LV12806B - Cc-1065 analogi ar divam cpi apaksvienibam - Google Patents

Cc-1065 analogi ar divam cpi apaksvienibam

Info

Publication number
LV12806B
LV12806B LV010180A LV010180A LV12806B LV 12806 B LV12806 B LV 12806B LV 010180 A LV010180 A LV 010180A LV 010180 A LV010180 A LV 010180A LV 12806 B LV12806 B LV 12806B
Authority
LV
Latvia
Prior art keywords
pct
formula
date mar
compounds
sec
Prior art date
Application number
LV010180A
Other languages
English (en)
Latvian (lv)
Other versions
LV12806A (en
Inventor
Robert C Kelly
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of LV12806A publication Critical patent/LV12806A/en
Publication of LV12806B publication Critical patent/LV12806B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Artificial Filaments (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Amplifiers (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Television Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Stereophonic System (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Television Receiver Circuits (AREA)
LV010180A 1988-09-12 2001-12-27 Cc-1065 analogi ar divam cpi apaksvienibam LV12806B (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (2)

Publication Number Publication Date
LV12806A LV12806A (en) 2002-03-20
LV12806B true LV12806B (lv) 2002-05-20

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
LV010180A LV12806B (lv) 1988-09-12 2001-12-27 Cc-1065 analogi ar divam cpi apaksvienibam

Country Status (14)

Country Link
US (1) US5541339A (cs)
JP (1) JP3380237B2 (cs)
KR (1) KR0137959B1 (cs)
AT (1) ATE198335T1 (cs)
AU (1) AU632288B2 (cs)
CA (1) CA1340215C (cs)
DE (1) DE68929275T2 (cs)
DK (1) DK175458B1 (cs)
FI (1) FI103668B1 (cs)
GR (1) GR3035589T3 (cs)
LV (1) LV12806B (cs)
NO (1) NO303498B1 (cs)
TW (1) TW217383B (cs)
WO (1) WO1990002746A1 (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2076465C (en) * 1992-03-25 2002-11-26 Ravi V. J. Chari Cell binding agent conjugates of analogues and derivatives of cc-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7589180B2 (en) 2001-05-11 2009-09-15 Abbott Laboratories Inc. Specific binding proteins and uses thereof
BR0214019A (pt) 2001-11-09 2004-10-13 Boehringer Ingelheim Phamaceut Benzimidazóis úteis como inibidores de proteìna quinase
EP1529046A1 (en) * 2002-08-08 2005-05-11 Boehringer Ingelheim Pharmaceuticals Inc. Substituted benzimidazole compounds
JP2006505571A (ja) * 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びｈｃｖ阻害剤としてのその使用
US20070213374A1 (en) * 2003-07-07 2007-09-13 Merck Patent Gmbh Malonamide Derivatives
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
US7446195B2 (en) * 2005-08-17 2008-11-04 Schering Corporation High affinity thiophene-based and furan-based kinase ligands
EP2126127B1 (en) 2007-01-25 2016-09-28 Dana-Farber Cancer Institute, Inc. Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
US9283276B2 (en) 2007-08-14 2016-03-15 Ludwig Institute For Cancer Research Ltd. Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof
MX2011004625A (es) 2008-11-03 2011-07-20 Syntarga Bv Analogos cc-1065 novedosos y sus conjugados.
CA2956934C (en) 2010-04-21 2019-07-09 Syntarga B.V. Novel conjugates of cc-1065 analogs and bifunctional linkers
WO2014066400A2 (en) 2012-10-22 2014-05-01 Arnold Glazier Methods for the effective treatment of metastatic cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
AU2015205574B2 (en) 2014-01-10 2019-08-15 Byondis B.V. Method for purifying Cys-linked antibody-drug conjugates
CA2937731C (en) * 2014-01-27 2019-09-24 Pfizer Inc. Bifunctional cytotoxic agents
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
WO2016151432A1 (en) * 2015-03-20 2016-09-29 Pfizer Inc. Bifunctional cytotoxic agents containing the cti pharmacophore

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
MX9203200A (es) * 1986-12-19 1992-09-01 Upjohn Co Analogos de cc. 1065 novedosos.

