LU87719A1 - Derives di-substitues des n,n'-ditrimethoxybenzoyl piperazines,un procede pour leur preparation et compositions therapeutiques en contenant - Google Patents

Derives di-substitues des n,n'-ditrimethoxybenzoyl piperazines,un procede pour leur preparation et compositions therapeutiques en contenant Download PDF

Info

Publication number: LU87719A1
Authority: LU; Luxembourg
Prior art keywords: general formula; piperazine; trimethoxy; benzoyl; compound
Prior art date: 1989-04-15

Application number

LU87719A

Other languages

English (en)

French (fr)

Inventor

Pierre Braquet

Eduardo Pirotzky

Jean-Jacques Godfroid

Francoise Heymans

Original Assignee

Scras

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-15

Filing date

1990-04-10

Publication date

1990-07-24

1990-04-10 Application filed by Scras filed Critical Scras

1990-07-24 Publication of LU87719A1 publication Critical patent/LU87719A1/fr

Links

0 C*C=C([*@](C(CCC(N(CC1)*[C@](C)N1C(C([C@](C)C(OC)=C1*)C=*1OC)=O)=O)OC)OC)OC Chemical compound C*C=C([*@](C(CCC(N(CC1)*[C@](C)N1C(C([C@](C)C(OC)=C1*)C=*1OC)=O)=O)OC)OC)OC 0.000 description 1
JOMNTHCQHJPVAZ-UHFFFAOYSA-N CC1NCCNC1 Chemical compound CC1NCCNC1 JOMNTHCQHJPVAZ-UHFFFAOYSA-N 0.000 description 1
ORJJRBCGFRWHAI-UHFFFAOYSA-N Cs1(=C)ccccc1 Chemical compound Cs1(=C)ccccc1 ORJJRBCGFRWHAI-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

LU87719A 1989-04-15 1990-04-10 Derives di-substitues des n,n'-ditrimethoxybenzoyl piperazines,un procede pour leur preparation et compositions therapeutiques en contenant LU87719A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898908587A GB8908587D0 (en)	1989-04-15	1989-04-15	New 2-substituted n,n'-ditrimethoxybenzoyl piperazines

Publications (1)

Publication Number	Publication Date
LU87719A1 true LU87719A1 (fr)	1990-07-24

Family

ID=10655129

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU87719A LU87719A1 (fr)	1989-04-15	1990-04-10	Derives di-substitues des n,n'-ditrimethoxybenzoyl piperazines,un procede pour leur preparation et compositions therapeutiques en contenant

Country Status (32)

