LV10292B - Derivatives of human bile salt stimulated lipase and pharmaceutical compositions containing them - Google Patents

Derivatives of human bile salt stimulated lipase and pharmaceutical compositions containing them Download PDF

Info

Publication number: LV10292B
Authority: LV; Latvia
Prior art keywords: protein; amino acid; lipase; bssl; protein according
Prior art date: 1990-06-01

Application number

LVP-93-1005A

Other languages

English (en)

Latvian (lv)

Other versions

LV10292A (lv

Inventor

Bjursell Karl Gunnar

Blackberg Lars Gustav

Carlsson Peter Nils Ivar

Enerback Curt Sven Magnus

Hernell Carl Olof Edward

Nilsson Jeanette Annika

Olivercrona Thomas

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-01

Filing date

1993-07-30

Publication date

1995-08-20

1993-07-30 Application filed by Astra Ab filed Critical Astra Ab

1994-10-20 Publication of LV10292A publication Critical patent/LV10292A/xx

1995-08-20 Publication of LV10292B publication Critical patent/LV10292B/en

Links

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VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 description 1
230000002183 duodenal effect Effects 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
235000004626 essential fatty acids Nutrition 0.000 description 1
239000002329 esterase inhibitor Substances 0.000 description 1
229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
238000005194 fractionation Methods 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000000499 gel Substances 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
210000004907 gland Anatomy 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
230000009931 harmful effect Effects 0.000 description 1
231100001261 hazardous Toxicity 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
239000002628 heparin derivative Substances 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
230000036046 immunoreaction Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
230000016507 interphase Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000002372 labelling Methods 0.000 description 1
230000004130 lipolysis Effects 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
230000003908 liver function Effects 0.000 description 1
235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 description 1
230000001071 malnutrition Effects 0.000 description 1
235000000824 malnutrition Nutrition 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000000693 micelle Substances 0.000 description 1
235000021239 milk protein Nutrition 0.000 description 1
238000007899 nucleic acid hybridization Methods 0.000 description 1
208000015380 nutritional deficiency disease Diseases 0.000 description 1
238000012856 packing Methods 0.000 description 1
230000004203 pancreatic function Effects 0.000 description 1
210000001819 pancreatic juice Anatomy 0.000 description 1
235000020200 pasteurised milk Nutrition 0.000 description 1
238000009928 pasteurization Methods 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
210000001322 periplasm Anatomy 0.000 description 1
239000012071 phase Substances 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229960001697 physostigmine Drugs 0.000 description 1
PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 description 1
230000008488 polyadenylation Effects 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
230000002797 proteolythic effect Effects 0.000 description 1
230000003252 repetitive effect Effects 0.000 description 1
230000028327 secretion Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
108020002447 serine esterase Proteins 0.000 description 1
102000005428 serine esterase Human genes 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
125000003203 triacylglycerol group Chemical group 0.000 description 1
239000001226 triphosphate Substances 0.000 description 1
235000011178 triphosphate Nutrition 0.000 description 1
241000701447 unidentified baculovirus Species 0.000 description 1
239000011800 void material Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Birds (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Zoology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

LVP-93-1005A 1990-06-01 1993-07-30 Derivatives of human bile salt stimulated lipase and pharmaceutical compositions containing them LV10292B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9001985A SE9001985D0 (sv)	1990-06-01	1990-06-01	New chemical products
PCT/SE1991/000381 WO1991018923A1 (fr)	1990-06-01	1991-05-30	Derives de la lipase stimulee par les sels biliaires de l'homme et compositions pharmaceutiques contenant ces derives

Publications (2)

Publication Number	Publication Date
LV10292A LV10292A (lv)	1994-10-20
LV10292B true LV10292B (en)	1995-08-20

Family

ID=20379662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-93-1005A LV10292B (en)	1990-06-01	1993-07-30	Derivatives of human bile salt stimulated lipase and pharmaceutical compositions containing them

Country Status (44)

