LU86172A1 - Composition aqueuse de cromoglycate de sodium - Google Patents

Composition aqueuse de cromoglycate de sodium Download PDF

Info

Publication number: LU86172A1
Authority: LU; Luxembourg
Prior art keywords: composition according; mpa; viscosity; solution; sodium cromoglycate
Prior art date: 1984-11-23

Application number

LU86172A

Other languages

English (en)

French (fr)

Inventor

Emmett Clemente

Henry Pfeifer

Vincent Hon-Kin Lee

Joseph Robinson

Original Assignee

Fisons Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-23

Filing date

1985-11-20

Publication date

1986-03-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24706028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU86172(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-11-20 Application filed by Fisons Plc filed Critical Fisons Plc

1986-03-24 Publication of LU86172A1 publication Critical patent/LU86172A1/fr

Links

239000000203 mixture Substances 0.000 title claims abstract description 43
229960000265 cromoglicic acid Drugs 0.000 title claims abstract description 25
IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical group O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 title abstract description 22
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 22
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 22
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 22
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 21
239000000243 solution Substances 0.000 claims description 34
239000003755 preservative agent Substances 0.000 claims description 10
239000007864 aqueous solution Substances 0.000 claims description 6
229960000686 benzalkonium chloride Drugs 0.000 claims description 6
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 6
230000002335 preservative effect Effects 0.000 claims description 6
229920002678 cellulose Polymers 0.000 claims description 5
239000001913 cellulose Substances 0.000 claims description 5
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
239000002997 ophthalmic solution Substances 0.000 claims description 3
229940054534 ophthalmic solution Drugs 0.000 claims description 3
239000008174 sterile solution Substances 0.000 claims description 3
239000012736 aqueous medium Substances 0.000 claims description 2
238000001879 gelation Methods 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 claims 3
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
238000000034 method Methods 0.000 abstract description 6
206010027654 Allergic conditions Diseases 0.000 abstract description 2
238000009472 formulation Methods 0.000 abstract 2
239000013011 aqueous formulation Substances 0.000 abstract 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
239000003795 chemical substances by application Substances 0.000 description 6
206010010741 Conjunctivitis Diseases 0.000 description 5
239000003814 drug Substances 0.000 description 5
239000011780 sodium chloride Substances 0.000 description 5
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 4
230000000172 allergic effect Effects 0.000 description 4
208000010668 atopic eczema Diseases 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
229940079593 drug Drugs 0.000 description 3
230000000694 effects Effects 0.000 description 3
229910052751 metal Inorganic materials 0.000 description 3
239000002184 metal Substances 0.000 description 3
150000002739 metals Chemical class 0.000 description 3
239000008213 purified water Substances 0.000 description 3
229910052708 sodium Inorganic materials 0.000 description 3
239000011734 sodium Substances 0.000 description 3
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
239000013566 allergen Substances 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
208000035475 disorder Diseases 0.000 description 2
238000001914 filtration Methods 0.000 description 2
206010023332 keratitis Diseases 0.000 description 2
229910021645 metal ion Inorganic materials 0.000 description 2
239000002674 ointment Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920002689 polyvinyl acetate Polymers 0.000 description 2
239000011118 polyvinyl acetate Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
230000001954 sterilising effect Effects 0.000 description 2
238000004659 sterilization and disinfection Methods 0.000 description 2
BDDLHHRCDSJVKV-UHFFFAOYSA-N 7028-40-2 Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O BDDLHHRCDSJVKV-UHFFFAOYSA-N 0.000 description 1
208000010370 Adenoviridae Infections Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
208000003556 Dry Eye Syndromes Diseases 0.000 description 1
206010013774 Dry eye Diseases 0.000 description 1
208000009889 Herpes Simplex Diseases 0.000 description 1
208000007514 Herpes zoster Diseases 0.000 description 1
206010022941 Iridocyclitis Diseases 0.000 description 1
229920003091 Methocel™ Polymers 0.000 description 1
208000036284 Rhinitis seasonal Diseases 0.000 description 1
206010039509 Scab Diseases 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
206010064996 Ulcerative keratitis Diseases 0.000 description 1
201000004612 anterior uveitis Diseases 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000006071 cream Substances 0.000 description 1
229940109248 cromoglycate Drugs 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000006196 drop Substances 0.000 description 1
208000030533 eye disease Diseases 0.000 description 1
239000003889 eye drop Substances 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
239000003885 eye ointment Substances 0.000 description 1
239000012467 final product Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
201000001371 inclusion conjunctivitis Diseases 0.000 description 1
230000008595 infiltration Effects 0.000 description 1
238000001764 infiltration Methods 0.000 description 1
239000000644 isotonic solution Substances 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
150000002731 mercury compounds Chemical class 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
229940100656 nasal solution Drugs 0.000 description 1
201000009240 nasopharyngitis Diseases 0.000 description 1
210000001989 nasopharynx Anatomy 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
239000000843 powder Substances 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
206010044325 trachoma Diseases 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Detergent Compositions (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)

