|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5336603A
(en)
*
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
|
US5750375A
(en)
*
|
1988-01-22 |
1998-05-12 |
Zymogenetics, Inc. |
Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
|
|
US6018026A
(en)
*
|
1988-01-22 |
2000-01-25 |
Zymogenetics, Inc. |
Biologically active dimerized and multimerized polypeptide fusions
|
|
US5567584A
(en)
*
|
1988-01-22 |
1996-10-22 |
Zymogenetics, Inc. |
Methods of using biologically active dimerized polypeptide fusions to detect PDGF
|
|
US6685941B1
(en)
|
1988-11-23 |
2004-02-03 |
The Regents Of The University Of Michigan |
Methods of treating autoimmune disease via CTLA-4Ig
|
|
US6406697B1
(en)
|
1989-02-23 |
2002-06-18 |
Genentech, Inc. |
Hybrid immunoglobulins
|
|
US5225538A
(en)
*
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
US5242687A
(en)
*
|
1989-03-15 |
1993-09-07 |
Tkb Associates Limited Partnership |
Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells
|
|
DK0393438T3
(da)
|
1989-04-21 |
2005-05-30 |
Amgen Inc |
TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor
|
|
US7264944B1
(en)
|
1989-04-21 |
2007-09-04 |
Amgen Inc. |
TNF receptors, TNF binding proteins and DNAs coding for them
|
|
IL95031A
(en)
|
1989-07-18 |
2007-03-08 |
Amgen Inc |
Method for the production of a human recombinant tumor necrosis factor inhibitor
|
|
US6143866A
(en)
*
|
1989-07-18 |
2000-11-07 |
Amgen, Inc. |
Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
|
|
US6267964B1
(en)
*
|
1989-08-01 |
2001-07-31 |
Affibody Technology Sweden Ab |
Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
|
|
NZ235148A
(en)
*
|
1989-09-05 |
1991-12-23 |
Immunex Corp |
Tumour necrosis factor receptor protein and dna sequences
|
|
US5605690A
(en)
*
|
1989-09-05 |
1997-02-25 |
Immunex Corporation |
Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
|
|
US5945397A
(en)
*
|
1989-09-05 |
1999-08-31 |
Immunex Corporation |
Purified p75 (type II) tumor necrosis factor receptor polypeptides
|
|
US5395760A
(en)
*
|
1989-09-05 |
1995-03-07 |
Immunex Corporation |
DNA encoding tumor necrosis factor-α and -β receptors
|
|
US6541610B1
(en)
|
1989-09-05 |
2003-04-01 |
Immunex Corporation |
Fusion proteins comprising tumor necrosis factor receptor
|
|
EP0939121B2
(de)
*
|
1989-09-12 |
2007-12-26 |
AHP Manufacturing B.V. |
TFN-bindende Proteine
|
|
US5216132A
(en)
*
|
1990-01-12 |
1993-06-01 |
Protein Design Labs, Inc. |
Soluble t-cell antigen receptor chimeric antigens
|
|
US6552170B1
(en)
|
1990-04-06 |
2003-04-22 |
Amgen Inc. |
PEGylation reagents and compounds formed therewith
|
|
GB9022543D0
(en)
*
|
1990-10-17 |
1990-11-28 |
Wellcome Found |
Antibody production
|
|
DE4037837A1
(de)
*
|
1990-11-28 |
1992-06-04 |
Behringwerke Ag |
Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung
|
|
US7070991B2
(en)
*
|
1991-02-08 |
2006-07-04 |
Progenics Pharmaceuticals, Inc. |
Cells expressing a CD4-IgG2 chimeric heterotetramer
|
|
JP3670276B2
(ja)
|
1991-02-08 |
2005-07-13 |
プロゲニクス・ファーマスーティカルズ、インコーポレイテッド |
CD4― ガンマ・2キメラ及びCD4 ― IgG2・キメラ
|
|
SG47766A1
(en)
*
|
1991-03-12 |
1998-04-17 |
Biogen Inc |
CD2-binding domain of lymphocyte function associated antigen 3
|
|
MX9203138A
(es)
*
|
1991-03-12 |
1992-09-01 |
Biogen Inc |
Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos.
|
|
US6582959B2
(en)
*
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
|
US20030206899A1
(en)
*
|
1991-03-29 |
2003-11-06 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
|
US5318890A
(en)
*
|
1991-05-06 |
1994-06-07 |
The Regents Of The University Of California |
Assays for inhibitors of leukocyte adhesion
|
|
US6797492B2
(en)
|
1991-05-17 |
2004-09-28 |
Merck & Co., Inc. |
Method for reducing the immunogenicity of antibody variable domains
|
|
US5851795A
(en)
*
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
|
US5844095A
(en)
*
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
|
EP0533006A1
(de)
*
|
1991-09-18 |
1993-03-24 |
F.Hoffmann-La Roche & Co. Aktiengesellschaft |
Chimäre Interleukin 5-Rezeptor/Immunoglobulin-Polypeptide
|
|
US6764681B2
(en)
*
|
1991-10-07 |
2004-07-20 |
Biogen, Inc. |
Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
|
|
US5871734A
(en)
*
|
1992-01-13 |
1999-02-16 |
Biogen, Inc. |
Treatment for asthma with VLA-4 blocking agents
|
|
US6399368B1
(en)
|
1992-01-17 |
2002-06-04 |
Board Of Regents, The University Of Texas System |
Secretion of T cell receptor fragments from recombinant Escherichia coli cells
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
US5932214A
(en)
*
|
1994-08-11 |
1999-08-03 |
Biogen, Inc. |
Treatment for inflammatory bowel disease with VLA-4 blockers
|
|
ATE242322T1
(de)
*
|
1992-03-30 |
2003-06-15 |
Immunex Corp |
Fusionsprotein , das zwei rezeptoren des tumornekrose-faktors enthält
|
|
CA2118508A1
(en)
*
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
US5540926A
(en)
*
|
1992-09-04 |
1996-07-30 |
Bristol-Myers Squibb Company |
Soluble and its use in B cell stimulation
|
|
WO1994005314A1
(en)
*
|
1992-09-08 |
1994-03-17 |
Centocor, Inc. |
Peptide inhibitors of leukocyte adhesion
|
|
AU670125B2
(en)
*
|
1992-09-15 |
1996-07-04 |
Immunex Corporation |
Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
|
|
CA2144081C
(en)
*
|
1992-09-16 |
2004-11-30 |
Filip Roos |
Protection against liver damage by hgf
|
|
WO1994006469A1
(en)
*
|
1992-09-18 |
1994-03-31 |
La Jolla Institute For Allergy And Immunology |
Hiv fusion polypeptide
|
|
US6270766B1
(en)
|
1992-10-08 |
2001-08-07 |
The Kennedy Institute Of Rheumatology |
Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
|
|
US5474766A
(en)
*
|
1992-12-18 |
1995-12-12 |
Washington University |
Methods and compositions for inhibition of hepatic clearance of tissue-type plasminogen activator
|
|
WO1994014836A1
(en)
*
|
1992-12-18 |
1994-07-07 |
Centocor, Inc. |
Peptide inhibitors of selectin binding
|
|
DE69415154T2
(de)
*
|
1993-01-25 |
1999-07-29 |
Dana-Farber Cancer Institute, Inc., Boston, Mass. |
Chimäre selektine erhältlich durch domänenaustauch und ihre verwendungen
|
|
US7537932B1
(en)
|
1993-05-19 |
2009-05-26 |
Schering Corporation |
Antibodies that bind purified mammalian FLT3 ligands
|
|
US6824779B1
(en)
|
1993-07-26 |
2004-11-30 |
Dana-Farber Cancer Institute, Inc. |
Methods for inhibiting the interaction of B7-2 with its natural ligand
|
|
US5861310A
(en)
*
|
1993-11-03 |
1999-01-19 |
Dana-Farber Cancer Institute |
Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
|
|
US6723705B1
(en)
|
1993-08-19 |
2004-04-20 |
Gentics Institute, Inc. |
Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
|
|
US6130316A
(en)
*
|
1993-07-26 |
2000-10-10 |
Dana Farber Cancer Institute |
Fusion proteins of novel CTLA4/CD28 ligands and uses therefore
|
|
US6084067A
(en)
*
|
1993-07-26 |
2000-07-04 |
Dana-Farber Cancer Institute |
CTLA4/CD28 ligands and uses therefor
|
|
US20050129670A1
(en)
*
|
1993-07-26 |
2005-06-16 |
Genetics Institute, Llc. |
Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
|
|
SE9302855D0
(sv)
*
|
1993-09-06 |
1993-09-06 |
Martin Lindberg |
Method and means for producing plasmaproteinase inhibitor binding proteins
|
|
WO1995014787A1
(en)
*
|
1993-11-22 |
1995-06-01 |
Centocor, Inc. |
Peptide inhibitors of selecting binding
|
|
EP0742830B1
(de)
*
|
1994-02-01 |
2001-07-18 |
THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services |
Fusionierte proteine die antikörper-teile und nicht-antikörper-teile enthalten
|
|
US7294331B2
(en)
*
|
1994-03-07 |
2007-11-13 |
Immunex Corporation |
Methods of using flt3-ligand in hematopoietic cell transplantation
|
|
ES2153895T3
(es)
*
|
1994-03-08 |
2001-03-16 |
Dana Farber Cancer Inst Inc |
Metodos para modular la insensibilidad de celulas t.
|
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
|
IL113484A0
(en)
*
|
1994-04-28 |
1995-07-31 |
Immunex Corp |
Viral proteins pharmaceutical compositions containing them their preparation and use
|
|
CA2189657C
(fr)
|
1994-05-06 |
2002-03-12 |
Florence Faure |
Fractions polypeptidiques solubles de la proteine lag-3; procede de production; composition therapeutique; anticorps anti-idiotype
|
|
US6350730B1
(en)
|
1994-08-17 |
2002-02-26 |
The Rockefeller University |
OB polypeptides and modified forms as modulators of body weight
|
|
US6001968A
(en)
|
1994-08-17 |
1999-12-14 |
The Rockefeller University |
OB polypeptides, modified forms and compositions
|
|
US6124448A
(en)
*
|
1994-08-17 |
2000-09-26 |
The Rockfeller University |
Nucleic acid primers and probes for the mammalian OB gene
|
|
US6471956B1
(en)
|
1994-08-17 |
2002-10-29 |
The Rockefeller University |
Ob polypeptides, modified forms and compositions thereto
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
US6429290B1
(en)
|
1994-08-17 |
2002-08-06 |
The Rockefeller University |
OB polypeptides, modified forms and derivatives
|
|
US6048837A
(en)
*
|
1994-08-17 |
2000-04-11 |
The Rockefeller University |
OB polypeptides as modulators of body weight
|
|
US5541087A
(en)
*
|
1994-09-14 |
1996-07-30 |
Fuji Immunopharmaceuticals Corporation |
Expression and export technology of proteins as immunofusins
|
|
US5814464A
(en)
*
|
1994-10-07 |
1998-09-29 |
Regeneron Pharma |
Nucleic acids encoding TIE-2 ligand-2
|
|
DE69534265T2
(de)
*
|
1994-12-12 |
2006-05-04 |
Beth Israel Deaconess Medical Center, Inc., Boston |
Chimäre zytokine und ihre verwendung
|
|
US6410008B1
(en)
*
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
|
US6808709B1
(en)
*
|
1994-12-30 |
2004-10-26 |
The Regents Of The University Of California |
Immunoglobulins containing protection proteins and their use
|
|
US6485726B1
(en)
*
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US6030613A
(en)
*
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US6086875A
(en)
*
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
|
US6455685B1
(en)
|
1995-03-03 |
2002-09-24 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
|
US6066322A
(en)
|
1995-03-03 |
2000-05-23 |
Millennium Pharmaceuticals, Inc. |
Methods for the treatment of immune disorders
|
|
US20030069196A1
(en)
*
|
1995-03-03 |
2003-04-10 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
|
US6211142B1
(en)
*
|
1995-03-10 |
2001-04-03 |
Genentech, Inc. |
Compositions comprising gas6 polypeptides and articles of manufacture comprising the same
|
|
US6680057B1
(en)
*
|
1995-03-23 |
2004-01-20 |
Immunex Corporation |
Methods of treating autoimmune disease by administering interleukin-17 receptor
|
|
NZ306653A
(en)
*
|
1995-03-23 |
1999-03-29 |
Immunex Corp |
Isolated dna il-17 receptors
|
|
IL117645A
(en)
*
|
1995-03-30 |
2005-08-31 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
|
|
US20060193862A1
(en)
*
|
1995-03-30 |
2006-08-31 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
|
US6113898A
(en)
|
1995-06-07 |
2000-09-05 |
Idec Pharmaceuticals Corporation |
Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
|
|
US7153508B2
(en)
*
|
1995-06-07 |
2006-12-26 |
Biogen Idec Inc. |
Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4
|
|
US7175847B1
(en)
*
|
1995-06-07 |
2007-02-13 |
Biogen Idec Inc. |
Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4
|
|
US20020034517A1
(en)
*
|
1995-10-04 |
2002-03-21 |
Kenneth Brasel |
Dendritic cell stimulatory factor
|
|
US7150992B1
(en)
|
1995-10-04 |
2006-12-19 |
Innunex Corporation |
Methods of preparing dendritic cells with flt3-ligand and antigen
|
|
US7361330B2
(en)
*
|
1995-10-04 |
2008-04-22 |
Immunex Corporation |
Methods of using flt3-ligand in the treatment of fibrosarcoma
|
|
US20030040467A1
(en)
*
|
1998-06-15 |
2003-02-27 |
Mary Ann Pelleymounter |
Ig/ob fusions and uses thereof.