Country	Link
US (1)	US5019576A (da)
JP (1)	JP2633709B2 (da)
KR (1)	KR900016178A (da)
AR (1)	AR247736A1 (da)
AT (1)	AT399337B (da)
AU (1)	AU631334B2 (da)
BE (1)	BE1007245A3 (da)
CA (1)	CA2014521C (da)
CH (1)	CH681301A5 (da)
DE (1)	DE4011925A1 (da)
DK (1)	DK91890A (da)
DZ (1)	DZ1407A1 (da)
ES (1)	ES2019554A6 (da)
FI (1)	FI92058C (da)
FR (2)	FR2645743B1 (da)
GB (2)	GB8908587D0 (da)
GR (1)	GR1000355B (da)
HK (1)	HK95092A (da)
IE (1)	IE65058B1 (da)
IN (1)	IN175799B (da)
IT (1)	IT1241631B (da)
LU (1)	LU87719A1 (da)
MA (1)	MA21805A1 (da)
NL (1)	NL9000798A (da)
NO (1)	NO176098C (da)
NZ (1)	NZ233250A (da)
OA (1)	OA09446A (da)
PT (1)	PT93736B (da)
SE (1)	SE505186C2 (da)
SG (1)	SG92092G (da)
TN (1)	TNSN90051A1 (da)
ZA (1)	ZA902566B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5344830A (en) *	1992-12-10	1994-09-06	Merck & Co., Inc.	N,N-diacylpiperazine tachykinin antagonists
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5883098A (en) *	1993-11-29	1999-03-16	Fujisawa Pharmaceutical Co., Ltd.	Piperazine derivatives
US5610165A (en) *	1994-02-17	1997-03-11	Merck & Co., Inc.	N-acylpiperidine tachykinin antagonists
US5795894A (en) *	1995-05-02	1998-08-18	Schering Corporation	Piperazino derivatives as neurokinn antagonists
JP4173912B2 (ja) *	1995-05-02	2008-10-29	シェーリングコーポレイション	ニューロキニンアンタゴニストとしてのピペラジノ誘導体
US5892039A (en) *	1995-08-31	1999-04-06	Schering Corporation	Piperazino derivatives as neurokinin antagonists
BR9610277A (pt) *	1995-08-31	1999-07-06	Schering Corp	Derivados de piperazino como antagonistas de neurowuinina
US5869488A (en) *	1996-05-01	1999-02-09	Schering Corporation	Piperazino derivatives as neurokinin antagonists
FR2780649B1 (fr) *	1998-07-06	2001-03-09	Univ Paris Vii Denis Diderot	Derives de la piperazine pour l'inhibition de la replication du virus de l'immunodeficience humaine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1243991A (en) *	1968-06-10	1971-08-25	Ici Ltd	Piperidine, morpholine and piperazine derivatives
FR2209560A1 (en) *	1972-12-07	1974-07-05	Degussa	N-(Trialkoxyaroyl)-ethylenediamine derivs - useful as cardioactive medicaments, exhibit anti-ischaemic activity comparable to nitroglycerin
IL85700A0 (en) *	1987-03-24	1988-08-31	Takeda Chemical Industries Ltd	1,4-disubstituted piperazine compounds,their production and use
EP0318235A3 (en) *	1987-11-25	1991-05-02	Takeda Chemical Industries, Ltd.	Paf antagonist, 1,4-disubstituted piperazine compounds and production thereof
KR900018073A (ko) *	1988-05-23	1990-12-20	추후보충	피페라진 화합물
GB8823776D0 (en) *	1988-10-11	1988-11-16	Scras	New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
GB8823775D0 (en) *	1988-10-11	1988-11-16	Scras	New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines
US4997836A (en) *	1988-11-11	1991-03-05	Takeda Chemical Industries, Ltd.	Trisubstituted piperazine compounds, their production and use

