LU91136I2 - 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte). - Google Patents

2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte).

Info

Publication number: LU91136I2
Authority: LU; Luxembourg
Prior art keywords: purin; dihydro; oxo; methoxy; amino
Prior art date: 1994-07-28

Application number

LU91136C

Other languages

English (en)

Original Assignee

Hoffmann Kla Roche Ag F

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-28

Filing date

2003-05-21

Publication date

2005-07-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91136(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-05-21 Application filed by Hoffmann Kla Roche Ag F filed Critical Hoffmann Kla Roche Ag F

2005-07-06 Publication of LU91136I2 publication Critical patent/LU91136I2/fr

Links

150000003839 salts Chemical class 0.000 title abstract 2
-1 2-Amino-1,6-dihydro-6-oxo-purin-9-yl Chemical group 0.000 title 1
WPVFJKSGQUFQAP-GKAPJAKFSA-N Valcyte Chemical compound N1C(N)=NC(=O)C2=C1N(COC(CO)COC(=O)[C@@H](N)C(C)C)C=N2 WPVFJKSGQUFQAP-GKAPJAKFSA-N 0.000 title 1
229940010343 valcyte Drugs 0.000 title 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

LU91136C 1994-07-28 2003-05-21 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte). LU91136I2 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28189394A	1994-07-28	1994-07-28

Publications (1)

Publication Number	Publication Date
LU91136I2 true LU91136I2 (fr)	2005-07-06

Family

ID=23079211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU91136C LU91136I2 (fr)	1994-07-28	2003-05-21	2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte).

Country Status (32)

Country	Link
EP (1)	EP0694547B1 (fr)
JP (1)	JP3090305B2 (fr)
KR (1)	KR100358626B1 (fr)
CN (1)	CN1045089C (fr)
AT (1)	ATE179173T1 (fr)
AU (1)	AU697107B2 (fr)
BR (1)	BR9503468A (fr)
CA (1)	CA2154721C (fr)
CO (1)	CO4410181A1 (fr)
CY (2)	CY2180B1 (fr)
CZ (1)	CZ290511B6 (fr)
DE (3)	DE694547T1 (fr)
DK (1)	DK0694547T3 (fr)
ES (1)	ES2083348T3 (fr)
FI (1)	FI112080B (fr)
GR (2)	GR960300021T1 (fr)
HU (1)	HU216867B (fr)
IL (1)	IL114735A (fr)
LU (1)	LU91136I2 (fr)
MA (1)	MA23631A1 (fr)
MY (1)	MY114393A (fr)
NL (1)	NL300071I2 (fr)
NO (2)	NO312899B1 (fr)
NZ (1)	NZ272652A (fr)
PE (1)	PE32296A1 (fr)
PL (1)	PL180609B1 (fr)
RU (1)	RU2133749C1 (fr)
SA (1)	SA95160158B1 (fr)
TR (1)	TR199500895A2 (fr)
TW (1)	TW434242B (fr)
UY (1)	UY24006A1 (fr)
ZA (1)	ZA956228B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
WO1997027194A1 (fr) *	1996-01-26	1997-07-31	F. Hoffmann-La Roche Ag	Procede pour preparer des derives de la purine
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
DE69714971T3 (de) *	1996-01-26	2005-12-15	F. Hoffmann-La Roche Ag	Verfahren zur herstellung von purin-derivaten
US5869493A (en) *	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
CA2572577C (fr) *	1997-02-10	2011-04-05	Medivir Ab	Synthese de derives de nucleoside acyclique
US6184376B1 (en)	1997-02-10	2001-02-06	Mediver Ab	Synthesis of acyclic nucleoside derivatives
PT988304E (pt) *	1997-08-15	2001-10-31	Medivir Ab	Analogos de nucleosidos tais como os antivirais que contem inibidores de transcritase reversa retroviral e de adn-polimerase do virus da hepatite b (hbv)
AU1711599A (en) *	1997-12-19	1999-07-12	Bristol-Myers Squibb Company	Prodrugs of lobucavir and methods of use
WO1999051613A1 (fr) *	1998-04-03	1999-10-14	Medivir Ab	Promedicaments de produits pharmaceutiques contenant du phosphore
JP2000256359A (ja) *	1999-03-11	2000-09-19	Japan Science & Technology Corp	面性キラリティーを有する分子群の高選択的不斉変換法
KR20030015655A (ko) *	2001-08-17	2003-02-25	한미약품공업 주식회사	항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
DE60328675D1 (de) *	2002-04-23	2009-09-17	Aventis Pharma Inc	3-(substitutierte amino)-1h-indole-2-carbonsäureester und 3-(substitutierte amino)-benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression
WO2004035052A1 (fr)	2002-10-16	2004-04-29	Takeda Pharmaceutical Company Limited	Preparations solides stables
DK1583542T3 (da)	2003-01-14	2008-09-22	Gilead Sciences Inc	Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
US20070129385A1 (en) *	2003-08-28	2007-06-07	Sharma Mukesh K	Amorphous valganciclovir hydrochloride
US8461187B2 (en)	2004-06-16	2013-06-11	Takeda Pharmaceuticals U.S.A., Inc.	Multiple PPI dosage form
RU2527893C2 (ru) *	2004-07-19	2014-09-10	Биокон Лимитед	Инсулин-олигомерные конъюгаты, их препараты и применения
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
ZA200702234B (en) *	2006-03-21	2008-07-30	Cipla Ltd	Preparation of ester of purine derivatives
WO2009049160A1 (fr)	2007-10-12	2009-04-16	Takeda Pharmaceuticals North America	Procédés de traitement de troubles gastro-intestinaux indépendants de la prise alimentaire
EP2714691B1 (fr) *	2011-05-31	2016-09-07	Pharmathen S.A.	Procédé de préparation d'un composé de 2-amino-9-((2-phényl-1,3-dioxan- 5-yloxy)-méthyl)-1h-purin-6(9h)-one utile dans la préparation du valganciclovir
KR102312533B1 (ko)	2021-02-24	2021-10-15	주식회사 이웅	자동 스패너