|
|
US6936439B2
(en)
*
|
1995-11-22 |
2005-08-30 |
Amgen Inc. |
OB fusion protein compositions and methods
|
|
US20030026779A1
(en)
*
|
1999-10-15 |
2003-02-06 |
Liming Yu |
Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
|
|
GB9526733D0
(en)
*
|
1995-12-30 |
1996-02-28 |
Delta Biotechnology Ltd |
Fusion proteins
|
|
AU721129B2
(en)
|
1996-01-08 |
2000-06-22 |
Genentech Inc. |
WSX receptor and ligands
|
|
US6750334B1
(en)
|
1996-02-02 |
2004-06-15 |
Repligen Corporation |
CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
|
|
US5917026A
(en)
*
|
1996-02-05 |
1999-06-29 |
Loewenadler; Bjoern |
Fusion proteins of immunopotentiating activity
|
|
SK288144B6
(sk)
|
1996-02-09 |
2013-12-02 |
Amgen, Inc. |
Pharmaceutical composition and its use for treating inflammatory diseases
|
|
BR9707589A
(pt)
*
|
1996-02-20 |
2000-01-04 |
Applied Research Systems |
Proteìna hìbrida, molécula de dna, vetor de expressão, célula hospedeira, composição farmacêutica e processos para produzir proteìna hìbrida e para induzir maturação folicular.
|
|
US6194177B1
(en)
*
|
1996-02-20 |
2001-02-27 |
Applied Research Systems Ars Holding N.V. |
DNA encoding a hybrid heterodimeric protein
|
|
GB9604518D0
(en)
*
|
1996-03-02 |
1996-05-01 |
Smithkline Beecham Plc |
Novel compounds
|
|
NZ331688A
(en)
*
|
1996-03-28 |
2000-02-28 |
Univ Johns Hopkins |
Soluble divalent and multivalent heterodimeric analogs of proteins
|
|
US6458354B1
(en)
|
1996-03-28 |
2002-10-01 |
The Johns Hopkins University |
Molecular complexes which modify immune responses
|
|
US6140305A
(en)
*
|
1996-04-04 |
2000-10-31 |
Bio-Rad Laboratories, Inc. |
Hereditary hemochromatosis gene products
|
|
US7026116B1
(en)
*
|
1996-04-04 |
2006-04-11 |
Bio-Rad Laboratories, Inc. |
Polymorphisms in the region of the human hemochromatosis gene
|
|
US7063965B2
(en)
*
|
1996-04-05 |
2006-06-20 |
Regeneron Pharmaceuticals, Inc. |
Nucleic acid encoding TIE-2 ligand
|
|
US6060054A
(en)
|
1996-04-10 |
2000-05-09 |
National Jewish Medical And Research Center |
Product for T lymphocyte immunosuppression
|
|
US6117977A
(en)
*
|
1996-04-24 |
2000-09-12 |
Genentech, Inc. |
Type C lectins
|
|
US6451308B1
(en)
|
1996-04-26 |
2002-09-17 |
Beth Israel Deaconess Medical Center |
Antagonists of interleukin-15
|
|
WO1997041232A1
(en)
*
|
1996-04-26 |
1997-11-06 |
Beth Israel Deaconess Medical Center |
Antagonists of interleukin-15
|
|
US6306395B1
(en)
|
1996-05-02 |
2001-10-23 |
Mochida Pharmaceutical Co., Ltd. |
Fas antigen derivatives
|
|
US6100071A
(en)
|
1996-05-07 |
2000-08-08 |
Genentech, Inc. |
Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
|
|
US6849399B1
(en)
|
1996-05-23 |
2005-02-01 |
Bio-Rad Laboratories, Inc. |
Methods and compositions for diagnosis and treatment of iron misregulation diseases
|
|
TW555765B
(en)
*
|
1996-07-09 |
2003-10-01 |
Amgen Inc |
Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
|
|
CA2258721C
(en)
*
|
1996-07-12 |
2014-09-09 |
Genentech, Inc. |
Chimeric heteromultimer adhesins
|
|
DE69732711T2
(de)
*
|
1996-07-12 |
2006-03-16 |
Genentech, Inc., South San Francisco |
Gamma-heregulin
|
|
US6159462A
(en)
*
|
1996-08-16 |
2000-12-12 |
Genentech, Inc. |
Uses of Wnt polypeptides
|
|
US5851984A
(en)
*
|
1996-08-16 |
1998-12-22 |
Genentech, Inc. |
Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
|
|
ES2312179T3
(es)
|
1996-12-06 |
2009-02-16 |
Amgen Inc. |
Terapia combinada que utiliza un inhibidor del il-1 para el tratamiento de enfermedades mediadas por el il-1.
|
|
WO1998024463A2
(en)
|
1996-12-06 |
1998-06-11 |
Amgen Inc. |
Combination therapy using a tnf binding protein for treating tnf-mediated diseases
|
|
CA2279547A1
(en)
*
|
1997-01-31 |
1998-08-06 |
University Of Rochester |
Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response
|
|
US6268411B1
(en)
|
1997-09-11 |
2001-07-31 |
The Johns Hopkins University |
Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
|
|
US20020137890A1
(en)
*
|
1997-03-31 |
2002-09-26 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US7435793B2
(en)
*
|
1998-05-15 |
2008-10-14 |
Genentech, Inc. |
Peptides that induce chondrocyte redifferentiation
|
|
DE69842225D1
(de)
|
1997-04-16 |
2011-05-26 |
Millennium Pharm Inc |
Zusammensetzung, umfassend einen Antikörper, der selektiv an ein cysteinreiches sekretiertes Protein (CRSP) bindet
|
|
US6190909B1
(en)
*
|
1997-04-17 |
2001-02-20 |
Millennium Pharmaceuticals, Inc. |
TH2-specific gene
|
|
CA2288351A1
(en)
*
|
1997-05-01 |
1998-11-05 |
Amgen Inc. |
Chimeric opg polypeptides
|
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
*
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
ATE299938T1
(de)
|
1997-05-02 |
2005-08-15 |
Genentech Inc |
Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
|
|
US20030207346A1
(en)
*
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
DE69841593D1
(de)
|
1997-06-13 |
2010-05-12 |
Bio Rad Laboratories |
Verfahren und Zusammensetzungen für die Diagnose und die Behandlung von Krankheiten, die mit Eisenüberschuss oder Eisenmangel assoziiert sind
|
|
US20030068623A1
(en)
*
|
1997-06-16 |
2003-04-10 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US20040191256A1
(en)
*
|
1997-06-24 |
2004-09-30 |
Genentech, Inc. |
Methods and compositions for galactosylated glycoproteins
|
|
KR100220645B1
(ko)
*
|
1997-07-04 |
1999-09-15 |
구광시 |
벤젠유도체의 제조방법
|
|
US6242570B1
(en)
|
1997-07-10 |
2001-06-05 |
Beth Israel Deaconess Medical Center |
Production and use of recombinant protein multimers with increased biological activity
|
|
US6165476A
(en)
*
|
1997-07-10 |
2000-12-26 |
Beth Israel Deaconess Medical Center |
Fusion proteins with an immunoglobulin hinge region linker
|
|
US6187564B1
(en)
|
1997-07-10 |
2001-02-13 |
Beth Israel Deaconess Medical Center |
DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
|
|
US20030022293A1
(en)
*
|
1997-09-18 |
2003-01-30 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US6391311B1
(en)
*
|
1998-03-17 |
2002-05-21 |
Genentech, Inc. |
Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
|
|
JP2001520039A
(ja)
*
|
1997-10-21 |
2001-10-30 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
ヒト腫瘍壊死因子レセプター様タンパク質、tr11,tr11sv1およびtr11sv2
|
|
US6503184B1
(en)
|
1997-10-21 |
2003-01-07 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
|
|
US6689607B2
(en)
|
1997-10-21 |
2004-02-10 |
Human Genome Sciences, Inc. |
Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
|
|
US20040136986A1
(en)
*
|
1997-10-31 |
2004-07-15 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
|
US6576743B1
(en)
*
|
1997-11-26 |
2003-06-10 |
Zymogenetics, Inc. |
Mammalian cytokine-like polypeptide-10
|
|
ES2590912T3
(es)
|
1997-12-08 |
2016-11-24 |
Merck Patent Gmbh |
Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario
|
|
US6207413B1
(en)
*
|
1998-01-22 |
2001-03-27 |
Regeneron Pharmaceuticals, Inc. |
Nucleic acids encoding novel orphan cytokine receptors
|
|
US20030105294A1
(en)
*
|
1998-02-25 |
2003-06-05 |
Stephen Gillies |
Enhancing the circulating half life of antibody-based fusion proteins
|
|
US7198789B2
(en)
*
|
1998-03-17 |
2007-04-03 |
Genetics Institute, Llc |
Methods and compositions for modulating interleukin-21 receptor activity
|
|
US6057128A
(en)
*
|
1998-03-17 |
2000-05-02 |
Genetics Institute, Inc. |
MU-1, member of the cytokine receptor family
|
|
US7189400B2
(en)
*
|
1998-03-17 |
2007-03-13 |
Genetics Institute, Llc |
Methods of treatment with antagonists of MU-1
|
|
US7371836B2
(en)
*
|
1998-03-27 |
2008-05-13 |
Genentech, Inc. |
PRO526 nucleic acids
|
|
US7723488B2
(en)
*
|
1998-03-27 |
2010-05-25 |
Genentech, Inc. |
Monoclonal antibodies to secreted and transmembrane polypeptides
|
|
ES2267263T3
(es)
*
|
1998-04-15 |
2007-03-01 |
Emd Lexigen Research Center Corp. |
Coadministracion de un inhibidor de la angiogenesis para reforzar la respuesta inmunologica por medio de la mediacion de una proteina de fusion de una citoquina con un anticuerpo.
