LU90484I2 - Novorapid - insuline asparte et ses sels et derives pharmaceutiquement acceptables - Google Patents

Novorapid - insuline asparte et ses sels et derives pharmaceutiquement acceptables

Info

Publication number
LU90484I2
LU90484I2 LU90484C LU90484C LU90484I2 LU 90484 I2 LU90484 I2 LU 90484I2 LU 90484 C LU90484 C LU 90484C LU 90484 C LU90484 C LU 90484C LU 90484 I2 LU90484 I2 LU 90484I2
Authority
LU
Luxembourg
Prior art keywords
novorapid
derivatives
pharmaceutically acceptable
acceptable salts
insulin aspart
Prior art date
Application number
LU90484C
Other languages
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK395685A external-priority patent/DK395685D0/da
Priority claimed from DK467785A external-priority patent/DK467785D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of LU90484I2 publication Critical patent/LU90484I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
LU90484C 1985-08-30 1999-12-21 Novorapid - insuline asparte et ses sels et derives pharmaceutiquement acceptables LU90484I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK395685A DK395685D0 (da) 1985-08-30 1985-08-30 Peptider
DK467785A DK467785D0 (da) 1985-10-14 1985-10-14 Peptider

Publications (1)

Publication Number Publication Date
LU90484I2 true LU90484I2 (fr) 2000-02-21

Family

ID=26067291

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90484C LU90484I2 (fr) 1985-08-30 1999-12-21 Novorapid - insuline asparte et ses sels et derives pharmaceutiquement acceptables

Country Status (25)

Country Link
US (1) US5618913A (fr)
EP (1) EP0214826B1 (fr)
JP (1) JP2662390B2 (fr)
KR (1) KR940000756B1 (fr)
CN (1) CN1029977C (fr)
AR (1) AR241801A1 (fr)
AT (1) ATE113061T1 (fr)
AU (1) AU593274B2 (fr)
CA (1) CA1306212C (fr)
CS (1) CS275613B6 (fr)
DD (1) DD268976A5 (fr)
DE (2) DE3650101T2 (fr)
ES (1) ES2001624A6 (fr)
FI (1) FI102182B (fr)
GR (1) GR862233B (fr)
HU (1) HU206518B (fr)
IE (1) IE66138B1 (fr)
IL (1) IL79887A (fr)
LU (1) LU90484I2 (fr)
NL (1) NL990042I2 (fr)
NO (2) NO177009C (fr)
NZ (1) NZ217406A (fr)
PH (1) PH25772A (fr)
PT (1) PT83278B (fr)
YU (2) YU46023B (fr)

