LU86574A1 - Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine - Google Patents

Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine Download PDF

Info

Publication number: LU86574A1
Authority: LU; Luxembourg
Prior art keywords: composition; composition according; hair; chosen; cosmetically
Prior art date: 1986-09-08

Application number

LU86574A

Other languages

English (en)

French (fr)

Inventor

Jean-Francois Grollier

Original Assignee

Oreal

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-08

Filing date

1986-09-08

Publication date

1988-04-05

1986-09-08 Application filed by Oreal filed Critical Oreal

1986-09-08 Priority to LU86574A priority Critical patent/LU86574A1/fr

1987-09-03 Priority to CA000546026A priority patent/CA1294883C/fr

1987-09-04 Priority to PT85653A priority patent/PT85653B/pt

1987-09-04 Priority to AT0224187A priority patent/AT400671B/de

1987-09-07 Priority to DE3729953A priority patent/DE3729953C2/de

1987-09-07 Priority to ES8702574A priority patent/ES2008735A6/es

1987-09-07 Priority to CH3434/87A priority patent/CH673391A5/fr

1987-09-07 Priority to IT8767764A priority patent/IT1211374B/it

1987-09-07 Priority to FR8712392A priority patent/FR2603482B1/fr

1987-09-07 Priority to AU78102/87A priority patent/AU609055B2/en

1987-09-07 Priority to GR871387A priority patent/GR871387B/el

1987-09-07 Priority to SE8703461A priority patent/SE504489C2/sv

1987-09-07 Priority to NL8702110A priority patent/NL193980C/nl

1987-09-08 Priority to BE8701009A priority patent/BE1001047A5/fr

1987-09-08 Priority to JP62223190A priority patent/JP2613222B2/ja

1987-09-08 Priority to DK198704686A priority patent/DK173080B1/da

1987-09-08 Priority to US07/093,709 priority patent/US4968685A/en

1987-09-08 Priority to GB8721105A priority patent/GB2194734B/en

1987-09-08 Priority to KR870009922A priority patent/KR880003611A/ko

1988-04-05 Publication of LU86574A1 publication Critical patent/LU86574A1/fr

1990-10-31 Priority to US07/606,154 priority patent/US5157036A/en

Links

239000000203 mixture Substances 0.000 title claims description 37
201000004384 Alopecia Diseases 0.000 title claims description 11
230000003779 hair growth Effects 0.000 title claims description 8
230000004936 stimulating effect Effects 0.000 title claims description 8
230000003676 hair loss Effects 0.000 title claims description 7
208000024963 hair loss Diseases 0.000 title claims description 6
230000001939 inductive effect Effects 0.000 title claims description 6
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title description 5
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title description 4
210000004209 hair Anatomy 0.000 claims description 30
150000003230 pyrimidines Chemical class 0.000 claims description 12
150000002148 esters Chemical class 0.000 claims description 11
239000002609 medium Substances 0.000 claims description 11
125000000217 alkyl group Chemical group 0.000 claims description 10
150000001875 compounds Chemical class 0.000 claims description 9
125000000623 heterocyclic group Chemical group 0.000 claims description 8
-1 alkyl nicotinates Chemical class 0.000 claims description 7
229920002678 cellulose Polymers 0.000 claims description 7
239000001913 cellulose Substances 0.000 claims description 7
125000002877 alkyl aryl group Chemical group 0.000 claims description 6
229910052739 hydrogen Inorganic materials 0.000 claims description 6
239000001257 hydrogen Substances 0.000 claims description 6
238000000034 method Methods 0.000 claims description 6
YNBADRVTZLEFNH-UHFFFAOYSA-N methyl nicotinate Chemical compound COC(=O)C1=CC=CN=C1 YNBADRVTZLEFNH-UHFFFAOYSA-N 0.000 claims description 6
150000003839 salts Chemical class 0.000 claims description 6