|
|
AU740405B2
(en)
*
|
1998-05-15 |
2001-11-01 |
Genentech Inc. |
IL-17 homologous polypeptides and therapeutic uses thereof
|
|
US20030092063A1
(en)
*
|
1998-05-15 |
2003-05-15 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
ATE443723T1
(de)
|
1998-06-12 |
2009-10-15 |
Genentech Inc |
Monoklonale antikörper, kreuz-reaktive antikörper und deren produktionsverfahren
|
|
DE69933216T2
(de)
*
|
1998-06-15 |
2007-09-20 |
GTC Biotherapeutics, Inc., Framingham |
Erythropoietin-analog-menschliches serum-albumin fusionsprotein
|
|
US20050181482A1
(en)
*
|
2004-02-12 |
2005-08-18 |
Meade Harry M. |
Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk
|
|
US20070003545A9
(en)
*
|
1999-06-02 |
2007-01-04 |
Eaton Dan L |
Interleukin-8 homologous polypeptides and therapeutic uses thereof
|
|
US20030065154A1
(en)
*
|
2000-03-30 |
2003-04-03 |
Genentech, Inc. |
Interleukin-8 homologous polypeptides and therapeutic uses thereof
|
|
US20020099197A1
(en)
*
|
1998-07-21 |
2002-07-25 |
Rory A.J. Curtis |
Novel potassium channel molecules and uses therefor
|
|
US20030166132A1
(en)
*
|
1998-08-26 |
2003-09-04 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
EE200100123A
(et)
*
|
1998-08-31 |
2002-06-17 |
Biogen, Incorporated |
CD2 siduva aine kasutamine ja mäluefektor-T-lümfotsüütide populatsioon
|
|
HU229888B1
(en)
|
1998-10-16 |
2014-11-28 |
Biogen Idec Ma Inc Cambridge |
Polymer conjugates of interferon betha-1a and uses
|
|
BR9915548A
(pt)
*
|
1998-10-16 |
2001-08-14 |
Biogen Inc |
Proteìnas de fusão de interferon-beta e usos
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
US7488590B2
(en)
*
|
1998-10-23 |
2009-02-10 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
MEP42108A
(en)
*
|
1998-10-23 |
2011-02-10 |
Kiren Amgen Inc |
Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
|
|
WO2000027885A1
(en)
*
|
1998-11-05 |
2000-05-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Novel chimeric polypeptide
|
|
US6495128B1
(en)
*
|
1998-11-10 |
2002-12-17 |
Human Genome Sciences, Inc. |
Human chemokine β-7 deletion and substitution proteins
|
|
US7294482B2
(en)
*
|
1998-11-19 |
2007-11-13 |
Millennium Pharmaceuticals, Inc. |
EGF-like nucleic acids
|
|
US7235642B1
(en)
*
|
1999-01-12 |
2007-06-26 |
Genentech, Inc. |
Anti-PRO 1313 antibodies
|
|
US6656728B1
(en)
|
1999-02-08 |
2003-12-02 |
Chiron Corporation |
Fibroblast growth factor receptor-immunoglobulin fusion
|
|
JP2002540078A
(ja)
|
1999-03-19 |
2002-11-26 |
ジェネンテック・インコーポレーテッド |
Lfa−1アンタゴニスト投与量の増加によるlfa−1関連疾患の治療
|
|
US7011833B1
(en)
*
|
1999-05-06 |
2006-03-14 |
Genetics Institute, Inc. |
Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent
|
|
US20050079577A1
(en)
*
|
1999-05-14 |
2005-04-14 |
Ashkenazi Avi J. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
RU2262510C9
(ru)
*
|
1999-05-19 |
2006-04-20 |
Лексиген Фармасьютикэлс Корп. |
Слитый белок, обладающий биологической активностью интерферона-альфа, димерный слитый белок, фармацевтическая композиция, их содержащая, молекула днк (варианты) и способ адресования интерферона-альфа в ткани печени
|
|
AU782493B2
(en)
*
|
1999-06-01 |
2005-08-04 |
Curis, Inc. |
Polymer conjugates of hedgehog proteins and uses
|
|
AU5309600A
(en)
*
|
1999-06-02 |
2000-12-18 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
|
US6924359B1
(en)
|
1999-07-01 |
2005-08-02 |
Yale University |
Neovascular-targeted immunoconjugates
|
|
AU779612C
(en)
|
1999-07-02 |
2005-12-15 |
Genentech Inc. |
Peptide compounds that bind HER2
|
|
IL147269A0
(en)
*
|
1999-07-02 |
2002-08-14 |
Genentech Inc |
FVIIa ANTAGONISTS
|
|
CA2378796A1
(en)
*
|
1999-07-12 |
2001-01-18 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Seripancrin
|
|
US7067110B1
(en)
|
1999-07-21 |
2006-06-27 |
Emd Lexigen Research Center Corp. |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
SK782002A3
(en)
*
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
AU6607100A
(en)
*
|
1999-07-23 |
2001-02-13 |
Regents Of The University Of California, The |
Anti-growth factor receptor avidin fusion proteins as universal vectors for drugdelivery
|
|
DE60014919T2
(de)
*
|
1999-08-06 |
2005-10-13 |
Genentech, Inc., South San Francisco |
Peptidantagonisten des faktors viia
|
|
MXPA02001417A
(es)
*
|
1999-08-09 |
2002-08-12 |
Lexigen Pharm Corp |
Complejos multiples de citosina-anticuerpo.
|
|
PL354286A1
(en)
|
1999-08-23 |
2003-12-29 |
Dana-Farber Cancer Institutedana-Farber Cancer Institute |
Pd-1, a receptor for b7-4, and uses therefor
|
|
US20020173627A1
(en)
*
|
1999-09-16 |
2002-11-21 |
Samuel Davis |
TIE-2 ligands, methods of making and uses thereof
|
|
US6323334B1
(en)
|
1999-09-24 |
2001-11-27 |
Millennium Pharmaceuticals, Inc. |
Nucleic acid molecules encoding a 103 gene product and uses therefor
|
|
EP1230271A1
(de)
*
|
1999-11-05 |
2002-08-14 |
Biogen, Inc. |
Hedgehog fusionsproteine und deren verwendung
|
|
CA2391080A1
(en)
|
1999-11-12 |
2001-05-25 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Erythropoietin forms with improved properties
|
|
US20050202538A1
(en)
*
|
1999-11-12 |
2005-09-15 |
Merck Patent Gmbh |
Fc-erythropoietin fusion protein with improved pharmacokinetics
|
|
US7122632B2
(en)
*
|
1999-12-23 |
2006-10-17 |
Zymogenetics, Inc. |
Soluble Interleukin-20 receptor
|
|
US7307153B2
(en)
*
|
1999-12-23 |
2007-12-11 |
Genentech, Inc. |
Antibodies that bind PRO9912
|
|
US6610286B2
(en)
*
|
1999-12-23 |
2003-08-26 |
Zymogenetics, Inc. |
Method for treating inflammation using soluble receptors to interleukin-20
|
|
US20030153015A1
(en)
*
|
2000-01-20 |
2003-08-14 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
HUP0204475A2
(en)
|
2000-02-11 |
2003-04-28 |
Merck Patent Gmbh |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
ME00546B
(me)
*
|
2000-02-21 |
2011-10-10 |
Serono Lab |
Korišćenje inhibitora il-18
|
|
US7541184B2
(en)
*
|
2000-02-24 |
2009-06-02 |
Invitrogen Corporation |
Activation and expansion of cells
|
|
US7572631B2
(en)
*
|
2000-02-24 |
2009-08-11 |
Invitrogen Corporation |
Activation and expansion of T cells
|
|
US6984519B2
(en)
|
2000-03-01 |
2006-01-10 |
Genetech, Inc. |
Nucleic acids encoding peptides that induce chondrocyte redifferentiation
|
|
US20060073547A1
(en)
*
|
2000-03-01 |
2006-04-06 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US20060002943A1
(en)
*
|
2000-03-02 |
2006-01-05 |
Genentech, Inc. |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
|
US20020064820A1
(en)
*
|
2000-03-13 |
2002-05-30 |
Jean-Michel Dayer |
Apo-A-I regulation of T-cell signaling
|
|
US7514239B2
(en)
*
|
2000-03-28 |
2009-04-07 |
Amgen Inc. |
Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
|
|
CA2405800A1
(en)
*
|
2000-04-10 |
2001-10-18 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Novel secreted protein
|
|
EP2213743A1
(de)
|
2000-04-12 |
2010-08-04 |
Human Genome Sciences, Inc. |
Albuminfusionsproteine
|
|
US6946134B1
(en)
|
2000-04-12 |
2005-09-20 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US20050100991A1
(en)
*
|
2001-04-12 |
2005-05-12 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
AU2001259142C1
(en)
*
|
2000-04-25 |
2006-11-23 |
Biogen Idec Inc. |
Intrathecal administration of rituximab for treatment of central nervous system lymphomas
|
|
US6756480B2
(en)
|
2000-04-27 |
2004-06-29 |
Amgen Inc. |
Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
|
|
US20060015969A1
(en)
*
|
2000-04-28 |
2006-01-19 |
Planet Biotechnology, Inc. |
Novel immunoadhesins for treating and prventing toxicity and pathogen-mediated diseases
|
|
CA2407426A1
(en)
*
|
2000-04-28 |
2001-11-08 |
Planet Biotechnology, Inc. |
Immunoadhesin for the prevention of rhinovirus infection
|
|
AU5943201A
(en)
*
|
2000-05-03 |
2001-11-12 |
Amgen Inc |
Modified peptides as therapeutic agents
|
|
US20020102232A1
(en)
*
|
2000-05-11 |
2002-08-01 |
Chang Tse W. |
Compositions and methods for induction of active autoimmunity
|
|
EP1284747A2
(de)
|
2000-05-12 |
2003-02-26 |
Beth Israel Deaconess Medical Center, Inc. |
Zusammensetzungen und verfahren zur erzielung einer immunsuppression
|
|
EP1714661A3
(de)
|
2000-05-19 |
2012-03-14 |
The Center for Blood Research, INC. |
Verfahren zur Diagnose und Behandlung von hämostatischen Störungen durch Modulation der P-Selectin Aktivität
|
|
US20040034193A1
(en)
*
|
2001-06-13 |
2004-02-19 |
Samy Ashkar |
Biosynthetic oncolytic molecules and uses therefor
|
|
US20050048614A1
(en)
*
|
2000-06-13 |
2005-03-03 |
Children's Medical Center Corporation |
Biosynthetic oncolytic molecules and uses therefor
|
|
CA2412239C
(en)
*
|
2000-06-26 |
2013-05-28 |
Zymogenetics, Inc. |
Cytokine receptor zcytor17
|
|
US20030096339A1
(en)
*
|
2000-06-26 |
2003-05-22 |
Sprecher Cindy A. |
Cytokine receptor zcytor17
|
|
EP1320599A2
(de)
|
2000-06-28 |
2003-06-25 |
Genetics Institute, LLC |
Pd-l2 moleküle: pd-l1 liganden und ihre verwendungen
|
|
KR20030064275A
(ko)
*
|
2000-06-29 |
2003-07-31 |
메르크 파텐트 게엠베하 |
면역싸이토카인 흡수 증강제와의 조합 치료에 의한항체-싸이토카인 융합 단백질 매개 면역 반응 증강
|
|
US6902734B2
(en)
|
2000-08-07 |
2005-06-07 |
Centocor, Inc. |
Anti-IL-12 antibodies and compositions thereof
|
|
US7288390B2
(en)
|
2000-08-07 |
2007-10-30 |
Centocor, Inc. |
Anti-dual integrin antibodies, compositions, methods and uses
|
|
UA81743C2
(uk)
|
2000-08-07 |
2008-02-11 |
Центокор, Инк. |
МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
|
|
DE60123998T2
(de)
*
|
2000-08-08 |
2007-09-06 |
Zymogenetics, Inc., Seattle |
Lösliche zcyctor 11 cytokinrezeptoren
|
|
US20030215916A1
(en)
*
|
2000-08-18 |
2003-11-20 |
Feder John N. |
Novel imidazoline receptor homologs
|
|
ATE448306T1
(de)
|
2000-09-01 |
2009-11-15 |
Blood Res Center |
Veränderte, in gewünschter konformation stabilisierte polypeptide und verfahren zu deren herstellung
|
|
US20020119148A1
(en)
|
2000-09-01 |
2002-08-29 |
Gerritsen Mary E. |
ErbB4 antagonists
|
|
EP1349873B1
(de)
*
|
2000-09-14 |
2009-04-01 |
Beth Israel Deaconess Medical Center, Inc. |
Modulierung von il-2 und il-15 vermittelten t zellantworten
|
|
KR20030036835A
(ko)
|
2000-09-26 |
2003-05-09 |
제넨테크, 인크. |
Ige 수용체 길항제
|
|
US7241590B2
(en)
*
|
2000-09-29 |
2007-07-10 |
Bristol-Myers Squibb Company |
Identification and cloning of a full-length human Clnk-related gene, MIST (mast cell immunoreceptor signal transducer)
|
|
US20030211549A1
(en)
*
|
2000-10-06 |
2003-11-13 |
Murphy Andrew J. |
Functional proteins and therapeutic and diagnostic methods for use thereof
|
|
JP2004528822A
(ja)
*
|
2000-11-07 |
2004-09-24 |
ボード・オブ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム |
筋特異的筋節カルシニューリン結合タンパク質(カルサルシン)に関する方法および組成物
|
|
JP2004515479A
(ja)
*
|
2000-12-04 |
2004-05-27 |
オークランド ユニサーヴィスィズ リミテッド |
免疫調節性構築物およびその使用
|
|
ATE320450T1
(de)
|
2000-12-05 |
2006-04-15 |
Alexion Pharma Inc |
Rationell entworfene antikörper
|
|
US20040253242A1
(en)
*
|
2000-12-05 |
2004-12-16 |
Bowdish Katherine S. |
Rationally designed antibodies
|
|
US7396917B2
(en)
|
2000-12-05 |
2008-07-08 |
Alexion Pharmaceuticals, Inc. |
Rationally designed antibodies
|
|
CA2438386A1
(en)
*
|
2001-02-16 |
2002-08-29 |
Bristol-Myers Squibb Company |
Polynucleotides encoding a novel glycine receptor alpha subunit expressed in the gastrointestinal tract, hgra4, and splice variant thereof
|
|
RU2003129528A
(ru)
*
|
2001-03-07 |
2005-04-10 |
Мерк Патент ГмбХ (DE) |
Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела
|
|
US8163289B2
(en)
|
2001-03-09 |
2012-04-24 |
Iterative Therapeutics, Inc. |
Methods and compositions involving polymeric immunoglobulin fusion proteins
|
|
AU2002250293B2
(en)
|
2001-03-09 |
2007-10-11 |
Arnason, Barry G. Mr |
Polymeric immunoglobulin fusion proteins that target low-affinity FCGammaReceptors
|
|
WO2002079415A2
(en)
*
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
|
WO2002079499A1
(en)
|
2001-04-02 |
2002-10-10 |
Wyeth |