Families Citing this family (221)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
WO1988006599A1 (fr) * 1987-02-25 1988-09-07 Novo Industri A/S Nouveaux derives d'insuline
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
US4992417A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogues
CA1340772C (fr) 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression et secretion de proteines heterologues dans une levure au moyen de sequences leader tronquees du facteur alpha
ATE93238T1 (de) * 1988-07-20 1993-09-15 Novo Nordisk As Menschliche insulinanalage und zubereitungen daraus.
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
HUT56857A (en) * 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
AU631868B2 (en) * 1989-04-20 1992-12-10 Mount Sinai School Of Medicine Of The City University Of New York, The Hepatospecific insulin analogues
US5208217A (en) * 1989-04-20 1993-05-04 Mount Sinai School Of Medicine Of The City University Of New York Hepatospecific insulin analogues
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
DK158390D0 (da) * 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
DK10191D0 (da) * 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
DK33591D0 (fr) * 1991-02-27 1991-02-27 Novo Nordisk As
NO922376L (no) * 1991-06-21 1992-12-22 Lilly Co Eli Insulinanaloger
JPH08504820A (ja) * 1992-12-18 1996-05-28 イーライ・リリー・アンド・カンパニー インシュリン類似体
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
JP2837956B2 (ja) * 1993-06-21 1998-12-16 ノボ ノルディスク アクティーゼルスカブ Ａｓｐ▲上Ｂ２８▼インスリン結晶
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
AU3562195A (en) * 1994-10-04 1996-04-26 Novo Nordisk A/S Preparations containing aspb28 human insulin and nicotinamide
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5646242A (en) 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
PT921812E (pt) * 1996-06-20 2002-04-29 Novo Nordisk As Preparacoes de insulina contendo um halogenuro
ZA984697B (en) * 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
SV1998000125A (es) 1997-10-24 1999-05-24 Lilly Co Eli Composiciones de insulina insoluble ref. x-11232
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
NZ506447A (en) * 1998-02-23 2002-11-26 Neurocrine Biosciences Inc Peptide analogues of insulin with alanine substitutions and pharmaceutical use
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
PT1141014E (pt) 1999-01-06 2005-04-29 Genentech Inc Variante mutante do factor de crescimento semelhante a insulina (igf-i)
DE60042550D1 (de) 1999-01-06 2009-08-27 Genentech Inc Mutierte varianten des insulin-ähnlichen wachstumsfaktor i (igf-i)
US6746853B1 (en) * 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
CN1125081C (zh) * 1999-09-08 2003-10-22 中国科学院上海生物化学研究所 重组天然和新型人胰岛素及其制备方法
US7022674B2 (en) * 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
JP2003528149A (ja) 2000-03-24 2003-09-24 ジェネンテック・インコーポレーテッド 軟骨性疾患の治療のためのインスリンの使用
AU2001254621A1 (en) * 2000-05-05 2001-11-20 K.U. Leuven R And D Critical illness neuropathy
ES2301547T3 (es) 2000-05-16 2008-07-01 Genentech, Inc. Tratamiento de trastornos del cartilago.
AR025646A1 (es) * 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
EP1444219A1 (fr) 2001-10-12 2004-08-11 Novo Nordisk A/S Piperidines substituees et leur utilisation dans le traitement de maladies liees au recepteur histaminique h3
ATE464390T1 (de) 2001-11-19 2010-04-15 Novo Nordisk As Verfahren zur herstellung von insulinverbindungen
GB0206792D0 (en) 2002-03-22 2002-05-01 Leuven K U Res & Dev Normoglycemia
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US7193035B2 (en) 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
US7871607B2 (en) * 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
EP1618090A1 (fr) 2003-04-11 2006-01-25 Novo Nordisk A/S COMPOSES ACTIFS DE LA 11ß-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1
