LU90311I2 - Précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en particulier le sel mésylate de celui-ci - Google Patents

Précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en particulier le sel mésylate de celui-ci

Info

Publication number: LU90311I2
Authority: LU; Luxembourg
Prior art keywords: amino acid; precursors; prodrugs; alatrofloxacin; trovafloxacin
Prior art date: 1989-08-16

Application number

LU90311C

Other languages

English (en)

French (fr)

Inventor

Katherine Elizabeth Brighty

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-16

Filing date

1998-11-04

Publication date

1999-01-25

1998-11-04 Application filed by Pfizer filed Critical Pfizer

1999-01-25 Publication of LU90311I2 publication Critical patent/LU90311I2/xx

Links

229940002612 prodrug Drugs 0.000 title abstract 2
239000000651 prodrug Substances 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
125000000539 amino acid group Chemical group 0.000 title 3
239000002243 precursor Substances 0.000 title 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title 1
UUZPPAMZDFLUHD-VUJLHGSVSA-N alatrofloxacin Chemical compound C([C@@H]1[C@H]([C@@H]1C1)NC(=O)[C@H](C)NC(=O)[C@@H](N)C)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F UUZPPAMZDFLUHD-VUJLHGSVSA-N 0.000 title 1
229960000919 alatrofloxacin Drugs 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
229920001184 polypeptide Chemical group 0.000 title 1
108090000765 processed proteins & peptides Chemical group 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 title 1
229960000497 trovafloxacin Drugs 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
-1 quinolone carboxylic acids Chemical class 0.000 abstract 2
XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 abstract 1
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
125000006519 CCH3 Chemical group 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
AQIAIZBHFAKICS-UHFFFAOYSA-N methylaminomethyl Chemical compound [CH2]NC AQIAIZBHFAKICS-UHFFFAOYSA-N 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
General Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

LU90311C 1989-08-16 1998-11-04 Précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en particulier le sel mésylate de celui-ci LU90311I2 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/003489 WO1991002526A1 (en)	1989-08-16	1989-08-16	Azabicyclo quinolone carboxylic acids

Publications (1)

Publication Number	Publication Date
LU90311I2 true LU90311I2 (fr)	1999-01-25

Family

ID=22215165

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LU90311C LU90311I2 (fr)	1989-08-16	1998-11-04	Précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en particulier le sel mésylate de celui-ci
LU90310C LU90310I2 (fr)	1989-08-16	1998-11-04	Trovafloxacine et ses sels pharmaceutiquement acceptables en particulier le sel mésylate de celui-ci et les précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en parti

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LU90310C LU90310I2 (fr)	1989-08-16	1998-11-04	Trovafloxacine et ses sels pharmaceutiquement acceptables en particulier le sel mésylate de celui-ci et les précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en parti

Country Status (29)

Country	Link
EP (1)	EP0413455B1 (el)
JP (2)	JPH072734B2 (el)
KR (1)	KR930004844B1 (el)
CN (1)	CN1025192C (el)
AT (1)	ATE124040T1 (el)
AU (1)	AU623801B2 (el)
BA (1)	BA98299A (el)
CA (2)	CA2127561C (el)
CY (2)	CY1969A (el)
CZ (1)	CZ281127B6 (el)
DD (1)	DD298399A5 (el)
DE (3)	DE19875050I2 (el)
DK (1)	DK0413455T3 (el)
EG (1)	EG19251A (el)
ES (1)	ES2074131T4 (el)
FI (2)	FI108228B (el)
GR (1)	GR3017072T3 (el)
HU (2)	HU219403B (el)
IE (1)	IE66202B1 (el)
IL (1)	IL95331A (el)
LU (2)	LU90311I2 (el)
NL (2)	NL980032I2 (el)
NO (1)	NO300214B1 (el)
NZ (1)	NZ234920A (el)
PL (1)	PL166381B1 (el)
PT (1)	PT94998B (el)
RU (1)	RU2049777C1 (el)
WO (1)	WO1991002526A1 (el)
ZA (1)	ZA906450B (el)