Pd-1, a receptor for b7-4, and uses therefor
|
|
US7507413B2
(en)
|
2001-04-12 |
2009-03-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US20050244931A1
(en)
*
|
2001-04-12 |
2005-11-03 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US20060084794A1
(en)
*
|
2001-04-12 |
2006-04-20 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US20050054051A1
(en)
*
|
2001-04-12 |
2005-03-10 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
ITRE20010042A1
(it)
*
|
2001-04-24 |
2002-10-24 |
Corghi Spa |
Dispositivo sollevatore per macchine smontagomme
|
|
US20050089932A1
(en)
*
|
2001-04-26 |
2005-04-28 |
Avidia Research Institute |
Novel proteins with targeted binding
|
|
US7265208B2
(en)
*
|
2001-05-01 |
2007-09-04 |
The Regents Of The University Of California |
Fusion molecules and treatment of IgE-mediated allergic diseases
|
|
EP1383785B1
(de)
|
2001-05-03 |
2011-03-16 |
Merck Patent GmbH |
Rekombinanter, tumorspezifischer antikörper und dessen verwendung
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
DK1385882T3
(da)
|
2001-05-11 |
2008-02-11 |
Amgen Inc |
Peptider og relaterede molekyler, der binder til TALL-1
|
|
JP2004537991A
(ja)
*
|
2001-06-15 |
2004-12-24 |
タノックス インコーポレーテッド |
アレルギー及び喘息治療用Fcε融合タンパク質
|
|
US20060073141A1
(en)
*
|
2001-06-28 |
2006-04-06 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
|
WO2003009740A2
(en)
*
|
2001-07-24 |
2003-02-06 |
Biogen Idec Ma Inc. |
Methods for treating or preventing sclerotic disorders using cd2-binding agents
|
|
WO2003015697A2
(en)
*
|
2001-08-13 |
2003-02-27 |
University Of Southern California |
Interleukin-2 mutants with reduced toxicity
|
|
US6900292B2
(en)
*
|
2001-08-17 |
2005-05-31 |
Lee-Hwei K. Sun |
Fc fusion proteins of human erythropoietin with increased biological activities
|
|
EP2311960A3
(de)
|
2001-08-29 |
2011-06-01 |
Genentech, Inc. |
Bv8-Nukleinsäuren und Polypeptide mit mitogener Aktivität
|
|
AU2002323501C1
(en)
*
|
2001-08-30 |
2010-04-29 |
Biorexis Technology, Inc |
Modified transferrin fusion proteins
|
|
US6797493B2
(en)
|
2001-10-01 |
2004-09-28 |
Lee-Hwei K. Sun |
Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
|
|
AU2002332041A1
(en)
*
|
2001-10-05 |
2003-04-22 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US7205275B2
(en)
*
|
2001-10-11 |
2007-04-17 |
Amgen Inc. |
Methods of treatment using specific binding agents of human angiopoietin-2
|
|
US7138370B2
(en)
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
|
AU2002337920A1
(en)
*
|
2001-10-19 |
2003-04-28 |
Zymogenetics, Inc. |
Dimerized growth factor and materials and methods for producing it
|
|
WO2003040311A2
(en)
*
|
2001-10-25 |
2003-05-15 |
The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services |
Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4
|
|
US20070118934A1
(en)
*
|
2001-10-26 |
2007-05-24 |
Planet Biotechnology, Inc. |
Chimeric toxin receptor proteins and chimeric toxin receptor proteins for treatment and prevention of anthrax
|
|
DK1454138T3
(da)
*
|
2001-12-04 |
2012-02-13 |
Merck Patent Gmbh |
Immunocytokiner med moduleret selektivitet
|
|
CA2471777A1
(en)
*
|
2001-12-18 |
2003-06-26 |
Endocube Sas |
Novel death associated proteins of the thap family and related par4 pathways involved in apoptosis control
|
|
US7858297B2
(en)
|
2001-12-18 |
2010-12-28 |
Centre National De La Recherche Scientifique Cnrs |
Chemokine-binding protein and methods of use
|
|
KR101271635B1
(ko)
*
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
알부민 융합 단백질
|
|
AU2002364586A1
(en)
|
2001-12-21 |
2003-07-30 |
Delta Biotechnology Limited |
Albumin fusion proteins
|
|
WO2005003296A2
(en)
|
2003-01-22 |
2005-01-13 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
WO2003059934A2
(en)
*
|
2001-12-21 |
2003-07-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
DK1961811T3
(da)
|
2002-01-18 |
2010-11-08 |
Zymogenetics Inc |
Cytokinligand til behandling af asthma og luftvejs-hyper-responsivitet
|
|
PT3025726T
(pt)
*
|
2002-01-18 |
2020-01-09 |
Biogen Ma Inc |
Compostos do polímero polialquileno e utilizações dos mesmos
|
|
US7164002B2
(en)
|
2002-02-06 |
2007-01-16 |
Genentech, Inc. |
FVIIa antagonists
|
|
US20030211470A1
(en)
*
|
2002-03-15 |
2003-11-13 |
Olson William C. |
CD4-IgG2-based salvage therapy of HIV-1 infection
|
|
AU2003240765A1
(en)
*
|
2002-04-10 |
2003-10-20 |
Applied Research Systems Ars Holding N.V. |
Novel antagonists of mcp proteins
|
|
US20040016010A1
(en)
*
|
2002-04-17 |
2004-01-22 |
Marion Kasaian |
IL-21 receptor knockout animal and methods of use thereof
|
|
EP1514927B1
(de)
|
2002-05-29 |
2010-05-19 |
Yamasa Corporation |
Verfahren zur produktion von nucleosid-diphosphat unter verwendung von polyphosphat: amp-phosphotransferase
|
|
ATE483472T1
(de)
*
|
2002-05-30 |
2010-10-15 |
Macrogenics Inc |
Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
|
|
NZ519371A
(en)
*
|
2002-06-04 |
2004-11-26 |
Auckland Uniservices Ltd |
Immunomodulatory constructs and their uses
|
|
EP1369128A1
(de)
*
|
2002-06-07 |
2003-12-10 |
Procorde GmbH |
Glycoprotein VI Inhibitoren und deren therapeutische Verwendung
|
|
US20090130021A1
(en)
*
|
2002-06-07 |
2009-05-21 |
Gotz Munch |
Methods, products and uses involving platelets and/or the vasculature
|
|
US7531178B2
(en)
*
|
2002-06-07 |
2009-05-12 |
Trigen Gmbh |
Immunoadhesin comprising a glycoprotein VI domain
|
|
US20070071744A1
(en)
*
|
2002-06-07 |
2007-03-29 |
Gotz Munch |
Agents which bind to epitopes of glycoprotein VI
|
|
US8025873B2
(en)
|
2002-06-20 |
2011-09-27 |
Paladin Labs, Inc. |
Chimeric antigens for eliciting an immune response
|
|
US8029803B2
(en)
|
2002-06-20 |
2011-10-04 |
Paladin Labs, Inc. |
Chimeric antigens for eliciting an immune response
|
|
US20070104710A1
(en)
*
|
2002-06-28 |
2007-05-10 |
Domants Limited |
Ligand that has binding specificity for IL-4 and/or IL-13
|
|
AU2003244817B2
(en)
*
|
2002-06-28 |
2010-08-26 |
Domantis Limited |
Antigen-binding immunoglobulin single variable domains and dual-specific constructs
|
|
CA2490409A1
(en)
|
2002-06-28 |
2004-01-08 |
Centocor, Inc. |
Mammalian ch1 deleted mimetibodies, compositions, methods and uses
|
|
CN1241946C
(zh)
*
|
2002-07-01 |
2006-02-15 |
美国福源集团 |
对多种细胞具刺激增生作用的人血清白蛋白重组融合蛋白
|
|
DE60334474D1
(de)
*
|
2002-07-12 |
2010-11-18 |
Univ Johns Hopkins |
Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren
|
|
US7314623B2
(en)
*
|
2002-07-15 |
2008-01-01 |
Wyeth |
Methods and compositions for modulating T helper (Th) cell development and function
|
|
US20040110681A1
(en)
*
|
2002-08-08 |
2004-06-10 |
Xiao-Min Fan |
Method to identify targeting molecules
|
|
JP2006508056A
(ja)
|
2002-08-28 |
2006-03-09 |
イミュネックス・コーポレーション |
心臓血管疾患を治療するための組成物および方法
|
|
DE10251463A1
(de)
*
|
2002-11-05 |
2004-05-19 |
BSH Bosch und Siemens Hausgeräte GmbH |
Elektrisch angetriebene Pumpe
|
|
US20050054054A1
(en)
*
|
2002-11-12 |
2005-03-10 |
Foss Francine M. |
Interleukin-7 molecules with altered biological properties
|
|
WO2004055056A1
(en)
*
|
2002-12-17 |
2004-07-01 |
Merck Patent Gmbh |
Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2
|
|
GB0230203D0
(en)
*
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
|
US20110223168A1
(en)
*
|
2002-12-27 |
2011-09-15 |
Greg Winter |
Ligand that has binding specificity for il-4 and/or il-13
|
|
EP1578801A2
(de)
*
|
2002-12-27 |
2005-09-28 |
Domantis Limited |
Dual-spezifischer einzeldomäne-antikörper welcher spezifisch ist für einen liganden und dessen rezeptor
|
|
CA2512974A1
(en)
*
|
2003-01-13 |
2004-07-29 |
Macrogenics, Inc. |
Soluble fc.gamma.r fusion proteins and methods of use thereof
|
|
US20060234340A1
(en)
*
|
2003-02-06 |
2006-10-19 |
Novozymes A/S |
Human heavy chain antibody expression in flamentous fungi
|
|
US20050096264A1
(en)
*
|
2003-02-25 |
2005-05-05 |
Macdonald Lynn |
Methods for treating obesity and related conditions with glycoprotein hormone beta family hormones
|
|
JP4912144B2
(ja)
|
2003-03-12 |
2012-04-11 |
ジェネンテック, インコーポレイテッド |
造血促進のためのbv8及び/又はeg−vegfの使用
|
|
WO2004084816A2
(en)
*
|
2003-03-21 |
2004-10-07 |
Progenics Pharmaceuticals, Inc. |
IMPROVED CD4-IgG2 FORMULATIONS
|
|
JP2007525438A
(ja)
*
|
2003-03-24 |
2007-09-06 |
ザイモジェネティクス, インコーポレイテッド |
抗il−22ra抗体および結合パートナー、ならびに炎症における使用法
|
|
PT1606318E
(pt)
|
2003-03-26 |
2009-11-10 |
Deutsches Krebsforsch |
Proteínas de fusão de fc melhoradas
|
|
US7348004B2
(en)
|
2003-05-06 |
2008-03-25 |
Syntonix Pharmaceuticals, Inc. |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
AU2004238263A1
(en)
*
|
2003-05-06 |
2004-11-25 |
Syntonix Pharmaceuticals, Inc. |
Inhibition of drug binding to serum albumin
|
|
TWI353991B
(en)
*
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
PL2298347T3
(pl)
*
|
2003-05-06 |
2016-03-31 |
Bioverativ Therapeutics Inc |
Białka chimeryczne czynnika krzepnięcia do leczenia zaburzenia hemostazy
|
|
US20040229878A1
(en)
*
|
2003-05-13 |
2004-11-18 |
Depuy Spine, Inc. |
Transdiscal administration of specific inhibitors of P38 kinase
|
|
US7344716B2
(en)
|
2003-05-13 |
2008-03-18 |
Depuy Spine, Inc. |
Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
|
|
BRPI0410331A
(pt)
|
2003-05-13 |
2006-05-30 |
Depuy Spine Inc |
método para tratar doença de disco degenerativa
|
|
US8273347B2
(en)
|
2003-05-13 |
2012-09-25 |
Depuy Spine, Inc. |
Autologous treatment of degenerated disc with cells
|
|
US20080076708A1
(en)
*
|
2003-05-13 |
2008-03-27 |
Valter Altarocca |
Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
|
|
US7429378B2
(en)
*
|
2003-05-13 |
2008-09-30 |
Depuy Spine, Inc. |
Transdiscal administration of high affinity anti-MMP inhibitors
|
|
US7553827B2
(en)
*
|
2003-08-13 |
2009-06-30 |
Depuy Spine, Inc. |
Transdiscal administration of cycline compounds
|
|
US7435808B2
(en)
|
2003-06-25 |
2008-10-14 |
Bristol-Myers Squibb Company |
Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
|
|
DE602004017726D1
(de)
*
|
2003-06-30 |
2008-12-24 |
Domantis Ltd |
Pegylierte Single-domain-antikörper (dAb)
|
|
US7569215B2
(en)
|
2003-07-18 |
2009-08-04 |
Massachusetts Institute Of Technology |
Mutant interleukin-2 (IL-2) polypeptides
|
|
US8361467B2
(en)
*
|
2003-07-30 |
2013-01-29 |
Depuy Spine, Inc. |
Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
|
|
US8007805B2
(en)
*
|
2003-08-08 |
2011-08-30 |
Paladin Labs, Inc. |
Chimeric antigens for breaking host tolerance to foreign antigens
|
|
US7850970B2
(en)
|
2003-08-26 |
2010-12-14 |
The Regents Of The University Of Colorado |
Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
|
|
US20050069521A1
(en)
*
|
2003-08-28 |
2005-03-31 |
Emd Lexigen Research Center Corp. |
Enhancing the circulating half-life of interleukin-2 proteins
|
|
UA89481C2
(uk)
|
2003-09-30 |
2010-02-10 |
Центокор, Инк. |
Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування
|
|
WO2005035569A2
(en)
*
|
2003-10-10 |
2005-04-21 |
Five Prime Therapeutics, Inc. |
Kiaa0779, splice variants thereof, and methods of their use
|
|
US20050239700A1
(en)
*
|
2003-10-14 |
2005-10-27 |
Biogen Idec Inc. |
Treatment of cancer using antibodies to LRRC15
|
|
WO2005042573A1
(en)
*
|
2003-10-24 |
2005-05-12 |
Dana-Farber Cancer Institute, Inc. |
Modulation of the interaction of muc1 with muc1 ligands
|
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
|
US8110665B2
(en)
|
2003-11-13 |
2012-02-07 |
Hanmi Holdings Co., Ltd. |
Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
|
|
ES2383300T3
(es)
|
2003-11-13 |
2012-06-20 |
Hanmi Holdings Co., Ltd |
Fragmento Fc de IgG para un vehículo de fármacos y procedimiento para su preparación
|
|
US8895540B2
(en)
|
2003-11-26 |
2014-11-25 |
DePuy Synthes Products, LLC |
Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
|
|
ES2305886T3
(es)
|
2003-12-30 |
2008-11-01 |
Merck Patent Gmbh |
Proteinas de fusion de il-7 con porciones de anticuerpo, su preparacion y su empleo.
