LT4530B - Farmacinės kompozicijos diklofenako pagrindu - Google Patents

Farmacinės kompozicijos diklofenako pagrindu Download PDF

Info

Publication number: LT4530B
Authority: LT; Lithuania
Prior art keywords: diclofenac; sodium; alkali metal; carbonates; acid carbonates
Prior art date: 1996-05-17

Application number

LT98-160A

Other languages

English (en)

Lithuanian (lt)

Other versions

LT98160A (en

Inventor

Alberto Reiner

Giorgio Reiner

Original Assignee

Apr Patent Holder Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-17

Filing date

1998-11-12

Publication date

1999-07-26

1998-11-12 Application filed by Apr Patent Holder Sa filed Critical Apr Patent Holder Sa

1999-03-25 Publication of LT98160A publication Critical patent/LT98160A/xx

1999-07-26 Publication of LT4530B publication Critical patent/LT4530B/lt

Links

DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 title claims abstract description 34
229960001259 diclofenac Drugs 0.000 title claims abstract description 28
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 13
239000000203 mixture Substances 0.000 claims abstract description 42
229910000288 alkali metal carbonate Inorganic materials 0.000 claims abstract description 8
150000008041 alkali metal carbonates Chemical class 0.000 claims abstract description 8
239000000126 substance Substances 0.000 claims abstract 3
239000002253 acid Substances 0.000 claims description 20
235000015497 potassium bicarbonate Nutrition 0.000 claims description 17
150000004649 carbonic acid derivatives Chemical class 0.000 claims description 15
235000006679 Mentha X verticillata Nutrition 0.000 claims description 13
235000002899 Mentha suaveolens Nutrition 0.000 claims description 13
235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 13
150000003839 salts Chemical group 0.000 claims description 12
239000011734 sodium Substances 0.000 claims description 10
229910052708 sodium Inorganic materials 0.000 claims description 10
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
235000012550 Pimpinella anisum Nutrition 0.000 claims description 8
235000007265 Myrrhis odorata Nutrition 0.000 claims description 7
239000002671 adjuvant Substances 0.000 claims description 7
239000000546 pharmaceutical excipient Substances 0.000 claims description 7
239000000796 flavoring agent Substances 0.000 claims description 5
235000013355 food flavoring agent Nutrition 0.000 claims description 5
235000011182 sodium carbonates Nutrition 0.000 claims description 5
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
229910052783 alkali metal Inorganic materials 0.000 claims 8
150000001340 alkali metals Chemical class 0.000 claims 8
240000009023 Myrrhis odorata Species 0.000 claims 2
159000000001 potassium salts Chemical class 0.000 claims 2
239000008203 oral pharmaceutical composition Substances 0.000 claims 1
230000000694 effects Effects 0.000 abstract description 7
235000019640 taste Nutrition 0.000 abstract description 5
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract description 2
239000000686 essence Substances 0.000 description 17
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
238000009472 formulation Methods 0.000 description 13
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 13
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
229920002774 Maltodextrin Polymers 0.000 description 10
239000005913 Maltodextrin Substances 0.000 description 10
229940035034 maltodextrin Drugs 0.000 description 10
239000004480 active ingredient Substances 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
KXZOIWWTXOCYKR-UHFFFAOYSA-M diclofenac potassium Chemical compound [K+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KXZOIWWTXOCYKR-UHFFFAOYSA-M 0.000 description 7
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 7
239000003826 tablet Substances 0.000 description 7
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
240000004760 Pimpinella anisum Species 0.000 description 6
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
229910000028 potassium bicarbonate Inorganic materials 0.000 description 6
239000011736 potassium bicarbonate Substances 0.000 description 6
239000000377 silicon dioxide Substances 0.000 description 6
108010011485 Aspartame Proteins 0.000 description 5
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 5
229930195725 Mannitol Natural products 0.000 description 5
239000000605 aspartame Substances 0.000 description 5
235000010357 aspartame Nutrition 0.000 description 5
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 5
229960003438 aspartame Drugs 0.000 description 5
239000008280 blood Substances 0.000 description 5
210000004369 blood Anatomy 0.000 description 5
235000019441 ethanol Nutrition 0.000 description 5
239000000594 mannitol Substances 0.000 description 5
235000010355 mannitol Nutrition 0.000 description 5
229940081974 saccharin Drugs 0.000 description 5
235000019204 saccharin Nutrition 0.000 description 5
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 5
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 5
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 5
239000000243 solution Substances 0.000 description 5
229920002261 Corn starch Polymers 0.000 description 4
235000019759 Maize starch Nutrition 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
229930006000 Sucrose Natural products 0.000 description 4
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
239000008187 granular material Substances 0.000 description 4
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 4
239000004296 sodium metabisulphite Substances 0.000 description 4