EP1641616B1 (fr) 2003-06-27 2011-04-13 Novo Nordisk A/S Contenant a fort effet de barriere contre l'humidite pour compositions medicales liquides
US20060183667A1 (en) * 2003-07-11 2006-08-17 Novo Nordisk A/S Stabilised insulin compositions
EP1644411A2 (fr) * 2003-07-11 2006-04-12 Novo Nordisk A/S Compositions d'insuline stabilisee
SI1648933T1 (sl) * 2003-07-25 2010-01-29 Conjuchem Biotechnologies Inc Dolgo delujoäś inzulinski derivat in metoda zanj
KR101159559B1 (ko) 2003-08-05 2012-06-26 노보 노르디스크 에이/에스 신규의 인슐린 유도체
KR101186851B1 (ko) 2003-08-05 2012-10-02 노보 노르디스크 에이/에스 신규의 인슐린 유도체
WO2005046716A1 (fr) * 2003-11-13 2005-05-26 Novo Nordisk A/S Compositions pharmaceutiques solubles destinées à l'administration parentérale comprenant un peptide glp-1 et un peptide d'insuline à temps d'action de courte durée, utiles pour le traitement du diabète et de la boulimie
US20060287221A1 (en) * 2003-11-13 2006-12-21 Novo Nordisk A/S Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia
DK3300721T4 (da) 2003-11-20 2025-03-03 Novo Nordisk As Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger
JP5697831B2 (ja) 2003-12-03 2015-04-08 ノヴォ ノルディスク アー／エス 単鎖インシュリン
CN1898087A (zh) 2003-12-22 2007-01-17 诺沃挪第克公司 用于储存药物液体的透明、柔性、不可渗透的塑料容器
EP2368579A1 (fr) 2004-01-21 2011-09-28 Novo Nordisk Health Care AG Conjugaison au moyen de transglutaminase de peptides
MX2007000883A (es) 2004-07-19 2007-04-02 Biocon Ltd Conjugados de insulina-oligomero, formulaciones y usos de los mismos.
CN101115900B (zh) 2004-11-04 2012-03-07 亨特道格拉斯有限公司 用于建筑开口的单轨道层叠板体遮蔽件
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
EP2256130B1 (fr) 2005-02-02 2013-09-25 Novo Nordisk A/S Nouveaux dérivés d'insuline
JP5410020B2 (ja) 2005-02-02 2014-02-05 ノヴォ ノルディスク アー／エス インスリン誘導体
MX2007015675A (es) 2005-07-04 2008-02-20 Novo Nordisk As Antagonistas del receptor de histamina h3.
WO2007015805A1 (fr) 2005-07-20 2007-02-08 Eli Lilly And Company Composés joints en position 1-amino
CN101243190B (zh) 2005-08-16 2015-05-13 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
PT1926749E (pt) 2005-09-14 2011-09-29 Sanofi Aventis Deutschland Clivagem de precursores de insulinas por uma variante de tripsina
WO2007123581A1 (fr) 2005-11-17 2007-11-01 Eli Lilly And Company Antagonistes des récepteurs du glucagon, leur préparation et leurs utilisations thérapeutiques
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
US8343914B2 (en) * 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
US20090069216A1 (en) * 2006-02-21 2009-03-12 Novo Nordisk A/S Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
DE602007009496D1 (de) 2006-02-27 2010-11-11 Novo Nordisk As Insulinderivate
ES2397659T3 (es) 2006-03-15 2013-03-08 Novo Nordisk A/S Mezclas de amilina e insulina
CN101410385B (zh) 2006-03-28 2011-08-24 高点制药有限责任公司 具有组胺h3受体活性的苯并噻唑类
JP5118692B2 (ja) 2006-04-24 2013-01-16 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロヘキシル置換ピロリジノン
US8796205B2 (en) 2006-05-09 2014-08-05 Novo Nordisk A/S Insulin derivative
EP2015770B1 (fr) 2006-05-09 2012-09-26 Novo Nordisk A/S Dérivé d'insuline
KR20090040259A (ko) 2006-05-29 2009-04-23 하이 포인트 파마슈티칼스, 엘엘씨 3-(1,3-벤조디옥솔-5-일)-6-(4-시클로프로필피페라진-1-일)-피리다진, 그것의 염과 용매화합물 및 그것의 히스타민 ｈ3 수용체 안타고니스트로서의 용도
JP2009539778A (ja) * 2006-06-08 2009-11-19 ダイアベコア メディカル インコーポレイテッド インスリンオリゴマー誘導体
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
EP2049149B1 (fr) 2006-07-31 2015-04-15 Novo Nordisk A/S Insulines pegylées à extensions
EP2404934A1 (fr) * 2006-09-22 2012-01-11 Novo Nordisk A/S Analogues d'insuline résistants à la protéase
ES2554773T3 (es) * 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
WO2008049711A1 (fr) * 2006-10-27 2008-05-02 Novo Nordisk A/S Insuline à peptide ajouté
US20120214963A1 (en) * 2011-02-23 2012-08-23 Elona Biotechnologies Aspart proinsulin compositions and methods of producing aspart insulin analogs therefrom