210000004761 scalp Anatomy 0.000 claims description 6
239000002562 thickening agent Substances 0.000 claims description 6
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 5
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 4
125000003342 alkenyl group Chemical group 0.000 claims description 4
125000004432 carbon atom Chemical group C* 0.000 claims description 4
239000002537 cosmetic Substances 0.000 claims description 4
125000000753 cycloalkyl group Chemical group 0.000 claims description 4
235000001968 nicotinic acid Nutrition 0.000 claims description 4
125000003386 piperidinyl group Chemical group 0.000 claims description 4
230000001476 alcoholic effect Effects 0.000 claims description 3
239000012736 aqueous medium Substances 0.000 claims description 3
239000003349 gelling agent Substances 0.000 claims description 3
229960001238 methylnicotinate Drugs 0.000 claims description 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
239000002253 acid Substances 0.000 claims description 2
125000003545 alkoxy group Chemical group 0.000 claims description 2
125000005055 alkyl alkoxy group Chemical group 0.000 claims description 2
125000004948 alkyl aryl alkyl group Chemical group 0.000 claims description 2
125000003710 aryl alkyl group Chemical group 0.000 claims description 2
125000003118 aryl group Chemical group 0.000 claims description 2
125000004429 atom Chemical group 0.000 claims description 2
125000002393 azetidinyl group Chemical group 0.000 claims description 2
125000004069 aziridinyl group Chemical group 0.000 claims description 2
QXNDZONIWRINJR-UHFFFAOYSA-N azocane Chemical compound C1CCCNCCC1 QXNDZONIWRINJR-UHFFFAOYSA-N 0.000 claims description 2
NRHDCQLCSOWVTF-UHFFFAOYSA-N azonane Chemical compound C1CCCCNCCC1 NRHDCQLCSOWVTF-UHFFFAOYSA-N 0.000 claims description 2
229910052799 carbon Inorganic materials 0.000 claims description 2
125000002034 haloarylalkyl group Chemical group 0.000 claims description 2
125000004634 hexahydroazepinyl group Chemical group N1(CCCCCC1)* 0.000 claims description 2
125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
229910052757 nitrogen Inorganic materials 0.000 claims description 2
125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
239000011664 nicotinic acid Substances 0.000 claims 2
229960003512 nicotinic acid Drugs 0.000 claims 2
PVNIIMVLHYAWGP-UHFFFAOYSA-N nicotinic acid Natural products OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
229920001222 biopolymer Polymers 0.000 description 11
230000003698 anagen phase Effects 0.000 description 7
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
230000003797 telogen phase Effects 0.000 description 6
230000003659 hair regrowth Effects 0.000 description 5
229920003145 methacrylic acid copolymer Polymers 0.000 description 5
231100000360 alopecia Toxicity 0.000 description 4
230000000694 effects Effects 0.000 description 4
235000019441 ethanol Nutrition 0.000 description 4
230000031774 hair cycle Effects 0.000 description 4
229920000642 polymer Polymers 0.000 description 4
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 3
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 3
125000000129 anionic group Chemical group 0.000 description 3
229920006317 cationic polymer Polymers 0.000 description 3
229920001577 copolymer Polymers 0.000 description 3
230000012010 growth Effects 0.000 description 3
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
230000006872 improvement Effects 0.000 description 3
239000000178 monomer Substances 0.000 description 3
229920001285 xanthan gum Polymers 0.000 description 3
ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 description 2
241000588986 Alcaligenes Species 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