LU86172A 1984-11-23 1985-11-20 Composition aqueuse de cromoglycate de sodium LU86172A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67428284A	1984-11-23	1984-11-23
US67428284		1984-11-23

Publications (1)

Publication Number	Publication Date
LU86172A1 true LU86172A1 (fr)	1986-03-24

Family

ID=24706028

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU86172A LU86172A1 (fr)	1984-11-23	1985-11-20	Composition aqueuse de cromoglycate de sodium

Country Status (18)

Country	Link
EP (1)	EP0183457B1 (de)
JP (1)	JPH0639379B2 (de)
AT (1)	ATE71524T1 (de)
AU (2)	AU4999785A (de)
BE (1)	BE903701A (de)
CA (1)	CA1267848A (de)
CH (1)	CH666816A5 (de)
DE (1)	DE3585211D1 (de)
DK (1)	DK541285A (de)
FR (1)	FR2573652B1 (de)
GB (1)	GB2167300B (de)
GR (1)	GR852791B (de)
IE (1)	IE59195B1 (de)
IL (1)	IL77086A0 (de)
LU (1)	LU86172A1 (de)
NZ (1)	NZ214295A (de)
PT (1)	PT81538A (de)
ZA (1)	ZA858914B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0770383A1 (de)	1995-10-24	1997-05-02	Dr. GERHARD MANN chem.-pharm. Fabrik GmbH	Ophthalmische Cromolyn-Gelzubereitung

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1317226C (en) *	1987-05-04	1993-05-04	Phillip E. Pennell	Viscoelastic fluid for ophthalmic surgery and method of using same
ES2012532A6 (es) *	1988-07-15	1990-04-01	Cusi Lab	Un procedimiento para la preparacion de una solucion acuosa de b-metil-4-(2' -tienilcarbonil)fenilacetato de lisina para aplicacion topica oftalmica.
IL97075A0 (en) *	1990-02-14	1992-03-29	Alcon Lab Inc	Topical pharmaceutical composition containing an alkyl saccharide
WO2000042986A2 (de) *	1999-01-19	2000-07-27	Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh	Künstliche tränenflüssigkeit in gelform
JP2002097129A (ja) *	2000-07-21	2002-04-02	Rohto Pharmaceut Co Ltd	点眼剤
JP5364658B2 (ja) *	2000-07-21	2013-12-11	ロート製薬株式会社	点眼剤
WO2005003111A1 (ja) *	2003-07-04	2005-01-13	Astellas Pharma Inc.	ウィルス性結膜炎の予防または治療剤
FR2860718B1 (fr) *	2003-10-09	2006-02-24	Jean Pascal Conduzorgues	Nouvelle formulation et ses applications dans le domaines cosmetiques ou pharmaceutiques
ES2457442T3 (es) *	2009-05-08	2014-04-25	Pari Pharma Gmbh	Formulaciones farmacéuticas concentradas estabilizadoras de los mastocitos
JP2013231185A (ja) *	2013-06-12	2013-11-14	Pfizer Products Inc	ヒドロキシプロピルメチルセルロース硬カプセルおよび製造方法
CN106535889A (zh)	2014-02-10	2017-03-22	帕塔拉制药有限责任公司	用于治疗肺疾病的肥大细胞稳定剂
CA2938994A1 (en)	2014-02-10	2015-08-13	Patara Pharma, LLC	Inhalable formulations of sodium cromolyn with improved bioavailability
US10265296B2 (en)	2015-08-07	2019-04-23	Respivant Sciences Gmbh	Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
EP3331522A1 (de)	2015-08-07	2018-06-13	Patara Pharma LLC	Verfahren zur behandlung von mastzellbedingten erkrankungen mit mastzellstabilisatoren
EP3506893A4 (de)	2016-08-31	2020-01-22	Respivant Sciences GmbH	Cromolynzusammensetzungen zur behandlung von chronischem husten aufgrund von idiopathischer pulmonaler fibrose
AU2017339366A1 (en)	2016-10-07	2019-04-11	Respivant Sciences Gmbh	Cromolyn compositions for treatment of pulmonary fibrosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1473318A (en) *	1973-05-25	1977-05-11	Fisons Ltd	Solution of 1,3-bis-2-carboxychromon-5-yloxy-propan-2-ol or salts thereof
US4053628A (en) *	1971-05-12	1977-10-11	Fisons Limited	Composition
FR2230358A2 (en) *	1973-05-25	1974-12-20	Fisons Ltd	Cromoglycate contg. solns. - contg. a second therapeutically active cpd. e.g. an antihistamine
IE41922B1 (en) *	1974-11-09	1980-04-23	Fisons Ltd	Pharmaceutical compositions containing bis-chromones
US4268519A (en) *	1979-06-05	1981-05-19	Fisons Limited	Method of treating otitis media
JPS5756448A (en) *	1980-09-22	1982-04-05	Mitsui Toatsu Chem Inc	Preparation of aromatic isocyanate