US10100098B2 (en) 2006-12-13 2018-10-16 Stelis Biopharma Private Limited Insulin production methods and proinsulin constructs
ES2563038T3 (es) 2007-04-30 2016-03-10 Novo Nordisk A/S Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca
WO2008139496A1 (fr) * 2007-05-16 2008-11-20 Bigtec Private Limited Insuline humaine de recombinaison et méthode associée
US20100190706A1 (en) 2007-06-01 2010-07-29 Novo Nordisk A/S Stable Non-Aqueous Pharmaceutical Compositions
EP2164466A1 (fr) 2007-06-01 2010-03-24 Novo Nordisk A/S Préconcentrés spontanément dispersibles comprenant un médicament peptidique dans un excipient solide ou semi-solide
WO2008152106A1 (fr) 2007-06-13 2008-12-18 Novo Nordisk A/S Formulation pharmaceutique contenant un dérivé d'insuline
EP2178911A2 (fr) * 2007-08-13 2010-04-28 Novo Nordisk A/S Analogues de l'insuline à action rapide
ES2558930T3 (es) 2007-08-13 2016-02-09 Novo Nordisk A/S Análogos de la insulina de acción rápida
CN101784563B (zh) 2007-08-15 2015-02-04 诺沃-诺迪斯克有限公司 具有包括含亚烷基二醇的氨基酸的重复单位的酰基部分的胰岛素
KR20100053561A (ko) 2007-08-15 2010-05-20 노보 노르디스크 에이/에스 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체
US8946148B2 (en) 2007-11-20 2015-02-03 Ambrx, Inc. Modified insulin polypeptides and their uses
PL2229407T3 (pl) 2008-01-09 2017-06-30 Sanofi-Aventis Deutschland Gmbh Nowe pochodne insuliny o ekstremalnie spowolnionym profilu czasu działania
MX2010009850A (es) 2008-03-18 2010-09-30 Novo Nordisk As Analogos de insulina acilados y etabilizados contra proteasas.
ES2563553T3 (es) 2008-04-01 2016-03-15 Novo Nordisk A/S Conjugados de insulina-albúmina
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
CN102065885A (zh) * 2008-04-22 2011-05-18 卡斯西部储备大学 同种型特异性的胰岛素类似物
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
KR20110059602A (ko) 2008-08-07 2011-06-02 바이오콘 리미티드 인슐린 화합물의 제조방법
DE102008051834A1 (de) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
EP3228320B1 (fr) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Combinaison d'une insuline et d'un antagoniste glp 1
DE102009038210A1 (de) 2009-08-20 2011-03-03 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
DE102008053048A1 (de) 2008-10-24 2010-04-29 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
CA2738615A1 (fr) 2008-10-30 2010-05-06 Novo Nordisk A/S Traitement du diabete a l'aide d'injections d'insuline avec une frequence inferieure a une injection par jour
MX2011005037A (es) 2008-11-21 2011-06-16 High Point Pharmaceuticals Llc Compuestos de adamantilo benzamida.
US9018190B2 (en) 2009-03-27 2015-04-28 Adocia Functionalized oligosaccharides
FR2943538B1 (fr) 2009-03-27 2011-05-20 Adocia Formulation a action rapide d'insuline recombinante humaine
EP3202394A1 (fr) 2009-07-06 2017-08-09 Sanofi-Aventis Deutschland GmbH Préparations aqueuses de l´insuline contenant de la méthionine
EP2451471A1 (fr) 2009-07-06 2012-05-16 Sanofi-Aventis Deutschland GmbH Préparations d'insuline à effet retard
US20120241356A1 (en) 2009-07-06 2012-09-27 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
AU2010277559B2 (en) 2009-07-31 2016-08-11 Sanofi-Aventis Deutschland Gmbh Prodrugs comprising an insulin linker conjugate
PT2459171T (pt) 2009-07-31 2017-08-16 Sanofi Aventis Deutschland Composição de insulina de atuação longa
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
PT2554183T (pt) 2009-11-13 2018-07-09 Sanofi Aventis Deutschland Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
PE20121316A1 (es) 2009-11-13 2012-10-05 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1 y metionina
US8637096B2 (en) 2009-12-04 2014-01-28 Curtis C. Stojan Compositions and method for enhancing insulin activity
NZ600477A (en) 2009-12-11 2014-07-25 Univ Case Western Reserve Insulin analogues with chlorinated amino acids
EP2359843A1 (fr) 2010-01-21 2011-08-24 Sanofi Composition pharmaceutique pour le traitement d'un syndrome métabolique
UY33326A (es) 2010-04-14 2011-12-01 Sanofi Aventis Conjugados de insulina-sirna