241000589516 Pseudomonas Species 0.000 description 2
230000009471 action Effects 0.000 description 2
IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
230000003778 catagen phase Effects 0.000 description 2
239000008103 glucose Substances 0.000 description 2
239000001863 hydroxypropyl cellulose Substances 0.000 description 2
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
230000003993 interaction Effects 0.000 description 2
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
239000011976 maleic acid Substances 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
230000008569 process Effects 0.000 description 2
125000001453 quaternary ammonium group Chemical group 0.000 description 2
239000000126 substance Substances 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
WECIKJKLCDCIMY-UHFFFAOYSA-N 2-chloro-n-(2-cyanoethyl)acetamide Chemical compound ClCC(=O)NCCC#N WECIKJKLCDCIMY-UHFFFAOYSA-N 0.000 description 1
ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
ZIMGGGWCDYVHOY-UHFFFAOYSA-N 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Chemical compound N=C1N(O)C(N)=CC(N2CCCCC2)=N1 ZIMGGGWCDYVHOY-UHFFFAOYSA-N 0.000 description 1
206010003694 Atrophy Diseases 0.000 description 1
241000195493 Cryptophyta Species 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
XLYMOEINVGRTEX-ARJAWSKDSA-N Ethyl hydrogen fumarate Chemical compound CCOC(=O)\C=C/C(O)=O XLYMOEINVGRTEX-ARJAWSKDSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
241000233866 Fungi Species 0.000 description 1
229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
229920003091 Methocel™ Polymers 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
241000194105 Paenibacillus polymyxa Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
NJSSICCENMLTKO-HRCBOCMUSA-N [(1r,2s,4r,5r)-3-hydroxy-4-(4-methylphenyl)sulfonyloxy-6,8-dioxabicyclo[3.2.1]octan-2-yl] 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)O[C@H]1C(O)[C@@H](OS(=O)(=O)C=2C=CC(C)=CC=2)[C@@H]2OC[C@H]1O2 NJSSICCENMLTKO-HRCBOCMUSA-N 0.000 description 1
150000003926 acrylamides Chemical class 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
230000032683 aging Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical group O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 1
150000005215 alkyl ethers Chemical class 0.000 description 1
238000000149 argon plasma sintering Methods 0.000 description 1
230000037444 atrophy Effects 0.000 description 1
210000004534 cecum Anatomy 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000000378 dietary effect Effects 0.000 description 1
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
229940097043 glucuronic acid Drugs 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
229920001519 homopolymer Polymers 0.000 description 1
125000002768 hydroxyalkyl group Chemical group 0.000 description 1
229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
244000005700 microbiome Species 0.000 description 1
230000000394 mitotic effect Effects 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
150000002814 niacins Chemical class 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
239000002453 shampoo Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
DGXNWWJYEMQHED-UHFFFAOYSA-N trimethyl-(4-methyl-3-oxopent-4-enyl)azanium Chemical class CC(=C)C(=O)CC[N+](C)(C)C DGXNWWJYEMQHED-UHFFFAOYSA-N 0.000 description 1
VZTGWJFIMGVKSN-UHFFFAOYSA-O trimethyl-[3-(2-methylprop-2-enoylamino)propyl]azanium Chemical compound CC(=C)C(=O)NCCC[N+](C)(C)C VZTGWJFIMGVKSN-UHFFFAOYSA-O 0.000 description 1
230000000304 vasodilatating effect Effects 0.000 description 1
230000024883 vasodilation Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

