LU91136I2 - 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte). - Google Patents

2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte).

Info

Publication number: LU91136I2
Authority: LU; Luxembourg
Prior art keywords: purin; dihydro; oxo; methoxy; amino
Prior art date: 1994-07-28

Application number

LU91136C

Other languages

English (en)

Original Assignee

Hoffmann Kla Roche Ag F

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-28

Filing date

2003-05-21

Publication date

2005-07-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91136(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-05-21 Application filed by Hoffmann Kla Roche Ag F filed Critical Hoffmann Kla Roche Ag F

2005-07-06 Publication of LU91136I2 publication Critical patent/LU91136I2/fr

Links

150000003839 salts Chemical class 0.000 title abstract 2
-1 2-Amino-1,6-dihydro-6-oxo-purin-9-yl Chemical group 0.000 title 1
WPVFJKSGQUFQAP-GKAPJAKFSA-N Valcyte Chemical compound N1C(N)=NC(=O)C2=C1N(COC(CO)COC(=O)[C@@H](N)C(C)C)C=N2 WPVFJKSGQUFQAP-GKAPJAKFSA-N 0.000 title 1
229940010343 valcyte Drugs 0.000 title 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

LU91136C 1994-07-28 2003-05-21 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte). LU91136I2 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28189394A	1994-07-28	1994-07-28

Publications (1)

Publication Number	Publication Date
LU91136I2 true LU91136I2 (fr)	2005-07-06

Family

ID=23079211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU91136C LU91136I2 (fr)	1994-07-28	2003-05-21	2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte).

Country Status (32)