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
US4897479A (en) *	1983-09-30	1990-01-30	Merck & Co., Inc.	Arylsulfonyloxy purine intermediates
IE842642L (en) *	1983-10-31	1985-04-30	Harvard College	Purine Derivatives
KR910000198B1 (ko) *	1984-12-12	1991-01-23	신텍스(유.에스.에이.) 인코포레이티드	글리세롤의 알콕시메틸 에테르 및 알콕시메틸 에스테르의 제조방법
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.
DE68922903T2 (de) *	1988-12-19	1995-11-23	Wellcome Found	Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.

1995
- 1995-07-10 PE PE1995273436A patent/PE32296A1/es not_active IP Right Cessation
- 1995-07-19 DE DE0694547T patent/DE694547T1/de active Pending
- 1995-07-19 DE DE69509173T patent/DE69509173T2/de not_active Expired - Lifetime
- 1995-07-19 AT AT95111319T patent/ATE179173T1/de active
- 1995-07-19 EP EP95111319A patent/EP0694547B1/fr not_active Expired - Lifetime
- 1995-07-19 DK DK95111319T patent/DK0694547T3/da active
- 1995-07-19 ES ES95111319T patent/ES2083348T3/es not_active Expired - Lifetime
- 1995-07-19 DE DE2002199032 patent/DE10299032I2/de active Active
- 1995-07-21 TR TR95/00895A patent/TR199500895A2/xx unknown
- 1995-07-26 CA CA002154721A patent/CA2154721C/fr not_active Expired - Lifetime
- 1995-07-26 MA MA23971A patent/MA23631A1/fr unknown
- 1995-07-26 AU AU27195/95A patent/AU697107B2/en not_active Expired
- 1995-07-26 HU HU9502238A patent/HU216867B/hu unknown
- 1995-07-26 ZA ZA956228A patent/ZA956228B/xx unknown
- 1995-07-26 IL IL114735A patent/IL114735A/en not_active IP Right Cessation
- 1995-07-26 NZ NZ272652A patent/NZ272652A/en not_active IP Right Cessation
- 1995-07-27 BR BR9503468A patent/BR9503468A/pt active Search and Examination
- 1995-07-27 JP JP07190953A patent/JP3090305B2/ja not_active Expired - Lifetime
- 1995-07-27 CO CO95033418A patent/CO4410181A1/es unknown
- 1995-07-27 KR KR1019950022600A patent/KR100358626B1/ko not_active Expired - Lifetime
- 1995-07-27 MY MYPI95002156A patent/MY114393A/en unknown
- 1995-07-27 UY UY24006A patent/UY24006A1/es not_active IP Right Cessation
- 1995-07-27 CZ CZ19951939A patent/CZ290511B6/cs not_active IP Right Cessation
- 1995-07-27 CN CN95109671A patent/CN1045089C/zh not_active Expired - Lifetime
- 1995-07-27 FI FI953592A patent/FI112080B/fi active Protection Beyond IP Right Term
- 1995-07-27 TW TW084107779A patent/TW434242B/zh not_active IP Right Cessation
- 1995-07-27 PL PL95309812A patent/PL180609B1/pl unknown
- 1995-07-27 RU RU95113148A patent/RU2133749C1/ru active
- 1995-07-27 NO NO19952977A patent/NO312899B1/no not_active IP Right Cessation
- 1995-08-14 SA SA95160158A patent/SA95160158B1/ar unknown
1996
- 1996-04-30 GR GR960300021T patent/GR960300021T1/el unknown
1999
- 1999-07-02 GR GR990401760T patent/GR3030678T3/el unknown
2000
- 2000-08-10 CY CY0000039A patent/CY2180B1/xx unknown
2001
- 2001-11-23 NL NL300071C patent/NL300071I2/nl unknown
2003
- 2003-01-10 NO NO2003001C patent/NO2003001I2/no unknown
- 2003-05-21 LU LU91136C patent/LU91136I2/fr unknown
2004
- 2004-10-20 CY CY200400003C patent/CY2004003I2/el unknown