LU86574A 1986-09-08 1986-09-08 Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine LU86574A1 (fr)

Priority Applications (20)

Application Number	Priority Date	Filing Date	Title
LU86574A LU86574A1 (fr)	1986-09-08	1986-09-08	Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine
CA000546026A CA1294883C (fr)	1986-09-08	1987-09-03	Composition pour induire et stimuler la croissance des cheveux et freiner leur chute a base d'esters nicotiniques et de derives de pyrimidine
PT85653A PT85653B (pt)	1986-09-08	1987-09-04	Processo para a preparacao de uma composicao para induzir e estimular o crescimento dos cabelos e diminuir a quedas destes, com base em esteres nicotinicos e derivados de pirimidina
AT0224187A AT400671B (de)	1986-09-08	1987-09-04	Verfahren zur herstellung eines mittels zur förderung und stimulierung des haarwachstums und zur verringerung von haarausfall
AU78102/87A AU609055B2 (en)	1986-09-08	1987-09-07	Composition for inducing and stimulating hair growth and retarding its loss, based on nicotinic esters and pyrimidine derivatives
ES8702574A ES2008735A6 (es)	1986-09-08	1987-09-07	Procedimiento de prpeparacion de una composicion para inducir y estimular el crecimiento de los cabellos y frenar su caida.
CH3434/87A CH673391A5 (de)	1986-09-08	1987-09-07
IT8767764A IT1211374B (it)	1986-09-08	1987-09-07	Composizione per rinforzare e stimolare la crescita dei capelli e rallentarne la caduta a base di esteri nicotinici e di derivati della pirimidina
FR8712392A FR2603482B1 (fr)	1986-09-08	1987-09-07	Composition pour induire et stimuler la croissance des cheveux et freiner leur chute, a base d'esters nicotiniques et de derives de pyrimidine
DE3729953A DE3729953C2 (de)	1986-09-08	1987-09-07	Mittel zur Förderung und Stimulierung des Haarwachstums und zur Verringerung von Haarausfall auf Basis von Nikotinsäureestern und Pyrimidinderivaten
GR871387A GR871387B (en)	1986-09-08	1987-09-07	Composition for hair growing and reducing the hair loss based on nicotinic esters and pypimidine derivatives
SE8703461A SE504489C2 (sv)	1986-09-08	1987-09-07	Komposition för att inducera och stimulera hårtillväxt och bromsa håravfall, vilken komposition är baserad på nikotinsyraestrar och pyrimidindierivat samt ett förfarande för kosmetisk behandling av hår
NL8702110A NL193980C (nl)	1986-09-08	1987-09-07	Preparaat om de haargroei op te wekken en te stimuleren en haaruitval te remmen, op basis van nicotine-esters en pyrimidinederivaten.
BE8701009A BE1001047A5 (fr)	1986-09-08	1987-09-08	Composition pour induire et stimuler la croissance des cheveux et freiner leur chute, a base d'esters nicotiniques et de derives de pyrimidine.
JP62223190A JP2613222B2 (ja)	1986-09-08	1987-09-08	ニコチン酸エステルとピリミジン誘導体をベースとする、毛髪の成長を誘発又は刺激すると共にその損失を減少させる組成物
DK198704686A DK173080B1 (da)	1986-09-08	1987-09-08	Præparat på basis af pyrimidinderivater og nikotinsyreestere til fremkaldelse og stimulering af hårvækst og til at bremse h
US07/093,709 US4968685A (en)	1986-09-08	1987-09-08	Composition for inducing and stimulating hair growth and retarding its loss, based on nicotinic esters and pyrimidine derivatives
GB8721105A GB2194734B (en)	1986-09-08	1987-09-08	Composition for inducing and stimulating hair growth or retarding hair loss
KR870009922A KR880003611A (ko)	1986-09-08	1987-09-08	니코틴 에스테르와 피리미딘 유도체에 기초하여 모발의 성장을 유발하고 촉진하며, 탈모를 지연시키기 위한 조성물
US07/606,154 US5157036A (en)	1986-09-08	1990-10-31	Composition for inducing and stimulating hair growth and retarding its loss, based on nicotinic esters and pyrimidine derivatives

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU86574A LU86574A1 (fr)	1986-09-08	1986-09-08	Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine
LU86574		1986-09-08

Publications (1)

Publication Number	Publication Date
LU86574A1 true LU86574A1 (fr)	1988-04-05

Family

ID=19730765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU86574A LU86574A1 (fr)	1986-09-08	1986-09-08	Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine

Country Status (19)