Country	Link
EP (1)	EP0694547B1 (fr)
JP (1)	JP3090305B2 (fr)
KR (1)	KR100358626B1 (fr)
CN (1)	CN1045089C (fr)
AT (1)	ATE179173T1 (fr)
AU (1)	AU697107B2 (fr)
BR (1)	BR9503468A (fr)
CA (1)	CA2154721C (fr)
CO (1)	CO4410181A1 (fr)
CY (2)	CY2180B1 (fr)
CZ (1)	CZ290511B6 (fr)
DE (3)	DE69509173T2 (fr)
DK (1)	DK0694547T3 (fr)
ES (1)	ES2083348T3 (fr)
FI (1)	FI112080B (fr)
GR (2)	GR960300021T1 (fr)
HU (1)	HU216867B (fr)
IL (1)	IL114735A (fr)
LU (1)	LU91136I2 (fr)
MA (1)	MA23631A1 (fr)
MY (1)	MY114393A (fr)
NL (1)	NL300071I2 (fr)
NO (2)	NO312899B1 (fr)
NZ (1)	NZ272652A (fr)
PE (1)	PE32296A1 (fr)
PL (1)	PL180609B1 (fr)
RU (1)	RU2133749C1 (fr)
SA (1)	SA95160158B1 (fr)
TR (1)	TR199500895A2 (fr)
TW (1)	TW434242B (fr)
UY (1)	UY24006A1 (fr)
ZA (1)	ZA956228B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
AU1592897A (en) *	1996-01-26	1997-08-20	F. Hoffmann-La Roche Ag	Process for preparing purine derivatives
WO1997027198A1 (fr) *	1996-01-26	1997-07-31	F.Hoffmann-La Roche Ag	Procede pour la preparation de derives de la purine
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
US5869493A (en) *	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
ATE227289T1 (de) *	1997-02-10	2002-11-15	Medivir Ab	Verfahren zur herstellung von azyklischen nukleosiden
US6184376B1 (en)	1997-02-10	2001-02-06	Mediver Ab	Synthesis of acyclic nucleoside derivatives
SI0988304T1 (en) *	1997-08-15	2001-08-31	Medivir Ab	Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv)
WO1999032490A1 (fr) *	1997-12-19	1999-07-01	Bristol-Myers Squibb Company	Promedicaments du lobucavir et leur mode d'utilisation
WO1999051613A1 (fr) *	1998-04-03	1999-10-14	Medivir Ab	Promedicaments de produits pharmaceutiques contenant du phosphore
JP2000256359A (ja) *	1999-03-11	2000-09-19	Japan Science & Technology Corp	面性キラリティーを有する分子群の高選択的不斉変換法
KR20030015655A (ko) *	2001-08-17	2003-02-25	한미약품공업 주식회사	항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
EP1501797B1 (fr) *	2002-04-23	2009-08-05	Aventis Pharmaceuticals Inc.	Ester de l'acide 3-amino-1h-indole-2-carboxylique et de l'acide 3-amino-benzo[b]thiophene-2-carboxylique utilisés en tant qu'inhibiteurs de l'expression du gene de l'interleukine-4
CA2771725C (fr)	2002-10-16	2015-08-18	Takeda Pharmaceutical Company Limited	Preparation solide comprenant une base non toxique et un inhibiteur de pompe a proton
SI1583542T1 (sl)	2003-01-14	2008-12-31	Gilead Sciences Inc	Sestavki in postopki za kombinacijsko antivirusnoterapijo
WO2005021549A1 (fr) *	2003-08-28	2005-03-10	Ranbaxy Laboratories Limited	Chlorhydrate de valganciclovir amorphe
EP1768668A2 (fr)	2004-06-16	2007-04-04	Tap Pharmaceutical Products, Inc.	Forme posologique a doses ppi multiples
MX2007000883A (es) *	2004-07-19	2007-04-02	Biocon Ltd	Conjugados de insulina-oligomero, formulaciones y usos de los mismos.
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
ZA200702234B (en) *	2006-03-21	2008-07-30	Cipla Ltd	Preparation of ester of purine derivatives
KR20100116165A (ko)	2007-10-12	2010-10-29	다케다 파마슈티칼스 노쓰 어메리카, 인코포레이티드	음식 섭취와 관계없이 위장 장애를 치료하는 방법
WO2012163373A1 (fr) *	2011-05-31	2012-12-06	Pharmathen S.A.	Procédé de préparation d'un composé de 2-amino-9-((2-phényl-1,3-dioxan- 5-yloxy)-méthyl)-1h-purin-6(9h)-one utile dans la préparation du valganciclovir
KR102312533B1 (ko)	2021-02-24	2021-10-15	주식회사 이웅	자동 스패너

Family Cites Families (6)

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Publication number	Priority date	Publication date	Assignee	Title
NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
US4897479A (en) *	1983-09-30	1990-01-30	Merck & Co., Inc.	Arylsulfonyloxy purine intermediates
IE842642L (en) *	1983-10-31	1985-04-30	Harvard College	Purine Derivatives
DK168213B1 (da) *	1984-12-12	1994-02-28	Syntex Inc	Alkoxymethylether- og alkoxymethylesterderivater af glycerol og fremgangsmåde til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin og ethere og estere deraf
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.
AU618436B2 (en) *	1988-12-19	1991-12-19	Wellcome Foundation Limited, The	Antiviral cytosine and guanine derivatives