235000010262 sodium metabisulphite Nutrition 0.000 description 4
239000005720 sucrose Substances 0.000 description 4
230000001225 therapeutic effect Effects 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000008119 colloidal silica Substances 0.000 description 3
229960001193 diclofenac sodium Drugs 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
238000000034 method Methods 0.000 description 3
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 3
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 3
FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
235000016623 Fragaria vesca Nutrition 0.000 description 2
235000011363 Fragaria x ananassa Nutrition 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
239000004141 Sodium laurylsulphate Substances 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
239000000205 acacia gum Substances 0.000 description 2
235000010489 acacia gum Nutrition 0.000 description 2
-1 alkaline earth metal salts Chemical class 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
230000036765 blood level Effects 0.000 description 2
239000012461 cellulose resin Substances 0.000 description 2
229960000913 crospovidone Drugs 0.000 description 2
238000001514 detection method Methods 0.000 description 2
238000009826 distribution Methods 0.000 description 2
238000001035 drying Methods 0.000 description 2
239000011521 glass Substances 0.000 description 2
238000005469 granulation Methods 0.000 description 2
230000003179 granulation Effects 0.000 description 2
238000001033 granulometry Methods 0.000 description 2
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
239000008101 lactose Substances 0.000 description 2
210000000867 larynx Anatomy 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
229920000609 methyl cellulose Polymers 0.000 description 2
239000001923 methylcellulose Substances 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
229940057847 polyethylene glycol 600 Drugs 0.000 description 2
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 2
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
229940085605 saccharin sodium Drugs 0.000 description 2
108700004121 sarkosyl Proteins 0.000 description 2
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
239000004299 sodium benzoate Substances 0.000 description 2
235000010234 sodium benzoate Nutrition 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
229910000029 sodium carbonate Inorganic materials 0.000 description 2
229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 2
KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 2
235000019333 sodium laurylsulphate Nutrition 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
238000012360 testing method Methods 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
JDMFXJULNGEPOI-UHFFFAOYSA-N 2,6-dichloroaniline Chemical compound NC1=C(Cl)C=CC=C1Cl JDMFXJULNGEPOI-UHFFFAOYSA-N 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
239000004475 Arginine Chemical class 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
244000307700 Fragaria vesca Species 0.000 description 1
240000009088 Fragaria x ananassa Species 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical class NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Chemical class NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Chemical class OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
230000000202 analgesic effect Effects 0.000 description 1
230000002456 anti-arthritic effect Effects 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000001754 anti-pyretic effect Effects 0.000 description 1
230000003356 anti-rheumatic effect Effects 0.000 description 1
239000002221 antipyretic Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical class OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
239000002585 base Substances 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
229940112822 chewing gum Drugs 0.000 description 1
235000015218 chewing gum Nutrition 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000010835 comparative analysis Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
235000009508 confectionery Nutrition 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000008298 dragée Substances 0.000 description 1
238000001647 drug administration Methods 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000013401 experimental design Methods 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000007794 irritation Effects 0.000 description 1
239000007942 layered tablet Substances 0.000 description 1
238000002386 leaching Methods 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
238000002156 mixing Methods 0.000 description 1
125000000896 monocarboxylic acid group Chemical group 0.000 description 1
210000000214 mouth Anatomy 0.000 description 1
239000002324 mouth wash Substances 0.000 description 1
229940051866 mouthwash Drugs 0.000 description 1
229940100688 oral solution Drugs 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
239000006072 paste Substances 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
235000011181 potassium carbonates Nutrition 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000005070 sampling Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940034610 toothpaste Drugs 0.000 description 1
239000000606 toothpaste Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
229940063674 voltaren Drugs 0.000 description 1
239000003643 water by type Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Oral & Maxillofacial Surgery (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Birds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