EP2569002B1 (fr) 2010-05-10 2016-10-26 Novo Nordisk A/S Procédé de préparation de complexes d'insuline et de zinc
WO2011159895A2 (fr) 2010-06-16 2011-12-22 Indiana University Research And Technology Corporation Agonistes de l'insuline à une seule chaîne très actifs au niveau du récepteur à l'insuline
WO2011161125A1 (fr) 2010-06-23 2011-12-29 Novo Nordisk A/S Dérivés d'insuline contenant des liaisons disulfure supplémentaires
EP3572091B1 (fr) 2010-08-17 2023-12-13 Ambrx, Inc. Polypeptides de relaxine modifiés et leurs utilisations
US20140148384A1 (en) 2010-08-30 2014-05-29 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
EP2438930A1 (fr) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Promédicaments comprenant un conjugué de liaison d'exendine
SI2632478T1 (sl) 2010-10-27 2019-11-29 Novo Nordisk As Zdravljenje sladkorne bolezni z uporabo inzulinskih injekcij, ki se dajejo v različnih injicirnih intervalih
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
US20130331320A1 (en) 2010-12-14 2013-12-12 Novo Nordisk A/S Fast-acting insulin in combination with long-acting insulin
JP6110312B2 (ja) * 2011-02-01 2017-04-05 ノヴォ ノルディスク アー／エス インスリンの精製
EP2670368A4 (fr) 2011-02-03 2015-04-15 Pharmedica Ltd Nouveaux films à dissolution orale pour administration d'insuline, pour traitement du diabète
WO2012115638A1 (fr) 2011-02-23 2012-08-30 Elona Biotechnologies Compositions de pro-insuline glargine et procédés de production d'analogues de l'insuline glargine à partir de celles-ci
WO2012115637A1 (fr) * 2011-02-23 2012-08-30 Elona Biotechnologies Compositions de pro-insuline aspart et procédés de production d'analogues de l'insuline aspart
WO2012123519A2 (fr) 2011-03-15 2012-09-20 Novo Nordisk A/S Analogues de l'insuline humaine et dérivés comprenant des substitutions de cystéine
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
US20130011378A1 (en) 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
EP2548570A1 (fr) 2011-07-19 2013-01-23 Sanofi Composition pharmaceutique pour le traitement d'un syndrome métabolique
CN108079281A (zh) 2011-08-29 2018-05-29 赛诺菲-安万特德国有限公司 用于2型糖尿病患者中的血糖控制的药物组合
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US20130231281A1 (en) 2011-11-02 2013-09-05 Adocia Rapid acting insulin formulation comprising an oligosaccharide
EP2784085A4 (fr) 2011-12-15 2015-07-08 Shanghai Hengrui Pharm Co Ltd Analogue d'insuline humaine et son dérivé acylé
US9573987B2 (en) 2011-12-20 2017-02-21 Indiana University Research And Technology Corporation CTP-based insulin analogs for treatment of diabetes
KR20150002777A (ko) 2012-04-11 2015-01-07 노보 노르디스크 에이/에스 인슐린 제제
WO2013164375A1 (fr) 2012-05-01 2013-11-07 Novo Nordisk A/S Composition pharmaceutique
WO2013173923A1 (fr) 2012-05-25 2013-11-28 Diamedica, Inc. Formulations de kallikréine 1 de tissu humain pour l'administration parentérale et procédés associés
EP2854841B1 (fr) 2012-06-04 2017-02-22 Diamedica Inc. Isoformes de glycosylation de la kallikréine-1 tissulaire d'origine humaine
CN108383902A (zh) 2012-09-26 2018-08-10 印第安纳大学研究及科技有限公司 胰岛素类似物二聚体
KR20150082640A (ko) 2012-11-13 2015-07-15 아도시아 치환된 음이온성 화합물을 포함하는 속효성 인슐린 제형
JP6735561B2 (ja) 2012-12-03 2020-08-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｏ−グリコシル化カルボキシ末端部分（ｃｔｐ）ペプチド系のインスリンおよびインスリン類似体
US9867869B2 (en) 2012-12-12 2018-01-16 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment
MX360420B (es) 2012-12-19 2018-10-31 Wockhardt Ltd Una composicion acuosa estable que comprende insulina humana o un analogo o derivado de la misma.
MX2015006997A (es) 2012-12-26 2015-09-23 Wockhardt Ltd Composicion farmaceutica.
TWI641381B (zh) 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
WO2014158900A1 (fr) 2013-03-14 2014-10-02 Indiana University Research And Technology Corporation Conjugués d'insuline-incrétine
WO2014177623A1 (fr) 2013-04-30 2014-11-06 Novo Nordisk A/S Schéma d'administration d'un nouveau type