Country	Link
US (1)	US4968685A (de)
JP (1)	JP2613222B2 (de)
KR (1)	KR880003611A (de)
AT (1)	AT400671B (de)
AU (1)	AU609055B2 (de)
BE (1)	BE1001047A5 (de)
CA (1)	CA1294883C (de)
CH (1)	CH673391A5 (de)
DE (1)	DE3729953C2 (de)
DK (1)	DK173080B1 (de)
ES (1)	ES2008735A6 (de)
FR (1)	FR2603482B1 (de)
GB (1)	GB2194734B (de)
GR (1)	GR871387B (de)
IT (1)	IT1211374B (de)
LU (1)	LU86574A1 (de)
NL (1)	NL193980C (de)
PT (1)	PT85653B (de)
SE (1)	SE504489C2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2653015B1 (fr) *	1989-10-12	1993-10-29	Oreal	Composition cosmetique ou pharmaceutique pour application topique contenant au moins un derive retinouide et au moins un derive de pyrimidine, son utilisation comme medicament et procede de traitement correspondant.
FR2653016B1 (fr) *	1989-10-13	1994-09-16	Oreal	Composition de lavage des matieres keratiniques, en particulier des cheveux et/ou de la peau.
US5043162A (en) *	1990-09-05	1991-08-27	Trager Seymour F	Hair growth promoter
GB9026354D0 (en) *	1990-12-04	1991-01-23	Unilever Plc	Cosmetic composition
FR2677884B1 (fr) *	1991-06-20	1993-07-09	Oreal	Composition pour freiner la chute des cheveux a base de pyrimidines n-oxyde trisubstitues ou leurs derives sulfoconjugues, nouveaux composes pyrimidines n-oxyde ou leurs derives sulfoconjugues.
WO1994017776A1 (en) *	1993-02-09	1994-08-18	Tulsa Forte Pharmacy Enterprises, Inc.	A method for stimulating hair growth with cationic derivatives of minoxidil using therapeutic iontophoresis
US5451407A (en) *	1993-06-21	1995-09-19	Alza Corporation	Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug
US5496827A (en) *	1994-07-15	1996-03-05	Patrick; Jay	Compositions for the transdermal delivery of nutrients
US5750108A (en) *	1995-09-18	1998-05-12	Regenix Marketing Systems, Inc.	Hair treatment system and kit for invigorating hair growth
US5738879A (en) *	1995-11-15	1998-04-14	Rine; Jasper M.	Scalp hair treatment method and composition
US6429218B1 (en)	1997-05-19	2002-08-06	Joseph Scivoletto	Method of controlling niacin concentration in lotion
US6248763B1 (en)	1998-05-19	2001-06-19	Scivoletto Rosemarie	Composition for treating skin conditions
EP1143954B1 (de)	1998-12-01	2004-08-11	University of Kentucky Research Foundation	Verwendung von nikotinsäurederivate zur behandlung von dna-schäden bei hautzellen
US7238375B1 (en)	2004-12-20	2007-07-03	Perry Stephen C	Composition and method to promote human hair growth

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2431558A (en) *	1945-05-22	1947-11-25	Winthrop Stearns Inc	Vasodilator compositions comprising alkyl nicotinates
DE835038C (de) *	1951-01-16	1952-03-27	Nordmark Werke Gmbh	Haarpflegemittel
US3168438A (en) *	1962-08-09	1965-02-02	Synergistics Inc	Vasodilation by nitric acid ester derivatives of nicotinic acid
US3382247A (en) *	1965-11-01	1968-05-07	Upjohn Co	6-amino-1, 2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidines
US4596812A (en) *	1976-05-24	1986-06-24	The Upjohn Company	Methods and solutions for treating male pattern alopecia
US4139619A (en) *	1976-05-24	1979-02-13	The Upjohn Company	6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
HU184626B (en) *	1979-06-01	1984-09-28	Ferrokemia Ipari	Congesting cosmetics first of all hair-restorers
IT1137375B (it) *	1981-04-15	1986-09-10	Lab Farmaco Biolog Crosara S R	Composto ad attivita' vasodilatatrice periferica utile come rubefacente, procedimento per la sua preparazione e composizioni farmaceutiche a base di detto composto
WO1983002558A1 (en) *	1981-11-09	1983-08-04	Gail Sansone Bazzano	The use of retinoids and minoxidil (2,4,-diamino-6-piperidino-pyrimidine-3-oxide) to increase the rate of growth of human scalp hair and to treat certain types of alopecias
JPS5888307A (ja) *	1981-11-19	1983-05-26	Takeo Kinji	ミノキシジル配合養毛剤
DE3480171D1 (en) *	1983-06-20	1989-11-23	Kao Corp	Hair growth promoting composition
JPS6064910A (ja) *	1983-09-20	1985-04-13	Shiseido Co Ltd	養毛料
DE3504695A1 (de) *	1985-02-12	1986-08-14	Roshdy Dipl.-Chem. Dr. 5000 Köln Ismail	Haarwuchsmittel
JPS6168408A (ja) *	1984-09-12	1986-04-08	Pola Chem Ind Inc	養毛料
NZ214397A (en) *	1984-12-21	1989-04-26	Richardson Vicks Inc	Minoxidil and acrylate polymer topical compositions
JPS61165312A (ja) *	1985-01-14	1986-07-26	Takeo Kinji	養毛化粧品
JPS61165311A (ja) *	1985-01-14	1986-07-26	Takeo Kinji	養毛化粧料
JPS6233111A (ja) *	1985-08-06	1987-02-13	Nakanishi Michio	養毛組成物
JPS62135409A (ja) *	1985-12-10	1987-06-18	Lion Corp	養毛化粧料
JPH072628B2 (ja) *	1986-03-31	1995-01-18	日東電工株式会社	養毛組成物
LU86547A1 (fr) *	1986-08-07	1988-03-02	Oreal	Suspension pour induire et stimuler la croissance des cheveux et diminuer leur chute a base de derives de la pyrimidine