LT98-160A 1996-05-17 1998-11-12 Farmacinės kompozicijos diklofenako pagrindu LT4530B (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT96MI000992A IT1283029B1 (it)	1996-05-17	1996-05-17	Composizioni farmaceutiche a base di diclofenac

Publications (2)

Publication Number	Publication Date
LT98160A LT98160A (en)	1999-03-25
LT4530B true LT4530B (lt)	1999-07-26

Family

ID=11374276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LT98-160A LT4530B (lt)	1996-05-17	1998-11-12	Farmacinės kompozicijos diklofenako pagrindu

Country Status (24)

Country	Link
EP (2)	EP1159960B1 (fr)
KR (1)	KR100441179B1 (fr)
AR (1)	AR007165A1 (fr)
AT (2)	ATE210976T1 (fr)
AU (1)	AU733083B2 (fr)
CA (1)	CA2254144C (fr)
DE (2)	DE69709349T2 (fr)
DK (2)	DK1159960T3 (fr)
EE (1)	EE9800400A (fr)
ES (2)	ES2187489T3 (fr)
HK (1)	HK1043939B (fr)
HR (1)	HRP970269A2 (fr)
IT (1)	IT1283029B1 (fr)
LT (1)	LT4530B (fr)
LV (1)	LV12250B (fr)
MA (1)	MA24183A1 (fr)
NZ (1)	NZ332655A (fr)
PL (1)	PL188883B1 (fr)
PT (2)	PT906092E (fr)
SK (1)	SK157698A3 (fr)
TW (1)	TW505525B (fr)
WO (1)	WO1997044023A1 (fr)
YU (1)	YU19797A (fr)
ZA (1)	ZA974270B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7687542B2 (en)	1996-05-17	2010-03-30	Kowa Pharmaeuticals America, Inc.	Rapidly bioavailable tablet and capsule formulations of diclofenac
DE10207394B4 (de) *	2002-02-21	2007-03-29	Lts Lohmann Therapie-Systeme Ag	Geschmacksmaskierte oblatenförmige Arzneizubereitung
WO2005115345A1 (fr)	2004-05-28	2005-12-08	Imaginot Pty Ltd	Systeme d'administration orale de compose therapeutique
JO3352B1 (ar)	2005-06-17	2019-03-13	Apr Applied Pharma Res Sa	صيغ دايكلوفيناك وطرق استخدامه
EP3263117A1 (fr)	2005-11-28	2018-01-03	Imaginot Pty Ltd.	Système d'administration d'un composé thérapeutique oral
US7939561B2 (en)	2006-02-07	2011-05-10	Apr Applied Pharma Research S.A.	Blister packaging for acute pain regimens
US7700125B2 (en)	2006-02-07	2010-04-20	Kowa Pharmaceuticals America, Inc.	Moisture resistant container systems for rapidly bioavailable dosage forms
CA2771831C (fr) *	2009-09-25	2018-03-06	Novartis Ag	Composition pharmaceutique orale contenant du diclofenac
WO2013156163A1 (fr)	2012-04-19	2013-10-24	Glatt Ag	Compositions pharmaceutiques au goût masqué contenant du diclofénac
WO2016193900A1 (fr) *	2015-06-05	2016-12-08	Lupin Limited	Compositions de diclofénac acide
IT201700009711A1 (it)	2017-01-30	2018-07-30	Applied Pharma Res	Sodium free Diclofenac potassium oral solutions Soluzioni orali di Diclofenac potassico prive di sodio
US11260026B2 (en)	2018-12-14	2022-03-01	Apr Applied Pharma Research Sa	Ready to use diclofenac stick packs
BR112022025132A2 (pt)	2020-06-10	2022-12-27	Applied Pharma Res	Formulações de diclofenaco à base de açúcar biodisponíveis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3607339A1 (de) *	1986-03-06	1987-09-10	Merck Patent Gmbh	Pharmazeutische zubereitung
EP0466650A2 (fr) *	1990-07-11	1992-01-15	Warner-Lambert Company	Traitements antiinflammatoires non-stéroidiens
DE4120311A1 (de) *	1991-06-20	1992-12-24	Kali Chemie Pharma Gmbh	Konservierte pharmazeutische zubereitungen
DE59410143D1 (de) *	1993-09-07	2002-08-01	Gergely Gerhard	Modifizierte Kristalle einer festen, essbaren, organischen Säure
BR9507768A (pt) *	1994-05-27	1997-09-02	Farmarc Nederland Bv	Composição farmacêutica
ZA959469B (en) *	1994-11-15	1996-05-15	South African Druggists Ltd	Pharmaceutical composition
IE80467B1 (en) *	1995-07-03	1998-07-29	Elan Corp Plc	Controlled release formulations for poorly soluble drugs