Country	Link
EP (1)	EP0535048B1 (fr)
JP (1)	JPH05507201A (fr)
KR (1)	KR100212411B1 (fr)
CN (2)	CN1075113C (fr)
AP (1)	AP207A (fr)
AT (1)	ATE151077T1 (fr)
AU (1)	AU651979B2 (fr)
BG (1)	BG61165B1 (fr)
CA (1)	CA2083396C (fr)
CZ (1)	CZ287470B6 (fr)
DE (1)	DE69125489T2 (fr)
DK (1)	DK0535048T3 (fr)
DZ (1)	DZ1503A1 (fr)
EG (1)	EG19937A (fr)
ES (1)	ES2099159T3 (fr)
FI (1)	FI114639B (fr)
GR (1)	GR3023618T3 (fr)
HK (1)	HK62497A (fr)
HR (1)	HRP920771B1 (fr)
HU (1)	HU215258B (fr)
IE (1)	IE911844A1 (fr)
IL (1)	IL98273A (fr)
IS (1)	IS1751B (fr)
JO (1)	JO1694B1 (fr)
LT (1)	LT4020B (fr)
LV (1)	LV10292B (fr)
MA (1)	MA22166A1 (fr)
MY (1)	MY111245A (fr)
NO (1)	NO322962B1 (fr)
NZ (1)	NZ238223A (fr)
PH (1)	PH30761A (fr)
PL (1)	PL166534B1 (fr)
PT (1)	PT97836B (fr)
RO (1)	RO114793B1 (fr)
RU (1)	RU2140983C1 (fr)
SE (1)	SE9001985D0 (fr)
SG (1)	SG48078A1 (fr)
SK (1)	SK281089B6 (fr)
TN (1)	TNSN91041A1 (fr)
TW (1)	TW221712B (fr)
UA (1)	UA39165C2 (fr)
WO (1)	WO1991018923A1 (fr)
YU (1)	YU49138B (fr)
ZA (1)	ZA913778B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP930935A2 (en) *	1992-06-11	1994-12-31	Astra Ab	New dna sequences
IS4130A (is) *	1993-03-01	1994-09-02	Ab Astra	Ný fjölpeptíð
SE9300686D0 (sv)	1993-03-01	1993-03-01	Astra Ab	Novel polypeptides
FR2754827B1 (fr) *	1996-10-17	1998-12-24	Biocem	Lipases pancreatiques et/ou colipases recombinantes et polypeptides dervies produits par les plantes, leurs procedes d'obtention et leurs utilisations
JP2000026311A (ja) *	1998-07-02	2000-01-25	Amano Pharmaceut Co Ltd	胃排出能亢進剤組成物
US20090226904A1 (en) *	2005-12-01	2009-09-10	University Of Bergen	Diagnosis and treatment of exocrine pancreatic dysfunction and diabetes
KR101742346B1 (ko)	2010-04-23	2017-06-15	시나게바 바이오파르마, 코포레이션	리소솜 축적병 효소
BR122019021757B1 (pt)	2010-09-09	2020-12-08	Alexion Pharmaceuticals, Inc	composição farmacêutica para tratamento de um paciente humano sofrendo de uma deficiência de lipase ácida lisossomal (lal)
JP5850940B2 (ja) *	2010-10-21	2016-02-03	スウェディッシュオーファンバイオビトラムパブリークアクチエボラグ	ヒト乳児の発育速度を増大させる方法
AU2010362575A1 (en)	2010-10-21	2013-04-11	Swedish Orphan Biovitrum Ab (Publ)	Method to increase the absorption of unsaturated fatty acids by human infants
BR112019025973A2 (pt)	2017-06-19	2020-07-07	Swedish Orphan Biovitrum Ab (Publ)	proteína de fusão com polipeptídeo de extensão de meia-vida
BR112022003705A2 (pt)	2019-08-30	2022-05-24	Codexis Inc	Lipase recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, composição farmacêutica para o tratamento de insuficiência pancreática, célula hospedeira, métodos para produzir uma lipase recombinante e para tratar e/ou prevenir os sintomas de insuficiência pancreática, e, uso

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60501758A (ja) *	1983-07-01	1985-10-17	セルテク　リミテツド	タンパク質、医薬構成物、遺伝子、ベクタ−宿主生物及びそれらの生産方法