1986
- 1986-09-08 LU LU86574A patent/LU86574A1/fr unknown
1987
- 1987-09-03 CA CA000546026A patent/CA1294883C/fr not_active Expired - Lifetime
- 1987-09-04 AT AT0224187A patent/AT400671B/de not_active IP Right Cessation
- 1987-09-04 PT PT85653A patent/PT85653B/pt not_active IP Right Cessation
- 1987-09-07 ES ES8702574A patent/ES2008735A6/es not_active Expired
- 1987-09-07 GR GR871387A patent/GR871387B/el unknown
- 1987-09-07 IT IT8767764A patent/IT1211374B/it active
- 1987-09-07 DE DE3729953A patent/DE3729953C2/de not_active Expired - Fee Related
- 1987-09-07 NL NL8702110A patent/NL193980C/nl not_active IP Right Cessation
- 1987-09-07 CH CH3434/87A patent/CH673391A5/fr not_active IP Right Cessation
- 1987-09-07 SE SE8703461A patent/SE504489C2/sv not_active IP Right Cessation
- 1987-09-07 FR FR8712392A patent/FR2603482B1/fr not_active Expired - Lifetime
- 1987-09-07 AU AU78102/87A patent/AU609055B2/en not_active Ceased
- 1987-09-08 KR KR870009922A patent/KR880003611A/ko not_active Withdrawn
- 1987-09-08 US US07/093,709 patent/US4968685A/en not_active Expired - Lifetime
- 1987-09-08 GB GB8721105A patent/GB2194734B/en not_active Expired - Lifetime
- 1987-09-08 DK DK198704686A patent/DK173080B1/da not_active IP Right Cessation
- 1987-09-08 JP JP62223190A patent/JP2613222B2/ja not_active Expired - Fee Related
- 1987-09-08 BE BE8701009A patent/BE1001047A5/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE504489C2 (sv)	1997-02-24
JPS6368515A (ja)	1988-03-28
SE8703461L (sv)	1988-03-09
GB2194734A (en)	1988-03-16
GR871387B (en)	1988-01-12
CH673391A5 (de)	1990-03-15
IT8767764A0 (it)	1987-09-07
ATA224187A (de)	1995-07-15
SE8703461D0 (sv)	1987-09-07
BE1001047A5 (fr)	1989-06-20
DE3729953C2 (de)	1996-10-31
DK468687A (da)	1988-03-09
PT85653B (pt)	1990-05-31
GB8721105D0 (en)	1987-10-14
US4968685A (en)	1990-11-06
IT1211374B (it)	1989-10-18
CA1294883C (fr)	1992-01-28
AU609055B2 (en)	1991-04-26
AU7810287A (en)	1988-03-10
NL193980C (nl)	2001-04-03
DE3729953A1 (de)	1988-03-17
JP2613222B2 (ja)	1997-05-21
NL8702110A (nl)	1988-04-05
AT400671B (de)	1996-02-26
ES2008735A6 (es)	1989-08-01
GB2194734B (en)	1991-03-27
FR2603482B1 (fr)	1991-10-04
KR880003611A (ko)	1988-05-28
PT85653A (fr)	1987-10-01
FR2603482A1 (fr)	1988-03-11
DK468687D0 (da)	1987-09-08
NL193980B (nl)	2000-12-01
DK173080B1 (da)	1999-12-20