1989
- 1989-04-15 GB GB898908587A patent/GB8908587D0/en active Pending
1990
- 1990-04-03 ZA ZA902566A patent/ZA902566B/xx unknown
- 1990-04-04 GB GB9007612A patent/GB2230262B/en not_active Expired - Lifetime
- 1990-04-05 NL NL9000798A patent/NL9000798A/nl not_active Application Discontinuation
- 1990-04-05 IN IN140DE1990D patent/IN175799B/en unknown
- 1990-04-06 SE SE9001269A patent/SE505186C2/sv not_active IP Right Cessation
- 1990-04-06 GR GR900100270A patent/GR1000355B/el unknown
- 1990-04-09 US US07/506,421 patent/US5019576A/en not_active Expired - Lifetime
- 1990-04-09 NZ NZ233250A patent/NZ233250A/en unknown
- 1990-04-10 LU LU87719A patent/LU87719A1/fr unknown
- 1990-04-10 CH CH1206/90A patent/CH681301A5/fr not_active IP Right Cessation
- 1990-04-10 NO NO901631A patent/NO176098C/no unknown
- 1990-04-10 AR AR90316593A patent/AR247736A1/es active
- 1990-04-10 MA MA22064A patent/MA21805A1/fr unknown
- 1990-04-11 ES ES9001056A patent/ES2019554A6/es not_active Expired - Lifetime
- 1990-04-11 DK DK091890A patent/DK91890A/da unknown
- 1990-04-11 IE IE131490A patent/IE65058B1/en not_active IP Right Cessation
- 1990-04-11 DZ DZ900066A patent/DZ1407A1/fr active
- 1990-04-11 BE BE9000408A patent/BE1007245A3/fr not_active IP Right Cessation
- 1990-04-11 PT PT93736A patent/PT93736B/pt not_active IP Right Cessation
- 1990-04-11 AT AT0086690A patent/AT399337B/de not_active IP Right Cessation
- 1990-04-12 DE DE4011925A patent/DE4011925A1/de not_active Ceased
- 1990-04-12 CA CA002014521A patent/CA2014521C/en not_active Expired - Fee Related
- 1990-04-12 TN TNTNSN90051A patent/TNSN90051A1/fr unknown
- 1990-04-12 IT IT20020A patent/IT1241631B/it active IP Right Grant
- 1990-04-12 OA OA59775A patent/OA09446A/xx unknown
- 1990-04-12 FI FI901883A patent/FI92058C/fi not_active IP Right Cessation
- 1990-04-13 JP JP2096620A patent/JP2633709B2/ja not_active Expired - Lifetime
- 1990-04-13 FR FR909004797A patent/FR2645743B1/fr not_active Expired - Lifetime
- 1990-04-13 FR FR909004798A patent/FR2645859B1/fr not_active Expired - Lifetime
- 1990-04-14 KR KR1019900005198A patent/KR900016178A/ko not_active Ceased
- 1990-04-17 AU AU53261/90A patent/AU631334B2/en not_active Ceased
1992
- 1992-09-11 SG SG920/92A patent/SG92092G/en unknown
- 1992-11-26 HK HK950/92A patent/HK95092A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATA86690A (de)	1994-09-15
HK95092A (en)	1992-12-04
NO176098C (no)	1995-02-01
GB8908587D0 (en)	1989-06-01
MA21805A1 (fr)	1990-12-31
IN175799B (da)	1995-08-26
PT93736A (pt)	1990-11-20
GR1000355B (el)	1992-06-25
NZ233250A (en)	1991-03-26
DK91890A (da)	1990-10-16
US5019576A (en)	1991-05-28
ES2019554A6 (es)	1991-06-16
NO901631D0 (no)	1990-04-10
AR247736A1 (es)	1995-03-31
AU5326190A (en)	1990-11-01
GB2230262A (en)	1990-10-17
TNSN90051A1 (fr)	1991-03-05
NO901631L (no)	1990-10-16
DK91890D0 (da)	1990-04-11
ZA902566B (en)	1991-01-30
SG92092G (en)	1992-12-04
FI901883A0 (fi)	1990-04-12
DZ1407A1 (fr)	2004-09-13
JP2633709B2 (ja)	1997-07-23
JPH02292266A (ja)	1990-12-03
GR900100270A (en)	1991-09-27
CA2014521C (en)	1997-09-09
KR900016178A (ko)	1990-11-12
SE505186C2 (sv)	1997-07-14
FR2645743B1 (fr)	1992-06-05
BE1007245A3 (fr)	1995-05-02
IT1241631B (it)	1994-01-25
GB9007612D0 (en)	1990-05-30
FI92058B (fi)	1994-06-15
DE4011925A1 (de)	1990-10-18
AU631334B2 (en)	1992-11-19
CH681301A5 (da)	1993-02-26
FR2645859A1 (fr)	1990-10-19
SE9001269L (sv)	1990-10-16
IE65058B1 (en)	1995-10-04
PT93736B (pt)	1996-09-30
IT9020020A1 (it)	1991-10-12
NL9000798A (nl)	1990-11-01
SE9001269D0 (sv)	1990-04-06
AT399337B (de)	1995-04-25
CA2014521A1 (en)	1990-10-15
IE901314L (en)	1990-10-15
GB2230262B (en)	1992-02-26
IT9020020A0 (it)	1990-04-12
OA09446A (fr)	1992-10-15
FR2645743A1 (fr)	1990-10-19
FR2645859B1 (fr)	1992-06-05
NO176098B (no)	1994-10-24
FI92058C (fi)	1994-09-26