1990
- 1990-06-01 SE SE9001985A patent/SE9001985D0/xx unknown
1991
- 1991-05-17 ZA ZA913778A patent/ZA913778B/xx unknown
- 1991-05-18 TW TW080103838A patent/TW221712B/zh not_active IP Right Cessation
- 1991-05-20 DZ DZ910064A patent/DZ1503A1/fr active
- 1991-05-22 NZ NZ238223A patent/NZ238223A/xx not_active IP Right Cessation
- 1991-05-23 MY MYPI91000877A patent/MY111245A/en unknown
- 1991-05-27 IL IL9827391A patent/IL98273A/xx not_active IP Right Cessation
- 1991-05-29 MA MA22438A patent/MA22166A1/fr unknown
- 1991-05-29 EG EG33391A patent/EG19937A/xx active
- 1991-05-29 YU YU95191A patent/YU49138B/sh unknown
- 1991-05-30 PL PL91296937A patent/PL166534B1/pl unknown
- 1991-05-30 UA UA93003780A patent/UA39165C2/uk unknown
- 1991-05-30 ES ES91911030T patent/ES2099159T3/es not_active Expired - Lifetime
- 1991-05-30 AU AU79645/91A patent/AU651979B2/en not_active Expired
- 1991-05-30 RU RU92016526/13A patent/RU2140983C1/ru active
- 1991-05-30 SG SG1996006887A patent/SG48078A1/en unknown
- 1991-05-30 HU HU9203774A patent/HU215258B/hu unknown
- 1991-05-30 IE IE184491A patent/IE911844A1/en not_active IP Right Cessation
- 1991-05-30 WO PCT/SE1991/000381 patent/WO1991018923A1/fr not_active Ceased
- 1991-05-30 EP EP91911030A patent/EP0535048B1/fr not_active Expired - Lifetime
- 1991-05-30 DK DK91911030.4T patent/DK0535048T3/da active
- 1991-05-30 DE DE69125489T patent/DE69125489T2/de not_active Expired - Lifetime
- 1991-05-30 RO RO92-01490A patent/RO114793B1/ro unknown
- 1991-05-30 CA CA002083396A patent/CA2083396C/fr not_active Expired - Lifetime
- 1991-05-30 JP JP91510382A patent/JPH05507201A/ja active Pending
- 1991-05-30 AT AT91911030T patent/ATE151077T1/de not_active IP Right Cessation
- 1991-05-31 PT PT97836A patent/PT97836B/pt not_active IP Right Cessation
- 1991-05-31 TN TNTNSN91041A patent/TNSN91041A1/fr unknown
- 1991-05-31 SK SK1644-91A patent/SK281089B6/sk not_active IP Right Cessation
- 1991-05-31 IS IS3710A patent/IS1751B/is unknown
- 1991-05-31 CZ CS19911644A patent/CZ287470B6/cs not_active IP Right Cessation
- 1991-06-01 AP APAP/P/1991/000270A patent/AP207A/en active
- 1991-06-01 JO JO19911694A patent/JO1694B1/en active
- 1991-06-01 CN CN91104368A patent/CN1075113C/zh not_active Expired - Lifetime
- 1991-10-11 PH PH43285A patent/PH30761A/en unknown
1992
- 1992-10-01 HR HRP-951/91A patent/HRP920771B1/xx not_active IP Right Cessation
- 1992-11-24 NO NO19924528A patent/NO322962B1/no not_active IP Right Cessation
- 1992-11-26 BG BG97123A patent/BG61165B1/bg unknown
- 1992-11-30 FI FI925453A patent/FI114639B/fi active IP Right Grant
- 1992-11-30 KR KR1019920703049A patent/KR100212411B1/ko not_active Expired - Lifetime
1993
- 1993-07-30 LV LVP-93-1005A patent/LV10292B/en unknown
- 1993-12-30 LT LTIP1736A patent/LT4020B/lt not_active IP Right Cessation
1997
- 1997-05-08 HK HK62497A patent/HK62497A/en not_active IP Right Cessation
- 1997-05-30 GR GR970401262T patent/GR3023618T3/el unknown
2000
- 2000-11-20 CN CN00130975A patent/CN1326782A/zh active Pending

