MA23631A1 - Ester derive au ganciclovir et de la l-valine ainsi qu'un procede pour sa preparation - Google Patents

Ester derive au ganciclovir et de la l-valine ainsi qu'un procede pour sa preparation

Info

Publication number: MA23631A1
Authority: MA; Morocco
Prior art keywords: ester derived; ganciclovir; valine; preparation; purin
Prior art date: 1994-07-28

Application number

MA23971A

Other languages

English (en)

Inventor

Maag Hans

W Wemble Scott

J Nestor John

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-28

Filing date

1995-07-26

Publication date

1996-04-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA23631(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-07-26 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1996-04-01 Publication of MA23631A1 publication Critical patent/MA23631A1/fr

Links

150000002148 esters Chemical class 0.000 title abstract 2
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 title abstract 2
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 title 1
229960002963 ganciclovir Drugs 0.000 title 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

MA23971A 1994-07-28 1995-07-26 Ester derive au ganciclovir et de la l-valine ainsi qu'un procede pour sa preparation MA23631A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28189394A	1994-07-28	1994-07-28

Publications (1)

Publication Number	Publication Date
MA23631A1 true MA23631A1 (fr)	1996-04-01

Family

ID=23079211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA23971A MA23631A1 (fr)	1994-07-28	1995-07-26	Ester derive au ganciclovir et de la l-valine ainsi qu'un procede pour sa preparation

Country Status (32)

Country	Link
EP (1)	EP0694547B1 (fr)
JP (1)	JP3090305B2 (fr)
KR (1)	KR100358626B1 (fr)
CN (1)	CN1045089C (fr)
AT (1)	ATE179173T1 (fr)
AU (1)	AU697107B2 (fr)
BR (1)	BR9503468A (fr)
CA (1)	CA2154721C (fr)
CO (1)	CO4410181A1 (fr)
CY (2)	CY2180B1 (fr)
CZ (1)	CZ290511B6 (fr)
DE (3)	DE694547T1 (fr)
DK (1)	DK0694547T3 (fr)
ES (1)	ES2083348T3 (fr)
FI (1)	FI112080B (fr)
GR (2)	GR960300021T1 (fr)
HU (1)	HU216867B (fr)
IL (1)	IL114735A (fr)
LU (1)	LU91136I2 (fr)
MA (1)	MA23631A1 (fr)
MY (1)	MY114393A (fr)
NL (1)	NL300071I2 (fr)
NO (2)	NO312899B1 (fr)
NZ (1)	NZ272652A (fr)
PE (1)	PE32296A1 (fr)
PL (1)	PL180609B1 (fr)
RU (1)	RU2133749C1 (fr)
SA (1)	SA95160158B1 (fr)
TR (1)	TR199500895A2 (fr)
TW (1)	TW434242B (fr)
UY (1)	UY24006A1 (fr)
ZA (1)	ZA956228B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
AU1592897A (en) *	1996-01-26	1997-08-20	F. Hoffmann-La Roche Ag	Process for preparing purine derivatives
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
KR100491941B1 (ko) *	1996-01-26	2005-08-05	에프. 호프만-라 로슈 아게	푸린유도체의제조방법
US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
US6184376B1 (en)	1997-02-10	2001-02-06	Mediver Ab	Synthesis of acyclic nucleoside derivatives
EP0971923B1 (fr) *	1997-02-10	2002-11-06	Medivir Ab	Synthese de derives de nucleoside acyclique
AU728892B2 (en) *	1997-08-15	2001-01-18	Medivir Ab	Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the DNA polymerase of hepatitis B virus (HBV)
WO1999032490A1 (fr) *	1997-12-19	1999-07-01	Bristol-Myers Squibb Company	Promedicaments du lobucavir et leur mode d'utilisation
WO1999051613A1 (fr) *	1998-04-03	1999-10-14	Medivir Ab	Promedicaments de produits pharmaceutiques contenant du phosphore
JP2000256359A (ja) *	1999-03-11	2000-09-19	Japan Science & Technology Corp	面性キラリティーを有する分子群の高選択的不斉変換法
KR20030015655A (ko) *	2001-08-17	2003-02-25	한미약품공업 주식회사	항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
DE60328675D1 (de) *	2002-04-23	2009-09-17	Aventis Pharma Inc	3-(substitutierte amino)-1h-indole-2-carbonsäureester und 3-(substitutierte amino)-benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression
EP1552833B1 (fr)	2002-10-16	2016-12-28	Takeda Pharmaceutical Company Limited	Procédé de préparation d'un iosmère optiquement actif du lansoprazole
EA015145B1 (ru)	2003-01-14	2011-06-30	Джилид Сайэнс, Инк.	Фармацевтическая композиция и пероральная фармацевтическая дозированная форма (варианты), проявляющие активность в отношении вич-инфекций, лечебный набор и таблетка и способ лечения или предотвращения симптомов или эффектов вич-инфекции
CN1860120A (zh) *	2003-08-28	2006-11-08	兰贝克赛实验室有限公司	无定形盐酸缬更昔洛韦
EP1768668A2 (fr)	2004-06-16	2007-04-04	Tap Pharmaceutical Products, Inc.	Forme posologique a doses ppi multiples
CN103223160B (zh) *	2004-07-19	2015-02-18	比奥孔有限公司	胰岛素-低聚物共轭物,制剂及其用途
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
ZA200702234B (en) *	2006-03-21	2008-07-30	Cipla Ltd	Preparation of ester of purine derivatives
CN102014638A (zh)	2007-10-12	2011-04-13	武田制药北美公司	与食物摄入无关的治疗胃肠病症的方法
CN103562207B (zh) *	2011-05-31	2016-08-17	法尔玛赞公司	用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法
KR102312533B1 (ko)	2021-02-24	2021-10-15	주식회사 이웅	자동 스패너

