1997-05-16
CA2083396A1 (fr)	1991-12-02
PT97836A (pt)	1992-02-28
CN1075113C (zh)	2001-11-21
CZ287470B6 (cs)	2000-12-13
DZ1503A1 (fr)	2004-09-13
FI925453A0 (fi)	1992-11-30
TNSN91041A1 (fr)	1992-10-25
KR100212411B1 (en)	1999-08-02
AU7964591A (en)	1991-12-31
ES2099159T3 (es)	1997-05-16
CZ164491A3 (cs)	1999-07-14
PT97836B (pt)	1998-11-30
NO322962B1 (no)	2006-12-18
BG61165B1 (bg)	1997-01-31
WO1991018923A1 (fr)	1991-12-12
SK281089B6 (sk)	2000-11-07
TW221712B (fr)	1994-03-11
ATE151077T1 (de)	1997-04-15
SG48078A1 (en)	1998-04-17
IS1751B (is)	2000-07-21
DK0535048T3 (da)	1997-09-29
UA39165C2 (uk)	2001-06-15
EG19937A (en)	2000-12-31
PL166534B1 (pl)	1995-05-31
RU2140983C1 (ru)	1999-11-10
CN1064313A (zh)	1992-09-09
JPH05507201A (ja)	1993-10-21
ZA913778B (en)	1992-02-26
CA2083396C (fr)	2006-09-19
PH30761A (en)	1997-10-17
LV10292B (en)	1995-08-20
AP207A (en)	1992-08-18
YU49138B (sh)	2004-03-12
FI114639B (fi)	2004-11-30
AU651979B2 (en)	1994-08-11
MY111245A (en)	1999-10-30
HU9203774D0 (en)	1993-03-29
IS3710A7 (is)	1991-12-02
MA22166A1 (fr)	1991-12-31
DE69125489D1 (de)	1997-05-07
YU95191A (sh)	1994-06-10
LV10292A (lv)	1994-10-20

Legal Events

Date

Code

Title

Description

2007-04-25

PC9A

Transfer of patents

Owner name: AREXIS AB, SE

Effective date: 20070307

2007-04-25

PD9A

Change of patent owner

Owner name: ASTRAZENECA AB, SE