|
|
RU2370276C2
(ru)
*
|
2003-12-31 |
2009-10-20 |
Мерк Патент Гмбх |
Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ
|
|
AU2005206277B2
(en)
|
2004-01-22 |
2011-06-23 |
Merck Patent Gmbh |
Anti-cancer antibodies with reduced complement fixation
|
|
WO2005077018A2
(en)
*
|
2004-02-06 |
2005-08-25 |
Astellas Us Llc |
Methods of treating skin disorders
|
|
NZ549040A
(en)
*
|
2004-02-17 |
2009-07-31 |
Schering Corp |
Use for interleukin-33 (IL33) and the IL-33 receptor complex
|
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
|
US20070135338A1
(en)
*
|
2004-03-31 |
2007-06-14 |
Karyn O'neil |
Human GLP-1 mimetibodies, compositions, methods and uses
|
|
MXPA06012744A
(es)
*
|
2004-05-04 |
2007-02-19 |
Genaissance Pharmaceutical Inc |
Marcadores de haplotipo y metodos para utilizarlos en la determinacion de la respuesta al tratamiento.
|
|
CA2565259A1
(en)
*
|
2004-05-07 |
2005-12-08 |
Astellas Us Llc |
Soluble lfa-3 polypeptide for treating viral disorders
|
|
US20060063208A1
(en)
*
|
2004-08-02 |
2006-03-23 |
Woolf Clifford J |
DRG11-responsive (DRAGON) gene and uses thereof
|
|
US7393662B2
(en)
*
|
2004-09-03 |
2008-07-01 |
Centocor, Inc. |
Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
|
|
PT2229956E
(pt)
|
2004-09-13 |
2013-07-31 |
Genzyme Corp |
Contruções multiméricas
|
|
WO2006036834A2
(en)
*
|
2004-09-24 |
2006-04-06 |
Amgen Inc. |
MODIFIED Fc MOLECULES
|
|
PT1802334E
(pt)
|
2004-10-21 |
2012-11-28 |
Genentech Inc |
Método para tratamento de doenças neovasculares intraoculares
|
|
AU2005299809B2
(en)
|
2004-10-22 |
2010-12-02 |
Zymogenetics, Inc. |
Anti-IL-22RA antibodies and binding partners and methods of using in inflammation
|
|
US20090311259A1
(en)
*
|
2004-11-17 |
2009-12-17 |
Victoria Smith |
Compositions and Methods for Treatment of Tumor of Hematopoietic Origin
|
|
RU2437893C2
(ru)
*
|
2004-12-09 |
2011-12-27 |
Мерк Патент Гмбх |
Варианты il-7 со сниженной иммуногенностью
|
|
CN100515491C
(zh)
*
|
2005-01-04 |
2009-07-22 |
健能隆医药技术(上海)有限公司 |
白介素-22的医药用途
|
|
EP1838736B1
(de)
|
2005-01-05 |
2013-03-06 |
Biogen Idec MA Inc. |
Cripto-bindende moleküle
|
|
DE602006017071D1
(de)
|
2005-01-25 |
2010-11-04 |
Five Prime Therapeutics Inc |
Zusammensetzungen und verfahren zur behandlung von herzkrankheiten
|
|
US20090155267A1
(en)
*
|
2005-02-09 |
2009-06-18 |
Apollo Life Sciences Limited |
Molecule and chimeric molecules thereof
|
|
KR100754667B1
(ko)
|
2005-04-08 |
2007-09-03 |
한미약품 주식회사 |
비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물
|
|
US9284375B2
(en)
|
2005-04-15 |
2016-03-15 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
US9963510B2
(en)
*
|
2005-04-15 |
2018-05-08 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
ES2971647T3
(es)
|
2005-04-15 |
2024-06-06 |
Macrogenics Inc |
Diacuerpos covalentes y usos de los mismos
|
|
US11254748B2
(en)
|
2005-04-15 |
2022-02-22 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
JO3058B1
(ar)
|
2005-04-29 |
2017-03-15 |
Applied Molecular Evolution Inc |
الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها
|
|
KR101443050B1
(ko)
*
|
2005-05-06 |
2014-09-22 |
지모제넥틱스, 인코포레이티드 |
Il-31 단클론성 항체 및 사용법
|
|
ZA200710330B
(en)
*
|
2005-06-17 |
2009-12-30 |
Wyeth Corp |
Methods of purifying FC region containing proteins
|
|
SI2452694T1
(sl)
|
2005-06-30 |
2019-05-31 |
Janssen Biotech, Inc. |
Protitelesa proti-IL-23, sestavki in postopki uporabe
|
|
HRP20131066T1
(hr)
|
2005-07-08 |
2013-12-06 |
Biogen Idec Ma Inc. |
Sp35 antitijela i njihova upotreba
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
WO2007021807A1
(en)
*
|
2005-08-12 |
2007-02-22 |
Schering Corporation |
Mcp1 fusions
|
|
EA013816B1
(ru)
|
2005-09-01 |
2010-08-30 |
Арес Трейдинг С.А. |
Лечение неврита зрительного нерва
|
|
US20070104689A1
(en)
*
|
2005-09-27 |
2007-05-10 |
Merck Patent Gmbh |
Compositions and methods for treating tumors presenting survivin antigens
|
|
CA2623329A1
(en)
*
|
2005-10-13 |
2007-04-19 |
Virexx Medical Corp. |
Chimeric antigen containing hepatitis c virus polypeptide and fc fragment for eliciting an immune response
|
|
TW200722436A
(en)
*
|
2005-10-21 |
2007-06-16 |
Hoffmann La Roche |
A peptide-immunoglobulin-conjugate
|
|
CN101356189A
(zh)
*
|
2005-11-10 |
2009-01-28 |
受体生物公司 |
肝细胞生长因子内含子融合蛋白
|
|
EP3069731A1
(de)
|
2005-11-14 |
2016-09-21 |
Labrys Biologics Inc. |
Antagonistische antikörper gegen calcitoningen-assoziiertes peptid und verfahren damit
|
|
JP2009519011A
(ja)
*
|
2005-12-01 |
2009-05-14 |
ドマンティス リミテッド |
インターロイキン1受容体1型に結合する非競合ドメイン抗体フォーマット
|
|
WO2007064911A1
(en)
*
|
2005-12-02 |
2007-06-07 |
Biogen Idec Inc. |
Anti-mouse cd20 antibodies and uses thereof
|
|
US20070161546A1
(en)
*
|
2005-12-15 |
2007-07-12 |
Colm King |
Methods and compositions for treatment of cancer
|
|
US20090148440A1
(en)
*
|
2005-12-22 |
2009-06-11 |
Dhy & Co., Ltd. |
Antibodies against interleukin-22 binding protein and its uses for the treatment of metabolic disorders
|
|
HUE034269T2
(en)
|
2005-12-29 |
2018-02-28 |
Janssen Biotech Inc |
Human anti-IL-23 antibodies, preparations, methods and applications
|
|
ES2365046T3
(es)
|
2005-12-30 |
2011-09-21 |
Merck Patent Gmbh |
Anticuerpos anti-cd19 con inmunogenicidad reducida.
|
|
PL1966238T3
(pl)
|
2005-12-30 |
2012-09-28 |
Merck Patent Gmbh |
Warianty interleukiny-12p40 o polepszonej stabilności
|
|
EP2749571A3
(de)
|
2006-01-10 |
2014-08-13 |
ZymoGenetics, Inc. |
Verfahren zur Behandlung von Schmerzen und Entzündungen in Nervengewebe mithilfe von IL-31RA- und OSMRb-Antagonisten
|
|
US7625564B2
(en)
|
2006-01-27 |
2009-12-01 |
Novagen Holding Corporation |
Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
|
|
EP1991577A2
(de)
|
2006-01-31 |
2008-11-19 |
Parkinson, John F. |
Modulation der mdl-1-aktivität zur behandlung entzündlicher krankheiten
|
|
GB0604187D0
(en)
*
|
2006-03-02 |
2006-04-12 |
Fusion Antibodies Ltd |
Peptide and uses thereof
|
|
US20090306349A1
(en)
*
|
2006-03-31 |
2009-12-10 |
Rampak Corp |
Binding partners with immunoglobulin domains modified to have extended half-life
|
|
WO2007135172A2
(en)
|
2006-05-24 |
2007-11-29 |
Laboratoires Serono S.A. |
Cladribine regimen for treating multiple sclerosis
|
|
JP2009539412A
(ja)
*
|
2006-06-12 |
2009-11-19 |
レセプター バイオロジックス, インコーポレイテッド |
汎細胞表面レセプター特異的な治療薬
|
|
AU2007261247A1
(en)
*
|
2006-06-22 |
2007-12-27 |
Vaccinex, Inc. |
Anti-C35 antibodies for treating cancer
|
|
WO2008036449A2
(en)
*
|
2006-06-29 |
2008-03-27 |
The Regents Of The University Of California |
Chemical antibodies for immunotherapy and imaging
|
|
EP2043603A4
(de)
|
2006-07-11 |
2010-10-27 |
Arubor Corp |
Prävention und therapie von rhinosinusitis mit proinflammatorischen zytokinhemmern
|
|
US20080014285A1
(en)
*
|
2006-07-13 |
2008-01-17 |
Di Mauro Thomas M |
Method of treating neurodegenerative brain disease with a composite comprising superparamagnetic nanoparticles and a therapeutic compound
|
|
HUE048024T2
(hu)
|
2006-08-10 |
2020-05-28 |
Roy C Levitt |
Anakinra bronchiolitis obliterans szindróma kezelésében való alkalmazásra
|
|
WO2008020079A1
(en)
|
2006-08-18 |
2008-02-21 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
|
|
US7767206B2
(en)
|
2006-10-02 |
2010-08-03 |
Amgen Inc. |
Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
|
|
US20120282245A1
(en)
|
2006-10-03 |
2012-11-08 |
Biogen Idec Ma Inc. |
Biomarkers and assays for the treatment of cancer
|
|
KR20090105913A
(ko)
|
2006-11-02 |
2009-10-07 |
다니엘 제이 카폰 |
이동 부분을 갖는 하이브리드 면역글로불린
|
|
AR063975A1
(es)
|
2006-11-28 |
2009-03-04 |
Centelion |
Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada
|
|
WO2008081008A1
(en)
|
2007-01-05 |
2008-07-10 |
University Of Zurich |
Method of providing disease-specific binding molecules and targets