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
US4897479A (en) *	1983-09-30	1990-01-30	Merck & Co., Inc.	Arylsulfonyloxy purine intermediates
IE842642L (en) *	1983-10-31	1985-04-30	Harvard College	Purine Derivatives
CA1330797C (fr) *	1984-12-12	1994-07-19	David J. Morgans, Jr.	Derives alkoxymethylether et alkoxymethylester
AP55A (en) *	1987-08-15	1989-09-26	The Wellcome Foundation Ltd	Therapeutic Acyclic Nucleosides
CA2005815C (fr) *	1988-12-19	1999-08-03	Wellcome Foundation Limited (The)	Derives antiviraux de nucleoside acyclique

1995
- 1995-07-10 PE PE1995273436A patent/PE32296A1/es not_active IP Right Cessation
- 1995-07-19 AT AT95111319T patent/ATE179173T1/de active
- 1995-07-19 DE DE0694547T patent/DE694547T1/de active Pending
- 1995-07-19 DE DE69509173T patent/DE69509173T2/de not_active Expired - Lifetime
- 1995-07-19 DK DK95111319T patent/DK0694547T3/da active
- 1995-07-19 ES ES95111319T patent/ES2083348T3/es not_active Expired - Lifetime
- 1995-07-19 DE DE2002199032 patent/DE10299032I2/de active Active
- 1995-07-19 EP EP95111319A patent/EP0694547B1/fr not_active Expired - Lifetime
- 1995-07-21 TR TR95/00895A patent/TR199500895A2/xx unknown
- 1995-07-26 HU HU9502238A patent/HU216867B/hu unknown
- 1995-07-26 IL IL114735A patent/IL114735A/en not_active IP Right Cessation
- 1995-07-26 MA MA23971A patent/MA23631A1/fr unknown
- 1995-07-26 NZ NZ272652A patent/NZ272652A/en not_active IP Right Cessation
- 1995-07-26 ZA ZA956228A patent/ZA956228B/xx unknown
- 1995-07-26 AU AU27195/95A patent/AU697107B2/en not_active Expired
- 1995-07-26 CA CA002154721A patent/CA2154721C/fr not_active Expired - Lifetime
- 1995-07-27 JP JP07190953A patent/JP3090305B2/ja not_active Expired - Lifetime
- 1995-07-27 RU RU95113148A patent/RU2133749C1/ru active
- 1995-07-27 BR BR9503468A patent/BR9503468A/pt active Search and Examination
- 1995-07-27 CZ CZ19951939A patent/CZ290511B6/cs not_active IP Right Cessation
- 1995-07-27 TW TW084107779A patent/TW434242B/zh not_active IP Right Cessation
- 1995-07-27 NO NO19952977A patent/NO312899B1/no not_active IP Right Cessation
- 1995-07-27 CO CO95033418A patent/CO4410181A1/es unknown
- 1995-07-27 PL PL95309812A patent/PL180609B1/pl unknown
- 1995-07-27 MY MYPI95002156A patent/MY114393A/en unknown
- 1995-07-27 FI FI953592A patent/FI112080B/fi active Protection Beyond IP Right Term
- 1995-07-27 KR KR1019950022600A patent/KR100358626B1/ko not_active Expired - Lifetime
- 1995-07-27 CN CN95109671A patent/CN1045089C/zh not_active Expired - Lifetime
- 1995-07-27 UY UY24006A patent/UY24006A1/es not_active IP Right Cessation
- 1995-08-14 SA SA95160158A patent/SA95160158B1/ar unknown
1996
- 1996-04-30 GR GR960300021T patent/GR960300021T1/el unknown
1999
- 1999-07-02 GR GR990401760T patent/GR3030678T3/el unknown
2000
- 2000-08-10 CY CY0000039A patent/CY2180B1/xx unknown
2001
- 2001-11-23 NL NL300071C patent/NL300071I2/nl unknown
2003
- 2003-01-10 NO NO2003001C patent/NO2003001I2/no unknown
- 2003-05-21 LU LU91136C patent/LU91136I2/fr unknown
2004
- 2004-10-20 CY CY200400003C patent/CY2004003I1/el unknown