Also Published As

Publication number Publication date
JP3380237B2 (ja) 2003-02-24
CA1340215C (en) 1998-12-15
DK41791A (da) 1991-03-08
WO1990002746A1 (en) 1990-03-22
DE68929275D1 (de) 2001-02-01
DK41791D0 (da) 1991-03-08
KR900701801A (ko) 1990-12-04
ATE198335T1 (de) 2001-01-15
TW217383B (cs) 1993-12-11
NO910958L (no) 1991-05-10
KR0137959B1 (ko) 1998-05-15
DK175458B1 (da) 2004-11-01
DE68929275T2 (de) 2001-05-23
FI103668B (fi) 1999-08-13
AU4192289A (en) 1990-04-02
JPH04500664A (ja) 1992-02-06
GR3035589T3 (en) 2001-06-29
LV12806A (en) 2002-03-20
US5541339A (en) 1996-07-30
NO910958D0 (no) 1991-03-11
NO303498B1 (no) 1998-07-20
AU632288B2 (en) 1992-12-24
FI103668B1 (fi) 1999-08-13
FI911193A0 (fi) 1991-03-11

Similar Documents

Publication Publication Date Title
DE68929275D1 (de) CC-1065-Analoge mit zwei CPI-Subeinheiten
ATE133181T1 (de) Dehydrodidemnin b
DK0631575T3 (da) Substituerede pyrimidiner samt deres anvendelse som fungicider
ES2075202T3 (es) Nuevas arilpiridazinas, su preparacion, su utilizacion, y medicamentos que las contienen.
TR200002616T2 (tr) Simetrik ve simetrik olmayan sübstitüe edilmiş difenil üreler kullanılarak raf kinazın inhibe edilmesi
PT653439E (pt) Oligonucleotidos e sua aplicacao
ATE112279T1 (de) Cc-1065 analoge.
TR200000152T2 (tr) Yeni bileşikler.
DK0509398T3 (da) Quinoxaliner, fremgangsmåder til deres fremstilling samt deres anvendelse
DE3774286D1 (de) (2,2-bis(aminomethyl)-1,3-propandiol-n,n')platin-komplexe.
ATE63111T1 (de) Substituierte oximether, ihre verwendung als bioregulatoren zur senkung des endogenen ethylenspiegels in pflanzen.
ES2135722T3 (es) 1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina.
ES2153814T3 (es) Analogos de cc-1065 que tienen dos subunidades cpi.
ES2061811T3 (es) Uso de compuestos de gamma-oxibutenolido conjugados para tratar ulcera.
DE3767308D1 (de) Verwendung von sulfonamidderivaten zur herstellung eines antivirusmittels.
DE3879478D1 (de) Ornithin-derivate und deren verwendung als inhibitoren von methothrexat resistenten zellen.
ES2095431T3 (es) N-(isoquinolein-5-il)-sulfonil-azacicloalcanos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DK24687A (da) 3-alkoxyflavonderivater samt antiviralt virksomme terapeutiske midler indeholdende disse
ES2037597B1 (es) Perfeccionamientos en o relacionados con compuestos organicos.
ES2083608T3 (es) Sintesis asimetrica de los compuestos furanosidos 3-sustituidos.
NO960271L (no) Tiokarbamoylforbindelser anvendt som mikrobiocider
DE3768322D1 (de) Substituierte alkynische thiocyanate, sie enthaltende biozide zusammensetzungen und deren verwendung.
ES2126015T3 (es) Uso de etofibrato y composiciones farmaceuticas que contienen etofibrato para el tratamiento de la angiopatia y la retinopatia diabeticas.
ATE3751T1 (de) Wasserloesliche polyester und polycarbonate zur verwendung als antitumorwirkstoffe.
DE60318033D1 (de) Biguanid-derivate und deren verwendung als antidiabetika