Similar Documents

Publication	Publication Date	Title
EP0042781B1 (fr)	1985-03-06	Nouveaux dérivés de (quinolyl-4)-1 (pipéridyl ou pyrrolidinyl-2 ou -3)-2 ou -3 éthanone ou propanone, procédés pour leur préparation, et leur utilisation comme médicaments
CH640837A5 (fr)	1984-01-31	Derives de l'imidazole.
EP0073161B1 (fr)	1986-10-22	Nouveaux dérivés de la pyrazine actifs sur le système nerveux central
BE1007245A3 (fr)	1995-05-02	Derives di-substitues des n, n'-ditrimethoxybenzoyle piperazine, un procede pour leur preparation et compositions therapeutiques en contenant.
CH680440A5 (da)	1992-08-31
EP0110755A1 (fr)	1984-06-13	Dérivés de la pipéridinedione protecteurs du myocarde présentant une activité antiarythmique, leur procédé de préparation et les médicaments qui contiennent lesdits dérivés
FR2468601A1 (fr)	1981-05-08	Nouveaux derives de flavanne utiles notamment comme anticonvulsivants
EP0239461A1 (fr)	1987-09-30	Dérivés de N-¬¬(hydroxy-2 phényl) (phényl) méthylène amino-2 éthyl acétamide, leur préparation et leur application en thérapeutique
EP0418933A1 (fr)	1991-03-27	Dérivés d'alcadiènes, leurs préparations, les médicaments les contenant et produits intermédiaires
EP0301936B1 (fr)	1992-12-16	Dérivés de pipéridine, leur préparation et leur application en thérapeutique
CA1209995A (fr)	1986-08-19	Procede pour la preparation de composes de nicotinamide 1-oxyde n-substitue et de ses sels, et les composes et sels ainsi obtenus
BE1003519A3 (fr)	1992-04-14	Nouveaux derives de la carbonyl-2 n,n'-di-(trimethoxybenzoyle) piperazine, un procede pour leur preparation et compositions therapeutiques en contenant.
FR2551063A1 (fr)	1985-03-01	Nouveaux dimethyl-2,5 pyrroles, leur procede de preparation et leur application en therapeutique
EP0294258A1 (fr)	1988-12-07	Dérivés d'hydrazine, procédé d'obtention et compositions pharmaceutiques les contenant
EP0002401B1 (fr)	1980-12-10	Dérivés de naphtalène, leur préparation et leur application en thérapeutique
FR2560873A1 (fr)	1985-09-13	Medicaments a base de derives de la piperidine, nouveaux derives de la piperidine et leurs procedes de preparation
BE1003518A3 (fr)	1992-04-14	Nouveaux derives de la methoxycarbonyl-2-n,n'-di-(trimethoxybenzoyle) piperazine, un procede pour leur preparation et compositions therapeutiques en contenant.
CA1123436A (fr)	1982-05-11	Derives du dithiepinno ¬1,4\|¬2,3-c\|pyrrole, leur preparation et les medicaments qui les contiennent
EP0221820B1 (fr)	1990-01-03	Dérivés de l'imino-3 pyridazine, procédé d'obtention et compositions pharmaceutiques en contenant
LU83827A1 (fr)	1982-05-07	Nouveaux composes heterocycliques azotes anti-inflammatoires et immunoregulateurs et composition pharmaceutique les contenant
EP0210885B1 (fr)	1990-07-11	Dérivés d'alcools primaires halogéno biphényles utiles en thérapeutique dans le traitement de l'athérosclérose
FR2692894A1 (fr)	1993-12-31	Aryl-1-(o-alcoxy-phényl-4-pipérazinyl-1)-2, 3- ou 4-alcanols, leur procédé de préparation et leur utilisation pour la préparation de médicaments.
EP0054593B1 (fr)	1985-03-13	Dérivés du pyrrole protecteurs du myocarde ayant une activité antiarythmique et antiagrégante plaquettaire, leur procédé de préparation et les médicaments en contenant
MC1054A1 (fr)	1976-02-20	Nouveaux ethers d'enol basiques,leurs sels et procedes pour leur preparation
BE806805A (fr)	1974-02-15	Composes d'acide tetrahydro-indazol-5-carboxylique, leurs sels metalliques et leurs procedes de production