1995
- 1995-07-10 PE PE1995273436A patent/PE32296A1/es not_active IP Right Cessation
- 1995-07-19 DE DE69509173T patent/DE69509173T2/de not_active Expired - Lifetime
- 1995-07-19 DE DE2002199032 patent/DE10299032I2/de active Active
- 1995-07-19 ES ES95111319T patent/ES2083348T3/es not_active Expired - Lifetime
- 1995-07-19 EP EP95111319A patent/EP0694547B1/fr not_active Expired - Lifetime
- 1995-07-19 DE DE0694547T patent/DE694547T1/de active Pending
- 1995-07-19 DK DK95111319T patent/DK0694547T3/da active
- 1995-07-19 AT AT95111319T patent/ATE179173T1/de active
- 1995-07-21 TR TR95/00895A patent/TR199500895A2/xx unknown
- 1995-07-26 MA MA23971A patent/MA23631A1/fr unknown
- 1995-07-26 AU AU27195/95A patent/AU697107B2/en not_active Expired
- 1995-07-26 IL IL114735A patent/IL114735A/en not_active IP Right Cessation
- 1995-07-26 NZ NZ272652A patent/NZ272652A/en not_active IP Right Cessation
- 1995-07-26 CA CA002154721A patent/CA2154721C/fr not_active Expired - Lifetime
- 1995-07-26 ZA ZA956228A patent/ZA956228B/xx unknown
- 1995-07-26 HU HU9502238A patent/HU216867B/hu unknown
- 1995-07-27 MY MYPI95002156A patent/MY114393A/en unknown
- 1995-07-27 CZ CZ19951939A patent/CZ290511B6/cs not_active IP Right Cessation
- 1995-07-27 CN CN95109671A patent/CN1045089C/zh not_active Expired - Lifetime
- 1995-07-27 TW TW084107779A patent/TW434242B/zh not_active IP Right Cessation
- 1995-07-27 RU RU95113148A patent/RU2133749C1/ru active
- 1995-07-27 PL PL95309812A patent/PL180609B1/pl unknown
- 1995-07-27 NO NO19952977A patent/NO312899B1/no not_active IP Right Cessation
- 1995-07-27 UY UY24006A patent/UY24006A1/es not_active IP Right Cessation
- 1995-07-27 KR KR1019950022600A patent/KR100358626B1/ko not_active Expired - Lifetime
- 1995-07-27 JP JP07190953A patent/JP3090305B2/ja not_active Expired - Lifetime
- 1995-07-27 BR BR9503468A patent/BR9503468A/pt active Search and Examination
- 1995-07-27 CO CO95033418A patent/CO4410181A1/es unknown
- 1995-07-27 FI FI953592A patent/FI112080B/fi active Protection Beyond IP Right Term
- 1995-08-14 SA SA95160158A patent/SA95160158B1/ar unknown
1996
- 1996-04-30 GR GR960300021T patent/GR960300021T1/el unknown
1999
- 1999-07-02 GR GR990401760T patent/GR3030678T3/el unknown
2000
- 2000-08-10 CY CY0000039A patent/CY2180B1/xx unknown
2001
- 2001-11-23 NL NL300071C patent/NL300071I2/nl unknown
2003
- 2003-01-10 NO NO2003001C patent/NO2003001I2/no unknown
- 2003-05-21 LU LU91136C patent/LU91136I2/fr unknown
2004
- 2004-10-20 CY CY200400003C patent/CY2004003I1/el unknown