1985
- 1985-11-15 GB GB08528190A patent/GB2167300B/en not_active Expired
- 1985-11-18 AU AU49997/85A patent/AU4999785A/en not_active Abandoned
- 1985-11-18 DE DE8585308367T patent/DE3585211D1/de not_active Expired - Fee Related
- 1985-11-18 EP EP85308367A patent/EP0183457B1/de not_active Expired - Lifetime
- 1985-11-18 AT AT85308367T patent/ATE71524T1/de not_active IP Right Cessation
- 1985-11-18 IL IL77086A patent/IL77086A0/xx unknown
- 1985-11-20 GR GR852791A patent/GR852791B/el unknown
- 1985-11-20 LU LU86172A patent/LU86172A1/fr unknown
- 1985-11-20 ZA ZA858914A patent/ZA858914B/xx unknown
- 1985-11-21 CH CH4978/85A patent/CH666816A5/fr not_active IP Right Cessation
- 1985-11-22 IE IE294285A patent/IE59195B1/en not_active IP Right Cessation
- 1985-11-22 FR FR8517331A patent/FR2573652B1/fr not_active Expired
- 1985-11-22 NZ NZ214295A patent/NZ214295A/xx unknown
- 1985-11-22 CA CA000496016A patent/CA1267848A/en not_active Expired - Fee Related
- 1985-11-22 DK DK541285A patent/DK541285A/da not_active Application Discontinuation
- 1985-11-22 BE BE0/215905A patent/BE903701A/fr not_active IP Right Cessation
- 1985-11-22 JP JP60261615A patent/JPH0639379B2/ja not_active Expired - Lifetime
- 1985-11-22 PT PT81538A patent/PT81538A/pt unknown
1989
- 1989-11-02 AU AU44311/89A patent/AU4431189A/en not_active Abandoned

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0770383A1 (de)	1995-10-24	1997-05-02	Dr. GERHARD MANN chem.-pharm. Fabrik GmbH	Ophthalmische Cromolyn-Gelzubereitung

Also Published As

Publication number	Publication date
AU4999785A (en)	1986-05-29
IE852942L (en)	1986-05-23
IL77086A0 (en)	1986-04-29
GB2167300A (en)	1986-05-29
IE59195B1 (en)	1994-01-26
DK541285A (da)	1986-05-24
EP0183457A3 (en)	1987-04-15
EP0183457A2 (de)	1986-06-04
CA1267848A (en)	1990-04-17
GB8528190D0 (en)	1985-12-18
JPS61143318A (ja)	1986-07-01
NZ214295A (en)	1988-07-28
CH666816A5 (fr)	1988-08-31
BE903701A (fr)	1986-05-22
GR852791B (de)	1986-03-21
EP0183457B1 (de)	1992-01-15
AU4431189A (en)	1990-02-22
FR2573652A1 (fr)	1986-05-30
GB2167300B (en)	1988-11-23
ATE71524T1 (de)	1992-02-15
FR2573652B1 (fr)	1988-09-02
JPH0639379B2 (ja)	1994-05-25
PT81538A (en)	1985-12-01
DE3585211D1 (de)	1992-02-27
ZA858914B (en)	1987-07-29
DK541285D0 (da)	1985-11-22

Publication	Publication Date	Title
EP0639069B1 (de)	1997-10-29	Okulaerdarreichungsform und verfahren zu ihrer herstellung
CH666816A5 (fr)	1988-08-31	Composition aqueuse de cromoglycate de sodium.
KR101433152B1 (ko)	2014-08-22	안과용 약물의 전달에 유용한 젤
FR2588189A1 (fr)	1987-04-10	Composition pharmaceutique de type a transition de phase liquide-gel
TWI287998B (en)	2007-10-11	Compositions containing alpha-2-adrenergic agonist components
FR2688405A1 (fr)	1993-09-17	Procede d'une preparation d'une solution medicinale stable pour voie orale a liberation controlee, a base d'un beta-bloquant, et composition pharmaceutique a base d'un beta-bloquant.
JP2000508646A (ja)	2000-07-11	眼における滞留時間の長い目薬組成物
FR2660193A1 (fr)	1991-10-04	Produit opthalmique comportant des nanocapsules, son procede de preparation et utilisation des nanocapsules.
EP0594770B1 (de)	1997-01-15	Oxicam und oxicamderivate enthaltende ophthalmische zusammensetzungen
OA12462A (fr)	2006-06-24	Composition pharmaceutique à base de macrolides pour application locale en ophtalmologie.
BE1005196A0 (fr)	1993-05-18	Compositions pharmaceutiques aqueuses de cromoglycate sodique.
LU87087A1 (fr)	1989-07-07	Compositions pharmaceutiques contenant des pyranoquinoleines
FR2529457A1 (fr)	1984-01-06	Pommade ophtalmique comprenant une ou plusieurs paraffines et de la lanoline acetylee et procede pour la produire
WO2017085407A1 (fr)	2017-05-26	Mirabégron pour le traitement de maladies rétiniennes
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BE547955A (de)

LU86172A1 - Composition aqueuse de cromoglycate de sodium - Google Patents

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