1996
- 1996-05-17 IT IT96MI000992A patent/IT1283029B1/it active IP Right Grant
1997
- 1997-05-15 ES ES01119117T patent/ES2187489T3/es not_active Expired - Lifetime
- 1997-05-15 AU AU31676/97A patent/AU733083B2/en not_active Expired
- 1997-05-15 PL PL97329919A patent/PL188883B1/pl unknown
- 1997-05-15 KR KR10-1998-0708925A patent/KR100441179B1/ko not_active Expired - Lifetime
- 1997-05-15 DK DK01119117T patent/DK1159960T3/da active
- 1997-05-15 EP EP01119117A patent/EP1159960B1/fr not_active Expired - Lifetime
- 1997-05-15 EP EP97927045A patent/EP0906092B1/fr not_active Expired - Lifetime
- 1997-05-15 WO PCT/EP1997/002709 patent/WO1997044023A1/fr not_active Ceased
- 1997-05-15 AT AT97927045T patent/ATE210976T1/de active
- 1997-05-15 DK DK97927045T patent/DK0906092T3/da active
- 1997-05-15 CA CA002254144A patent/CA2254144C/fr not_active Expired - Lifetime
- 1997-05-15 PT PT97927045T patent/PT906092E/pt unknown
- 1997-05-15 NZ NZ332655A patent/NZ332655A/xx not_active IP Right Cessation
- 1997-05-15 PT PT01119117T patent/PT1159960E/pt unknown
- 1997-05-15 DE DE69709349T patent/DE69709349T2/de not_active Expired - Lifetime
- 1997-05-15 AT AT01119117T patent/ATE229801T1/de active
- 1997-05-15 ES ES97927045T patent/ES2170396T3/es not_active Expired - Lifetime
- 1997-05-15 SK SK1576-98A patent/SK157698A3/sk unknown
- 1997-05-15 DE DE69718077T patent/DE69718077T2/de not_active Expired - Lifetime
- 1997-05-15 EE EE9800400A patent/EE9800400A/xx unknown
- 1997-05-16 MA MA24621A patent/MA24183A1/fr unknown
- 1997-05-16 AR ARP970102060A patent/AR007165A1/es active IP Right Grant
- 1997-05-16 YU YU19797A patent/YU19797A/sh unknown
- 1997-05-16 ZA ZA9704270A patent/ZA974270B/xx unknown
- 1997-05-16 HR HRMI96A000992A patent/HRP970269A2/xx not_active Application Discontinuation
- 1997-05-16 TW TW086106570A patent/TW505525B/zh not_active IP Right Cessation
1998
- 1998-11-12 LT LT98-160A patent/LT4530B/lt not_active IP Right Cessation
- 1998-11-17 LV LVP-98-269A patent/LV12250B/en unknown
2002
- 2002-06-05 HK HK02104270.1A patent/HK1043939B/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL329919A1 (en)	1999-04-26
AU733083B2 (en)	2001-05-03
LV12250B (en)	1999-09-20
EP1159960A1 (fr)	2001-12-05
PT906092E (pt)	2002-06-28
EP1159960B1 (fr)	2002-12-18
KR100441179B1 (ko)	2004-11-26
DE69709349D1 (de)	2002-01-31
DE69709349T2 (de)	2002-07-25
HRP970269A2 (en)	1998-04-30
KR20000010792A (ko)	2000-02-25
CA2254144C (fr)	2007-11-20
EE9800400A (et)	1999-06-15
EP0906092A1 (fr)	1999-04-07
PL188883B1 (pl)	2005-05-31
SK157698A3 (en)	2000-11-07
YU19797A (sh)	1999-07-28
AR007165A1 (es)	1999-10-13
ITMI960992A0 (fr)	1996-05-17
ATE229801T1 (de)	2003-01-15
PT1159960E (pt)	2003-03-31
ATE210976T1 (de)	2002-01-15
HK1043939A1 (en)	2002-10-04
CA2254144A1 (fr)	1997-11-27
EP0906092B1 (fr)	2001-12-19
DK0906092T3 (da)	2002-04-15
ZA974270B (en)	1998-01-30
WO1997044023A1 (fr)	1997-11-27
ITMI960992A1 (it)	1997-11-17
ES2187489T3 (es)	2003-06-16
LV12250A (lv)	1999-04-20
DK1159960T3 (da)	2003-03-31
DE69718077D1 (de)	2003-01-30
TW505525B (en)	2002-10-11
LT98160A (en)	1999-03-25
NZ332655A (en)	2000-04-28
HK1043939B (en)	2003-05-16
AU3167697A (en)	1997-12-09
MA24183A1 (fr)	1997-12-31
IT1283029B1 (it)	1998-04-03
DE69718077T2 (de)	2003-09-11
ES2170396T3 (es)	2002-08-01