|
|
BRPI0806340B8
(pt)
|
2007-01-09 |
2021-05-25 |
Biogen Idec Inc |
anticorpo isolado que se liga especificamente a sp35, seu uso e composição farmacêutica
|
|
EP2769731A1
(de)
|
2007-02-23 |
2014-08-27 |
The Trustees of Columbia University in the City of New York |
Verfahren zur Aktivierung oder Blockierung des HLA-E/QA-1-eingeschränkten CD8+-T-Zellen-Regulationsweges zur Behandlung von Immunerkrankungen
|
|
AU2008227024A1
(en)
*
|
2007-03-07 |
2008-09-18 |
Glycofi, Inc. |
Production of glycoproteins with modified fucosylation
|
|
CN101743249B
(zh)
|
2007-05-11 |
2017-08-08 |
阿尔托生物科学有限公司 |
融合分子与il‑15变异体
|
|
US7906149B2
(en)
*
|
2007-05-25 |
2011-03-15 |
Boval Company, L.P. |
Method for treating allergic dermatitis
|
|
US8263064B2
(en)
*
|
2007-06-04 |
2012-09-11 |
Rappaport Family Institute For Research In The Medical Sciences |
Method of suppressing disease severity of multiple sclerosis using chemokine CXC11
|
|
JP2010528647A
(ja)
*
|
2007-06-06 |
2010-08-26 |
ドマンティス リミテッド |
ポリペプチド、抗体可変ドメインおよびアンタゴニスト
|
|
BRPI0814465B1
(pt)
|
2007-07-26 |
2021-11-23 |
Novagen Holding Corporation |
Proteína de fusão, dímero, método para produzir uma proteína de fusão, linhagem de célula, usos de uma proteína de fusão e de uma composição farmacêutica e composição farmacêutica
|
|
GB0717337D0
(en)
*
|
2007-09-06 |
2007-10-17 |
Ucb Pharma Sa |
Method of treatment
|
|
EP2573112A1
(de)
|
2007-10-11 |
2013-03-27 |
The Hospital For Sick Children |
Modulation der SIRPa-CD47-Interaktion zur Erhöhung der Transplantatakzeptanz von menschlichen hämatopoetische Stammzellen und Verbindungen dafür
|
|
AU2008312580A1
(en)
*
|
2007-10-16 |
2009-04-23 |
Symphogen A/S |
Compositions comprising optimized Her1 and Her3 multimers and methods of use thereof
|
|
EP2612867A1
(de)
*
|
2007-11-01 |
2013-07-10 |
Perseid Therapeutics LLC |
Immunsuppressive Polypeptide und Nucleinsäuren
|
|
WO2009061853A2
(en)
*
|
2007-11-05 |
2009-05-14 |
Massachusetts Institute Of Technology |
Mutant interleukin-2 (il-2) polypeptides
|
|
KR20100090683A
(ko)
|
2007-11-09 |
2010-08-16 |
제넨테크, 인크. |
액티빈 수용체-유사 키나제-i 길항제 조성물 및 사용 방법
|
|
JP2011504371A
(ja)
|
2007-11-21 |
2011-02-10 |
オレゴン ヘルス アンド サイエンス ユニバーシティー |
抗第xi因子モノクローナル抗体およびその使用方法
|
|
US20090312249A1
(en)
*
|
2007-12-06 |
2009-12-17 |
Korea Advanced Institute Of Science And Technology |
TLR4 decoy receptor protein
|
|
ME03057B
(de)
|
2007-12-07 |
2019-01-20 |
Zymogenetics Inc |
Für IL-31 spezifische humanisierte Antikörpermoleküle
|
|
US20090162351A1
(en)
*
|
2007-12-21 |
2009-06-25 |
Depuy Spine, Inc. |
Transdiscal administration of inhibitors of p38 MAP kinase
|
|
US8986696B2
(en)
*
|
2007-12-21 |
2015-03-24 |
Depuy Mitek, Inc. |
Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
|
|
RU2522493C2
(ru)
|
2008-03-04 |
2014-07-20 |
Пфайзер Лимитед |
Способы лечения хронической боли
|
|
ES2589912T3
(es)
|
2008-04-02 |
2016-11-17 |
Macrogenics, Inc. |
Anticuerpos específicos para el complejo BCR y procedimientos de uso de los mismos
|
|
EA201001734A1
(ru)
*
|
2008-05-02 |
2011-10-31 |
Новартис Аг |
Улучшенные связывающие молекулы на основе фибронектина и их применение
|
|
SG190596A1
(en)
|
2008-05-06 |
2013-06-28 |
Genentech Inc |
Affinity matured crig variants
|
|
US20110081347A1
(en)
*
|
2008-06-04 |
2011-04-07 |
Macrogenics, Inc. |
Antibodies with Altered Binding to FcRn and Methods of Using Same
|
|
CA2729961C
(en)
|
2008-07-09 |
2018-05-01 |
Biogen Idec Ma Inc. |
Li113, li62 variant co2, anti-lingo antibodies
|
|
MX2011000861A
(es)
|
2008-07-23 |
2011-06-21 |
Hanmi Holdings Co Ltd |
Un complejo polipeptidico que consiste en un polimero no-peptidil que posee tres terminaciones funcionales.
|
|
CN102317316B
(zh)
|
2008-12-19 |
2014-08-13 |
帕尼玛制药股份公司 |
人抗α突触核蛋白自身抗体
|
|
US20100159485A1
(en)
*
|
2008-12-19 |
2010-06-24 |
Centre For Dna Fingerprinting And Diagnostics |
Detection of mycobacterium tuberculosis
|
|
JP2012514458A
(ja)
|
2008-12-31 |
2012-06-28 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
抗リンホトキシン抗体
|
|
WO2010111180A1
(en)
|
2009-03-24 |
2010-09-30 |
Teva Biopharmaceuticals Usa, Inc. |
Humanized antibodies against light and uses thereof
|
|
MA33248B1
(fr)
|
2009-04-01 |
2012-05-02 |
Genentech Inc |
Traitement de troubles résistant à l'insuline
|
|
WO2010115995A2
(en)
|
2009-04-10 |
2010-10-14 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
NZ595461A
(en)
|
2009-04-10 |
2013-01-25 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
JP5727459B2
(ja)
|
2009-04-22 |
2015-06-03 |
アルテオゼン, インクAlteogen, Inc |
体内持続性を維持することにより体内半減期が増加したタンパク質またはペプチド融合体
|
|
SG175233A1
(en)
|
2009-04-22 |
2011-11-28 |
Merck Patent Gmbh |
Antibody fusion proteins with modified fcrn binding sites
|
|
WO2010129917A2
(en)
|
2009-05-08 |
2010-11-11 |
Vaccinex, Inc. |
Anti-cd100 antibodies and methods for using the same
|
|
HRP20150553T1
(hr)
|
2009-05-15 |
2015-08-28 |
University Health Network |
Sastavi i metode za lijeäśenje hematoloških maligniteta ciljajuä†i sirp - cd47 interakciju
|
|
CN102482324B
(zh)
|
2009-06-15 |
2014-07-02 |
拜欧肯疗法有限公司 |
能够抑制自身免疫、炎症和癌症进程的新型趋化因子结合多肽
|
|
US20110039300A1
(en)
|
2009-08-10 |
2011-02-17 |
Robert Bayer |
Antibodies with enhanced adcc functions
|
|
US20110053223A1
(en)
|
2009-08-14 |
2011-03-03 |
Robert Bayer |
Cell culture methods to make antibodies with enhanced adcc function
|
|
CN102740884A
(zh)
|
2009-08-28 |
2012-10-17 |
瑞纳神经科学公司 |
通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法
|
|
JP5898082B2
(ja)
|
2009-10-07 |
2016-04-06 |
マクロジェニクス,インコーポレーテッド |
フコシル化程度の変更により改良されたエフェクター機能を示すFc領域含有ポリペプチドおよびその使用法
|
|
TW201117824A
(en)
|
2009-10-12 |
2011-06-01 |
Amgen Inc |
Use of IL-17 receptor a antigen binding proteins
|
|
WO2011056502A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Bone morphogenetic protein receptor type ii compositions and methods of use
|
|
WO2011056494A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations
|
|
WO2011056497A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor type iib compositions and methods of use
|
|
US20110165122A1
(en)
*
|
2009-11-10 |
2011-07-07 |
The Regents Of The University Of California |
Method for targeted and sustained antiviral therapy
|
|
WO2011071957A1
(en)
|
2009-12-07 |
2011-06-16 |
Sea Lane Biotechnologies, Llc |
Conjugates comprising an antibody surrogate scaffold with improved pharmacokinetic properties
|
|
WO2011079308A2
(en)
|
2009-12-23 |
2011-06-30 |
Emergent Product Development Seattle, Llc |
Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof
|
|
US8637637B2
(en)
|
2010-01-12 |
2014-01-28 |
Bill Nai-Chau Sun |
Fc fusion proteins of human growth hormone
|
|
PH12012501364A1
(en)
|
2010-01-15 |
2012-10-22 |
Amgen K A Inc |
Antibody formulation and therapeutic regimens
|
|
EP2536435B1
(de)
|
2010-02-18 |
2017-11-15 |
Janssen Biotech, Inc. |
Affenhomolog von menschlichem interferon omega
|
|
EP2542256B1
(de)
|
2010-03-04 |
2019-05-22 |
MacroGenics, Inc. |
Mit b7-h3 reagierende antikörper, immunologisch wirkende fragmente davon und verwendungen davon
|
|
PH12012501751A1
(en)
|
2010-03-04 |
2012-11-12 |
Macrogenics Inc |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
|
WO2011109280A1
(en)
|
2010-03-05 |
2011-09-09 |
Lerner Research Institute |
Methods and compositions to treat immune-mediated disorders
|
|
US10745467B2
(en)
|
2010-03-26 |
2020-08-18 |
The Trustees Of Dartmouth College |
VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
|
|
US20150231215A1
(en)
|
2012-06-22 |
2015-08-20 |
Randolph J. Noelle |
VISTA Antagonist and Methods of Use
|
|
MX374075B
(es)
|
2010-03-26 |
2025-03-05 |
Dartmouth College |
Proteina mediadora de celula t regulatoria vista, agentes de enlace de vista y uso de los mismos.