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US5527910A (en) *	1992-12-30	1996-06-18	Cheil Foods & Chemicals, Inc.	Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5591766A (en) *	1993-12-03	1997-01-07	Cheil Foods & Chemicals, Inc.	Solid oral formulations of pyridone carboxylic acids
US5990106A (en) *	1994-02-04	1999-11-23	Dainippon Pharmaceutical Co., Ltd.	Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
WO1996023782A1 (en) *	1995-02-02	1996-08-08	Daiichi Pharmaceutical Co., Ltd.	Heterocyclic compounds
JPH08213881A (ja) *	1995-02-02	1996-08-20	Fujitsu Ltd	周波数制御回路
WO1996024593A1 (en) *	1995-02-07	1996-08-15	Daiichi Pharmaceutical Co., Ltd.	Heterocyclic spiro derivatives
DK0789697T3 (da) *	1995-06-06	1998-10-19	Pfizer	Krystalform af vandfrit 7-([1alfa, 5alfa, 6alfa,]-6-amino-3-azabicyclo[3.1.0]hex-3-yl)-6-fluor-1-(2,4-difluorphenyl)-1,4-d
DE69622715T2 (de) *	1995-06-15	2002-11-14	Pfizer Inc., New York	Verfahren zur herstellung von derivaten der ein peptid enthaltenden azabizylo-naphtyridin-carbonsäure
ATE229950T1 (de) *	1996-02-09	2003-01-15	Toyama Chemical Co Ltd	Chinolin carbonsaure-derivate und ihre salze
AP788A (en) *	1996-08-26	1999-12-03	Pfizer	Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
TW519542B (en) *	1996-09-27	2003-02-01	Daiichi Seiyaku Co	Bicyclic amine derivative
US6384050B1 (en) *	1996-10-25	2002-05-07	Daiichi Pharmaceutical Co., Ltd.	Tricyclic amine derivatives
MA24500A1 (fr)	1997-03-21	1998-10-01	Lg Life Sciences Ltd	Derive du sel d'acide carboxylique de naphthyridine .
US20020032216A1 (en)	1997-03-21	2002-03-14	Lg Chemical Ltd.	Salt of naphthyridine carboxylic acid derivative
DE19733439A1 (de) *	1997-08-02	1999-02-04	Bayer Ag	Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften
SK286420B6 (sk)	1997-09-15	2008-09-05	The Procter & Gamble Company	Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
US6184380B1 (en) *	1999-01-25	2001-02-06	Pfizer Inc.	Process for preparing naphthyridones and intermediates
US7019142B2 (en)	1998-01-16	2006-03-28	Pfizer Inc.	Process for preparing naphthyridones and intermediates
PA8464701A1 (es) *	1998-01-16	2000-09-29	Pfizer Prod Inc	Procedimiento e intermedios para preparar naftiridonas
GB9820405D0 (en) *	1998-09-18	1998-11-11	Smithkline Beecham Plc	Process
AU3192700A (en)	1999-03-17	2000-10-04	Daiichi Pharmaceutical Co., Ltd.	Medicinal compositions
GB9920919D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel compound
GB9920917D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel process
ATE304539T1 (de)	2000-12-14	2005-09-15	Procter & Gamble	Antimikrobielle chinolone
HUP0303457A3 (en)	2000-12-14	2008-05-28	Procter & Gamble	Antimicrobial 2-pyridones, compositions containing them and their use
KR100517638B1 (ko)	2002-04-08	2005-09-28	주식회사 엘지생명과학	게미플록사신 산염의 새로운 제조방법
AU2002345266B2 (en)	2002-07-08	2009-07-02	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
EP1534675B1 (en)	2002-08-23	2009-02-25	Ranbaxy Laboratories, Ltd.	Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists
EP1618091A1 (en)	2003-04-09	2006-01-25	Ranbaxy Laboratories, Ltd.	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EA009059B1 (ru)	2003-04-10	2007-10-26	Рэнбакси Лабораториз Лимитед	Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
JP2006522787A (ja)	2003-04-11	2006-10-05	ランバクシーラボラトリーズリミテッド	ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体
WO2005026147A1 (ja)	2003-09-10	2005-03-24	Kyorin Pharmaceutical Co., Ltd.	７−（４−置換−３−シクロプロピルアミノメチル−１−ピロリジニル）キノロンカルボン酸誘導体
EP1670759A1 (en) *	2003-09-18	2006-06-21	Ranbaxy Laboratories Limited	PROCESS FOR THE PREPARATION OF (1a, 5a, 6a)-6-AMINOME THYL-3-BENZYL-3-AZABICYCLO 3.1.0 HEXANE
TWI391378B (zh) *	2006-03-16	2013-04-01	Astellas Pharma Inc	喹啉酮衍生物或其製藥學上可被容許之鹽
MX2008012488A (es)	2006-03-28	2008-10-10	Procter & Gamble	Un proceso de acoplamiento para preparar intermedios de quinolona.
EP2001862B1 (en)	2006-03-28	2011-04-27	Warner Chilcott Company, LLC	Malate salts, and polymorphs of (3s,5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
US7902227B2 (en) *	2007-07-27	2011-03-08	Janssen Pharmaceutica Nv.	C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
BR112013007566A2 (pt)	2010-09-28	2016-08-02	Panacea Biotec Ltd	novos compostos bicíclicos
WO2020073031A1 (en) *	2018-10-05	2020-04-09	New York University	Fused bicyclic heterocycles as thereapeutic agents
CN112442084B (zh) *	2020-12-03	2022-09-09	国药集团致君（深圳）制药有限公司	一种抗菌药中间体的制备方法
CN113307768B (zh) *	2021-04-29	2023-12-12	中国农业科学院兰州畜牧与兽药研究所	喹诺酮类衍生物及其制备方法和用途