Also Published As

Publication number	Publication date
JP3090305B2 (ja)	2000-09-18
IL114735A (en)	1998-06-15
EP0694547A2 (fr)	1996-01-31
KR960004345A (ko)	1996-02-23
UY24006A1 (es)	2001-07-31
CN1122804A (zh)	1996-05-22
CA2154721A1 (fr)	1996-01-29
ES2083348T1 (es)	1996-04-16
BR9503468A (pt)	1996-02-27
EP0694547A3 (fr)	1996-06-05
CY2004003I2 (el)	2009-11-04
NO952977L (no)	1996-01-29
ATE179173T1 (de)	1999-05-15
KR100358626B1 (ko)	2003-01-14
CN1045089C (zh)	1999-09-15
ZA956228B (en)	1996-02-22
HK1012339A1 (en)	1999-07-30
NO312899B1 (no)	2002-07-15
EP0694547B1 (fr)	1999-04-21
DE10299032I2 (de)	2006-06-14
CY2004003I1 (el)	2009-11-04
PL180609B1 (pl)	2001-03-30
CO4410181A1 (es)	1997-01-09
PL309812A1 (en)	1996-02-05
GR3030678T3 (en)	1999-11-30
CA2154721C (fr)	2001-01-02
DE694547T1 (de)	1996-10-24
DE69509173D1 (de)	1999-05-27
MA23631A1 (fr)	1996-04-01
CZ290511B6 (cs)	2002-08-14
NZ272652A (en)	1996-12-20
JPH0841061A (ja)	1996-02-13
FI953592A0 (fi)	1995-07-27
HU216867B (hu)	1999-09-28
TR199500895A2 (tr)	1996-06-21
SA95160158B1 (ar)	2006-05-20
NO952977D0 (no)	1995-07-27
RU2133749C1 (ru)	1999-07-27
AU697107B2 (en)	1998-09-24
NO2003001I2 (no)	2007-06-11
DE69509173T2 (de)	1999-10-21
DE10299032I1 (de)	2003-01-23
CZ193995A3 (en)	1996-02-14
RU95113148A (ru)	1997-06-27
HUT73246A (en)	1996-07-29
HU9502238D0 (en)	1995-09-28
PE32296A1 (es)	1996-08-07
AU2719595A (en)	1996-02-08
NL300071I1 (nl)	2002-02-01
ES2083348T3 (es)	1999-08-01
GR960300021T1 (en)	1996-04-30
CY2180B1 (en)	2002-08-23
FI953592L (fi)	1996-01-29
MY114393A (en)	2002-10-31
TW434242B (en)	2001-05-16
DK0694547T3 (da)	2000-01-03
IL114735A0 (en)	1995-11-27
FI112080B (fi)	2003-10-31
NL300071I2 (nl)	2002-03-01

Publication	Publication Date	Title
LU91136I2 (fr)	2005-07-06	2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-3-hydroxy-1-propanyl-L-valinate et les sels pharmaceutiquement acceptables de celui-ci (valcyte).
YU101791A (sh)	1997-08-22	Supstituisani ftalidi i heterociklični ftalidi
EP0648477A3 (fr)	1995-09-13	Tête de perçage du canal médullaire.
DE59709902D1 (de)	2003-05-28	Hochgeschwindigkeitsdrehmaschine zum Herstellen optisch aktiver Oberflächen
NL300241I1 (nl)	2006-12-01	Hydroxymethyl(methyleencyclopentyl)uurines en -pyrimidines.
DE59102489D1 (de)	1994-09-15	Aufprallträger.
MX9204190A (es)	1993-01-01	Derivdos de 2-(4-hidroxipiperidino)-1-alcanol como agentes antiisquemicos.
FI940102A0 (fi)	1994-01-10	Foerfarande och anordning foer hoejande av en materialbanas glans och ytjaemnhet
FI923347L (fi)	1992-07-23	Blodfaktorer producerade med rekombinant-dna-teknik och foerfarande foer expression av naemnda blodfaktorer samt i naemnda foerfarande anvaenda rekombinanta kokoppvirus.
FI916018A7 (fi)	1992-06-21	1,3-dioksolaanijohdannaisia kolesterolia alentavina aineina
NO912979D0 (no)	1991-07-31	Fremgangsmaate for fremstilling av 2-(9-fluorenoyl)-carbapenederivater.
FI924440A7 (fi)	1992-10-02	Heterosykliset yhdisteet aldoosireduktaasi-inhibiitteinä
FI890642A0 (fi)	1989-02-10	Laser/med infraroed foeremaolskopia.
SG32424A1 (en)	1995-08-13	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propanediol derivative
LT2417B (lt)	1994-02-15	Mo budas vaiku astrios leukozes nepalankios eigos isaiskini
FI934510A0 (fi)	1993-10-12	Lins till solkraftverk och anordning foer producering och ackumulering av vaete, elektricitet, aonga och vaerme
KR940026833U (ko)	1994-12-09	직기용 경사절사감지기의 바디
FI930480A0 (fi)	1993-02-03	Foerfarande och anordning foer belaeggning av en pappersbana