|
|
US20110243943A1
(en)
*
|
2010-04-02 |
2011-10-06 |
Athena Discovery, Inc. |
Treatment using relaxin-fusion proteins with extended in vivo half-lives
|
|
WO2011130533A1
(en)
|
2010-04-16 |
2011-10-20 |
Centocor Ortho Biotech Inc. |
Engineered plant cysteine proteases and their uses
|
|
US8524217B2
(en)
|
2010-05-11 |
2013-09-03 |
Merck Sharp & Dohme Corp. |
MCP1-Ig fusion variants
|
|
CA2802994A1
(en)
|
2010-06-17 |
2011-12-22 |
The United States Of America As Represented By The Secretary, National I Nstitutes Of Health |
Compositions and methods for treating inflammatory conditions
|
|
EP3508573A1
(de)
|
2010-07-09 |
2019-07-10 |
Bioverativ Therapeutics Inc. |
Systeme für faktor viii-verarbeitung und verfahren davon
|
|
AU2011286024B2
(en)
|
2010-08-02 |
2014-08-07 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
EP3327032A1
(de)
|
2010-08-06 |
2018-05-30 |
Genzyme Corporation |
Vegf-antagonisten-zusammensetzungen und verwendungen davon
|
|
SG188285A1
(en)
|
2010-09-02 |
2013-04-30 |
Vaccinex Inc |
Anti-cxcl13 antibodies and methods of using the same
|
|
US8507222B2
(en)
|
2010-09-21 |
2013-08-13 |
Altor Bioscience Corporation |
Multimeric IL-15 soluble fusion molecules and methods of making and using same
|
|
US11053299B2
(en)
|
2010-09-21 |
2021-07-06 |
Immunity Bio, Inc. |
Superkine
|
|
ES2757857T3
(es)
|
2010-09-27 |
2020-04-30 |
Janssen Biotech Inc |
Anticuerpos de unión a colágeno II humano
|
|
CA2813493C
(en)
|
2010-10-11 |
2019-07-09 |
University Of Zurich |
Human anti-tau antibodies
|
|
US8883134B2
(en)
*
|
2010-10-20 |
2014-11-11 |
Handok Pharmaceuticals, Inc. |
Human interleukin-1 receptor antagonist—hybrid Fc fusion protein
|
|
US20120201821A1
(en)
|
2010-10-25 |
2012-08-09 |
Gonzalez Jr Lino |
Treatment of Gastrointestinal Inflammation and Psoriasis and Asthma
|
|
AU2011328246B2
(en)
|
2010-11-08 |
2016-06-30 |
Ablynx N.V. |
CXCR2 binding polypeptides
|
|
AU2011343161B2
(en)
|
2010-12-17 |
2017-02-02 |
Neurimmune Holding Ag |
Human anti-SOD1 antibodies
|
|
TWI705825B
(zh)
|
2011-05-20 |
2020-10-01 |
美商艾爾德生物控股有限責任公司 |
抗降血鈣素基因相關胜肽(anti-cgrp)或抗降血鈣素基因相關胜肽受器(anti-cgrp-r)抗體或抗體片段治療或預防慢性及急性型腹瀉之用途
|
|
PE20141787A1
(es)
|
2011-05-20 |
2014-12-07 |
Alderbio Holdings Llc |
Composiciones anti-cgrp y uso de las mismas
|
|
CN107827982B
(zh)
|
2011-05-20 |
2021-07-06 |
H.伦德贝克公司 |
抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途
|
|
BR112013029892A2
(pt)
|
2011-05-21 |
2016-12-20 |
Macrogenics Inc |
polipeptídeo, molécula de ligação a antígeno, diacorpo e uso de uma porção polipeptídica de uma proteína de ligação a soro desimunizada
|
|
ES2765874T3
(es)
|
2011-05-25 |
2020-06-11 |
Innate Pharma Sa |
Anticuerpos anti-KIR para el tratamiento de trastornos inflamatorios
|
|
SI2723379T1
(sl)
|
2011-06-23 |
2019-03-29 |
Biogen International Neuroscience Gmbh |
Molekule, ki se vežejo ma anti alfa-sinuklein
|
|
WO2012178102A2
(en)
|
2011-06-24 |
2012-12-27 |
The Regents Of The Unversity Of Colorado, A Body Corporate |
Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
|
|
KR20140039257A
(ko)
*
|
2011-07-08 |
2014-04-01 |
바이엘 인텔렉쳐 프로퍼티 게엠베하 |
릴랙신을 방출하는 융합 단백질 및 이의 용도
|
|
WO2013012733A1
(en)
|
2011-07-15 |
2013-01-24 |
Biogen Idec Ma Inc. |
Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
|
|
WO2013016220A1
(en)
|
2011-07-22 |
2013-01-31 |
Amgen Inc. |
Il-17 receptor a is required for il-17c biology
|
|
WO2013041722A1
(en)
|
2011-09-23 |
2013-03-28 |
Ablynx Nv |
Prolonged inhibition of interleukin-6 mediated signaling
|
|
EP2766035B1
(de)
|
2011-10-11 |
2018-03-28 |
Universität Zürich Prorektorat MNW |
Kombinationsmedikament mit il-12 und einem mittel zur blockade von t-zellen-hemmer-molekülen zur tumortherapie
|
|
US11951157B2
(en)
|
2011-10-11 |
2024-04-09 |
Universitat Zurich |
Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
|
|
JP6162707B2
(ja)
|
2011-10-24 |
2017-07-12 |
ハロザイム インコーポレイテッド |
抗ヒアルロナン剤治療のためのコンパニオン診断およびその使用方法
|
|
CA2896951A1
(en)
|
2012-01-10 |
2013-07-18 |
The Regents Of The University Of Colorado, A Body Corporate |
Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
|
|
NZ629828A
(en)
|
2012-03-02 |
2017-05-26 |
Vaccinex Inc |
Methods for the treatment of b cell-mediated inflammatory diseases
|
|
AU2013263349B2
(en)
|
2012-05-17 |
2016-09-08 |
Extend Biosciences, Inc |
Carriers for improved drug delivery
|
|
EP2852610B1
(de)
|
2012-05-23 |
2018-07-11 |
Glykos Finland Oy |
Herstellung von fucosylierten glykoproteinen
|
|
JP6285923B2
(ja)
|
2012-06-22 |
2018-02-28 |
トラスティーズ・オブ・ダートマス・カレッジ |
新規VISTA−Igコンストラクト及び自己免疫、アレルギー性及び炎症性障害の処置のためのVISTA−Igの使用
|
|
US9890215B2
(en)
|
2012-06-22 |
2018-02-13 |
King's College London |
Vista modulators for diagnosis and treatment of cancer
|
|
CA2878404A1
(en)
|
2012-07-10 |
2014-01-16 |
The Trustees Of The University Of Pennsylvania |
Biomaterials for enhanced implant-host integration
|
|
EP2879710B1
(de)
|
2012-08-03 |
2019-11-13 |
Dana-Farber Cancer Institute, Inc. |
Medizinische verwendungen von immunzellenaktivierungsmodulierenden substanzen und entsprechende screeningverfahren
|
|
ES2702315T3
(es)
|
2012-08-24 |
2019-02-28 |
Univ California |
Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis
|
|
US9381244B2
(en)
|
2012-09-07 |
2016-07-05 |
King's College London |
VISTA modulators for diagnosis and treatment of cancer
|
|
WO2014062856A1
(en)
|
2012-10-16 |
2014-04-24 |
Halozyme, Inc. |
Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
|
|
PL3575326T3
(pl)
|
2012-12-17 |
2022-07-11 |
Pf Argentum Ip Holdings Llc |
Leczenie komórek chorobowych cd47+ z użyciem fuzji sirp alfa-fc
|
|
EP4282419A1
(de)
|
2012-12-20 |
2023-11-29 |
Purdue Research Foundation |
Chimären antigenrezeptor exprimierende t-zellen als antikrebsmittel
|
|
CA2896066C
(en)
|
2012-12-21 |
2022-07-12 |
Biogen Ma Inc. |
Human anti-tau antibodies
|
|
CN104936980B
(zh)
|
2012-12-31 |
2019-06-07 |
生物控股有限公司 |
用于治疗和预防多瘤病毒相关的疾病的重组人抗体
|
|
US9487587B2
(en)
|
2013-03-05 |
2016-11-08 |
Macrogenics, Inc. |
Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
|
|
AU2013205589A1
(en)
|
2013-03-08 |
2014-09-25 |
Vaccinex, Inc. |
Anti-CXCL13 antibodies and associated epitope sequences
|
|
PH12022550138A1
(en)
|
2013-03-13 |
2023-03-06 |
Amgen Inc |
Proteins specific for baff and b7rp1 and uses thereof
|
|
US9458246B2
(en)
|
2013-03-13 |
2016-10-04 |
Amgen Inc. |
Proteins specific for BAFF and B7RP1
|
|
SMT202100464T1
(it)
|
2013-03-14 |
2021-11-12 |
Macrogenics Inc |
Molecole bispecifiche che sono immunoreattive con cellule effettrici immunitarie che esprimono un recettore di attivazione
|
|
ES2708565T3
(es)
|
2013-03-15 |
2019-04-10 |
Atyr Pharma Inc |
Conjugados de Fc-histidil-ARNt sintetasa
|
|
WO2014145016A2
(en)
|
2013-03-15 |
2014-09-18 |
Genentech, Inc. |
Il-22 polypeptides and il-22 fc fusion proteins and methods of use
|
|
WO2014144549A1
(en)
|
2013-03-15 |
2014-09-18 |
Biogen Idec Ma Inc. |
Factor ix polypeptide formulations
|
|
RS61778B1
(sr)
|
2013-05-06 |
2021-06-30 |
Scholar Rock Inc |
Kompozicije i postupci za modulaciju faktora rasta
|
|
EP3293275B1
(de)
|
2013-06-06 |
2021-08-04 |
Dana-Farber Cancer Institute, Inc. |
Zusammensetzung und verfahren zur identifikation, beurteilung, vorbeugung und behandlung von krebs mit pd-l1-isoformen
|
|
US20170114122A1
(en)
|
2015-10-23 |
2017-04-27 |
Alderbio Holdings Llc |
Regulation of glucose metabolism using anti-cgrp antibodies
|
|
AR096891A1
(es)
|
2013-07-12 |
2016-02-03 |
Hanmi Pharm Ind Co Ltd |
Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo
|
|
UA116479C2
(uk)
|
2013-08-09 |
2018-03-26 |
Макродженікс, Інк. |
БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ
|
|
US11384149B2
(en)
|
2013-08-09 |
2022-07-12 |
Macrogenics, Inc. |
Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
|
|
EP2840091A1
(de)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bispezifische Diabodies, die gpA33 und CD3 binden können und Anwendungen dieser
|
|
EP2839842A1
(de)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bispezifische monovalente Diabodies mit Fähigkeit zur Bindung von CD123 und CD3 und Verwendungen davon
|
|
WO2015048312A1
(en)
|
2013-09-26 |
2015-04-02 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
EP3077048B1
(de)
|
2013-12-07 |
2019-07-17 |
Case Western Reserve University |
Zusammensetzungen und verfahren zur behandlung von thrombose
|
|
WO2015095868A1
(en)
|
2013-12-20 |
2015-06-25 |
Wake Forest University Health Sciences |
Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines
|
|
WO2015097536A2
(en)
|
2013-12-24 |
2015-07-02 |
Janssen Pharmaceutical Nv |
Anti-vista antibodies and fragments
|
|
US11014987B2
(en)
|
2013-12-24 |
2021-05-25 |
Janssen Pharmaceutics Nv |
Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
|
|
AU2015206603B9
(en)
|
2014-01-14 |
2019-07-18 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using PD-L1 isoforms
|
|
EP3096776B1
(de)
*
|
2014-01-22 |
2020-12-02 |
Antagonis Biotherapeutics GmbH |
Neuartige glycosaminoglycan-antagonisierende fusionsproteine und verfahren zur verwendung davon
|
|
US10556945B2
(en)
|
2014-03-21 |
2020-02-11 |
Teva Pharmaceuticals International Gmbh |
Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
|
|
AU2015230933B2
(en)
|
2014-03-21 |
2020-08-13 |
Teva Pharmaceuticals International Gmbh |
Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
|
|
CA2944605C
(en)
|
2014-03-31 |
2023-10-17 |
Kirin-Amgen, Inc. |
Methods of treating nail and scalp psoriasis
|
|
US11123426B2
(en)
|
2014-06-11 |
2021-09-21 |
The Trustees Of Dartmouth College |
Use of vista agonists and antagonists to suppress or enhance humoral immunity
|
|
KR102762243B1
(ko)
|
2014-06-30 |
2025-02-05 |
알토 바이오사이언스 엘엘씨 |
Il-15-베이즈드 분자 및 이의 사용 방법
|
|
SG11201700446XA
(en)
|
2014-07-21 |
2017-02-27 |
Glykos Finland Oy |
Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
|
|
CA2954738A1
(en)
|
2014-07-29 |
2016-02-04 |
Neurimmune Holding Ag |
Human-derived anti-huntingtin (htt) antibodies and uses thereof
|
|
WO2016022597A1
(en)
|
2014-08-04 |
2016-02-11 |
Case Western Reserve University |
Targeting peptides and methods of use
|
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
|
MX386297B
(es)
|
2014-09-29 |
2025-03-18 |
Univ Duke |
Moleculas biespecificas que comprenden un brazo orientado a la envoltura vih-1.
|
|
SG10201902850TA
(en)
|
2014-09-30 |
2019-04-29 |
Neurimmune Holding Ag |
Human-derived anti-dipeptide repeats (dprs) antibody
|
|
CA2963712A1
(en)
|
2014-10-21 |
2016-04-28 |
Ablynx Nv |
Treatment of il-6r related diseases
|
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
|
US9616109B2
(en)
|
2014-10-22 |
2017-04-11 |
Extend Biosciences, Inc. |
Insulin vitamin D conjugates
|
|
WO2016065042A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Therapeutic vitamin d conjugates
|
|
CA2969730A1
(en)
|
2014-12-05 |
2016-06-09 |
Immunext, Inc. |
Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators
|
|
ES3015000T3
(en)
|
2014-12-08 |
2025-04-28 |
Dana Farber Cancer Inst Inc |
Methods for upregulating immune responses using combinations of anti-rgmb and anti-pd-1 agents
|
|
JP2018506275A
(ja)
|
2015-01-28 |
2018-03-08 |
ジェネンテック, インコーポレイテッド |
多発性硬化症の遺伝子発現マーカー及び治療
|
|
US10676723B2
(en)
|
2015-05-11 |
2020-06-09 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
US11820807B2
(en)
|
2015-06-12 |
2023-11-21 |
Ubi Pharma Inc |
Immunoglobulin fusion proteins and uses thereof
|
|
CA2990360C
(en)
|
2015-06-24 |
2024-02-13 |
Janssen Pharmaceutica Nv |
Anti-vista antibodies and fragments
|
|
AU2016304794B2
(en)
|
2015-08-07 |
2021-07-15 |
ALX Oncology Inc. |
Constructs having a SIRP-alpha domain or variant thereof
|
|
HK1258218A1
(zh)
|
2015-09-15 |
2019-11-08 |
Board Of Regents, The University Of Texas System |
T细胞受体(tcr)结合抗体及其应用
|
|
US11338065B2
(en)
|
2015-10-08 |
2022-05-24 |
Massachusetts Institute Of Technology |
In situ expansion of engineered devices for regeneration
|
|
US11207393B2
(en)
|
2015-10-16 |
2021-12-28 |
President And Fellows Of Harvard College |
Regulatory T cell PD-1 modulation for regulating T cell effector immune responses
|
|
AU2016371466B2
(en)
|
2015-12-17 |
2020-04-09 |
Alonbio Ltd |
Small Molecules for Inhibiting Chemokine Activity and/or Cancer Cells Growth
|
|
EP3390378B1
(de)
|
2015-12-17 |
2022-03-30 |
AlonBio Ltd. |
Kleine moleküle gegen krebs
|
|
WO2017117558A1
(en)
|
2015-12-31 |
2017-07-06 |
The Regents Of The University Of Colorado, A Body Corporate |
Methods and uses for alpha-1 antitrypsin or recombinant forms thereof, on steroid-refractory graft versus host disease involving gastrointestinal complications
|
|
WO2017137830A1
(en)
|
2016-02-12 |
2017-08-17 |
Janssen Pharmaceutica Nv |
Anti-vista (b7h5) antibodies
|
|
AU2017231833B2
(en)
|
2016-03-10 |
2024-03-14 |
Viela Bio, Inc. |
ILT7 binding molecules and methods of using the same
|
|
EP3439675A4
(de)
|
2016-04-08 |
2019-12-18 |
Purdue Research Foundation |
Verfahren und zusammensetzungen für car-t-zelltherapie
|
|
GEP20227398B
(en)
|
2016-04-15 |
2022-07-25 |
Macrogenics Inc |
Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof
|
|
KR20230119259A
(ko)
|
2016-04-15 |
2023-08-16 |
이뮤넥스트, 인크. |
항-인간 vista 항체 및 이의 용도
|
|
US10865230B2
(en)
|
2016-05-27 |
2020-12-15 |
Altor Bioscience, Llc |
Construction and characterization of multimeric IL-15-based molecules with CD3 binding domains
|
|
JP2018035137A
(ja)
|
2016-07-13 |
2018-03-08 |
マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag |
新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用
|
|
CN109952314A
(zh)
|
2016-09-23 |
2019-06-28 |
泰瓦制药国际有限公司 |
治疗难治性偏头痛
|
|
EP4613776A3
(de)
|
2016-10-21 |
2025-11-26 |
Altor BioScience Corporation |
Multimere il-15-basierte moleküle
|
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
|
WO2018140121A1
(en)
|
2017-01-30 |
2018-08-02 |
Janssen Biotech, Inc. |
Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis
|
|
MX2019009377A
(es)
|
2017-02-07 |
2019-12-11 |
Janssen Biotech Inc |
Anticuerpos anti-tnf, composiciones y metodos para el tratamiento de la espondilitis anquilosante activa.