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1989
- 1989-08-16 WO PCT/US1989/003489 patent/WO1991002526A1/en not_active Ceased
- 1989-08-16 PL PL90286484A patent/PL166381B1/pl unknown
- 1989-08-16 RU SU5011662/04A patent/RU2049777C1/ru not_active IP Right Cessation
- 1989-08-16 IE IE295090A patent/IE66202B1/en not_active IP Right Cessation
- 1989-08-16 HU HU9200460A patent/HU219403B/hu not_active IP Right Cessation
1990
- 1990-07-30 DE DE19875050C patent/DE19875050I2/de active Active
- 1990-07-30 DE DE69020262T patent/DE69020262T2/de not_active Expired - Fee Related
- 1990-07-30 DE DE19875052C patent/DE19875052I2/de active Active
- 1990-07-30 AT AT90308331T patent/ATE124040T1/de active
- 1990-07-30 ES ES90308331T patent/ES2074131T4/es not_active Expired - Lifetime
- 1990-07-30 EP EP90308331A patent/EP0413455B1/en not_active Expired - Lifetime
- 1990-07-30 DK DK90308331.9T patent/DK0413455T3/da active
- 1990-08-09 IL IL9533190A patent/IL95331A/en not_active IP Right Cessation
- 1990-08-14 CA CA002127561A patent/CA2127561C/en not_active Expired - Lifetime
- 1990-08-14 KR KR1019900012528A patent/KR930004844B1/ko not_active Expired - Fee Related
- 1990-08-14 EG EG48390A patent/EG19251A/xx active
- 1990-08-14 PT PT94998A patent/PT94998B/pt not_active IP Right Cessation
- 1990-08-14 CA CA002023217A patent/CA2023217C/en not_active Expired - Lifetime
- 1990-08-15 NZ NZ234920A patent/NZ234920A/en unknown
- 1990-08-15 CN CN90106794A patent/CN1025192C/zh not_active Expired - Fee Related
- 1990-08-15 DD DD90343474A patent/DD298399A5/de unknown
- 1990-08-15 AU AU61042/90A patent/AU623801B2/en not_active Expired
- 1990-08-15 ZA ZA906450A patent/ZA906450B/xx unknown
- 1990-08-16 CZ CS904027A patent/CZ281127B6/cs not_active IP Right Cessation
- 1990-08-16 JP JP2216461A patent/JPH072734B2/ja not_active Expired - Fee Related
1992
- 1992-02-14 NO NO920599A patent/NO300214B1/no not_active IP Right Cessation
- 1992-02-14 FI FI920632A patent/FI108228B/fi active Protection Beyond IP Right Term
1994
- 1994-07-08 JP JP6157008A patent/JPH0819099B2/ja not_active Expired - Fee Related
1995
- 1995-06-22 HU HU95P/P00380P patent/HU211681A9/hu unknown
- 1995-08-09 GR GR950402200T patent/GR3017072T3/el unknown
1996
- 1996-11-11 FI FI964520A patent/FI103879B/fi active
1997
- 1997-09-05 CY CY196997A patent/CY1969A/xx unknown
1998
- 1998-03-30 BA BA980299A patent/BA98299A/bs unknown
- 1998-11-04 LU LU90311C patent/LU90311I2/xx unknown
- 1998-11-04 LU LU90310C patent/LU90310I2/xx unknown
- 1998-11-17 NL NL980032C patent/NL980032I2/nl unknown
- 1998-11-17 NL NL980033C patent/NL980033I2/nl unknown
1999
- 1999-05-24 CY CY1999010C patent/CY99010I2/el unknown