Also Published As

Publication number	Publication date
TR199500895A2 (tr)	1996-06-21
PL309812A1 (en)	1996-02-05
ZA956228B (en)	1996-02-22
NO952977L (no)	1996-01-29
UY24006A1 (es)	2001-07-31
GR960300021T1 (en)	1996-04-30
KR960004345A (ko)	1996-02-23
DE10299032I2 (de)	2006-06-14
FI953592A0 (fi)	1995-07-27
DE69509173T2 (de)	1999-10-21
JP3090305B2 (ja)	2000-09-18
KR100358626B1 (ko)	2003-01-14
ATE179173T1 (de)	1999-05-15
TW434242B (en)	2001-05-16
CN1045089C (zh)	1999-09-15
EP0694547A2 (fr)	1996-01-31
IL114735A (en)	1998-06-15
IL114735A0 (en)	1995-11-27
FI953592L (fi)	1996-01-29
CY2180B1 (en)	2002-08-23
NL300071I1 (nl)	2002-02-01
CO4410181A1 (es)	1997-01-09
NO2003001I2 (no)	2007-06-11
SA95160158B1 (ar)	2006-05-20
PE32296A1 (es)	1996-08-07
AU2719595A (en)	1996-02-08
CY2004003I2 (el)	2009-11-04
LU91136I2 (fr)	2005-07-06
RU2133749C1 (ru)	1999-07-27
NO952977D0 (no)	1995-07-27
MY114393A (en)	2002-10-31
PL180609B1 (pl)	2001-03-30
DK0694547T3 (da)	2000-01-03
HU216867B (hu)	1999-09-28
RU95113148A (ru)	1997-06-27
CY2004003I1 (el)	2009-11-04
ES2083348T3 (es)	1999-08-01
EP0694547A3 (fr)	1996-06-05
DE694547T1 (de)	1996-10-24
DE69509173D1 (de)	1999-05-27
ES2083348T1 (es)	1996-04-16
HK1012339A1 (en)	1999-07-30
NZ272652A (en)	1996-12-20
CA2154721A1 (fr)	1996-01-29
CN1122804A (zh)	1996-05-22
HUT73246A (en)	1996-07-29
FI112080B (fi)	2003-10-31
GR3030678T3 (en)	1999-11-30
CZ290511B6 (cs)	2002-08-14
CZ193995A3 (en)	1996-02-14
JPH0841061A (ja)	1996-02-13
AU697107B2 (en)	1998-09-24
DE10299032I1 (de)	2003-01-23
NL300071I2 (nl)	2002-03-01
HU9502238D0 (en)	1995-09-28
EP0694547B1 (fr)	1999-04-21
NO312899B1 (no)	2002-07-15
CA2154721C (fr)	2001-01-02
BR9503468A (pt)	1996-02-27

Publication	Publication Date	Title
HU9502238D0 (en)	1995-09-28	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanodiol derivative
NO180407C (no)	1997-04-16	Anvendelse av 1,3-oksatiolannukleosidanaloger ved fremstilling av et medikament for behandling av hepatitt B
FI102069B1 (fi)	1998-10-15	Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi
FR2695369B1 (fr)	1995-02-10	Procédé pour la régulation de la stabilité d'un véhicule.
PT99775A (pt)	1992-11-30	Processo para a preparacao de novos derivados de di-hidroisoquinolina
NO913136L (no)	1992-02-14	Fremgangsmaate for fremstilling av et preparat for oeyedraaper
ES2091324T3 (es)	1996-11-01	Proceso para la preparacion de aspartama a partir de una dicetopiperazina y nuevos compuestos intermedios y derivados para dicho proceso.
SE8600017D0 (sv)	1986-01-03	New compound
FR2700845B1 (fr)	1996-03-29	Procédé pour déterminer la position d'u casque fixé sur la tête d'un porteur.
DK0751117T3 (da)	2000-07-10	Fremstilling af bicyclohexanderivat
FI921717L (fi)	1992-04-16	Menetelmä terapeuttisesti käyttökelpoisten 4-metoksi-10-(1-hydroksietyyli)-11-okso-1-atsatrisyklo/7.2.0.03,8/-undek-2-eeni-2-karboksyylihappojen asyylioksialkyyliestereiden valmistamiseksi
CY2207B1 (en)	2002-11-08	Pharmaceutical for the treatment f skin disorders
IT9022209A0 (it)	1990-11-27	Processo per la granulazione di sali potessici
FR2688503B1 (fr)	1994-05-06	Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
DZ1598A1 (fr)	2002-02-17	Procédé de production de vanadium-bis arènes à partir d'exychlorure de vanadium.
FR2684673B1 (fr)	1994-01-21	Procede de preparation d'un derive de l'amino-2 naphtyridine racemique.
ITTO930336A1 (it)	1994-11-14	Procedimento per la produzione dell'estere metilico di alfa-l-aspartil -l-fenilalanina.
ITAN910040A1 (it)	1993-04-18	Processo di lavorazione per la realizzazione di un intersuola per calzature, avente rigidita' differenziata.
IT221288Z2 (it)	1994-02-25	Congegno a strappo per l'apertura dei films termoretraenti di imbal= laggio.