|
|
US11649288B2
(en)
|
2017-02-07 |
2023-05-16 |
Seattle Children's Hospital |
Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
|
|
WO2018160622A1
(en)
|
2017-02-28 |
2018-09-07 |
Endocyte, Inc. |
Compositions and methods for car t cell therapy
|
|
TW202428301A
(zh)
|
2017-02-28 |
2024-07-16 |
法商賽諾菲公司 |
治療性rna
|
|
KR102867975B1
(ko)
|
2017-03-06 |
2025-10-14 |
알토 바이오사이언스 엘엘씨 |
Il-12 및 il-18로의 il-15-기반 융합
|
|
US20190048055A1
(en)
|
2017-03-31 |
2019-02-14 |
Altor Bioscience Corporation |
Alt-803 in combination with anti-cd38 antibody for cancer therapies
|
|
CA3060514A1
(en)
|
2017-04-20 |
2018-10-25 |
Atyr Pharma, Inc. |
Compositions and methods for treating lung inflammation
|
|
CA3061963A1
(en)
|
2017-05-05 |
2018-11-08 |
Vaccinex, Inc. |
Human anti-semaphorin 4d antibody
|
|
JP2020533971A
(ja)
|
2017-08-28 |
2020-11-26 |
アルター・バイオサイエンス・コーポレーション |
Il−15をベースとするil−7及びil−21への融合物
|
|
AR113906A1
(es)
|
2017-11-24 |
2020-06-24 |
Merck Patent Ges Mit Beschraenkter Haftung |
Régimen con cladribina para tratar formas progresivas de la esclerosis múltiple
|
|
US11311576B2
(en)
|
2018-01-22 |
2022-04-26 |
Seattle Children's Hospital |
Methods of use for CAR T cells
|
|
CN112020365A
(zh)
|
2018-01-26 |
2020-12-01 |
豪夫迈·罗氏有限公司 |
组合物和使用方法
|
|
CR20200327A
(es)
|
2018-01-26 |
2020-11-05 |
Genentech Inc |
Proteínas de fusión fc il-22 y métodos de uso
|
|
US12312416B2
(en)
|
2018-02-06 |
2025-05-27 |
Seattle Children's Hospital |
Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors
|
|
KR20200123118A
(ko)
|
2018-02-21 |
2020-10-28 |
제넨테크, 인크. |
IL-22 Fc 융합 단백질로 치료를 위한 투약
|
|
AU2019225174B2
(en)
|
2018-02-23 |
2025-11-20 |
Endocyte, Inc. |
Sequencing method for CAR T cell therapy
|
|
WO2019168897A2
(en)
|
2018-02-28 |
2019-09-06 |
Dana-Farber Cancer Institute, Inc. |
Methods for treating cancer using combinations of anti-btnl2 and immune checkpoint blockade agents
|
|
US11168138B2
(en)
|
2018-03-26 |
2021-11-09 |
Altor Bioscience, Llc |
Anti-PDL1, IL-15 and TGF-beta receptor combination molecules
|
|
JP7429192B2
(ja)
|
2018-04-06 |
2024-02-07 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
Hhla2受容体としてのkir3dl3、抗hhla2抗体、およびその使用
|
|
CN110396133B
(zh)
|
2018-04-25 |
2021-07-23 |
免疫靶向有限公司 |
一种以白介素12为活性成分的融合蛋白型药物前体
|
|
KR102194644B1
(ko)
|
2018-04-26 |
2020-12-24 |
주식회사 굳티셀 |
신규한 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물
|
|
KR20250156190A
(ko)
|
2018-06-22 |
2025-10-31 |
큐진 인크. |
인터루킨-2 변이체 및 이의 사용 방법
|
|
WO2020003978A1
(ja)
*
|
2018-06-28 |
2020-01-02 |
国立大学法人 岡山大学 |
好中球貪食能増強剤
|
|
US20210347849A1
(en)
*
|
2018-07-24 |
2021-11-11 |
Good T Cells, Inc. |
Composition for Preventing or Treating Immune-Related Diseases
|
|
JP7490925B2
(ja)
|
2018-07-26 |
2024-05-28 |
エータイアー ファーマ, インコーポレイテッド |
Nrp2関連疾患を治療するための組成物および方法
|
|
CN110964116A
(zh)
|
2018-09-26 |
2020-04-07 |
北京辅仁瑞辉生物医药研究院有限公司 |
GLP1-Fc融合蛋白及其缀合物
|
|
JP2022513082A
(ja)
|
2018-11-19 |
2022-02-07 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
免疫応答を調節するためのIRE1α-XBP1シグナル伝達経路バイオマーカーの使用
|
|
WO2020146527A1
(en)
|
2019-01-08 |
2020-07-16 |
Alder Biopharmaceuticals, Inc. |
Acute treatment and rapid treatment of headache using anti-cgrp antibodies
|
|
JP7689074B2
(ja)
|
2019-01-15 |
2025-06-05 |
ヤンセン バイオテツク,インコーポレーテツド |
若年性特発性関節炎の治療のための抗tnf抗体、組成物、及び方法
|
|
WO2020152544A1
(en)
|
2019-01-23 |
2020-07-30 |
Janssen Biotech, Inc. |
Anti-tnf antibody compositions for use in methods for the treatment of psoriatic arthritis
|
|
CA3130103A1
(en)
|
2019-02-13 |
2020-08-20 |
The Brigham And Women's Hospital, Inc. |
Anti-peripheral lymph node addressin antibodies and uses thereof
|
|
EA202192505A1
(ru)
|
2019-03-14 |
2022-03-29 |
Янссен Байотек, Инк. |
Способы получения композиций антитела к фно
|
|
KR20210141998A
(ko)
|
2019-03-14 |
2021-11-23 |
얀센 바이오테크 인코포레이티드 |
항-tnf 항체 조성물의 제조 방법
|
|
WO2020183269A1
(en)
|
2019-03-14 |
2020-09-17 |
Janssen Biotech, Inc. |
Manufacturing methods for producing anti-tnf antibody compositions
|
|
EP3962529A4
(de)
|
2019-04-30 |
2023-11-01 |
Dana-Farber Cancer Institute, Inc. |
Verfahren zur krebsbehandlung unter verwendung von kombinationen aus anti-cx3cr1 und immuncheckpoint-blockierungsreagenzien
|
|
ES3014809T3
(en)
|
2019-05-15 |
2025-04-25 |
Alonbio Ltd |
Small molecules for treating cancer, inhibiting chemokine activity and/or inducing cell death
|
|
JP7489407B2
(ja)
|
2019-05-21 |
2024-05-23 |
ノバルティス アーゲー |
Cd19結合分子及びその使用
|
|
JP7805788B2
(ja)
|
2019-05-23 |
2026-01-26 |
ヤンセン バイオテツク,インコーポレーテツド |
Il-23及びtnfアルファに対する抗体の併用療法による炎症性腸疾患の治療方法
|
|
CN114126648A
(zh)
|
2019-05-31 |
2022-03-01 |
Alx肿瘤生物技术公司 |
用SIRPα Fc融合体组合免疫检查点抑制剂治疗癌症的方法
|
|
JP2022536279A
(ja)
|
2019-06-03 |
2022-08-15 |
ヤンセン バイオテツク,インコーポレーテツド |
乾癬性関節炎を治療するための抗tnf抗体組成物及び方法
|
|
MX2021014882A
(es)
|
2019-06-03 |
2022-03-25 |
Janssen Biotech Inc |
Anticuerpos anti-tnf, composiciones y métodos para el tratamiento de la espondilitis anquilosante activa.
|
|
WO2021028752A1
(en)
|
2019-08-15 |
2021-02-18 |
Janssen Biotech, Inc. |
Anti-tfn antibodies for treating type i diabetes
|
|
CN121243368A
(zh)
|
2019-11-27 |
2026-01-02 |
Alx肿瘤生物技术公司 |
用于治疗癌症的组合疗法
|
|
JP7807076B2
(ja)
|
2019-12-13 |
2026-01-27 |
キュージーン インコーポレイテッド |
新規インターロイキン-15(il-15)融合タンパク質およびその使用
|
|
EP4093513A4
(de)
|
2020-01-24 |
2024-05-08 |
Dana-Farber Cancer Institute, Inc. |
Verwendung von biomarkern zur verbesserung der immuntherapie
|
|
CN115210252A
(zh)
|
2020-02-04 |
2022-10-18 |
西雅图儿童医院(Dba西雅图儿童研究所) |
抗二硝基苯酚的嵌合抗原受体
|
|
US20230220085A1
(en)
|
2020-02-28 |
2023-07-13 |
The Brigham And Women’S Hospital, Inc. |
Selective modulation of transforming growth factor beta superfamily signaling via multi-specific antibodies
|
|
US11725043B2
(en)
|
2020-03-05 |
2023-08-15 |
DiaMedica USA Inc. |
Ulinastatin polypeptides
|
|
CA3077973A1
(en)
|
2020-04-06 |
2021-10-06 |
H. Lundbeck A/S |
Treatment of most bothersome symptom (mbs) associated with migraine using anti-cgrp antibodies
|
|
WO2021207662A1
(en)
|
2020-04-10 |
2021-10-14 |
Genentech, Inc. |
Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome
|
|
US20230227511A1
(en)
*
|
2020-05-14 |
2023-07-20 |
Nippon Medical School Foundation |
Therapeutic or preventive agent for infectious disease
|
|
IL298389A
(en)
|
2020-05-21 |
2023-01-01 |
Janssen Biotech Inc |
Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha
|
|
BR112023003432A2
(pt)
|
2020-09-10 |
2023-03-21 |
Merck Patent Gmbh |
Regime de tratamento para o tratamento de doenças autoimunes
|
|
JP2024520902A
(ja)
|
2021-05-13 |
2024-05-27 |
エーエルエックス オンコロジー インコーポレイテッド |
がんを治療するための併用療法
|
|
US20240280561A1
(en)
|
2021-06-08 |
2024-08-22 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
|
|
US12534524B2
(en)
|
2021-07-09 |
2026-01-27 |
Janssen Biotech, Inc. |
Manufacturing methods for producing anti-TNF antibody compositions
|
|
EP4367136A1
(de)
|
2021-07-09 |
2024-05-15 |
Janssen Biotech, Inc. |
Herstellungsverfahren zur herstellung von anti-tnf-antikörperzusammensetzungen
|
|
WO2023097119A2
(en)
|
2021-11-29 |
2023-06-01 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions to modulate riok2
|
|
WO2023168426A1
(en)
|
2022-03-03 |
2023-09-07 |
Enosi Therapeutics Corporation |
Compositions and cells containing mixtures of oligo-trap fusion proteins (ofps) and uses thereof
|
|
WO2023173084A1
(en)
|
2022-03-11 |
2023-09-14 |
University Of Rochester |
Cyclopeptibodies and uses thereof
|
|
IL316249A
(en)
|
2022-05-02 |
2024-12-01 |
Novo Nordisk As |
Novel anti-angptl3 antibodies suitable for high concentration compositions and subcutaneous administration
|
|
KR20250075704A
(ko)
|
2022-09-30 |
2025-05-28 |
익스텐드 바이오사이언시즈, 인크. |
장기-지속형 부갑상선 호르몬
|
|
WO2024186690A2
(en)
|
2023-03-03 |
2024-09-12 |
Enosi Therapeutics Corporation |
Oligo-trap fusion proteins (ofps) and uses thereof
|
|
KR20260010739A
(ko)
|
2023-05-11 |
2026-01-21 |
유니버시티 하스피탈즈 클리블랜드 메디컬 센터 |
항불안 치료
|