Also Published As

Publication number	Publication date
EP0413455A2 (en)	1991-02-20
FI103879B1 (fi)	1999-10-15
PT94998A (pt)	1991-04-18
GR3017072T3 (en)	1995-11-30
NO300214B1 (no)	1997-04-28
FI964520A0 (fi)	1996-11-11
CN1025192C (zh)	1994-06-29
CA2127561A1 (en)	1991-02-17
AU623801B2 (en)	1992-05-21
NO920599D0 (no)	1992-02-14
NZ234920A (en)	1992-06-25
NL980032I2 (nl)	1999-05-03
BA98299A (bs)	2001-09-14
DE19875052I2 (de)	2009-05-28
ZA906450B (en)	1992-03-25
KR910004572A (ko)	1991-03-28
CY1969A (en)	1997-09-05
JPH07149758A (ja)	1995-06-13
HU211681A9 (en)	1995-12-28
EP0413455A3 (en)	1991-10-09
PT94998B (pt)	1997-05-28
AU6104290A (en)	1991-02-21
CZ402790A3 (en)	1996-04-17
FI108228B (fi)	2001-12-14
DK0413455T3 (da)	1995-08-14
NL980032I1 (nl)	1999-02-01
FI920632A0 (fi)	1992-02-14
ES2074131T3 (es)	1995-09-01
HU219403B (hu)	2001-04-28
JPH072734B2 (ja)	1995-01-18
IL95331A0 (en)	1991-06-30
CZ281127B6 (cs)	1996-06-12
KR930004844B1 (ko)	1993-06-09
PL166381B1 (pl)	1995-05-31
CN1049501A (zh)	1991-02-27
DE19875050I2 (de)	2009-05-28
ES2074131T4 (es)	1996-05-01
DD298399A5 (de)	1992-02-20
NL980033I1 (nl)	1999-02-01
DE69020262T2 (de)	1995-10-26
HK1000207A1 (en)	1998-02-06
IE66202B1 (en)	1995-12-13
JPH0386875A (ja)	1991-04-11
IE902950A1 (en)	1991-02-27
IL95331A (en)	1995-07-31
WO1991002526A1 (en)	1991-03-07
FI964520L (fi)	1996-11-11
CA2023217C (en)	1996-12-10
NL980033I2 (nl)	1999-05-03
EP0413455B1 (en)	1995-06-21
FI103879B (fi)	1999-10-15
CA2127561C (en)	1998-07-28
JPH0819099B2 (ja)	1996-02-28
NO920599L (no)	1992-04-14
PL286484A1 (en)	1991-05-20
LU90310I2 (fr)	1999-01-25
CY99010I2 (en)	2010-07-28
EG19251A (en)	1994-09-29
RU2049777C1 (ru)	1995-12-10
ATE124040T1 (de)	1995-07-15
CA2023217A1 (en)	1991-02-17
DE69020262D1 (de)	1995-07-27

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