Also Published As

Publication number	Publication date
TR199500895A2 (tr)	1996-06-21
BR9503468A (pt)	1996-02-27
PL309812A1 (en)	1996-02-05
CZ193995A3 (en)	1996-02-14
FI953592A0 (fi)	1995-07-27
DK0694547T3 (da)	2000-01-03
CY2004003I1 (el)	2009-11-04
UY24006A1 (es)	2001-07-31
NO2003001I2 (no)	2007-06-11
NL300071I1 (nl)	2002-02-01
RU95113148A (ru)	1997-06-27
MA23631A1 (fr)	1996-04-01
CA2154721C (fr)	2001-01-02
ZA956228B (en)	1996-02-22
FI953592L (fi)	1996-01-29
NO312899B1 (no)	2002-07-15
TW434242B (en)	2001-05-16
HUT73246A (en)	1996-07-29
IL114735A (en)	1998-06-15
DE10299032I1 (de)	2003-01-23
NO952977L (no)	1996-01-29
KR960004345A (ko)	1996-02-23
NZ272652A (en)	1996-12-20
SA95160158B1 (ar)	2006-05-20
EP0694547A2 (fr)	1996-01-31
CY2004003I2 (el)	2009-11-04
AU697107B2 (en)	1998-09-24
CZ290511B6 (cs)	2002-08-14
ES2083348T3 (es)	1999-08-01
GR960300021T1 (en)	1996-04-30
HU216867B (hu)	1999-09-28
JPH0841061A (ja)	1996-02-13
NL300071I2 (nl)	2002-03-01
GR3030678T3 (en)	1999-11-30
RU2133749C1 (ru)	1999-07-27
HK1012339A1 (en)	1999-07-30
CA2154721A1 (fr)	1996-01-29
EP0694547A3 (fr)	1996-06-05
JP3090305B2 (ja)	2000-09-18
ES2083348T1 (es)	1996-04-16
AU2719595A (en)	1996-02-08
DE694547T1 (de)	1996-10-24
DE69509173D1 (de)	1999-05-27
HU9502238D0 (en)	1995-09-28
MY114393A (en)	2002-10-31
PL180609B1 (pl)	2001-03-30
EP0694547B1 (fr)	1999-04-21
ATE179173T1 (de)	1999-05-15
DE69509173T2 (de)	1999-10-21
KR100358626B1 (ko)	2003-01-14
DE10299032I2 (de)	2006-06-14
CY2180B1 (en)	2002-08-23
CN1122804A (zh)	1996-05-22
CN1045089C (zh)	1999-09-15
NO952977D0 (no)	1995-07-27
CO4410181A1 (es)	1997-01-09
IL114735A0 (en)	1995-11-27
PE32296A1 (es)	1996-08-07
FI112080B (fi)	2003-10-31

Publication	Publication Date	Title
LU91136I2 (fr)	2005-07-06	2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte).
PT97890A (pt)	1992-03-31	Processo para a preparacao de ftalidas substituidas e de ftalidas heterociclicas
EP0648477A3 (fr)	1995-09-13	Tête de perçage du canal médullaire.
DE59709902D1 (de)	2003-05-28	Hochgeschwindigkeitsdrehmaschine zum Herstellen optisch aktiver Oberflächen
DK0641325T3 (da)	2001-04-17	Inhibitorer af retroviral protease
MX9204190A (es)	1993-01-01	Derivdos de 2-(4-hidroxipiperidino)-1-alcanol como agentes antiisquemicos.
FI940102A0 (fi)	1994-01-10	Foerfarande och anordning foer hoejande av en materialbanas glans och ytjaemnhet
FI980860A0 (fi)	1998-04-17	Laserarrangemang med reglerbar vaoglaengd
NO912979D0 (no)	1991-07-31	Fremgangsmaate for fremstilling av 2-(9-fluorenoyl)-carbapenederivater.
FI924440A7 (fi)	1992-10-02	Heterosykliset yhdisteet aldoosireduktaasi-inhibiitteinä
RU1809521C (ru)	1993-04-15	Генератор плазмы
FI934920A0 (fi)	1993-11-05	Gjutstycke, foerfarande foer dess framstaellning och anvaendning av det
SG32424A1 (en)	1995-08-13	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propanediol derivative
KR940026833U (ko)	1994-12-09	직기용 경사절사감지기의 바디