IN2013MU03124A (fr) 2013-09-30 2015-07-31 Wockhardt Ltd
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
RU2016132340A (ru) 2014-01-09 2018-02-14 Санофи Стабилизированные фармацевтические составы на основе инсулина аспарта
CN105899191B (zh) 2014-01-09 2020-06-16 赛诺菲 胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂
KR20160104724A (ko) 2014-01-09 2016-09-05 사노피 인슐린 유사체 및/또는 인슐린 유도체의 안정화된 약제학적 제형
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
US9656017B2 (en) 2014-06-20 2017-05-23 Howard E. Greene Infusion delivery devices and methods
WO2016001862A1 (fr) 2014-07-04 2016-01-07 Wockhardt Limited Formulations à libération prolongée d'insulines
ES2822994T3 (es) 2014-09-24 2021-05-05 Univ Indiana Res & Tech Corp Conjugados de incretina-insulina
CN107108716A (zh) 2014-10-06 2017-08-29 卡斯西部储备大学 双相性单链胰岛素类似物
SG10201809457YA (en) 2014-11-21 2018-11-29 Merck Sharp & Dohme Insulin receptor partial agonists
TWI758239B (zh) 2014-12-12 2022-03-21 德商賽諾菲阿凡提斯德意志有限公司 甘精胰島素/利司那肽固定比率配製劑
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
CN105884879A (zh) * 2015-01-26 2016-08-24 漳州博欣生物技术有限公司 一种胰岛素类似物的化学合成方法
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CA2996455A1 (fr) 2015-08-25 2017-03-02 Novo Nordisk A/S Nouveaux derives d'insuline et leurs utilisations medicales
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
WO2017180988A2 (fr) 2016-04-15 2017-10-19 Indiana University Research And Technology Corporation Optimisation peptidique à fgf21 c-terminal
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
EP3922260A3 (fr) 2016-05-24 2022-06-15 Merck Sharp & Dohme Corp. Agonistes partiels du récepteur de l'insuline et analogues du glp-1
WO2017205309A1 (fr) 2016-05-25 2017-11-30 Merck Sharp & Dohme Corp. Agonistes partiels du récepteur de l'insuline
TWI747929B (zh) 2016-08-02 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 一種人胰島素或其類似物的醯化衍生物
AU2017334290B2 (en) 2016-09-29 2023-04-20 Arecor Limited Novel formulations
MA49116A (fr) 2016-12-16 2020-03-25 Novo Nordisk As Compositions pharmaceutiques contenant de l'insuline
AU2018230478B2 (en) 2017-03-09 2025-01-23 Diamedica Inc. Dosage forms of tissue kallikrein 1
GB201707187D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
GB201707188D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
GB201707189D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
WO2018222787A1 (fr) 2017-06-01 2018-12-06 Eli Lilly And Company Compositions d'insuline à action rapide
PE20211264A1 (es) 2017-08-17 2021-07-15 Novo Nordisk As Analogos de insulina acilados novedosos y usos de estos
US20210113763A1 (en) 2018-04-04 2021-04-22 Arecor Limited Medical infusion pump system for the delivery of an insulin compound
IL277721B2 (en) 2018-04-04 2024-03-01 Arecor Ltd Medical infusion pump system for the delivery of an insulin compound
WO2019193349A1 (fr) 2018-04-04 2019-10-10 Arecor Limited Système de pompe à perfusion médicale pour l'administration d'un composé d'insuline
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
US12325732B2 (en) 2018-09-12 2025-06-10 Amphastar Nanjing Pharmaceuticals Inc Pro-insulin aspart structure and method for preparing insulin aspart
KR20200082618A (ko) 2018-12-31 2020-07-08 주식회사 폴루스 인슐린 과발현용 램프 태그 및 이를 이용한 인슐린의 제조방법
CN114096269B (zh) 2019-07-12 2024-06-11 诺和诺德股份有限公司 高浓度胰岛素制剂
FI4073097T3 (fi) * 2019-12-11 2024-08-13 Novo Nordisk As Uusia insuliinianalogeja ja niiden käyttötapoja
CN119060162A (zh) 2019-12-30 2024-12-03 甘李药业股份有限公司 长效glp-1化合物
CN118772259A (zh) 2019-12-30 2024-10-15 甘李药业股份有限公司 胰岛素衍生物
GB202004814D0 (en) 2020-04-01 2020-05-13 Arecor Ltd Novel formulations
EP4471053A1 (fr) 2022-01-28 2024-12-04 Gan & Lee Pharmaceuticals Co., Ltd. Insuline acylée
AR129357A1 (es) 2022-05-18 2024-08-14 Protomer Tech Inc Compuestos aromáticos que contienen boro y análogos de insulina relacionados