Legal Events

Date	Code	Title	Description
2003-01-27	MM9A	Lapsed patents	Effective date: 20020515

Publication	Publication Date	Title
RU2184570C2 (ru)	2002-07-10	Препараты для орального введения
US20130142874A1 (en)	2013-06-06	Pharmaceutical compositions based on diclofenac
CA1320192C (fr)	1993-07-13	Compositions pharmaceutiques
US4760094A (en)	1988-07-26	Spray dried acetaminophen
NL194067C (nl)	2001-06-05	Farmaceutisch wateroplosbaar bruispreparaat dat N-acetylcysteine en aspartame bevat.
JPS6341420A (ja)	1988-02-22	鎮痛作用を有する医薬組成物
BG65043B1 (bg)	2007-01-31	Ефервесцентни форми
KR20020002321A (ko)	2002-01-09	미감이 차폐된 약제학적 입자
LT4530B (lt)	1999-07-26	Farmacinės kompozicijos diklofenako pagrindu
US4771077A (en)	1988-09-13	Spray dried acetaminophen
BRPI0315248B1 (pt)	2016-08-02	comprimido não-efervescente para administração oral de ibuprofeno de sódio e processo de preparação do mesmo
ES2912897T3 (es)	2022-05-30	Formulaciones de diclofenaco y métodos de uso
PL183266B1 (pl)	2002-06-28	Doustna kompozycja farmaceutyczna,sposób wytwarzania doustnej kompozycji farmaceutycznej oraz zastosowanie doustnej kompozycji farmaceutycznej
JPH07112973B2 (ja)	1995-12-06	イブプロフェン又はその塩を活物質とする可溶性の消炎性組成物及びその製造方法
JP4526247B2 (ja)	2010-08-18	経口用セファロスポリン製剤
US20060013896A1 (en)	2006-01-19	Methods of treating acute pain using diclofenac
JPH0276826A (ja)	1990-03-16	経口固形製剤
US20040151768A1 (en)	2004-08-05	Pharmaceutical compositions containing an effervescent acid-base couple
JP2005272401A (ja)	2005-10-06	チュアブル錠
RU2276982C2 (ru)	2006-05-27	Средство, обладающее противовоспалительным, анальгетическим, жаропонижающим действием в форме таблетки
JP2004161700A (ja)	2004-06-10	システイン類の苦味及び臭気が軽減された組成物
CZ366998A3 (cs)	2000-01-12	Farmaceutická kompozice pro orální podávání obsahující diklofenak a jejich výroba
JPH11349492A (ja)	1999-12-21	苦味を低減した経口用医薬組成物および苦味低減化方法