Publication	Publication Date	Title
EP0336812B1 (de)	1992-08-26	Assoziat, bestehend aus Pyrimidin-Derivaten und Harnstoff- und/oder Allantoin-Derivaten zum Induzieren und Stimulieren des Haarwuchses und zum Vermindern des Haarausfalles
BE1001045A5 (fr)	1989-06-20	Composition sous forme de gel pour induire et stimuler la croissance des cheveux et diminuer leur chute a base de derives de piperidino-pyrimidine.
BE1001047A5 (fr)	1989-06-20	Composition pour induire et stimuler la croissance des cheveux et freiner leur chute, a base d'esters nicotiniques et de derives de pyrimidine.
BE1000320A3 (fr)	1988-10-18	Nouveaux derives de piperazinyl-1 pyrimidine, leur preparation et leur application en therapeutique et en cosmetique.
LU86969A1 (fr)	1989-03-08	Association de derives de pyrimidine et de retinoides en composants separes pour induire et stimuler la croissance des cheveux et diminuer leur chute
US5157036A (en)	1992-10-20	Composition for inducing and stimulating hair growth and retarding its loss, based on nicotinic esters and pyrimidine derivatives
EP0321952B1 (de)	1992-08-19	Mischung, bestehend aus Pyrimidinderivaten und nichtsteroidalen entzündungshemmenden Mitteln zum Induzieren und Stimulieren des Haarwuchses und zum Vermindern des Haarausfalles
EP0319983B1 (de)	1992-06-03	Mischung, bestehend aus Pyrimidinderivaten und Calcium-Antagonisten zum Induzieren und Stimulieren des Haarwuchses und zum Vermindern des Haarausfalls
EP0357484B1 (de)	1992-07-15	Zusammensetzung bestehend aus Alkyl-Polyglycosid und einem Pyrimidinderivat zum Induzieren und Stimulieren des Haarwuchses und/oder zum Vermindern des Haarausfalles
LU87188A1 (fr)	1989-10-26	Association de derives de pyrimidine et de derives d'uree et/ou d'allantoine pour induire et stimuler la croissance des cheveux et diminuer leur chute
BE1000621A3 (fr)	1989-02-21	Composition pour induire et stimuler la croissance des cheveux et diminuer la chute a base de derives d'alkylene diamino quinazoline.
CA1294882C (fr)	1992-01-28	Compositions pour induire et stimuler la croissance des cheveux et diminuer leur chute a base de derives de la pyrimidine
WO1997032562A1 (fr)	1997-09-12	Utilisation de n-aryl-2-hydroxyalkylamides pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
EP0915857B1 (de)	2002-07-17	Verbindungen aus der gruppe der 3-aryl-2,4-dioxo-oxazolidine und ihre verwendung in der kosmetik und pharmazie
EP2542237A1 (de)	2013-01-09	Paraconitsäuren als pigmentierungsaktivatoren
EP0319991A1 (de)	1989-06-14	Mischung, bestehend aus Pyrimidinderivaten und antibakteriellen Wirkstoffen zum Induzieren und Stimulieren des Haarwuchses und zum Vermindern des Haarausfalls