Also Published As

Publication number	Publication date
IE911844A1 (en)	1991-12-04
IL98273A (en)	2005-11-20
RU2140983C1 (ru)	1999-11-10
FI925453A0 (fi)	1992-11-30
HU9203774D0 (en)	1993-03-29
ES2099159T3 (es)	1997-05-16
SK164491A3 (en)	1995-07-11
SE9001985D0 (sv)	1990-06-01
WO1991018923A1 (fr)	1991-12-12
IL98273A0 (en)	1992-06-21
FI925453L (fi)	1992-11-30
HRP920771A2 (en)	1997-04-30
CZ287470B6 (cs)	2000-12-13
IS1751B (is)	2000-07-21
EP0535048A1 (fr)	1993-04-07
BG97123A (bg)	1993-12-24
JO1694B1 (en)	1992-08-09
AU651979B2 (en)	1994-08-11
IS3710A7 (is)	1991-12-02
SG48078A1 (en)	1998-04-17
CN1075113C (zh)	2001-11-21
DE69125489D1 (de)	1997-05-07
YU95191A (sh)	1994-06-10
TNSN91041A1 (fr)	1992-10-25
CN1326782A (zh)	2001-12-19
EP0535048B1 (fr)	1997-04-02
DK0535048T3 (da)	1997-09-29
HU215258B (hu)	1998-11-30
GR3023618T3 (en)	1997-08-29
JPH05507201A (ja)	1993-10-21
HUT63184A (en)	1993-07-28
NO924528D0 (no)	1992-11-24
RO114793B1 (ro)	1999-07-30
CN1064313A (zh)	1992-09-09
LT4020B (en)	1996-08-26
AP207A (en)	1992-08-18
KR100212411B1 (en)	1999-08-02
YU49138B (sh)	2004-03-12
PH30761A (en)	1997-10-17
BG61165B1 (bg)	1997-01-31
HK62497A (en)	1997-05-16
MA22166A1 (fr)	1991-12-31
AP9100270A0 (en)	1991-07-31
ZA913778B (en)	1992-02-26
AU7964591A (en)	1991-12-31
PT97836B (pt)	1998-11-30
PL166534B1 (pl)	1995-05-31
EG19937A (en)	2000-12-31
CZ164491A3 (cs)	1999-07-14
FI114639B (fi)	2004-11-30
NO924528L (no)	1992-11-24
PT97836A (pt)	1992-02-28
DE69125489T2 (de)	1997-08-14
LTIP1736A (en)	1995-08-25
TW221712B (fr)	1994-03-11
LV10292A (lv)	1994-10-20
CA2083396A1 (fr)	1991-12-02
HRP920771B1 (en)	1999-10-31
UA39165C2 (uk)	2001-06-15
MY111245A (en)	1999-10-30
SK281089B6 (sk)	2000-11-07
CA2083396C (fr)	2006-09-19
ATE151077T1 (de)	1997-04-15
NO322962B1 (no)	2006-12-18
DZ1503A1 (fr)	2004-09-13
NZ238223A (en)	1993-05-26

Publication	Publication Date	Title
Nilsson et al.	1990	cDNA cloning of human‐milk bile‐salt‐stimulated lipase and evidence for its identity to pancreatic carboxylic ester hydrolase
Reue et al.	1991	cDNA cloning of carboxyl ester lipase from human pancreas reveals a unique proline-rich repeat unit.
Lowe et al.	1989	Cloning and characterization of human pancreatic lipase cDNA
McLean et al.	1986	Cloning and expression of human lecithin-cholesterol acyltransferase cDNA.
Morimoto et al.	1989	Saposin A: second cerebrosidase activator protein.
AU651979B2 (en)	1994-08-11	Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them
Baba et al.	1991	Structure of human milk bile salt activated lipase
Lee et al.	1993	Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase.
US6645934B1 (en)	2003-11-11	Peptide with radio protective effect
BG61451B1 (en)	1997-08-29	Dimer of molecular alternative of apolipoprotein and method for its preparation
SK285420B6 (sk)	2007-01-04	Varianty lipázy stimulovanej soľou žlčových kyselín, DNA molekuly ich kódujúce a transgénne cicavceodlišné od človeka
JP2004331566A (ja)	2004-11-25	皮膚コラーゲン産生促進剤
EP0131418A1 (fr)	1985-01-16	Protéines, compositions pharmaceutiques, gènes, vecteurs, organismes hôtes et procédés pour leur préparation
Knipping	1986	Isolation and properties of porcine lecithin: cholesterol acyltransferase
de Araújo et al.	1994	Purification of an acidic phospholipase A2 from Bothrops lanceolatus (fer de lance) venom: molecular and enzymatic properties
Kumar	1993	Cloning and expression of rabbit pancreatic phospholipase A2
JP2004331565A (ja)	2004-11-25	皮膚コラーゲン産生促進剤
Sklan et al.	1983	Lipolysis in Turkey Muscle: Association of Lipid Hydrolase Activities with Zinc and Copper Metalloproteins in a High‐Molecular Weight Lipid‐Protein Aggregate
Timmermans	1996	Purification, mofecular cloning and expression of the cDNA of bovine pregastric esterase
JP2003219815A (ja)	2003-08-05	緩衝液からなるローヤルゼリーの鮮度保持剤
WO2001089553A1 (fr)	2001-11-29	Coefficient d'utilisation digestive de triglycerides ameliore dans une carence en sels biliaires
JPH023699A (ja)	1990-01-09	細胞増殖促進性タンパク質、用途並びに単離方法