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2252157C3 (de) * 1972-10-25 1976-03-18 Hoechst Ag Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten
US4652525A (en) * 1978-04-19 1987-03-24 The Regents Of The University Of California Recombinant bacterial plasmids containing the coding sequences of insulin genes
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
US4340674A (en) * 1980-05-05 1982-07-20 The Upjohn Company Cointegrate plasmids and their construction from plasmids of Escherichia and Streptomyces
US4351901A (en) * 1980-03-24 1982-09-28 Cetus Corporation Method for single nucleotide alteration
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
ZA824218B (en) * 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
US5559094A (en) * 1994-08-02 1996-09-24 Eli Lilly And Company AspB1 insulin analogs

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CN86106574A (zh) 1988-08-03
CA1306212C (fr) 1992-08-11
ATE113061T1 (de) 1994-11-15
EP0214826A2 (fr) 1987-03-18
JPS6253999A (ja) 1987-03-09
EP0214826A3 (en) 1987-06-03
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AU6206686A (en) 1987-03-05
CN1029977C (zh) 1995-10-11
YU46857B (sh) 1994-06-24
CS275613B6 (en) 1992-03-18
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PH25772A (en) 1991-10-18
DD268976A5 (de) 1989-06-14
NO177009B (no) 1995-03-27
FI102182B1 (fi) 1998-10-30
DE10075008I1 (de) 2000-05-18
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AU593274B2 (en) 1990-02-08
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PT83278A (en) 1986-09-01
US5618913A (en) 1997-04-08
KR870002165A (ko) 1987-03-30
IL79887A (en) 1991-11-21
IL79887A0 (en) 1986-11-30
NO863474L (no) 1987-03-02
DE3650101D1 (de) 1994-11-24
PT83278B (pt) 1989-03-30
DE3650101T2 (de) 1995-02-23
IE862317L (en) 1987-02-28
NL990042I1 (nl) 2000-02-01
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EP0214826B1 (fr) 1994-10-19
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YU46023B (sh) 1992-12-21
DE10075008I2 (de) 2004-10-21
NO2000005I1 (no) 2000-07-21
CS8606310A2 (en) 1990-09-12
NO177009C (no) 1995-07-05
IE66138B1 (en) 1995-12-13
HU206518B (en) 1992-11-30
FI863512L (fi) 1987-03-01
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